Effects of complete and partial lesions of the dopaminergic mesotelencephalic system on skilled forelimb use in the rat
Identifieur interne : 004824 ( Main/Curation ); précédent : 004823; suivant : 004825Effects of complete and partial lesions of the dopaminergic mesotelencephalic system on skilled forelimb use in the rat
Auteurs : P. Barnéoud [France] ; S. Parmentier [France] ; M. Mazadier [France] ; J. M. Miquet [France] ; A. Boireau [France] ; P. Dubédat [France] ; J.-C. Blanchard [France]Source :
- Neuroscience [ 0306-4522 ] ; 1995.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- 6-OHDA, Animal model, Animals, Apomorphine (pharmacology), Behavior, Animal, Body movement, Brain (vertebrata), DA, Disease Models, Animal, Dopamine, Dopamine (metabolism), EDTA, Forelimb, Forelimb (physiology), HVA, Lesion, Parkinson Disease, Parkinson disease, Rat, Rats, Rats, Inbred Strains, Rotation, SH.
- MESH :
- chemical , metabolism : Dopamine.
- chemical , pharmacology : Apomorphine.
- physiology : Forelimb.
- Animals, Behavior, Animal, Disease Models, Animal, Parkinson Disease, Rats, Rats, Inbred Strains, Rotation.
Abstract
Abstract: This study compares certain behavioural consequences of partial and complete unilateral lesions of the dopaminergic mesotelencephalic system. We investigated skilled forelimb use, rotations induced by apomorphine and amphetamine, and dopaminergic metabolism of the nigrostriatal system of rats that had received a unilateral injection of 6-hydroxydopamine into the medial forebrain bundle. The rats classified Apo(+), that rotated after the administrations of apomorphine, had a complete lesion of the nigrostriatal system, whereas those classified Apo(−), that did not rotate after the administration of apomorphine, had a partial lesion of the nigrostriatal system. In the Apo(+) rats, 99.8% of the dopamine in the striatum was depleted, as was 85% of that in the substantia nigra. For the Apo(−) rats, 72% of the dopamine in the striatum was depleted as was 56% of that in the substantia nigra. When investigated with the staircase test, the animals with the most severe dopamine depletions were those most impaired in the paw reaching task. Complete and partial unilateral depletions of the dopaminergic mesotelencephalic system impaired the heirarhic phases of paw reaching differently. A complete dopamine depletion, but not a partial one, decreased the number of attempts made with the contralateral paw, and induced a bias towards the ipsilateral paw. A partial dopamine lesion impaired the sensorimotor co-ordination of both paws, whereas the complete dopamine lesion had a greater effect on the contralateral paw than on the ipsilateral paw.The mild paw reaching impairments observed in animals with moderate depletions of dopamine are proposed as a model of the early symptoms of Parkinson's disease that may be useful for the development of protective or restorative therapies.
