Effects of the method of drawing regions of interest on the differential diagnosis of extrapyramidal syndromes using 123I-iodolisuride SPET
Identifieur interne : 003F15 ( Main/Curation ); précédent : 003F14; suivant : 003F16Effects of the method of drawing regions of interest on the differential diagnosis of extrapyramidal syndromes using 123I-iodolisuride SPET
Auteurs : J.-L. Baulieu [France] ; M.-J. Ribeiro [Portugal] ; C. Levilion-Prunier [France] ; F. Tranquart [France] ; J.-R. Chartier [France] ; D. Guilloteau [France] ; J.-P. Cottier [France] ; J.-C. Besnard [France] ; L. Pourcelot [France] ; A. Autret [France]Source :
- Nuclear medicine communications [ 0143-3636 ] ; 1999.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme, Iode, Anatomie, Analyse quantitative.
English descriptors
- KwdEn :
- Adult, Aged, Anatomy, Basal Ganglia Diseases (diagnostic imaging), Basal Ganglia Diseases (metabolism), Brain (diagnostic imaging), Brain Chemistry, Caudate Nucleus (chemistry), Caudate Nucleus (diagnostic imaging), Corpus Striatum (chemistry), Corpus Striatum (diagnostic imaging), Cysteine (analogs & derivatives), D2 Dopamine receptor, Differential diagnostic, Emission tomography, Extrapyramidal syndrome, Female, Frontal Lobe (chemistry), Frontal Lobe (diagnostic imaging), Human, Humans, Iodine, Iodine Radioisotopes, Lisuride (analogs & derivatives), Localization, Male, Occipital Lobe (chemistry), Occipital Lobe (diagnostic imaging), Organotechnetium Compounds, Parkinson Disease (diagnostic imaging), Parkinson Disease (metabolism), Perfusion, Photon, Quantitative analysis, Radiopharmaceuticals, Receptors, Dopamine D2 (analysis), Tomography, Emission-Computed, Single-Photon.
- MESH :
- chemical , analogs & derivatives : Cysteine, Lisuride.
- chemical , analysis : Receptors, Dopamine D2.
- chemistry : Caudate Nucleus, Corpus Striatum, Frontal Lobe, Occipital Lobe.
- diagnostic imaging : Basal Ganglia Diseases, Brain, Caudate Nucleus, Corpus Striatum, Frontal Lobe, Occipital Lobe, Parkinson Disease.
- metabolism : Basal Ganglia Diseases, Parkinson Disease.
- Adult, Aged, Brain Chemistry, Female, Humans, Iodine Radioisotopes, Male, Organotechnetium Compounds, Perfusion, Radiopharmaceuticals, Tomography, Emission-Computed, Single-Photon.
Abstract
Various parameters are currently used for the semi-quantitative assessment of dopamine D2 receptors and differ according to the delineation of the striatal region of interest (ROI) and the choice of the reference ROI. The aim of this study was to assess the value of different ROI approaches in differentiating patients with normal or increased numbers of D2 dopamine receptors (group 1 = Parkinson's disease, n = 8) from patients with decreased dopamine D2 receptors (group 2 = other extrapyramidal syndromes, n = 9) using 123I-iodolisuride SPET (ILIS-SPET). 123I-iodolisuride (190 ± 31 MBq) and 99Tcm-ethyl cysteinate dimer (99Tcm-ECD) perfusion SPET were performed in the the same position, with a dual-headed gamera camera equipped with fan beam collimators. Both a geometric approach (ellipse, circle or rectangle) and an anatomical approach using the CT scan and perfusion SPET as anatomical guides were used to draw striatal and reference ROIs. A total of 33 different parameters were calculated for each patient, indicating the ratio of counts between the striatal and reference ROIs (frontal, occipital cortex or cerebellum) and the asymmetry between the right and left striatum. More significant differences between group 1 and group 2 were found by using geometric ROIs than by using anatomical ROIs. The most discriminant ratios were the caudate/occipital, caudate/frontal and striatum/occipital ratios (P = 0.001, P = 0.002, P = 0.003 respectively). A close correlation was found between the striatum/caudate and striatum/occipital ratios, but not between the striatum/frontal and striatum/occipital ratios or between the striatum/frontal and striatum/caudate ratios. We conclude that the occipital cortex is the best reference for the semi-quantitative evaluation of dopamine D2 receptors as the frontal cortex could include some dopamine D2 receptor-bound radioligand, and that the caudate/occipital ratio is an appropriate parameter for differentiating Parkinson's disease from non-Parkinson extrapyramidal syndrome by 1-iodolisuride SPET.
