ParkinsonFranceV1, Main, Curation, bibRecord, 003393

Behavioural disorders, Parkinson's disease and subthalamic stimulation

Identifieur interne : 003393 ( Main/Curation ); précédent : 003392; suivant : 003394

Behavioural disorders, Parkinson's disease and subthalamic stimulation

Auteurs : J L Houeto [France] ; V. Mesnage [France] ; L. Mallet [France] ; B. Pillon [France] ; M. Gargiulo [France] ; S Tezenas Du Moncel [France] ; A M Bonnet [France] ; B. Pidoux [France] ; D. Dormont [France] ; P. Cornu [France] ; Yves Agid [France]

Source :

Journal of Neurology, Neurosurgery & Psychiatry [ 0022-3050 ] ; 2002-06.

RBID : ISTEX:176B41D8319AC2E36282D9C5568DEA05FC0C4088

Descripteurs français

Pascal (Inist)
- Bilatéral, Complication, Fréquence, Homme, Noyau sousthalamique, Parkinson maladie, Stimulation instrumentale, Trouble comportement.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Anxiety (etiology), Behavioral disorder, Bilateral, Complication, Depression (etiology), Electric Stimulation Therapy (adverse effects), Female, Frequency, Human, Humans, ISPC, IOWA scales of personality change, Instrumental stimulation, MINI, mini international neuropsychiatric inventory, Male, Mental Status Schedule, Middle Aged, Motor Skills Disorders (etiology), Motor Skills Disorders (therapy), Parkinson Disease (pathology), Parkinson Disease (therapy), Parkinson disease, Parkinson's disease, Personality, Quality of Life, SAS, social adjustment scale, STN, subthalamic nucleus, Social Behavior, Substance-Related Disorders, Subthalamic Nucleus (physiology), Subthalamic nucleus, Treatment Outcome, UPDRS, unified Parkinson's disease rating scale, behavioural disorders, high frequency stimulation, psychiatry, subthalamic nucleus.
MESH :
- adverse effects : Electric Stimulation Therapy.
- etiology : Anxiety, Depression, Motor Skills Disorders.
- pathology : Parkinson Disease.
- physiology : Subthalamic Nucleus.
- therapy : Motor Skills Disorders, Parkinson Disease.
- Female, Humans, Male, Mental Status Schedule, Middle Aged, Personality, Quality of Life, Social Behavior, Substance-Related Disorders, Treatment Outcome.

Abstract

Objective: to analyse 24 parkinsonian patients successfully treated by bilateral STN stimulation for the presence of behavioural disorders. Method: patients were evaluated retrospectively for adjustment disorders (social adjustment scale, SAS), psychiatric disorders (comparison of the results of psychiatric interview and the mini international neuropsychiatric inventory) and personality changes (IOWA scale of personality changes). Results: parkinsonian motor disability was improved by 69.5% and the levodopa equivalent daily dosage was reduced by 60.5%. Social adjustment (SAS) was considered good or excellent in nine patients, moderately (n=14), or severely (n=1) impaired in 15 patients. Psychiatric disorders consisted of amplification or decompensation of previously existing disorders that had sometimes passed unnoticed, such as depressive episodes (n=4), generalised anxiety (n=18), and behavioural disorders with drug dependence (n=2). Appearance of mild to moderate emotional hyperreactivity was reported in 15 patients. Personality traits (IOWA scale) were improved in eight patients, unchanged in seven, and aggravated in eight Conclusion: Improvement in parkinsonian motor disability induced by STN stimulation is not necessarily accompanied by improvement in psychic function and quality of life. Attention is drawn to the possible appearance of personality disorders and decompensation of previous psychiatric disorders in parkinsonian patients who are suitable candidates for neurosurgery. We suggest that a careful psychological and psychiatric interview be performed before surgery, and emphasise the need for psychological follow up to ensure the best possible outcome.

Url:

DOI: 10.1136/jnnp.72.6.701

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ISTEX:176B41D8319AC2E36282D9C5568DEA05FC0C4088

