ParkinsonFranceV1, Main, Curation, bibRecord, 003008

Is the subthalamic nucleus hypointense on T2-weighted images? A correlation study using MR imaging and stereotactic atlas data

Identifieur interne : 003008 ( Main/Curation ); précédent : 003007; suivant : 003009

Is the subthalamic nucleus hypointense on T2-weighted images? A correlation study using MR imaging and stereotactic atlas data

Auteurs : Didier Dormont [France] ; Kenneth G. Ricciardi [France] ; Dominique Tande [France] ; Karine Parain [France] ; Carole Menuel [France] ; Damien Galanaud [France] ; Soledad Navarro [France] ; Philippe Cornu [France] ; Yves Agid [France] ; Jérome Yelnik [France]

Source :

American journal of neuroradiology [ 0195-6108 ] ; 2004.

RBID : Pascal:04-0588707

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Radiodiagnostic, Noyau sousthalamique, Imagerie RMN, Stéréotaxie, Atlas.
Wicri :
- topic : Atlas.

English descriptors

KwdEn :
- Adult, Aged, Atlas, Brain Mapping, Female, Humans, Image Interpretation, Computer-Assisted, Iron (metabolism), Magnetic Resonance Imaging (statistics & numerical data), Male, Middle Aged, Nervous system diseases, Neurons (pathology), Nuclear magnetic resonance imaging, Parkinson Disease (diagnosis), Parkinson Disease (pathology), Parkinson Disease (surgery), Radiodiagnosis, Sensitivity and Specificity, Statistics as Topic, Stereotaxia, Stereotaxic Techniques (statistics & numerical data), Subthalamic Nucleus (pathology), Subthalamic nucleus.
MESH :
- chemical , metabolism : Iron.
- diagnosis : Parkinson Disease.
- pathology : Neurons, Parkinson Disease, Subthalamic Nucleus.
- statistics & numerical data : Magnetic Resonance Imaging, Stereotaxic Techniques.
- surgery : Parkinson Disease.
- Adult, Aged, Brain Mapping, Female, Humans, Image Interpretation, Computer-Assisted, Male, Middle Aged, Sensitivity and Specificity, Statistics as Topic.

Abstract

BACKGROUND AND PURPOSE: Although the subthalamic nucleus is the most frequently used target for surgical treatment of Parkinson's disease, the criteria on which it can be identified on T2-weighted images have never been clearly defined. This study was conducted to characterize the precise anatomic distribution of T2-weighted hyposignal in the subthalamic region and to correlate this hyposignal with iron content in the subthalamic nucleus. METHODS: The T2-weighted MR imaging acquisitions of 15 patients with Parkinson's disease were fused with a digitized version of the Schaltenbrand and Wahren anatomic atlas. The MR signal intensity within the anatomic limits of the subthalamic nucleus was evaluated. An anatomic specimen obtained at autopsy was used to evaluate iron content. RESULTS: In all patients, the subthalamic nucleus was hypointense on both sides in the anterior half of the nucleus. At more posterior levels of the nucleus, hypointensity was less frequently observed (20-80%). Hypointensity was never observed at the most posterior pole. Iron was present in the anteromedial part of the nucleus but absent at the most posterior levels. CONCLUSION: The hypointense signal intensity located lateral to the red nucleus and dorsolateral to the substantia nigra correlates with the presence of iron and corresponds anatomically to the subthalamic nucleus. It can therefore be used as a landmark for electrode implantation in patients with Parkinson's disease. It should, however, be emphasized that although hypointensity was always present in the anterior half of the subthalamic nucleus, the posterior part of the nucleus was not visible in most cases.