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Pascal:99-0094911Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Effects of the method of drawing regions of interest on the differential diagnosis of extrapyramidal syndromes using <sup>123</sup>
I-iodolisuride SPET</title>
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<series><title level="j" type="main">Nuclear medicine communications</title>
<title level="j" type="abbreviated">Nucl. med. common.</title>
<idno type="ISSN">0143-3636</idno>
<imprint><date when="1999">1999</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Nuclear medicine communications</title>
<title level="j" type="abbreviated">Nucl. med. common.</title>
<idno type="ISSN">0143-3636</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Anatomy</term>
<term>Basal Ganglia Diseases (diagnostic imaging)</term>
<term>Basal Ganglia Diseases (metabolism)</term>
<term>Brain (diagnostic imaging)</term>
<term>Brain Chemistry</term>
<term>Caudate Nucleus (chemistry)</term>
<term>Caudate Nucleus (diagnostic imaging)</term>
<term>Corpus Striatum (chemistry)</term>
<term>Corpus Striatum (diagnostic imaging)</term>
<term>Cysteine (analogs & derivatives)</term>
<term>D2 Dopamine receptor</term>
<term>Differential diagnostic</term>
<term>Emission tomography</term>
<term>Extrapyramidal syndrome</term>
<term>Female</term>
<term>Frontal Lobe (chemistry)</term>
<term>Frontal Lobe (diagnostic imaging)</term>
<term>Human</term>
<term>Humans</term>
<term>Iodine</term>
<term>Iodine Radioisotopes</term>
<term>Lisuride (analogs & derivatives)</term>
<term>Localization</term>
<term>Male</term>
<term>Occipital Lobe (chemistry)</term>
<term>Occipital Lobe (diagnostic imaging)</term>
<term>Organotechnetium Compounds</term>
<term>Parkinson Disease (diagnostic imaging)</term>
<term>Parkinson Disease (metabolism)</term>
<term>Perfusion</term>
<term>Photon</term>
<term>Quantitative analysis</term>
<term>Radiopharmaceuticals</term>
<term>Receptors, Dopamine D2 (analysis)</term>
<term>Tomography, Emission-Computed, Single-Photon</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Cysteine</term>
<term>Lisuride</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Receptors, Dopamine D2</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Caudate Nucleus</term>
<term>Corpus Striatum</term>
<term>Frontal Lobe</term>
<term>Occipital Lobe</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Basal Ganglia Diseases</term>
<term>Brain</term>
<term>Caudate Nucleus</term>
<term>Corpus Striatum</term>
<term>Frontal Lobe</term>
<term>Occipital Lobe</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Basal Ganglia Diseases</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Brain Chemistry</term>
<term>Female</term>
<term>Humans</term>
<term>Iodine Radioisotopes</term>
<term>Male</term>
<term>Organotechnetium Compounds</term>
<term>Perfusion</term>
<term>Radiopharmaceuticals</term>
<term>Tomography, Emission-Computed, Single-Photon</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Extrapyramidal syndrome</term>
<term>Homme</term>
<term>Iode</term>
<term>Tomoscintigraphie</term>
<term>Photon</term>
<term>Diagnostic différentiel</term>
<term>Récepteur dopaminergique D2</term>
<term>Anatomie</term>
<term>Localisation</term>
<term>Analyse quantitative</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
<term>Iode</term>
<term>Anatomie</term>
<term>Analyse quantitative</term>
</keywords>
</textClass>
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</teiHeader>
<front><div type="abstract" xml:lang="en">Various parameters are currently used for the semi-quantitative assessment of dopamine D<sub>2</sub>
receptors and differ according to the delineation of the striatal region of interest (ROI) and the choice of the reference ROI. The aim of this study was to assess the value of different ROI approaches in differentiating patients with normal or increased numbers of D<sub>2</sub>
dopamine receptors (group 1 = Parkinson's disease, n = 8) from patients with decreased dopamine D2 receptors (group 2 = other extrapyramidal syndromes, n = 9) using <sup>123</sup>
