ParkinsonFranceV1, Main, Curation, bibRecord, 003F16

Effect of stimulation of the subthalamic nucleus on oral control of patients with parkinsonism

Identifieur interne : 003F16 ( Main/Curation ); précédent : 003F15; suivant : 003F17

Effect of stimulation of the subthalamic nucleus on oral control of patients with parkinsonism

Auteurs : M. Gentil [France] ; P. Garcia-Ruiz [Espagne] ; P. Pollak [France] ; A.-L. Benabid [France]

Source :

Journal of neurology, neurosurgery and psychiatry [ 0022-3050 ] ; 1999.

RBID : Pascal:99-0438704

Descripteurs français

Pascal (Inist)
- Parkinsonisme, Noyau sousthalamique, Stimulus électrique, Bilatéral, Contrôle moteur, Parole, Articulation parole, Trouble moteur, Traitement instrumental, Adulte.
Wicri :
- topic : Adulte.

English descriptors

KwdEn :
- Adult, Articulation, Bilateral, Electrical stimulus, Female, Humans, Instrumentation therapy, Male, Middle Aged, Motor control, Motor system disorder, Parkinson Disease (physiopathology), Parkinsonism, Speech, Speech (physiology), Subthalamic nucleus, Thalamic Nuclei (physiopathology), Time Factors.
MESH :
- physiology : Speech.
- physiopathology : Parkinson Disease, Thalamic Nuclei.
- Female, Humans, Male, Middle Aged, Time Factors.

Abstract

Objectives-To assess the oral system of parkinsonian patients treated with chronic stimulation of the bilateral subthalamic nucleus (STN) to evaluate precisely the effectiveness of this procedure on the articulatory organs. Methods-Load sensitive cantilevers were used to sample ramp and hold force contractions generated by the upper lip, lower lip, and tongue. The subject was given the instruction to produce forces as rapidly and as accurately as possible in response to the target signal (ranging from 0.25 to 2 N), which appeared on a screen. Maximal force of each effector organ was also measured. Fourteen healthy control subjects and 10 patients participated in this study. After an overnight fast the patients were evaluated in the morning under two conditions: during bilateral stimulation and 1 hour after stopping STN stimulation. Results-During STN stimulation, dynamic and static control of the articulatory organs were improved: the maximal strength of the articulatory organs, their accuracy to reach the target, and the precision of the hold phase increased. In addition, the reaction time and the rise time of the ramp phase decreased. Patients' speech as assessed by the item 18 of the unified Parkinson's disease rating scale (UPDRS) was greatly improved by electrical stimulation of the STN Conclusions-Improvement of oral control of the stimulated patients suggests that STN stimulation modulates neuronal structures involved in speech. However, more patients have to be evaluated for a fuller understanding of the effect of this surgical procedure on speech.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1736540

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Pascal:99-0438704

Le document en format XML

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<author><name sortKey="Garcia Ruiz, P" sort="Garcia Ruiz, P" uniqKey="Garcia Ruiz P" first="P." last="Garcia-Ruiz">P. Garcia-Ruiz</name>
</author>
<author><name sortKey="Pollak, P" sort="Pollak, P" uniqKey="Pollak P" first="P." last="Pollak">P. Pollak</name>
</author>
<author><name sortKey="Benabid, A" sort="Benabid, A" uniqKey="Benabid A" first="A." last="Benabid">A. Benabid</name>
</author>
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<idno type="pmid">10449555</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Effect of stimulation of the subthalamic nucleus on oral control
of patients with parkinsonism</title>
<author><name sortKey="Gentil, M" sort="Gentil, M" uniqKey="Gentil M" first="M." last="Gentil">M. Gentil</name>
</author>
<author><name sortKey="Garcia Ruiz, P" sort="Garcia Ruiz, P" uniqKey="Garcia Ruiz P" first="P." last="Garcia-Ruiz">P. Garcia-Ruiz</name>
</author>
<author><name sortKey="Pollak, P" sort="Pollak, P" uniqKey="Pollak P" first="P." last="Pollak">P. Pollak</name>
</author>
<author><name sortKey="Benabid, A" sort="Benabid, A" uniqKey="Benabid A" first="A." last="Benabid">A. Benabid</name>
</author>
</analytic>
<series><title level="j">Journal of Neurology, Neurosurgery, and Psychiatry</title>
<idno type="ISSN">0022-3050</idno>
<idno type="eISSN">1468-330X</idno>
<imprint><date when="1999">1999</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Speech (physiology)</term>
<term>Thalamic Nuclei (physiopathology)</term>
<term>Time Factors</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Speech</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term>
<term>Thalamic Nuclei</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Time Factors</term>
</keywords>
</textClass>
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<front><div type="abstract" xml:lang="en"><p><italic>OBJECTIVES</italic>—To assess
the oral system of parkinsonian patients treated with
chronic stimulation of the bilateral
subthalamic nucleus (STN) to evaluate precisely the effectiveness of
this procedure on the articulatory organs. <italic>METHODS</italic>—Load sensitive
cantilevers were used to sample ramp and hold force contractions
generated by the upper lip, lower lip, and tongue. The subject was
given the instruction to produce forces as rapidly and as accurately as
possible in response to the target signal (ranging from 0.25 to 2 N),
which appeared on a screen. Maximal force of each effector organ was
also measured. Fourteen healthy control subjects and 10 patients
participated in this study. After an overnight fast the patients were
evaluated in the morning under two conditions: during bilateral
stimulation and 1 hour after stopping STN stimulation. <italic>RESULTS</italic>—During STN
stimulation, dynamic and static control of the articulatory organs were
improved: the maximal strength of the articulatory organs, their
accuracy to reach the target, and the precision of the hold phase
increased. In addition, the reaction time and the rise time of the ramp
phase decreased. Patients' speech as assessed by the item 18 of the
unified Parkinson's disease rating scale (UPDRS) was greatly improved
by electrical stimulation of the STN <italic>CONCLUSIONS</italic>—Improvement
of oral control of the stimulated patients suggests that STN
stimulation modulates neuronal structures involved in speech. However,
more patients have to be evaluated for a fuller understanding of the
effect of this surgical procedure on speech.  </p>
</div>
</front>
</TEI>
</PMC>
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	La maladie de Parkinson en France (serveur d'exploration)
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Effect of stimulation of the subthalamic nucleus on oral control of patients with parkinsonism

Effect of stimulation of the subthalamic nucleus on oral control of patients with parkinsonism

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