GM-1 ganglioside promotes the recovery of surviving midbrain dopaminergic neurons in MPTP-treated monkeys
Identifieur interne : 001879 ( PascalFrancis/Checkpoint ); précédent : 001878; suivant : 001880GM-1 ganglioside promotes the recovery of surviving midbrain dopaminergic neurons in MPTP-treated monkeys
Auteurs : M. T. Herrero [France] ; I. Perez-Otano ; C. Oset ; A. Kastner [France] ; E. C. Hirsch [France] ; Yves Agid [France] ; M. R. Luquin ; J. A. Obeso ; J. Del RioSource :
- Neuroscience [ 0306-4522 ] ; 1993.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Singe.
English descriptors
- KwdEn :
Abstract
We have examined the influence of chronic GM-1 treatment (20 mg/kg i.m. for 16 consecufive days) on the extent of dopaminergic damage induced by acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration in cynomolgus monkeys using immunohistochemical and neurochemical analysis. The total number of tyrosine hydroxylase-immunoreactive neurons was reduced in different catecholaminergic mesencephalic regions of MPTP-treated monkeys such as substantia nigra pars compacta, mainly in the ventral portion of the nucleus (39% reduction), substantia nigra pars lateralis (31%), peri- and retrorubral catecholaminergic cell group and ventral tegmental area (A8 and A10 respectively, 20% reduction)
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
Pascal:93-0673676Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">GM-1 ganglioside promotes the recovery of surviving midbrain dopaminergic neurons in MPTP-treated monkeys</title><author><name sortKey="Herrero, M T" sort="Herrero, M T" uniqKey="Herrero M" first="M. T." last="Herrero">M. T. Herrero</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>INSERM, U289</s1><s2>75013 Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Perez Otano, I" sort="Perez Otano, I" uniqKey="Perez Otano I" first="I." last="Perez-Otano">I. Perez-Otano</name></author><author><name sortKey="Oset, C" sort="Oset, C" uniqKey="Oset C" first="C." last="Oset">C. Oset</name></author><author><name sortKey="Kastner, A" sort="Kastner, A" uniqKey="Kastner A" first="A." last="Kastner">A. Kastner</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>INSERM, U289</s1><s2>75013 Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Hirsch, E C" sort="Hirsch, E C" uniqKey="Hirsch E" first="E. C." last="Hirsch">E. C. Hirsch</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>INSERM, U289</s1><s2>75013 Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y." last="Agid">Yves Agid</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>INSERM, U289</s1><s2>75013 Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName></affiliation></author><author><name sortKey="Luquin, M R" sort="Luquin, M R" uniqKey="Luquin M" first="M. R." last="Luquin">M. R. Luquin</name></author><author><name sortKey="Obeso, J A" sort="Obeso, J A" uniqKey="Obeso J" first="J. A." last="Obeso">J. A. Obeso</name></author><author><name sortKey="Del Rio, J" sort="Del Rio, J" uniqKey="Del Rio J" first="J." last="Del Rio">J. Del Rio</name></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">93-0673676</idno><date when="1993">1993</date><idno type="stanalyst">PASCAL 93-0673676 INIST</idno><idno type="RBID">Pascal:93-0673676</idno><idno type="wicri:Area/PascalFrancis/Corpus">001A08</idno><idno type="wicri:Area/PascalFrancis/Curation">001643</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001879</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">001879</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">GM-1 ganglioside promotes the recovery of surviving midbrain dopaminergic neurons in MPTP-treated monkeys</title><author><name sortKey="Herrero, M T" sort="Herrero, M T" uniqKey="Herrero M" first="M. T." last="Herrero">M. T. Herrero</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>INSERM, U289</s1><s2>75013 Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Perez Otano, I" sort="Perez Otano, I" uniqKey="Perez Otano I" first="I." last="Perez-Otano">I. Perez-Otano</name></author><author><name sortKey="Oset, C" sort="Oset, C" uniqKey="Oset C" first="C." last="Oset">C. Oset</name></author><author><name sortKey="Kastner, A" sort="Kastner, A" uniqKey="Kastner A" first="A." last="Kastner">A. Kastner</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>INSERM, U289</s1><s2>75013 Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Hirsch, E C" sort="Hirsch, E C" uniqKey="Hirsch E" first="E. C." last="Hirsch">E. C. Hirsch</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>INSERM, U289</s1><s2>75013 Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y." last="Agid">Yves Agid</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>INSERM, U289</s1><s2>75013 Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName></affiliation></author><author><name sortKey="Luquin, M R" sort="Luquin, M R" uniqKey="Luquin M" first="M. R." last="Luquin">M. R. Luquin</name></author><author><name sortKey="Obeso, J A" sort="Obeso, J A" uniqKey="Obeso J" first="J. A." last="Obeso">J. A. Obeso</name></author><author><name sortKey="Del Rio, J" sort="Del Rio, J" uniqKey="Del Rio J" first="J." last="Del Rio">J. Del Rio</name></author></analytic><series><title level="j" type="main">Neuroscience</title><title level="j" type="abbreviated">Neuroscience</title><idno type="ISSN">0306-4522</idno><imprint><date when="1993">1993</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Neuroscience</title><title level="j" type="abbreviated">Neuroscience</title><idno type="ISSN">0306-4522</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal model</term><term>Dopaminergic neuron</term><term>GM1 ganglioside</term><term>Macaca fascicularis</term><term>Midbrain</term><term>Monkey</term><term>Neurotoxin</term><term>Parkinson disease</term><term>Survival</term><term>Treatment</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Survie</term><term>Mésencéphale</term><term>Neurone dopaminergique</term><term>Neurotoxine</term><term>Parkinson maladie</term><term>Traitement</term><term>Modèle animal</term><term>Singe</term><term>Macaca fascicularis</term><term>MPTP</term><term>Ganglioside GM1</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Singe</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We have examined the influence of chronic GM-1 treatment (20 mg/kg i.m. for 16 consecufive days) on the extent of dopaminergic damage induced by acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration in cynomolgus monkeys using immunohistochemical and neurochemical analysis. The total number of tyrosine hydroxylase-immunoreactive neurons was reduced in different catecholaminergic mesencephalic regions of MPTP-treated monkeys such as substantia nigra pars compacta, mainly in the ventral portion of the nucleus (39% reduction), substantia nigra pars lateralis (31%), peri- and retrorubral catecholaminergic cell group and ventral tegmental area (A8 and A10 respectively, 20% reduction)</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0306-4522</s0></fA01><fA02 i1="01"><s0>NRSCDN</s0></fA02><fA03 i2="1"><s0>Neuroscience</s0></fA03><fA05><s2>56</s2></fA05><fA06><s2>4</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>GM-1 ganglioside promotes the recovery of surviving midbrain dopaminergic neurons in MPTP-treated monkeys</s1></fA08><fA11 i1="01" i2="1"><s1>HERRERO (M. T.)</s1></fA11><fA11 i1="02" i2="1"><s1>PEREZ-OTANO (I.)</s1></fA11><fA11 i1="03" i2="1"><s1>OSET (C.)</s1></fA11><fA11 i1="04" i2="1"><s1>KASTNER (A.)</s1></fA11><fA11 i1="05" i2="1"><s1>HIRSCH (E. C.)</s1></fA11><fA11 i1="06" i2="1"><s1>AGID (Y.)</s1></fA11><fA11 i1="07" i2="1"><s1>LUQUIN (M. R.)</s1></fA11><fA11 i1="08" i2="1"><s1>OBESO (J. A.)</s1></fA11><fA11 i1="09" i2="1"><s1>DEL RIO (J.)</s1></fA11><fA14 i1="01"><s1>INSERM, U289</s1><s2>75013 Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></fA14><fA20><s1>965-972</s1></fA20><fA21><s1>1993</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>17194</s2><s5>354000048190180160</s5></fA43><fA44><s0>0000</s0></fA44><fA45><s0>42 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>93-0673676</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i2="1"><s0>Neuroscience</s0></fA64><fA66 i1="01"><s0>GBR</s0></fA66><fC01 i1="01" l="ENG"><s0>We have examined the influence of chronic GM-1 treatment (20 mg/kg i.m. for 16 consecufive days) on the extent of dopaminergic damage induced by acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration in cynomolgus monkeys using immunohistochemical and neurochemical analysis. The total number of tyrosine hydroxylase-immunoreactive neurons was reduced in different catecholaminergic mesencephalic regions of MPTP-treated monkeys such as substantia nigra pars compacta, mainly in the ventral portion of the nucleus (39% reduction), substantia nigra pars lateralis (31%), peri- and retrorubral catecholaminergic cell group and ventral tegmental area (A8 and A10 respectively, 20% reduction)</s0></fC01><fC02 i1="01" i2="X"><s0>002B17B</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Survie</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Survival</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Sobrevivencia</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Mésencéphale</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Midbrain</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Mesencéfalo</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Neurone dopaminergique</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Dopaminergic neuron</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Neurona