I-iodolisuride SPET (ILIS-SPET). <sup>123</sup>
I-iodolisuride (190 ± 31 MBq) and <sup>99</sup>
Tc<sup>m</sup>
-ethyl cysteinate dimer (<sup>99</sup>
Tc<sup>m</sup>
-ECD) perfusion SPET were performed in the the same position, with a dual-headed gamera camera equipped with fan beam collimators. Both a geometric approach (ellipse, circle or rectangle) and an anatomical approach using the CT scan and perfusion SPET as anatomical guides were used to draw striatal and reference ROIs. A total of 33 different parameters were calculated for each patient, indicating the ratio of counts between the striatal and reference ROIs (frontal, occipital cortex or cerebellum) and the asymmetry between the right and left striatum. More significant differences between group 1 and group 2 were found by using geometric ROIs than by using anatomical ROIs. The most discriminant ratios were the caudate/occipital, caudate/frontal and striatum/occipital ratios (P = 0.001, P = 0.002, P = 0.003 respectively). A close correlation was found between the striatum/caudate and striatum/occipital ratios, but not between the striatum/frontal and striatum/occipital ratios or between the striatum/frontal and striatum/caudate ratios. We conclude that the occipital cortex is the best reference for the semi-quantitative evaluation of dopamine D<sub>2</sub>
receptors as the frontal cortex could include some dopamine D<sub>2</sub>
receptor-bound radioligand, and that the caudate/occipital ratio is an appropriate parameter for differentiating Parkinson's disease from non-Parkinson extrapyramidal syndrome by 1-iodolisuride SPET.</div>
</front>
</TEI>
<double idat="0143-3636:1999:Baulieu J:effects:of:the"><INIST><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Effects of the method of drawing regions of interest on the differential diagnosis of extrapyramidal syndromes using <sup>123</sup>
I-iodolisuride SPET</title>
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</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">99-0094911</idno>
<date when="1999">1999</date>
<idno type="stanalyst">PASCAL 99-0094911 INIST</idno>
<idno type="RBID">Pascal:99-0094911</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001541</idno>
<idno type="wicri:Area/PascalFrancis/Curation">001B04</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">001343</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">001343</idno>
<idno type="wicri:doubleKey">0143-3636:1999:Baulieu J:effects:of:the</idno>
<idno type="wicri:Area/Main/Merge">004657</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Effects of the method of drawing regions of interest on the differential diagnosis of extrapyramidal syndromes using <sup>123</sup>
I-iodolisuride SPET</title>
<author><name sortKey="Baulieu, J L" sort="Baulieu, J L" uniqKey="Baulieu J" first="J.-L." last="Baulieu">J.-L. Baulieu</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Departments of Nuclear Medicine, Neurology and Neuroradiology, INSERM U316, CHU Tours</s1>
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</affiliation>
</author>
<author><name sortKey="Ribeiro, M J" sort="Ribeiro, M J" uniqKey="Ribeiro M" first="M.-J." last="Ribeiro">M.-J. Ribeiro</name>
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</inist:fA14>
<country>Portugal</country>
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</affiliation>
</author>
<author><name sortKey="Levilion Prunier, C" sort="Levilion Prunier, C" uniqKey="Levilion Prunier C" first="C." last="Levilion-Prunier">C. Levilion-Prunier</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Departments of Nuclear Medicine, Neurology and Neuroradiology, INSERM U316, CHU Tours</s1>
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</affiliation>
</author>
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</affiliation>
</author>
<author><name sortKey="Chartier, J R" sort="Chartier, J R" uniqKey="Chartier J" first="J.-R." last="Chartier">J.-R. Chartier</name>
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</affiliation>
</author>
<author><name sortKey="Guilloteau, D" sort="Guilloteau, D" uniqKey="Guilloteau D" first="D." last="Guilloteau">D. Guilloteau</name>
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</affiliation>
</author>
<author><name sortKey="Cottier, J P" sort="Cottier, J P" uniqKey="Cottier J" first="J.-P." last="Cottier">J.-P. Cottier</name>
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</affiliation>
</author>
<author><name sortKey="Besnard, J C" sort="Besnard, J C" uniqKey="Besnard J" first="J.-C." last="Besnard">J.-C. Besnard</name>
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</affiliation>
</author>
<author><name sortKey="Pourcelot, L" sort="Pourcelot, L" uniqKey="Pourcelot L" first="L." last="Pourcelot">L. Pourcelot</name>
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<wicri:noRegion>CHU Tours</wicri:noRegion>
<wicri:noRegion>Departments of Nuclear Medicine, Neurology and Neuroradiology, INSERM U316, CHU Tours</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Autret, A" sort="Autret, A" uniqKey="Autret A" first="A." last="Autret">A. Autret</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Departments of Nuclear Medicine, Neurology and Neuroradiology, INSERM U316, CHU Tours</s1>
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<series><title level="j" type="main">Nuclear medicine communications</title>
<title level="j" type="abbreviated">Nucl. med. common.</title>
<idno type="ISSN">0143-3636</idno>
<imprint><date when="1999">1999</date>
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<seriesStmt><title level="j" type="main">Nuclear medicine communications</title>
<title level="j" type="abbreviated">Nucl. med. common.</title>
<idno type="ISSN">0143-3636</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anatomy</term>
<term>D2 Dopamine receptor</term>
<term>Differential diagnostic</term>
<term>Emission tomography</term>
<term>Extrapyramidal syndrome</term>
<term>Human</term>
<term>Iodine</term>
<term>Localization</term>
<term>Photon</term>
<term>Quantitative analysis</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Extrapyramidal syndrome</term>
<term>Homme</term>
<term>Iode</term>
<term>Tomoscintigraphie</term>
<term>Photon</term>
<term>Diagnostic différentiel</term>
<term>Récepteur dopaminergique D2</term>
<term>Anatomie</term>
<term>Localisation</term>
<term>Analyse quantitative</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
<term>Iode</term>
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<front><div type="abstract" xml:lang="en">Various parameters are currently used for the semi-quantitative assessment of dopamine D<sub>2</sub>
receptors and differ according to the delineation of the striatal region of interest (ROI) and the choice of the reference ROI. The aim of this study was to assess the value of different ROI approaches in differentiating patients with normal or increased numbers of D<sub>2</sub>
dopamine receptors (group 1 = Parkinson's disease, n = 8) from patients with decreased dopamine D2 receptors (group 2 = other extrapyramidal syndromes, n = 9) using <sup>123</sup>
I-iodolisuride SPET (ILIS-SPET). <sup>123</sup>
I-iodolisuride (190 ± 31 MBq) and <sup>99</sup>
Tc<sup>m</sup>
-ethyl cysteinate dimer (<sup>99</sup>
Tc<sup>m</sup>
-ECD) perfusion SPET were performed in the the same position, with a dual-headed gamera camera equipped with fan beam collimators. Both a geometric approach (ellipse, circle or rectangle) and an anatomical approach using the CT scan and perfusion SPET as anatomical guides were used to draw striatal and reference ROIs. A total of 33 different parameters were calculated for each patient, indicating the ratio of counts between the striatal and reference ROIs (frontal, occipital cortex or cerebellum) and the asymmetry between the right and left striatum. More significant differences between group 1 and group 2 were found by using geometric ROIs than by using anatomical ROIs. The most discriminant ratios were the caudate/occipital, caudate/frontal and striatum/occipital ratios (P = 0.001, P = 0.002, P = 0.003 respectively). A close correlation was found between the striatum/caudate and striatum/occipital ratios, but not between the striatum/frontal and striatum/occipital ratios or between the striatum/frontal and striatum/caudate ratios. We conclude that the occipital cortex is the best reference for the semi-quantitative evaluation of dopamine D<sub>2</sub>
receptors as the frontal cortex could include some dopamine D<sub>2</sub>
receptor-bound radioligand, and that the caudate/occipital ratio is an appropriate parameter for differentiating Parkinson's disease from non-Parkinson extrapyramidal syndrome by 1-iodolisuride SPET.</div>
</front>
</TEI>
</INIST>
<PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effects of the method of drawing regions of interest on the differential diagnosis of extrapyramidal syndromes using 123I-iodolisuride SPET.</title>
<author><name sortKey="Baulieu, J L" sort="Baulieu, J L" uniqKey="Baulieu J" first="J L" last="Baulieu">J L Baulieu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Nuclear Medicine, INSERM U316, CHU Tours, France. baulieu@med.univtours.fr</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Nuclear Medicine, INSERM U316, CHU Tours</wicri:regionArea>
<wicri:noRegion>CHU Tours</wicri:noRegion>
<wicri:noRegion>CHU Tours</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ribeiro, M J" sort="Ribeiro, M J" uniqKey="Ribeiro M" first="M J" last="Ribeiro">M J Ribeiro</name>
</author>
<author><name sortKey="Levilion Prunier, C" sort="Levilion Prunier, C" uniqKey="Levilion Prunier C" first="C" last="Levilion-Prunier">C. Levilion-Prunier</name>
</author>
<author><name sortKey="Tranquart, F" sort="Tranquart, F" uniqKey="Tranquart F" first="F" last="Tranquart">F. Tranquart</name>
</author>
<author><name sortKey="Chartier, J R" sort="Chartier, J R" uniqKey="Chartier J" first="J R" last="Chartier">J R Chartier</name>
</author>
<author><name sortKey="Guilloteau, D" sort="Guilloteau, D" uniqKey="Guilloteau D" first="D" last="Guilloteau">D. Guilloteau</name>
</author>
<author><name sortKey="Cottier, J P" sort="Cottier, J P" uniqKey="Cottier J" first="J P" last="Cottier">J P Cottier</name>
</author>
<author><name sortKey="Besnard, J C" sort="Besnard, J C" uniqKey="Besnard J" first="J C" last="Besnard">J C Besnard</name>
</author>
<author><name sortKey="Pourcelot, L" sort="Pourcelot, L" uniqKey="Pourcelot L" first="L" last="Pourcelot">L. Pourcelot</name>
</author>
<author><name sortKey="Autret, A" sort="Autret, A" uniqKey="Autret A" first="A" last="Autret">A. Autret</name>
</author>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Effects of the method of drawing regions of interest on the differential diagnosis of extrapyramidal syndromes using 123I-iodolisuride SPET.</title>
<author><name sortKey="Baulieu, J L" sort="Baulieu, J L" uniqKey="Baulieu J" first="J L" last="Baulieu">J L Baulieu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Nuclear Medicine, INSERM U316, CHU Tours, France. baulieu@med.univtours.fr</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Nuclear Medicine, INSERM U316, CHU Tours</wicri:regionArea>
<wicri:noRegion>CHU Tours</wicri:noRegion>
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</affiliation>
</author>
<author><name sortKey="Ribeiro, M J" sort="Ribeiro, M J" uniqKey="Ribeiro M" first="M J" last="Ribeiro">M J Ribeiro</name>
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<author><name sortKey="Levilion Prunier, C" sort="Levilion Prunier, C" uniqKey="Levilion Prunier C" first="C" last="Levilion-Prunier">C. Levilion-Prunier</name>
</author>
<author><name sortKey="Tranquart, F" sort="Tranquart, F" uniqKey="Tranquart F" first="F" last="Tranquart">F. Tranquart</name>
</author>
<author><name sortKey="Chartier, J R" sort="Chartier, J R" uniqKey="Chartier J" first="J R" last="Chartier">J R Chartier</name>
</author>
<author><name sortKey="Guilloteau, D" sort="Guilloteau, D" uniqKey="Guilloteau D" first="D" last="Guilloteau">D. Guilloteau</name>
</author>
<author><name sortKey="Cottier, J P" sort="Cottier, J P" uniqKey="Cottier J" first="J P" last="Cottier">J P Cottier</name>
</author>
<author><name sortKey="Besnard, J C" sort="Besnard, J C" uniqKey="Besnard J" first="J C" last="Besnard">J C Besnard</name>
</author>
<author><name sortKey="Pourcelot, L" sort="Pourcelot, L" uniqKey="Pourcelot L" first="L" last="Pourcelot">L. Pourcelot</name>