Url:
DOI: 10.1016/0306-4522(95)00112-V
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We investigated skilled forelimb use, rotations induced by apomorphine and amphetamine, and dopaminergic metabolism of the nigrostriatal system of rats that had received a unilateral injection of 6-hydroxydopamine into the medial forebrain bundle. The rats classified Apo(+), that rotated after the administrations of apomorphine, had a complete lesion of the nigrostriatal system, whereas those classified Apo(−), that did not rotate after the administration of apomorphine, had a partial lesion of the nigrostriatal system. In the Apo(+) rats, 99.8% of the dopamine in the striatum was depleted, as was 85% of that in the substantia nigra. For the Apo(−) rats, 72% of the dopamine in the striatum was depleted as was 56% of that in the substantia nigra. When investigated with the staircase test, the animals with the most severe dopamine depletions were those most impaired in the paw reaching task. Complete and partial unilateral depletions of the dopaminergic mesotelencephalic system impaired the heirarhic phases of paw reaching differently. A complete dopamine depletion, but not a partial one, decreased the number of attempts made with the contralateral paw, and induced a bias towards the ipsilateral paw. A partial dopamine lesion impaired the sensorimotor co-ordination of both paws, whereas the complete dopamine lesion had a greater effect on the contralateral paw than on the ipsilateral paw.The mild paw reaching impairments observed in animals with moderate depletions of dopamine are proposed as a model of the early symptoms of Parkinson's disease that may be useful for the development of protective or restorative therapies.</div></front></TEI><double idat="0306-4522:1995:Barneoud P:effects:of:complete"><INIST><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Effects of complete and partial lesions of the dopaminergic mesotelencephalic system on skilled forelimb use in the rat</title><author><name sortKey="Barneoud, P" sort="Barneoud, P" uniqKey="Barneoud P" first="P." last="Barneoud">P. Barneoud</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Rhône-Poulenc Rorer SA, cent. rech. Vitry-Alfortville, dép. biologie</s1><s2>94403 Vitry-sur-Seine</s2><s3>FRA</s3></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Vitry-sur-Seine</settlement></placeName></affiliation></author><author><name sortKey="Parmentier, S" sort="Parmentier, S" uniqKey="Parmentier S" first="S." last="Parmentier">S. Parmentier</name></author><author><name sortKey="Mazadier, M" sort="Mazadier, M" uniqKey="Mazadier M" first="M." last="Mazadier">M. Mazadier</name></author><author><name sortKey="Miquet, J M" sort="Miquet, J M" uniqKey="Miquet J" first="J. M." last="Miquet">J. M. Miquet</name></author><author><name sortKey="Boireau, A" sort="Boireau, A" uniqKey="Boireau A" first="A." last="Boireau">A. Boireau</name></author><author><name sortKey="Dubedat, P" sort="Dubedat, P" uniqKey="Dubedat P" first="P." last="Dubedat">P. Dubedat</name></author><author><name sortKey="Blanchard, J C" sort="Blanchard, J C" uniqKey="Blanchard J" first="J.-C." last="Blanchard">J.-C. Blanchard</name></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">95-0399725</idno><date when="1995">1995</date><idno type="stanalyst">PASCAL 95-0399725 INIST</idno><idno type="RBID">Pascal:95-0399725</idno><idno type="wicri:Area/PascalFrancis/Corpus">001878</idno><idno type="wicri:Area/PascalFrancis/Curation">001769</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001728</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">001728</idno><idno type="wicri:doubleKey">0306-4522:1995:Barneoud P:effects:of:complete</idno><idno type="wicri:Area/Main/Merge">005209</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Effects of complete and partial lesions of the dopaminergic mesotelencephalic system on skilled forelimb use in the rat</title><author><name sortKey="Barneoud, P" sort="Barneoud, P" uniqKey="Barneoud P" first="P." last="Barneoud">P. Barneoud</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Rhône-Poulenc Rorer SA, cent. rech. Vitry-Alfortville, dép. biologie</s1><s2>94403 Vitry-sur-Seine</s2><s3>FRA</s3></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Vitry-sur-Seine</settlement></placeName></affiliation></author><author><name