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Le document en format XML

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<term>Aged</term>
<term>Atlas</term>
<term>Brain Mapping</term>
<term>Female</term>
<term>Humans</term>
<term>Image Interpretation, Computer-Assisted</term>
<term>Iron (metabolism)</term>
<term>Magnetic Resonance Imaging (statistics & numerical data)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Nervous system diseases</term>
<term>Neurons (pathology)</term>
<term>Nuclear magnetic resonance imaging</term>
<term>Parkinson Disease (diagnosis)</term>
<term>Parkinson Disease (pathology)</term>
<term>Parkinson Disease (surgery)</term>
<term>Radiodiagnosis</term>
<term>Sensitivity and Specificity</term>
<term>Statistics as Topic</term>
<term>Stereotaxia</term>
<term>Stereotaxic Techniques (statistics & numerical data)</term>
<term>Subthalamic Nucleus (pathology)</term>
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<front><div type="abstract" xml:lang="en">BACKGROUND AND PURPOSE: Although the subthalamic nucleus is the most frequently used target for surgical treatment of Parkinson's disease, the criteria on which it can be identified on T2-weighted images have never been clearly defined. This study was conducted to characterize the precise anatomic distribution of T2-weighted hyposignal in the subthalamic region and to correlate this hyposignal with iron content in the subthalamic nucleus. METHODS: The T2-weighted MR imaging acquisitions of 15 patients with Parkinson's disease were fused with a digitized version of the Schaltenbrand and Wahren anatomic atlas. The MR signal intensity within the anatomic limits of the subthalamic nucleus was evaluated. An anatomic specimen obtained at autopsy was used to evaluate iron content. RESULTS: In all patients, the subthalamic nucleus was hypointense on both sides in the anterior half of the nucleus. At more posterior levels of the nucleus, hypointensity was less frequently observed (20-80%). Hypointensity was never observed at the most posterior pole. Iron was present in the anteromedial part of the nucleus but absent at the most posterior levels. CONCLUSION: The hypointense signal intensity located lateral to the red nucleus and dorsolateral to the substantia nigra correlates with the presence of iron and corresponds anatomically to the subthalamic nucleus. It can therefore be used as a landmark for electrode implantation in patients with Parkinson's disease. It should, however, be emphasized that although hypointensity was always present in the anterior half of the subthalamic nucleus, the posterior part of the nucleus was not visible in most cases.</div>
</front>
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<double idat="0195-6108:2004:Dormont D:is:the:subthalamic"><INIST><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Is the subthalamic nucleus hypointense on T2-weighted images? A correlation study using MR imaging and stereotactic atlas data</title>
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<sZ>1 aut.</sZ>
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<author><name sortKey="Ricciardi, Kenneth G" sort="Ricciardi, Kenneth G" uniqKey="Ricciardi K" first="Kenneth G." last="Ricciardi">Kenneth G. Ricciardi</name>
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</author>
<author><name sortKey="Tande, Dominique" sort="Tande, Dominique" uniqKey="Tande D" first="Dominique" last="Tande">Dominique Tande</name>
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</author>
<author><name sortKey="Parain, Karine" sort="Parain, Karine" uniqKey="Parain K" first="Karine" last="Parain">Karine Parain</name>
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</author>
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<sZ>9 aut.</sZ>
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<author><name sortKey="Menuel, Carole" sort="Menuel, Carole" uniqKey="Menuel C" first="Carole" last="Menuel">Carole Menuel</name>
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<sZ>1 aut.</sZ>
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<wicri:noRegion> Paris</wicri:noRegion>
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<author><name sortKey="Galanaud, Damien" sort="Galanaud, Damien" uniqKey="Galanaud D" first="Damien" last="Galanaud">Damien Galanaud</name>
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<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
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<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
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<author><name sortKey="Navarro, Soledad" sort="Navarro, Soledad" uniqKey="Navarro S" first="Soledad" last="Navarro">Soledad Navarro</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Neurosurgery, Pitié-Salpêtrière Hospital</s1>
<s2> Paris</s2>
<s3>FRA</s3>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
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<author><name sortKey="Cornu, Philippe" sort="Cornu, Philippe" uniqKey="Cornu P" first="Philippe" last="Cornu">Philippe Cornu</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Neurosurgery, Pitié-Salpêtrière Hospital</s1>
<s2> Paris</s2>
<s3>FRA</s3>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
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<wicri:noRegion> Paris</wicri:noRegion>
<wicri:noRegion>Pitié-Salpêtrière Hospital</wicri:noRegion>
<wicri:noRegion> Paris</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1> Department ofNeurology, Pitié-Salpêtrière Hospital</s1>
<s2> Paris</s2>
<s3>FRA</s3>
<sZ>9 aut.</sZ>
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<wicri:noRegion> Paris</wicri:noRegion>
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<author><name sortKey="Yelnik, Jerome" sort="Yelnik, Jerome" uniqKey="Yelnik J" first="Jérome" last="Yelnik">Jérome Yelnik</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>INSERM U289, Pitié-Salpêtrière Hospital</s1>
<s2> Paris</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
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<wicri:noRegion> Paris</wicri:noRegion>
<wicri:noRegion>Pitié-Salpêtrière Hospital</wicri:noRegion>
<wicri:noRegion> Paris</wicri:noRegion>
</affiliation>
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</analytic>
<series><title level="j" type="main">American journal of neuroradiology</title>
<title level="j" type="abbreviated">Am. j. neuroradiol.</title>
<idno type="ISSN">0195-6108</idno>
<imprint><date when="2004">2004</date>
</imprint>
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<term>Nervous system diseases</term>
<term>Nuclear magnetic resonance imaging</term>
<term>Radiodiagnosis</term>
<term>Stereotaxia</term>
<term>Subthalamic nucleus</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term>
<term>Radiodiagnostic</term>
<term>Noyau sousthalamique</term>
<term>Imagerie RMN</term>
<term>Stéréotaxie</term>
<term>Atlas</term>
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<front><div type="abstract" xml:lang="en">BACKGROUND AND PURPOSE: Although the subthalamic nucleus is the most frequently used target for surgical treatment of Parkinson's disease, the criteria on which it can be identified on T2-weighted images have never been clearly defined. This study was conducted to characterize the precise anatomic distribution of T2-weighted hyposignal in the subthalamic region and to correlate this hyposignal with iron content in the subthalamic nucleus. METHODS: The T2-weighted MR imaging acquisitions of 15 patients with Parkinson's disease were fused with a digitized version of the Schaltenbrand and Wahren anatomic atlas. The MR signal intensity within the anatomic limits of the subthalamic nucleus was evaluated. An anatomic specimen obtained at autopsy was used to evaluate iron content. RESULTS: In all patients, the subthalamic nucleus was hypointense on both sides in the anterior half of the nucleus. At more posterior levels of the nucleus, hypointensity was less frequently observed (20-80%). Hypointensity was never observed at the most posterior pole. Iron was present in the anteromedial part of the nucleus but absent at the most posterior levels. CONCLUSION: The hypointense signal intensity located lateral to the red nucleus and dorsolateral to the substantia nigra correlates with the presence of iron and corresponds anatomically to the subthalamic nucleus. It can therefore be used as a landmark for electrode implantation in patients with Parkinson's disease. It should, however, be emphasized that although hypointensity was always present in the anterior half of the subthalamic nucleus, the posterior part of the nucleus was not visible in most cases.</div>
</front>
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<affiliation wicri:level="3"><nlm:affiliation>Department of Neuroradiology, Pitié-Salpêtrière Hospital, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Neuroradiology, Pitié-Salpêtrière Hospital, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
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</author>
<author><name sortKey="Ricciardi, Kenneth G" sort="Ricciardi, Kenneth G" uniqKey="Ricciardi K" first="Kenneth G" last="Ricciardi">Kenneth G. Ricciardi</name>
</author>
<author><name sortKey="Tande, Dominique" sort="Tande, Dominique" uniqKey="Tande D" first="Dominique" last="Tandé">Dominique Tandé</name>
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<author><name sortKey="Parain, Karine" sort="Parain, Karine" uniqKey="Parain K" first="Karine" last="Parain">Karine Parain</name>
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<author><name sortKey="Menuel, Carole" sort="Menuel, Carole" uniqKey="Menuel C" first="Carole" last="Menuel">Carole Menuel</name>
</author>
<author><name sortKey="Galanaud, Damien" sort="Galanaud, Damien" uniqKey="Galanaud D" first="Damien" last="Galanaud">Damien Galanaud</name>
</author>
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</author>
<author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name>
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<placeName><settlement type="city">Paris</settlement>
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</placeName>
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<country>France</country>
<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
<orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName>
</affiliation>
</author>
<author><name sortKey="Yelnik, Jerome" sort="Yelnik, Jerome" uniqKey="Yelnik J" first="Jérôme" last="Yelnik">Jérôme Yelnik</name>
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<date when="2004">2004</date>
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<idno type="wicri:doubleKey">0195-6108:2004:Dormont D:is:the:subthalamic</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Is the subthalamic nucleus hypointense on T2-weighted images? A correlation study using MR imaging and stereotactic atlas data.</title>
<author><name sortKey="Dormont, Didier" sort="Dormont, Didier" uniqKey="Dormont D" first="Didier" last="Dormont">Didier Dormont</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Neuroradiology, Pitié-Salpêtrière Hospital, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Neuroradiology, Pitié-Salpêtrière Hospital, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ricciardi, Kenneth G" sort="Ricciardi, Kenneth G" uniqKey="Ricciardi K" first="Kenneth G" last="Ricciardi">Kenneth G. Ricciardi</name>
</author>
<author><name sortKey="Tande, Dominique" sort="Tande, Dominique" uniqKey="Tande D" first="Dominique" last="Tandé">Dominique Tandé</name>
</author>
<author><name sortKey="Parain, Karine" sort="Parain, Karine" uniqKey="Parain K" first="Karine" last="Parain">Karine Parain</name>
</author>
<author><name sortKey="Menuel, Carole" sort="Menuel, Carole" uniqKey="Menuel C" first="Carole" last="Menuel">Carole Menuel</name>
</author>
<author><name sortKey="Galanaud, Damien" sort="Galanaud, Damien" uniqKey="Galanaud D" first="Damien" last="Galanaud">Damien Galanaud</name>
</author>
<author><name sortKey="Navarro, Soledad" sort="Navarro, Soledad" uniqKey="Navarro S" first="Soledad" last="Navarro">Soledad Navarro</name>
</author>
<author><name sortKey="Cornu, Philippe" sort="Cornu, Philippe" uniqKey="Cornu P" first="Philippe" last="Cornu">Philippe Cornu</name>
</author>
<author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name>
<affiliation><country>France</country>
<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
<orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
<orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName>
</affiliation>
</author>
<author><name sortKey="Yelnik, Jerome" sort="Yelnik, Jerome" uniqKey="Yelnik J" first="Jérôme" last="Yelnik">Jérôme Yelnik</name>
</author>
</analytic>
<series><title level="j">AJNR. American journal of neuroradiology</title>
<idno type="ISSN">0195-6108</idno>
<imprint><date when="2004" type="published">2004</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Brain Mapping</term>
<term>Female</term>
<term>Humans</term>
<term>Image Interpretation, Computer-Assisted</term>
<term>Iron (metabolism)</term>
<term>Magnetic Resonance Imaging (statistics & numerical data)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neurons (pathology)</term>
<term>Parkinson Disease (diagnosis)</term>
<term>Parkinson Disease (pathology)</term>
<term>Parkinson Disease (surgery)</term>
<term>Sensitivity and Specificity</term>
<term>Statistics as Topic</term>
<term>Stereotaxic Techniques (statistics & numerical data)</term>
<term>Subthalamic Nucleus (pathology)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Iron</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Neurons</term>
<term>Parkinson Disease</term>
<term>Subthalamic Nucleus</term>
</keywords>
<keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Magnetic Resonance Imaging</term>
<term>Stereotaxic Techniques</term>
</keywords>
<keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Brain Mapping</term>
<term>Female</term>
<term>Humans</term>
<term>Image Interpretation, Computer-Assisted</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Sensitivity and Specificity</term>
<term>Statistics as Topic</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Although the subthalamic nucleus is the most frequently used target for surgical treatment of Parkinson's disease, the criteria on which it can be identified on T2-weighted images have never been clearly defined. This study was conducted to characterize the precise anatomic distribution of T2-weighted hyposignal in the subthalamic region and to correlate this hyposignal with iron content in the subthalamic nucleus.</div>
</front>
</TEI>
</PubMed>
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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

Is the subthalamic nucleus hypointense on T2-weighted images? A correlation study using MR imaging and stereotactic atlas data

Is the subthalamic nucleus hypointense on T2-weighted images? A correlation study using MR imaging and stereotactic atlas data

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