Effects of complete and partial lesions of the dopaminergic mesotelencephalic system on skilled forelimb use in the rat.
Identifieur interne : 001C70 ( Ncbi/Curation ); précédent : 001C69; suivant : 001C71Effects of complete and partial lesions of the dopaminergic mesotelencephalic system on skilled forelimb use in the rat.
Auteurs : P. Barnéoud [France] ; S. Parmentier ; M. Mazadier ; J M Miquet ; A. Boireau ; P. Dubédat ; J C BlanchardSource :
- Neuroscience [ 0306-4522 ] ; 1995.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Dopamine.
- chemical , pharmacology : Apomorphine.
- physiology : Forelimb.
- Animals, Behavior, Animal, Disease Models, Animal, Parkinson Disease, Rats, Rats, Inbred Strains, Rotation.
Abstract
This study compares certain behavioural consequences of partial and complete unilateral lesions of the dopaminergic mesotelencephalic system. We investigated skilled forelimb use, rotations induced by apomorphine and amphetamine, and dopaminergic metabolism of the nigrostriatal system of rats that had received a unilateral injection of 6-hydroxydopamine into the medial forebrain bundle. The rats classified Apo(+), that rotated after the administration of apomorphine, had a complete lesion of the nigrostriatal system, whereas those classified Apo(-), that did not rotate after the administration of apomorphine, had a partial lesion of the nigrostriatal system. In the Apo(+) rats, 99.8% of the dopamine in the striatum was depleted, as was 85% of that in the substantia nigra. For the Apo(-) rats, 72% of the dopamine in the striatum was depleted as was 56% of that in the substantia nigra. When investigated with the staircase test, the animals with the most severe dopamine depletions were those most impaired in the paw reaching task. Complete and partial unilateral depletions of the dopaminergic mesotelencephalic system impaired the hierarchic phases of paw reaching differently. A complete dopamine depletion, but not a partial one, decreased the number of attempts made with the contralateral paw, and induced a bias towards the ipsilateral paw. A partial dopamine lesion impaired the sensorimotor co-ordination of both paws, whereas the complete dopamine lesion had a greater effect on the contralateral paw than on the ipsilateral paw. The mild paw reaching impairments observed in animals with moderate depletions of dopamine are proposed as a model of the early symptoms of Parkinson's disease that may be useful for the development of protective or restorative therapies.
PubMed: 7675209
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001624
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :001583
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001583
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :001C70
Links to Exploration step
pubmed:7675209Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effects of complete and partial lesions of the dopaminergic mesotelencephalic system on skilled forelimb use in the rat.</title>
<author><name sortKey="Barneoud, P" sort="Barneoud, P" uniqKey="Barneoud P" first="P" last="Barnéoud">P. Barnéoud</name>
<affiliation wicri:level="1"><nlm:affiliation>Rhône-Poulenc Rorer S.A., Département de Biologie, Vitry-sur-Seine, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Rhône-Poulenc Rorer S.A., Département de Biologie, Vitry-sur-Seine</wicri:regionArea>
<wicri:noRegion>Vitry-sur-Seine</wicri:noRegion>
<wicri:noRegion>Vitry-sur-Seine</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Parmentier, S" sort="Parmentier, S" uniqKey="Parmentier S" first="S" last="Parmentier">S. Parmentier</name>
</author>
<author><name sortKey="Mazadier, M" sort="Mazadier, M" uniqKey="Mazadier M" first="M" last="Mazadier">M. Mazadier</name>
</author>
<author><name sortKey="Miquet, J M" sort="Miquet, J M" uniqKey="Miquet J" first="J M" last="Miquet">J M Miquet</name>
</author>
<author><name sortKey="Boireau, A" sort="Boireau, A" uniqKey="Boireau A" first="A" last="Boireau">A. Boireau</name>
</author>
<author><name sortKey="Dubedat, P" sort="Dubedat, P" uniqKey="Dubedat P" first="P" last="Dubédat">P. Dubédat</name>
</author>
<author><name sortKey="Blanchard, J C" sort="Blanchard, J C" uniqKey="Blanchard J" first="J C" last="Blanchard">J C Blanchard</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="1995">1995</date>
<idno type="RBID">pubmed:7675209</idno>
<idno type="pmid">7675209</idno>
<idno type="wicri:Area/PubMed/Corpus">001624</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001624</idno>
<idno type="wicri:Area/PubMed/Curation">001583</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001583</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001583</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001583</idno>