sortKey="Parmentier, S" sort="Parmentier, S" uniqKey="Parmentier S" first="S." last="Parmentier">S. Parmentier</name></author><author><name sortKey="Mazadier, M" sort="Mazadier, M" uniqKey="Mazadier M" first="M." last="Mazadier">M. Mazadier</name></author><author><name sortKey="Miquet, J M" sort="Miquet, J M" uniqKey="Miquet J" first="J. M." last="Miquet">J. M. Miquet</name></author><author><name sortKey="Boireau, A" sort="Boireau, A" uniqKey="Boireau A" first="A." last="Boireau">A. Boireau</name></author><author><name sortKey="Dubedat, P" sort="Dubedat, P" uniqKey="Dubedat P" first="P." last="Dubedat">P. Dubedat</name></author><author><name sortKey="Blanchard, J C" sort="Blanchard, J C" uniqKey="Blanchard J" first="J.-C." last="Blanchard">J.-C. Blanchard</name></author></analytic><series><title level="j" type="main">Neuroscience</title><title level="j" type="abbreviated">Neuroscience</title><idno type="ISSN">0306-4522</idno><imprint><date when="1995">1995</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Neuroscience</title><title level="j" type="abbreviated">Neuroscience</title><idno type="ISSN">0306-4522</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal model</term><term>Body movement</term><term>Brain (vertebrata)</term><term>Dopamine</term><term>Forelimb</term><term>Lesion</term><term>Parkinson disease</term><term>Rat</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Modèle animal</term><term>Lésion</term><term>Dopamine</term><term>Encéphale</term><term>Membre thoracique</term><term>Mouvement corporel</term><term>Parkinson maladie</term><term>Rat</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study compares certain behavioural consequences of partial and complete unilateral lesions of the dopaminergic mesotelencephalic system. We investigated skilled forelimb use, rotations induced by apomorphine and amphetamine, and dopaminergic metabolism of the nigrostriatal system of rats that had received a unilateral injection of 6-hydroxydopamine into the medial forebrain bundle. The rats classified Apo(+), that rotated after the administration of apomorphine, had a complete lesion of the nigrostriatal system, whereas those classified Apo(-), that did not rotate after the administration of apomorphine, had a partial lesion of the nigrostriatal system. In the Apo(+) rats, 99.8% of the dopamine in the striatum was depleted, as was 85% of that in the substantia nigra. For the Apo( -) rats, 72% of the dopamine in the striatum was depleted as was 56% of that in the substantia nigra. When investigated with the staircase test, the animals with the most severe dopamine depletions were those most impaired in the paw reaching task. Complete and partial unilateral depletions of the dopaminergic mesotelencephalic system impaired the hierarchic phases of paw reaching differently. A complete dopamine depletion, but not a partial one, decreased the number of attempts made with the contralateral paw, and induced a bias towards the ipsilateral paw. A partial dopamine lesion impaired the sensorimotor co-ordination of both paws, whereas the complete dopamine lesion had a greater effect on the contralateral paw than on the ipsilateral paw. The mild paw reaching impairments observed in animals with moderate depletions of dopamine are proposed as a model of the early symptoms of Parkinson's disease that may be useful for the development of protective or restorative therapies.</div></front></TEI></INIST><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effects of complete and partial lesions of the dopaminergic mesotelencephalic system on skilled forelimb use in the rat</title><author><name sortKey="Barneoud, P" sort="Barneoud, P" uniqKey="Barneoud P" first="P." last="Barnéoud">P. Barnéoud</name></author><author><name sortKey="Parmentier, S" sort="Parmentier, S" uniqKey="Parmentier S" first="S." last="Parmentier">S. Parmentier</name></author><author><name sortKey="Mazadier, M" sort="Mazadier, M" uniqKey="Mazadier M" first="M." last="Mazadier">M. Mazadier</name></author><author><name sortKey="Miquet, J M" sort="Miquet, J M" uniqKey="Miquet J" first="J. M." last="Miquet">J. M. Miquet</name></author><author><name sortKey="Boireau, A" sort="Boireau, A" uniqKey="Boireau A" first="A." last="Boireau">A. Boireau</name></author><author><name sortKey="Dubedat, P" sort="Dubedat, P" uniqKey="Dubedat P" first="P." last="Dubédat">P. Dubédat</name></author><author><name sortKey="Blanchard, J C" sort="Blanchard, J C" uniqKey="Blanchard J" first="J.