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<term>Electric Stimulation Therapy (adverse effects)</term>
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<term>Parkinson disease</term>
<term>Parkinson's disease</term>
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<term>STN, subthalamic nucleus</term>
<term>Social Behavior</term>
<term>Substance-Related Disorders</term>
<term>Subthalamic Nucleus (physiology)</term>
<term>Subthalamic nucleus</term>
<term>Treatment Outcome</term>
<term>UPDRS, unified Parkinson's disease rating scale</term>
<term>behavioural disorders</term>
<term>high frequency stimulation</term>
<term>psychiatry</term>
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<front><div type="abstract" xml:lang="en">Objective: to analyse 24 parkinsonian patients successfully treated by bilateral STN stimulation for the presence of behavioural disorders. Method: patients were evaluated retrospectively for adjustment disorders (social adjustment scale, SAS), psychiatric disorders (comparison of the results of psychiatric interview and the mini international neuropsychiatric inventory) and personality changes (IOWA scale of personality changes). Results: parkinsonian motor disability was improved by 69.5% and the levodopa equivalent daily dosage was reduced by 60.5%. Social adjustment (SAS) was considered good or excellent in nine patients, moderately (n=14), or severely (n=1) impaired in 15 patients. Psychiatric disorders consisted of amplification or decompensation of previously existing disorders that had sometimes passed unnoticed, such as depressive episodes (n=4), generalised anxiety (n=18), and behavioural disorders with drug dependence (n=2). Appearance of mild to moderate emotional hyperreactivity was reported in 15 patients. Personality traits (IOWA scale) were improved in eight patients, unchanged in seven, and aggravated in eight Conclusion: Improvement in parkinsonian motor disability induced by STN stimulation is not necessarily accompanied by improvement in psychic function and quality of life. Attention is drawn to the possible appearance of personality disorders and decompensation of previous psychiatric disorders in parkinsonian patients who are suitable candidates for neurosurgery. We suggest that a careful psychological and psychiatric interview be performed before surgery, and emphasise the need for psychological follow up to ensure the best possible outcome.</div>
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<series><title level="j" type="main">Journal of neurology, neurosurgery and psychiatry</title>
<title level="j" type="abbreviated">J. neurol. neurosurg. psychiatry</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Behavioral disorder</term>
<term>Bilateral</term>
<term>Complication</term>
<term>Frequency</term>
<term>Human</term>
<term>Instrumental stimulation</term>
<term>Parkinson disease</term>
<term>Subthalamic nucleus</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term>
<term>Stimulation instrumentale</term>
<term>Noyau sousthalamique</term>
<term>Bilatéral</term>
<term>Trouble comportement</term>
<term>Complication</term>
<term>Fréquence</term>
<term>Homme</term>
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<front><div type="abstract" xml:lang="en">Objective: to analyse 24 parkinsonian patients successfully treated by bilateral STN stimulation for the presence of behavioural disorders. Method: patients were evaluated retrospectively for adjustment disorders (social adjustment scale, SAS), psychiatric disorders (comparison of the results of psychiatric interview and the mini international neuropsychiatric inventory) and personality changes (IOWA scale of personality changes). Results: parkinsonian motor disability was improved by 69.5% and the levodopa equivalent daily dosage was reduced by 60.5%. Social adjustment (SAS) was considered good or excellent in nine patients, moderately (n=14), or severely (n=1) impaired in 15 patients. Psychiatric disorders consisted of amplification or decompensation of previously existing disorders that had sometimes passed unnoticed, such as depressive episodes (n=4), generalised anxiety (n=18), and behavioural disorders with drug dependence (n=2). Appearance of mild to moderate emotional hyperreactivity was reported in 15 patients. Personality traits (IOWA scale) were improved in eight patients, unchanged in seven, and aggravated in eight Conclusion: Improvement in parkinsonian motor disability induced by STN stimulation is not necessarily accompanied by improvement in psychic function and quality of life. Attention is drawn to the possible appearance of personality disorders and decompensation of previous psychiatric disorders in parkinsonian patients who are suitable candidates for neurosurgery. We suggest that a careful psychological and psychiatric interview be performed before surgery, and emphasise the need for psychological follow up to ensure the best possible outcome.</div>
</front>
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</affiliation>
</author>
<author><name sortKey="Mesnage, V" sort="Mesnage, V" uniqKey="Mesnage V" first="V" last="Mesnage">V. Mesnage</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Centre d'Investigation Clinique, Fédération de Neurologie and INSERM U 289</wicri:regionArea>
<wicri:noRegion>Fédération de Neurologie and INSERM U 289</wicri:noRegion>
<wicri:noRegion>Fédération de Neurologie and INSERM U 289</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mallet, L" sort="Mallet, L" uniqKey="Mallet L" first="L" last="Mallet">L. Mallet</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Services de Psychiatrie, Hôpital de la Salpêtriére, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pillon, B" sort="Pillon, B" uniqKey="Pillon B" first="B" last="Pillon">B. Pillon</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>INSERM E 007</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gargiulo, M" sort="Gargiulo, M" uniqKey="Gargiulo M" first="M" last="Gargiulo">M. Gargiulo</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Centre d'Investigation Clinique, Fédération de Neurologie and INSERM U 289</wicri:regionArea>
<wicri:noRegion>Fédération de Neurologie and INSERM U 289</wicri:noRegion>
