ParkinsonFranceV1, Main, Curation, bibRecord, 004C56

GM-1 ganglioside promotes the recovery of surviving midbrain dopaminergic neurons in MPTP-treated monkeys

Identifieur interne : 004C56 ( Main/Curation ); précédent : 004C55; suivant : 004C57

GM-1 ganglioside promotes the recovery of surviving midbrain dopaminergic neurons in MPTP-treated monkeys

Auteurs : M. T. Herrero [France] ; I. Perez-Otano ; C. Oset ; A. Kastner [France] ; E. C. Hirsch [France] ; Yves Agid [France] ; M. R. Luquin ; J. A. Obeso ; J. Del Rio

Source :

Neuroscience [ 0306-4522 ] ; 1993.

RBID : Pascal:93-0673676

Descripteurs français

Pascal (Inist)
- Survie, Mésencéphale, Neurone dopaminergique, Neurotoxine, Parkinson maladie, Traitement, Modèle animal, Singe, Macaca fascicularis, MPTP, Ganglioside GM1.
Wicri :
- topic : Singe.

English descriptors

KwdEn :
- Animal model, Dopaminergic neuron, GM1 ganglioside, Macaca fascicularis, Midbrain, Monkey, Neurotoxin, Parkinson disease, Survival, Treatment.

Abstract

We have examined the influence of chronic GM-1 treatment (20 mg/kg i.m. for 16 consecufive days) on the extent of dopaminergic damage induced by acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration in cynomolgus monkeys using immunohistochemical and neurochemical analysis. The total number of tyrosine hydroxylase-immunoreactive neurons was reduced in different catecholaminergic mesencephalic regions of MPTP-treated monkeys such as substantia nigra pars compacta, mainly in the ventral portion of the nucleus (39% reduction), substantia nigra pars lateralis (31%), peri- and retrorubral catecholaminergic cell group and ventral tegmental area (A8 and A10 respectively, 20% reduction)

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Pascal:93-0673676

Le document en format XML

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<front><div type="abstract" xml:lang="en">We have examined the influence of chronic GM-1 treatment (20 mg/kg i.m. for 16 consecufive days) on the extent of dopaminergic damage induced by acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration in cynomolgus monkeys using immunohistochemical and neurochemical analysis. The total number of tyrosine hydroxylase-immunoreactive neurons was reduced in different catecholaminergic mesencephalic regions of MPTP-treated monkeys such as substantia nigra pars compacta, mainly in the ventral portion of the nucleus (39% reduction), substantia nigra pars lateralis (31%), peri- and retrorubral catecholaminergic cell group and ventral tegmental area (A8 and A10 respectively, 20% reduction)</div>
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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

GM-1 ganglioside promotes the recovery of surviving midbrain dopaminergic neurons in MPTP-treated monkeys

GM-1 ganglioside promotes the recovery of surviving midbrain dopaminergic neurons in MPTP-treated monkeys

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri