GM-1 ganglioside promotes the recovery of surviving midbrain dopaminergic neurons in MPTP-treated monkeys
Identifieur interne : 005663 ( Main/Merge ); précédent : 005662; suivant : 005664GM-1 ganglioside promotes the recovery of surviving midbrain dopaminergic neurons in MPTP-treated monkeys
Auteurs : M. T. Herrero [France] ; I. Perez-Otano ; C. Oset ; A. Kastner [France] ; E. C. Hirsch [France] ; Yves Agid [France] ; M. R. Luquin ; J. A. Obeso ; J. Del RioSource :
- Neuroscience [ 0306-4522 ] ; 1993.
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- Pascal (Inist)
- Wicri :
- topic : Singe.
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- KwdEn :
Abstract
We have examined the influence of chronic GM-1 treatment (20 mg/kg i.m. for 16 consecufive days) on the extent of dopaminergic damage induced by acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration in cynomolgus monkeys using immunohistochemical and neurochemical analysis. The total number of tyrosine hydroxylase-immunoreactive neurons was reduced in different catecholaminergic mesencephalic regions of MPTP-treated monkeys such as substantia nigra pars compacta, mainly in the ventral portion of the nucleus (39% reduction), substantia nigra pars lateralis (31%), peri- and retrorubral catecholaminergic cell group and ventral tegmental area (A8 and A10 respectively, 20% reduction)
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal model</term>
<term>Dopaminergic neuron</term>
<term>GM1 ganglioside</term>
<term>Macaca fascicularis</term>
<term>Midbrain</term>
<term>Monkey</term>
<term>Neurotoxin</term>
<term>Parkinson disease</term>
<term>Survival</term>
<term>Treatment</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Survie</term>
<term>Mésencéphale</term>
<term>Neurone dopaminergique</term>
<term>Neurotoxine</term>
<term>Parkinson maladie</term>
<term>Traitement</term>
<term>Modèle animal</term>
<term>Singe</term>
<term>Macaca fascicularis</term>
<term>MPTP</term>
<term>Ganglioside GM1</term>
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<front><div type="abstract" xml:lang="en">We have examined the influence of chronic GM-1 treatment (20 mg/kg i.m. for 16 consecufive days) on the extent of dopaminergic damage induced by acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration in cynomolgus monkeys using immunohistochemical and neurochemical analysis. The total number of tyrosine hydroxylase-immunoreactive neurons was reduced in different catecholaminergic mesencephalic regions of MPTP-treated monkeys such as substantia nigra pars compacta, mainly in the ventral portion of the nucleus (39% reduction), substantia nigra pars lateralis (31%), peri- and retrorubral catecholaminergic cell group and ventral tegmental area (A8 and A10 respectively, 20% reduction)</div>
</front>
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<tree><noCountry><name sortKey="Del Rio, J" sort="Del Rio, J" uniqKey="Del Rio J" first="J." last="Del Rio">J. Del Rio</name>
<name sortKey="Luquin, M R" sort="Luquin, M R" uniqKey="Luquin M" first="M. R." last="Luquin">M. R. Luquin</name>
<name sortKey="Obeso, J A" sort="Obeso, J A" uniqKey="Obeso J" first="J. A." last="Obeso">J. A. Obeso</name>
<name sortKey="Oset, C" sort="Oset, C" uniqKey="Oset C" first="C." last="Oset">C. Oset</name>
<name sortKey="Perez Otano, I" sort="Perez Otano, I" uniqKey="Perez Otano I" first="I." last="Perez-Otano">I. Perez-Otano</name>
</noCountry>
<country name="France"><region name="Île-de-France"><name sortKey="Herrero, M T" sort="Herrero, M T" uniqKey="Herrero M" first="M. T." last="Herrero">M. T. Herrero</name>
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<name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y." last="Agid">Yves Agid</name>
<name sortKey="Hirsch, E C" sort="Hirsch, E C" uniqKey="Hirsch E" first="E. C." last="Hirsch">E. C. Hirsch</name>
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