<wicri:noRegion>Fédération de Neurologie and INSERM U 289</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Du Moncel, S Tezenas" sort="Du Moncel, S Tezenas" uniqKey="Du Moncel S" first="S Tezenas" last="Du Moncel">S Tezenas Du Moncel</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Services de Informatique Médicale, Hôpital de la Salpêtriére, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bonnet, A M" sort="Bonnet, A M" uniqKey="Bonnet A" first="A M" last="Bonnet">A M Bonnet</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Centre d'Investigation Clinique, Fédération de Neurologie and INSERM U 289</wicri:regionArea>
<wicri:noRegion>Fédération de Neurologie and INSERM U 289</wicri:noRegion>
<wicri:noRegion>Fédération de Neurologie and INSERM U 289</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pidoux, B" sort="Pidoux, B" uniqKey="Pidoux B" first="B" last="Pidoux">B. Pidoux</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Fédération de Neurophysiologie Clinique, Hôpital de la Salpêtriére, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dormont, D" sort="Dormont, D" uniqKey="Dormont D" first="D" last="Dormont">D. Dormont</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Services de Neuroradiologie, Hôpital de la Salpêtriére, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cornu, P" sort="Cornu, P" uniqKey="Cornu P" first="P" last="Cornu">P. Cornu</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Services de Neurochirurgie, Hôpital de la Salpêtriére, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y" last="Agid">Yves Agid</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Centre d'Investigation Clinique, Fédération de Neurologie and INSERM U 289</wicri:regionArea>
<wicri:noRegion>Fédération de Neurologie and INSERM U 289</wicri:noRegion>
<wicri:noRegion>Fédération de Neurologie and INSERM U 289</wicri:noRegion>
<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
<orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Journal of Neurology, Neurosurgery & Psychiatry</title>
<title level="j" type="abbrev">J Neurol Neurosurg Psychiatry</title>
<idno type="ISSN">0022-3050</idno>
<idno type="eISSN">1468-330X</idno>
<imprint><publisher>BMJ Publishing Group Ltd</publisher>
<date type="published" when="2002-06">2002-06</date>
<biblScope unit="volume">72</biblScope>
<biblScope unit="issue">6</biblScope>
<biblScope unit="page" from="701">701</biblScope>
</imprint>
<idno type="ISSN">0022-3050</idno>
</series>
<idno type="istex">176B41D8319AC2E36282D9C5568DEA05FC0C4088</idno>
<idno type="DOI">10.1136/jnnp.72.6.701</idno>
<idno type="href">jnnp-72-701.pdf</idno>
<idno type="PMID">12023409</idno>
<idno type="local">0720701</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0022-3050</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anxiety (etiology)</term>
<term>Depression (etiology)</term>
<term>Electric Stimulation Therapy (adverse effects)</term>
<term>Female</term>
<term>Humans</term>
<term>ISPC, IOWA scales of personality change</term>
<term>MINI, mini international neuropsychiatric inventory</term>
<term>Male</term>
<term>Mental Status Schedule</term>
<term>Middle Aged</term>
<term>Motor Skills Disorders (etiology)</term>
<term>Motor Skills Disorders (therapy)</term>
<term>Parkinson Disease (pathology)</term>
<term>Parkinson Disease (therapy)</term>
<term>Parkinson's disease</term>
<term>Personality</term>
<term>Quality of Life</term>
<term>SAS, social adjustment scale</term>
<term>STN, subthalamic nucleus</term>
<term>Social Behavior</term>
<term>Substance-Related Disorders</term>
<term>Subthalamic Nucleus (physiology)</term>
<term>Treatment Outcome</term>
<term>UPDRS, unified Parkinson's disease rating scale</term>
<term>behavioural disorders</term>
<term>high frequency stimulation</term>
<term>psychiatry</term>
<term>subthalamic nucleus</term>
</keywords>
<keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Electric Stimulation Therapy</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Anxiety</term>
<term>Depression</term>
<term>Motor Skills Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Subthalamic Nucleus</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Motor Skills Disorders</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Mental Status Schedule</term>
<term>Middle Aged</term>
<term>Personality</term>
<term>Quality of Life</term>
<term>Social Behavior</term>
<term>Substance-Related Disorders</term>
<term>Treatment Outcome</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Objective: to analyse 24 parkinsonian patients successfully treated by bilateral STN stimulation for the presence of behavioural disorders. Method: patients were evaluated retrospectively for adjustment disorders (social adjustment scale, SAS), psychiatric disorders (comparison of the results of psychiatric interview and the mini international neuropsychiatric inventory) and personality changes (IOWA scale of personality changes). Results: parkinsonian motor disability was improved by 69.5% and the levodopa equivalent daily dosage was reduced by 60.5%. Social adjustment (SAS) was considered good or excellent in nine patients, moderately (n=14), or severely (n=1) impaired in 15 patients. Psychiatric disorders consisted of amplification or decompensation of previously existing disorders that had sometimes passed unnoticed, such as depressive episodes (n=4), generalised anxiety (n=18), and behavioural disorders with drug dependence (n=2). Appearance of mild to moderate emotional hyperreactivity was reported in 15 patients. Personality traits (IOWA scale) were improved in eight patients, unchanged in seven, and aggravated in eight Conclusion: Improvement in parkinsonian motor disability induced by STN stimulation is not necessarily accompanied by improvement in psychic function and quality of life. Attention is drawn to the possible appearance of personality disorders and decompensation of previous psychiatric disorders in parkinsonian patients who are suitable candidates for neurosurgery. We suggest that a careful psychological and psychiatric interview be performed before surgery, and emphasise the need for psychological follow up to ensure the best possible outcome.</div>
</front>
</TEI>
</ISTEX>
</double>
</record>

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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

Behavioural disorders, Parkinson's disease and subthalamic stimulation

Behavioural disorders, Parkinson's disease and subthalamic stimulation

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