<idno type="wicri:Area/Ncbi/Merge">001C70</idno>
<idno type="wicri:Area/Ncbi/Curation">001C70</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Effects of complete and partial lesions of the dopaminergic mesotelencephalic system on skilled forelimb use in the rat.</title>
<author><name sortKey="Barneoud, P" sort="Barneoud, P" uniqKey="Barneoud P" first="P" last="Barnéoud">P. Barnéoud</name>
<affiliation wicri:level="1"><nlm:affiliation>Rhône-Poulenc Rorer S.A., Département de Biologie, Vitry-sur-Seine, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Rhône-Poulenc Rorer S.A., Département de Biologie, Vitry-sur-Seine</wicri:regionArea>
<wicri:noRegion>Vitry-sur-Seine</wicri:noRegion>
<wicri:noRegion>Vitry-sur-Seine</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Parmentier, S" sort="Parmentier, S" uniqKey="Parmentier S" first="S" last="Parmentier">S. Parmentier</name>
</author>
<author><name sortKey="Mazadier, M" sort="Mazadier, M" uniqKey="Mazadier M" first="M" last="Mazadier">M. Mazadier</name>
</author>
<author><name sortKey="Miquet, J M" sort="Miquet, J M" uniqKey="Miquet J" first="J M" last="Miquet">J M Miquet</name>
</author>
<author><name sortKey="Boireau, A" sort="Boireau, A" uniqKey="Boireau A" first="A" last="Boireau">A. Boireau</name>
</author>
<author><name sortKey="Dubedat, P" sort="Dubedat, P" uniqKey="Dubedat P" first="P" last="Dubédat">P. Dubédat</name>
</author>
<author><name sortKey="Blanchard, J C" sort="Blanchard, J C" uniqKey="Blanchard J" first="J C" last="Blanchard">J C Blanchard</name>
</author>
</analytic>
<series><title level="j">Neuroscience</title>
<idno type="ISSN">0306-4522</idno>
<imprint><date when="1995" type="published">1995</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Apomorphine (pharmacology)</term>
<term>Behavior, Animal</term>
<term>Disease Models, Animal</term>
<term>Dopamine (metabolism)</term>
<term>Forelimb (physiology)</term>
<term>Parkinson Disease</term>
<term>Rats</term>
<term>Rats, Inbred Strains</term>
<term>Rotation</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Apomorphine</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Forelimb</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Behavior, Animal</term>
<term>Disease Models, Animal</term>
<term>Parkinson Disease</term>
<term>Rats</term>
<term>Rats, Inbred Strains</term>
<term>Rotation</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">This study compares certain behavioural consequences of partial and complete unilateral lesions of the dopaminergic mesotelencephalic system. We investigated skilled forelimb use, rotations induced by apomorphine and amphetamine, and dopaminergic metabolism of the nigrostriatal system of rats that had received a unilateral injection of 6-hydroxydopamine into the medial forebrain bundle. The rats classified Apo(+), that rotated after the administration of apomorphine, had a complete lesion of the nigrostriatal system, whereas those classified Apo(-), that did not rotate after the administration of apomorphine, had a partial lesion of the nigrostriatal system. In the Apo(+) rats, 99.8% of the dopamine in the striatum was depleted, as was 85% of that in the substantia nigra. For the Apo(-) rats, 72% of the dopamine in the striatum was depleted as was 56% of that in the substantia nigra. When investigated with the staircase test, the animals with the most severe dopamine depletions were those most impaired in the paw reaching task. Complete and partial unilateral depletions of the dopaminergic mesotelencephalic system impaired the hierarchic phases of paw reaching differently. A complete dopamine depletion, but not a partial one, decreased the number of attempts made with the contralateral paw, and induced a bias towards the ipsilateral paw. A partial dopamine lesion impaired the sensorimotor co-ordination of both paws, whereas the complete dopamine lesion had a greater effect on the contralateral paw than on the ipsilateral paw. The mild paw reaching impairments observed in animals with moderate depletions of dopamine are proposed as a model of the early symptoms of Parkinson's disease that may be useful for the development of protective or restorative therapies.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001C70 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 001C70 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonFranceV1 |flux= Ncbi |étape= Curation |type= RBID |clé= pubmed:7675209 |texte= Effects of complete and partial lesions of the dopaminergic mesotelencephalic system on skilled forelimb use in the rat. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:7675209" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \ | NlmPubMed2Wicri -a ParkinsonFranceV1
This area was generated with Dilib version V0.6.29. |