-C." last="Blanchard">J.-C. Blanchard</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:88F30D08C9B0F050F665BCBA52C0A90643D2405A</idno><date when="1995" year="1995">1995</date><idno type="doi">10.1016/0306-4522(95)00112-V</idno><idno type="url">https://api.istex.fr/document/88F30D08C9B0F050F665BCBA52C0A90643D2405A/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001165</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001165</idno><idno type="wicri:Area/Istex/Curation">001163</idno><idno type="wicri:Area/Istex/Checkpoint">001945</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001945</idno><idno type="wicri:doubleKey">0306-4522:1995:Barneoud P:effects:of:complete</idno><idno type="wicri:Area/Main/Merge">005134</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Effects of complete and partial lesions of the dopaminergic mesotelencephalic system on skilled forelimb use in the rat</title><author><name sortKey="Barneoud, P" sort="Barneoud, P" uniqKey="Barneoud P" first="P." last="Barnéoud">P. Barnéoud</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Rhoˆne-Poulenc Rorer S.A., Centre de Recherches de Vitry-Alfortville, Département de Biologie, 13 quai Jules Guesde, F-94403, Vitry-sur-Seine Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Vitry-sur-Seine</settlement></placeName></affiliation></author><author><name sortKey="Parmentier, S" sort="Parmentier, S" uniqKey="Parmentier S" first="S." last="Parmentier">S. Parmentier</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Rhoˆne-Poulenc Rorer S.A., Centre de Recherches de Vitry-Alfortville, Département de Biologie, 13 quai Jules Guesde, F-94403, Vitry-sur-Seine Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Vitry-sur-Seine</settlement></placeName></affiliation></author><author><name sortKey="Mazadier, M" sort="Mazadier, M" uniqKey="Mazadier M" first="M." last="Mazadier">M. Mazadier</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Rhoˆne-Poulenc Rorer S.A., Centre de Recherches de Vitry-Alfortville, Département de Biologie, 13 quai Jules Guesde, F-94403, Vitry-sur-Seine Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Vitry-sur-Seine</settlement></placeName></affiliation></author><author><name sortKey="Miquet, J M" sort="Miquet, J M" uniqKey="Miquet J" first="J. M." last="Miquet">J. M. Miquet</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Rhoˆne-Poulenc Rorer S.A., Centre de Recherches de Vitry-Alfortville, Département de Biologie, 13 quai Jules Guesde, F-94403, Vitry-sur-Seine Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Vitry-sur-Seine</settlement></placeName></affiliation></author><author><name sortKey="Boireau, A" sort="Boireau, A" uniqKey="Boireau A" first="A." last="Boireau">A. Boireau</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Rhoˆne-Poulenc Rorer S.A., Centre de Recherches de Vitry-Alfortville, Département de Biologie, 13 quai Jules Guesde, F-94403, Vitry-sur-Seine Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Vitry-sur-Seine</settlement></placeName></affiliation></author><author><name sortKey="Dubedat, P" sort="Dubedat, P" uniqKey="Dubedat P" first="P." last="Dubédat">P. Dubédat</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Rhoˆne-Poulenc Rorer S.A., Centre de Recherches de Vitry-Alfortville, Département de Biologie, 13 quai Jules Guesde, F-94403, Vitry-sur-Seine Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Vitry-sur-Seine</settlement></placeName></affiliation></author><author><name sortKey="Blanchard, J C" sort="Blanchard, J C" uniqKey="Blanchard J" first="J.-C." last="Blanchard">J.