</author>
<author><name sortKey="Autret, A" sort="Autret, A" uniqKey="Autret A" first="A" last="Autret">A. Autret</name>
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<series><title level="j">Nuclear medicine communications</title>
<idno type="ISSN">0143-3636</idno>
<imprint><date when="1999" type="published">1999</date>
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<term>Aged</term>
<term>Basal Ganglia Diseases (diagnostic imaging)</term>
<term>Basal Ganglia Diseases (metabolism)</term>
<term>Brain (diagnostic imaging)</term>
<term>Brain Chemistry</term>
<term>Caudate Nucleus (chemistry)</term>
<term>Caudate Nucleus (diagnostic imaging)</term>
<term>Corpus Striatum (chemistry)</term>
<term>Corpus Striatum (diagnostic imaging)</term>
<term>Cysteine (analogs & derivatives)</term>
<term>Female</term>
<term>Frontal Lobe (chemistry)</term>
<term>Frontal Lobe (diagnostic imaging)</term>
<term>Humans</term>
<term>Iodine Radioisotopes</term>
<term>Lisuride (analogs & derivatives)</term>
<term>Male</term>
<term>Occipital Lobe (chemistry)</term>
<term>Occipital Lobe (diagnostic imaging)</term>
<term>Organotechnetium Compounds</term>
<term>Parkinson Disease (diagnostic imaging)</term>
<term>Parkinson Disease (metabolism)</term>
<term>Perfusion</term>
<term>Radiopharmaceuticals</term>
<term>Receptors, Dopamine D2 (analysis)</term>
<term>Tomography, Emission-Computed, Single-Photon</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Cysteine</term>
<term>Lisuride</term>
</keywords>
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</keywords>
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<term>Corpus Striatum</term>
<term>Frontal Lobe</term>
<term>Occipital Lobe</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Basal Ganglia Diseases</term>
<term>Brain</term>
<term>Caudate Nucleus</term>
<term>Corpus Striatum</term>
<term>Frontal Lobe</term>
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<front><div type="abstract" xml:lang="en">Various parameters are currently used for the semi-quantitative assessment of dopamine D2 receptors and differ according to the delineation of the striatal region of interest (ROI) and the choice of the reference ROI. The aim of this study was to assess the value of different ROI approaches in differentiating patients with normal or increased numbers of D2 dopamine receptors (group 1 = Parkinson's disease, n = 8) from patients with decreased dopamine D2 receptors (group 2 = other extrapyramidal syndromes, n = 9) using 123I-iodolisuride SPET (ILIS-SPET). 123I-iodolisuride (190 +/- 31 MBq) and 99Tcm-ethyl cysteinate dimer (99Tcm-ECD) perfusion SPET were performed in the same position, with a dual-headed gamera camera equipped with fan beam collimators. Both a geometric approach (ellipse, circle or rectangle) and an anatomical approach using the CT scan and perfusion SPET as anatomical guides were used to draw striatal and reference ROIs. A total of 33 different parameters were calculated for each patient, indicating the ratio of counts between the striatal and reference ROIs (frontal, occipital cortex or cerebellum) and the asymmetry between the right and left striatum. More significant differences between group 1 and group 2 were found by using geometric ROIs than by using anatomical ROIs. The most discriminant ratios were the caudate/occipital, caudate/frontal and striatum/occipital ratios (P = 0.001, P = 0.002, P = 0.003 respectively). A close correlation was found between the striatum/caudate and striatum/occipital ratios, but not between the striatum/frontal and striatum/occipital ratios or between the striatum/frontal and striatum/caudate ratios. We conclude that the occipital cortex is the best reference for the semi-quantitative evaluation of dopamine D2 receptors as the frontal cortex could include some dopamine D2 receptor-bound radioligand, and that the caudate/occipital ratio is an appropriate parameter for differentiating Parkinson's disease from non-Parkinson extrapyramidal syndrome by 123I-iodolisuride SPET.</div>
</front>
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