Supplementary and primary sensory motor area activity in Parkinson's disease. Regional cerebral blood flow changes during finger movements and effects of apomorphine.
Identifieur interne : 000713 ( Ncbi/Checkpoint ); précédent : 000712; suivant : 000714Supplementary and primary sensory motor area activity in Parkinson's disease. Regional cerebral blood flow changes during finger movements and effects of apomorphine.
Auteurs : O. Rascol [France] ; U. Sabatini ; F. Chollet ; P. Celsis ; J L Montastruc ; J P Marc-Vergnes ; A. RascolSource :
- Archives of neurology [ 0003-9942 ] ; 1992.
English descriptors
- KwdEn :
- Aged, Apomorphine (pharmacology), Brain Mapping, Cerebrovascular Circulation (drug effects), Female, Fingers (physiology), Humans, Male, Middle Aged, Motor Cortex (diagnostic imaging), Motor Cortex (physiopathology), Movement, Parkinson Disease (diagnostic imaging), Parkinson Disease (physiopathology), Tomography, Emission-Computed, Single-Photon.
- MESH :
- chemical , pharmacology : Apomorphine.
- diagnostic imaging : Motor Cortex, Parkinson Disease.
- drug effects : Cerebrovascular Circulation.
- physiology : Fingers.
- physiopathology : Motor Cortex, Parkinson Disease.
- Aged, Brain Mapping, Female, Humans, Male, Middle Aged, Movement, Tomography, Emission-Computed, Single-Photon.
Abstract
We have measured with single-photon emission tomography the regional cerebral blood flow changes that occurred in the supplementary motor areas and in the primary sensory motor areas during sequential finger-to-thumb opposition movements of the right hand in seven akinetic patients with Parkinson's disease and in nine normal volunteers. Parkinsonian patients were studied before ("off" condition) and after a subcutaneous injection of apomorphine hydrochloride which was able to switch them "on" (on condition). In normal volunteers and parkinsonian patients in the on condition, regional cerebral blood flow significantly increased in the supplementary motor areas and in the contralateral primary sensory motor cortex but not in the ipsilateral primary sensory motor cortex. On the contrary, no significant regional cerebral blood flow change was observed in these areas in parkinsonian patients in the off condition. These results support the hypothesis that a functional cortical motor area deafferentation is involved in the pathophysiological makeup of akinesia and that this abnormality is reversed by dopaminergic drugs.
PubMed: 1736846
Affiliations:
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Rascol</name><affiliation wicri:level="3"><nlm:affiliation>Medical and Clinical Pharmacology Service, Faculty of Medicine, Purpan University Hospital Center, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Medical and Clinical Pharmacology Service, Faculty of Medicine, Purpan University Hospital Center, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Sabatini, U" sort="Sabatini, U" uniqKey="Sabatini U" first="U" last="Sabatini">U. Sabatini</name></author><author><name sortKey="Chollet, F" sort="Chollet, F" uniqKey="Chollet F" first="F" last="Chollet">F. Chollet</name></author><author><name sortKey="Celsis, P" sort="Celsis, P" uniqKey="Celsis P" first="P" last="Celsis">P. Celsis</name></author><author><name sortKey="Montastruc, J L" sort="Montastruc, J L" uniqKey="Montastruc J" first="J L" last="Montastruc">J L Montastruc</name></author><author><name sortKey="Marc Vergnes, J P" sort="Marc Vergnes, J P" uniqKey="Marc Vergnes J" first="J P" last="Marc-Vergnes">J P Marc-Vergnes</name></author><author><name sortKey="Rascol, A" sort="Rascol, A" uniqKey="Rascol A" first="A" last="Rascol">A. Rascol</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1992">1992</date><idno type="RBID">pubmed:1736846</idno><idno type="pmid">1736846</idno><idno type="wicri:Area/PubMed/Corpus">001768</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001768</idno><idno type="wicri:Area/PubMed/Curation">001727</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001727</idno><idno type="wicri:Area/PubMed/Checkpoint">001727</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001727</idno><idno type="wicri:Area/Ncbi/Merge">000713</idno><idno type="wicri:Area/Ncbi/Curation">000713</idno><idno type="wicri:Area/Ncbi/Checkpoint">000713</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Supplementary and primary sensory motor area activity in Parkinson's disease. Regional cerebral blood flow changes during finger movements and effects of apomorphine.