-C. Blanchard</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Rhoˆne-Poulenc Rorer S.A., Centre de Recherches de Vitry-Alfortville, Département de Biologie, 13 quai Jules Guesde, F-94403, Vitry-sur-Seine Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Vitry-sur-Seine</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Neuroscience</title><title level="j" type="abbrev">NSC</title><idno type="ISSN">0306-4522</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1995">1995</date><biblScope unit="volume">67</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="837">837</biblScope><biblScope unit="page" to="848">848</biblScope></imprint><idno type="ISSN">0306-4522</idno></series><idno type="istex">88F30D08C9B0F050F665BCBA52C0A90643D2405A</idno><idno type="DOI">10.1016/0306-4522(95)00112-V</idno><idno type="PII">0306-4522(95)00112-V</idno><idno type="ArticleID">9500112V</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0306-4522</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>6-OHDA</term><term>DA</term><term>EDTA</term><term>HVA</term><term>SH</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: This study compares certain behavioural consequences of partial and complete unilateral lesions of the dopaminergic mesotelencephalic system. We investigated skilled forelimb use, rotations induced by apomorphine and amphetamine, and dopaminergic metabolism of the nigrostriatal system of rats that had received a unilateral injection of 6-hydroxydopamine into the medial forebrain bundle. The rats classified Apo(+), that rotated after the administrations of apomorphine, had a complete lesion of the nigrostriatal system, whereas those classified Apo(−), that did not rotate after the administration of apomorphine, had a partial lesion of the nigrostriatal system. In the Apo(+) rats, 99.8% of the dopamine in the striatum was depleted, as was 85% of that in the substantia nigra. For the Apo(−) rats, 72% of the dopamine in the striatum was depleted as was 56% of that in the substantia nigra. When investigated with the staircase test, the animals with the most severe dopamine depletions were those most impaired in the paw reaching task. Complete and partial unilateral depletions of the dopaminergic mesotelencephalic system impaired the heirarhic phases of paw reaching differently. A complete dopamine depletion, but not a partial one, decreased the number of attempts made with the contralateral paw, and induced a bias towards the ipsilateral paw. A partial dopamine lesion impaired the sensorimotor co-ordination of both paws, whereas the complete dopamine lesion had a greater effect on the contralateral paw than on the ipsilateral paw.The mild paw reaching impairments observed in animals with moderate depletions of dopamine are proposed as a model of the early symptoms of Parkinson's disease that may be useful for the development of protective or restorative therapies.</div></front></TEI></ISTEX><PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effects of complete and partial lesions of the dopaminergic mesotelencephalic system on skilled forelimb use in the rat.</title><author><name sortKey="Barneoud, P" sort="Barneoud, P" uniqKey="Barneoud P" first="P" last="Barnéoud">P. Barnéoud</name><affiliation wicri:level="1"><nlm:affiliation>Rhône-Poulenc Rorer S.A., Département de Biologie, Vitry-sur-Seine, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Rhône-Poulenc Rorer S.A., Département de Biologie, Vitry-sur-Seine</wicri:regionArea><wicri:noRegion>Vitry-sur-Seine</wicri:noRegion><wicri:noRegion>Vitry-sur-Seine</wicri:noRegion></affiliation></author><author><name sortKey="Parmentier, S" sort="Parmentier, S" uniqKey="Parmentier S" first="S" last="Parmentier">S. Parmentier</name></author><author><name sortKey="Mazadier, M" sort="Mazadier, M" uniqKey="Mazadier M" first="M" last="Mazadier">M. Mazadier</name></author><author><name sortKey="Miquet, J M" sort="Miquet, J M" uniqKey="Miquet J" first="J M" last="Miquet">J M Miquet</name></author><author><name sortKey="Boireau, A" sort="Boireau, A" uniqKey="Boireau A" first="A" last="Boireau">A. Boireau</name></author><author><name sortKey="Dubedat, P" sort="Dubedat, P" uniqKey="Dubedat P" first="P" last="Dubédat">P. Dubédat</name></author><author><name sortKey="Blanchard, J C" sort="Blanchard, J C" uniqKey="Blanchard J" first="J C" last="Blanchard">J C Blanchard</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1995">1995</date><idno type="RBID">pubmed:7675209</idno><idno type="pmid">7675209</idno><idno type="wicri:Area/PubMed/Corpus">001624</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001624</idno><idno type="wicri:Area/PubMed/Curation">001583</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001583</idno><idno type="wicri:Area/PubMed/Checkpoint">001583</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001583</idno><idno type="wicri:Area/Ncbi/Merge">001C70</idno><idno type="wicri:Area/Ncbi/Curation">001C70</idno><idno type="wicri:Area/Ncbi/Checkpoint">001C70</idno><idno type="wicri:doubleKey">0306-4522:1995:Barneoud P:effects:of:complete</idno><idno type="wicri:Area/Main/Merge">004F98</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Effects of complete and partial lesions of the dopaminergic mesotelencephalic system on skilled forelimb use in the rat.