dopaminérgica</s0><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Neurotoxine</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Neurotoxin</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Neurotoxina</s0><s5>04</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Parkinson maladie</s0><s2>NM</s2><s5>05</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Parkinson disease</s0><s2>NM</s2><s5>05</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Parkinson enfermedad</s0><s2>NM</s2><s5>05</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Traitement</s0><s5>06</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Treatment</s0><s5>06</s5></fC03><fC03 i1="06" i2="X" l="GER"><s0>Aufbereiten</s0><s5>06</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Tratamiento</s0><s5>06</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Modèle animal</s0><s5>10</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Animal model</s0><s5>10</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Modelo animal</s0><s5>10</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Singe</s0><s5>53</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Monkey</s0><s5>53</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Mono</s0><s5>53</s5></fC03><fC03 i1="09" i2="X" l="FRE"><s0>Macaca fascicularis</s0><s2>NS</s2><s5>54</s5></fC03><fC03 i1="09" i2="X" l="ENG"><s0>Macaca fascicularis</s0><s2>NS</s2><s5>54</s5></fC03><fC03 i1="09" i2="X" l="SPA"><s0>Macaca fascicularis</s0><s2>NS</s2><s5>54</s5></fC03><fC03 i1="10" i2="X" l="FRE"><s0>MPTP</s0><s4>INC</s4><s5>86</s5></fC03><fC03 i1="11" i2="X" l="FRE"><s0>Ganglioside GM1</s0><s4>CD</s4><s5>96</s5></fC03><fC03 i1="11" i2="X" l="ENG"><s0>GM1 ganglioside</s0><s4>CD</s4><s5>96</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Système nerveux central</s0><s5>20</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Central nervous system</s0><s5>20</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Sistema nervioso central</s0><s5>20</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>29</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>29</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>29</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Système nerveux pathologie</s0><s5>30</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>30</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>30</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Primates</s0><s2>NS</s2></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Primates</s0><s2>NS</s2></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Primates</s0><s2>NS</s2></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Mammalia</s0><s2>NS</s2></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Mammalia</s0><s2>NS</s2></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Mammalia</s0><s2>NS</s2></fC07><fC07 i1="06" i2="X" l="FRE"><s0>Vertebrata</s0><s2>NS</s2></fC07><fC07 i1="06" i2="X" l="ENG"><s0>Vertebrata</s0><s2>NS</s2></fC07><fC07 i1="06" i2="X" l="SPA"><s0>Vertebrata</s0><s2>NS</s2></fC07><fC07 i1="07" i2="X" l="FRE"><s0>Simioidea</s0><s2>NS</s2></fC07><fC07 i1="07" i2="X" l="ENG"><s0>Simioidea</s0><s2>NS</s2></fC07><fC07 i1="07" i2="X" l="SPA"><s0>Simioidea</s0><s2>NS</s2></fC07><fN21><s1>342</s1></fN21></pA></standard></inist><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement><orgName><li>Hôpital de la Salpêtrière</li></orgName></list><tree><noCountry><name sortKey="Del Rio, J" sort="Del Rio, J" uniqKey="Del Rio J" first="J." last="Del Rio">J. Del Rio</name><name sortKey="Luquin, M R" sort="Luquin, M R" uniqKey="Luquin M" first="M. R." last="Luquin">M. R. Luquin</name><name sortKey="Obeso, J A" sort="Obeso, J A" uniqKey="Obeso J" first="J. A." last="Obeso">J. A. Obeso</name><name sortKey="Oset, C" sort="Oset, C" uniqKey="Oset C" first="C." last="Oset">C. Oset</name><name sortKey="Perez Otano, I" sort="Perez Otano, I" uniqKey="Perez Otano I" first="I." last="Perez-Otano">I. Perez-Otano</name></noCountry><country name="France"><region name="Île-de-France"><name sortKey="Herrero, M T" sort="Herrero, M T" uniqKey="Herrero M" first="M. T." last="Herrero">M. T. Herrero</name></region><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y." last="Agid">Yves Agid</name><name sortKey="Hirsch, E C" sort="Hirsch, E C" uniqKey="Hirsch E" first="E. C." last="Hirsch">E. C. Hirsch</name><name sortKey="Kastner, A" sort="Kastner, A" uniqKey="Kastner A" first="A." last="Kastner">A. Kastner</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/PascalFrancis/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001879 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PascalFrancis/Checkpoint/biblio.hfd -nk 001879 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= PascalFrancis
|étape= Checkpoint
|type= RBID
|clé= Pascal:93-0673676
|texte= GM-1 ganglioside promotes the recovery of surviving midbrain dopaminergic neurons in MPTP-treated monkeys
}}
| This area was generated with Dilib version V0.6.29. |  |