</title><author><name sortKey="Rascol, O" sort="Rascol, O" uniqKey="Rascol O" first="O" last="Rascol">O. Rascol</name><affiliation wicri:level="3"><nlm:affiliation>Medical and Clinical Pharmacology Service, Faculty of Medicine, Purpan University Hospital Center, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Medical and Clinical Pharmacology Service, Faculty of Medicine, Purpan University Hospital Center, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Sabatini, U" sort="Sabatini, U" uniqKey="Sabatini U" first="U" last="Sabatini">U. Sabatini</name></author><author><name sortKey="Chollet, F" sort="Chollet, F" uniqKey="Chollet F" first="F" last="Chollet">F. Chollet</name></author><author><name sortKey="Celsis, P" sort="Celsis, P" uniqKey="Celsis P" first="P" last="Celsis">P. Celsis</name></author><author><name sortKey="Montastruc, J L" sort="Montastruc, J L" uniqKey="Montastruc J" first="J L" last="Montastruc">J L Montastruc</name></author><author><name sortKey="Marc Vergnes, J P" sort="Marc Vergnes, J P" uniqKey="Marc Vergnes J" first="J P" last="Marc-Vergnes">J P Marc-Vergnes</name></author><author><name sortKey="Rascol, A" sort="Rascol, A" uniqKey="Rascol A" first="A" last="Rascol">A. Rascol</name></author></analytic><series><title level="j">Archives of neurology</title><idno type="ISSN">0003-9942</idno><imprint><date when="1992" type="published">1992</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Apomorphine (pharmacology)</term><term>Brain Mapping</term><term>Cerebrovascular Circulation (drug effects)</term><term>Female</term><term>Fingers (physiology)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Motor Cortex (diagnostic imaging)</term><term>Motor Cortex (physiopathology)</term><term>Movement</term><term>Parkinson Disease (diagnostic imaging)</term><term>Parkinson Disease (physiopathology)</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Apomorphine</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Motor Cortex</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cerebrovascular Circulation</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Fingers</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Motor Cortex</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Brain Mapping</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Movement</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We have measured with single-photon emission tomography the regional cerebral blood flow changes that occurred in the supplementary motor areas and in the primary sensory motor areas during sequential finger-to-thumb opposition movements of the right hand in seven akinetic patients with Parkinson's disease and in nine normal volunteers. Parkinsonian patients were studied before ("off" condition) and after a subcutaneous injection of apomorphine hydrochloride which was able to switch them "on" (on condition). In normal volunteers and parkinsonian patients in the on condition, regional cerebral blood flow significantly increased in the supplementary motor areas and in the contralateral primary sensory motor cortex but not in the ipsilateral primary sensory motor cortex. On the contrary, no significant regional cerebral blood flow change was observed in these areas in parkinsonian patients in the off condition. These results support the hypothesis that a functional cortical motor area deafferentation is involved in the pathophysiological makeup of akinesia and that this abnormality is reversed by dopaminergic drugs.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Midi-Pyrénées</li><li>Occitanie (région administrative)</li></region><settlement><li>Toulouse</li></settlement></list><tree><noCountry><name sortKey="Celsis, P" sort="Celsis, P" uniqKey="Celsis P" first="P" last="Celsis">P. Celsis</name><name sortKey="Chollet, F" sort="Chollet, F" uniqKey="Chollet F" first="F" last="Chollet">F. Chollet</name><name sortKey="Marc Vergnes, J P" sort="Marc Vergnes, J P" uniqKey="Marc Vergnes J" first="J P" last="Marc-Vergnes">J P Marc-Vergnes</name><name sortKey="Montastruc, J L" sort="Montastruc, J L" uniqKey="Montastruc J" first="J L" last="Montastruc">J L Montastruc</name><name sortKey="Rascol, A" sort="Rascol, A" uniqKey="Rascol A" first="A" last="Rascol">A. Rascol</name><name sortKey="Sabatini, U" sort="Sabatini, U" uniqKey="Sabatini U" first="U" last="Sabatini">U. Sabatini</name></noCountry><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Rascol, O" sort="Rascol, O" uniqKey="Rascol O" first="O" last="Rascol">O. Rascol</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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