Relationship between levodopa-independent symptoms and central atrophy evaluated by magnetic resonance imaging in Parkinson's disease
Identifieur interne : 004E34 ( Main/Curation ); précédent : 004E33; suivant : 004E35Relationship between levodopa-independent symptoms and central atrophy evaluated by magnetic resonance imaging in Parkinson's disease
Auteurs : F. Durif [France] ; P. Pollak [France] ; M. Hommel ; C. Ardouin ; J. F. Le Bas ; G. Crouzet ; J. PerretSource :
- European neurology [ 0014-3022 ] ; 1992.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Aged, Atrophia, Atrophy, Basal ganglion, Brain (vertebrata), Degenerative disease, Equilibrium disorder, Exploration, Female, Frontal Lobe (pathology), Gait disorder, Human, Humans, Levodopa (therapeutic use), Magnetic Resonance Imaging, Male, Motor system disorder, Nervous system diseases, Neurologic Examination, Nuclear magnetic resonance imaging, Parkinson Disease (diagnosis), Parkinson Disease (drug therapy), Parkinson Disease (pathology), Parkinson disease.
- MESH :
- chemical , therapeutic use : Levodopa.
- diagnosis : Parkinson Disease.
- drug therapy : Parkinson Disease.
- pathology : Frontal Lobe, Parkinson Disease.
- Aged, Atrophy, Female, Humans, Magnetic Resonance Imaging, Male, Neurologic Examination.
Abstract
Thirty patients with Parkinson's disease were studied for the purpose of investigation relations between motor symptoms and cerebral atrophy evaluated by magnetic resonance imaging (MRI). Axial symptoms (gait disorder, postural instability and difficulty in arising from a chair), assessed at the time of maximum clinical improvement, were significantly correlated with frontal atrophy, while no correlation was found between the basal parkinsonian disability score and cerebral atrophy. It is suggested that frontal atrophy observed by MRI is linked with axial motor symptoms resulting from non-dopaminergic lesions
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Pascal:92-0160305Le document en format XML
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<front><div type="abstract" xml:lang="en">Thirty patients with Parkinson's disease were studied for the purpose of investigation relations between motor symptoms and cerebral atrophy evaluated by magnetic resonance imaging (MRI). Axial symptoms (gait disorder, postural instability and difficulty in arising from a chair), assessed at the time of maximum clinical improvement, were significantly correlated with frontal atrophy, while no correlation was found between the basal parkinsonian disability score and cerebral atrophy. It is suggested that frontal atrophy observed by MRI is linked with axial motor symptoms resulting from non-dopaminergic lesions</div>
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<author><name sortKey="Le Bas, J F" sort="Le Bas, J F" uniqKey="Le Bas J" first="J F" last="Le Bas">J F Le Bas</name>
</author>
<author><name sortKey="Crouzet, G" sort="Crouzet, G" uniqKey="Crouzet G" first="G" last="Crouzet">G. Crouzet</name>
</author>
<author><name sortKey="Perret, J" sort="Perret, J" uniqKey="Perret J" first="J" last="Perret">J. Perret</name>
</author>
</analytic>
<series><title level="j">European neurology</title>
<idno type="ISSN">0014-3022</idno>
<imprint><date when="1992" type="published">1992</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Atrophy</term>
<term>Female</term>
<term>Frontal Lobe (pathology)</term>
<term>Humans</term>
<term>Levodopa (therapeutic use)</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Neurologic Examination</term>
<term>Parkinson Disease (diagnosis)</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Parkinson Disease (pathology)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Levodopa</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Frontal Lobe</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Atrophy</term>
<term>Female</term>
<term>Humans</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Neurologic Examination</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Thirty patients with Parkinson's disease were studied for the purpose of investigation relations between motor symptoms and cerebral atrophy evaluated by magnetic resonance imaging (MRI). Axial symptoms (gait disorder, postural instability and difficulty in arising from a chair), assessed at the time of maximum clinical improvement, were significantly correlated with frontal atrophy, while no correlation was found between the basal parkinsonian disability score and cerebral atrophy. It is suggested that frontal atrophy observed by MRI is linked with axial motor symptoms resulting from non-dopaminergic lesions. The origin of this atrophy is unknown.</div>
</front>
</TEI>
</PubMed>
</double>
</record>
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