</title><author><name sortKey="Barneoud, P" sort="Barneoud, P" uniqKey="Barneoud P" first="P" last="Barnéoud">P. Barnéoud</name><affiliation wicri:level="1"><nlm:affiliation>Rhône-Poulenc Rorer S.A., Département de Biologie, Vitry-sur-Seine, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Rhône-Poulenc Rorer S.A., Département de Biologie, Vitry-sur-Seine</wicri:regionArea><wicri:noRegion>Vitry-sur-Seine</wicri:noRegion><wicri:noRegion>Vitry-sur-Seine</wicri:noRegion></affiliation></author><author><name sortKey="Parmentier, S" sort="Parmentier, S" uniqKey="Parmentier S" first="S" last="Parmentier">S. Parmentier</name></author><author><name sortKey="Mazadier, M" sort="Mazadier, M" uniqKey="Mazadier M" first="M" last="Mazadier">M. Mazadier</name></author><author><name sortKey="Miquet, J M" sort="Miquet, J M" uniqKey="Miquet J" first="J M" last="Miquet">J M Miquet</name></author><author><name sortKey="Boireau, A" sort="Boireau, A" uniqKey="Boireau A" first="A" last="Boireau">A. Boireau</name></author><author><name sortKey="Dubedat, P" sort="Dubedat, P" uniqKey="Dubedat P" first="P" last="Dubédat">P. Dubédat</name></author><author><name sortKey="Blanchard, J C" sort="Blanchard, J C" uniqKey="Blanchard J" first="J C" last="Blanchard">J C Blanchard</name></author></analytic><series><title level="j">Neuroscience</title><idno type="ISSN">0306-4522</idno><imprint><date when="1995" type="published">1995</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Apomorphine (pharmacology)</term><term>Behavior, Animal</term><term>Disease Models, Animal</term><term>Dopamine (metabolism)</term><term>Forelimb (physiology)</term><term>Parkinson Disease</term><term>Rats</term><term>Rats, Inbred Strains</term><term>Rotation</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Apomorphine</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Forelimb</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Behavior, Animal</term><term>Disease Models, Animal</term><term>Parkinson Disease</term><term>Rats</term><term>Rats, Inbred Strains</term><term>Rotation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study compares certain behavioural consequences of partial and complete unilateral lesions of the dopaminergic mesotelencephalic system. We investigated skilled forelimb use, rotations induced by apomorphine and amphetamine, and dopaminergic metabolism of the nigrostriatal system of rats that had received a unilateral injection of 6-hydroxydopamine into the medial forebrain bundle. The rats classified Apo(+), that rotated after the administration of apomorphine, had a complete lesion of the nigrostriatal system, whereas those classified Apo(-), that did not rotate after the administration of apomorphine, had a partial lesion of the nigrostriatal system. In the Apo(+) rats, 99.8% of the dopamine in the striatum was depleted, as was 85% of that in the substantia nigra. For the Apo(-) rats, 72% of the dopamine in the striatum was depleted as was 56% of that in the substantia nigra. When investigated with the staircase test, the animals with the most severe dopamine depletions were those most impaired in the paw reaching task. Complete and partial unilateral depletions of the dopaminergic mesotelencephalic system impaired the hierarchic phases of paw reaching differently. A complete dopamine depletion, but not a partial one, decreased the number of attempts made with the contralateral paw, and induced a bias towards the ipsilateral paw. A partial dopamine lesion impaired the sensorimotor co-ordination of both paws, whereas the complete dopamine lesion had a greater effect on the contralateral paw than on the ipsilateral paw. The mild paw reaching impairments observed in animals with moderate depletions of dopamine are proposed as a model of the early symptoms of Parkinson's disease that may be useful for the development of protective or restorative therapies.</div></front></TEI></PubMed></double></record>Pour manipuler ce document sous Unix (Dilib)
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