Is the subthalamic nucleus hypointense on T2-weighted images? A correlation study using MR imaging and stereotactic atlas data
Identifieur interne :
000684 ( PascalFrancis/Curation );
précédent :
000683;
suivant :
000685
Is the subthalamic nucleus hypointense on T2-weighted images? A correlation study using MR imaging and stereotactic atlas data
Auteurs : Didier Dormont [
France] ;
Kenneth G. Ricciardi [
France] ;
Dominique Tande [
France] ;
Karine Parain [
France] ;
Carole Menuel [
France] ;
Damien Galanaud [
France] ;
Soledad Navarro [
France] ;
Philippe Cornu [
France] ;
Yves Agid [
France] ;
Jérome Yelnik [
France]
Source :
-
American journal of neuroradiology [ 0195-6108 ] ; 2004.
RBID : Pascal:04-0588707
Descripteurs français
English descriptors
Abstract
BACKGROUND AND PURPOSE: Although the subthalamic nucleus is the most frequently used target for surgical treatment of Parkinson's disease, the criteria on which it can be identified on T2-weighted images have never been clearly defined. This study was conducted to characterize the precise anatomic distribution of T2-weighted hyposignal in the subthalamic region and to correlate this hyposignal with iron content in the subthalamic nucleus. METHODS: The T2-weighted MR imaging acquisitions of 15 patients with Parkinson's disease were fused with a digitized version of the Schaltenbrand and Wahren anatomic atlas. The MR signal intensity within the anatomic limits of the subthalamic nucleus was evaluated. An anatomic specimen obtained at autopsy was used to evaluate iron content. RESULTS: In all patients, the subthalamic nucleus was hypointense on both sides in the anterior half of the nucleus. At more posterior levels of the nucleus, hypointensity was less frequently observed (20-80%). Hypointensity was never observed at the most posterior pole. Iron was present in the anteromedial part of the nucleus but absent at the most posterior levels. CONCLUSION: The hypointense signal intensity located lateral to the red nucleus and dorsolateral to the substantia nigra correlates with the presence of iron and corresponds anatomically to the subthalamic nucleus. It can therefore be used as a landmark for electrode implantation in patients with Parkinson's disease. It should, however, be emphasized that although hypointensity was always present in the anterior half of the subthalamic nucleus, the posterior part of the nucleus was not visible in most cases.
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| C01 | 01 | | ENG | @0 BACKGROUND AND PURPOSE: Although the subthalamic nucleus is the most frequently used target for surgical treatment of Parkinson's disease, the criteria on which it can be identified on T2-weighted images have never been clearly defined. This study was conducted to characterize the precise anatomic distribution of T2-weighted hyposignal in the subthalamic region and to correlate this hyposignal with iron content in the subthalamic nucleus. METHODS: The T2-weighted MR imaging acquisitions of 15 patients with Parkinson's disease were fused with a digitized version of the Schaltenbrand and Wahren anatomic atlas. The MR signal intensity within the anatomic limits of the subthalamic nucleus was evaluated. An anatomic specimen obtained at autopsy was used to evaluate iron content. RESULTS: In all patients, the subthalamic nucleus was hypointense on both sides in the anterior half of the nucleus. At more posterior levels of the nucleus, hypointensity was less frequently observed (20-80%). Hypointensity was never observed at the most posterior pole. Iron was present in the anteromedial part of the nucleus but absent at the most posterior levels. CONCLUSION: The hypointense signal intensity located lateral to the red nucleus and dorsolateral to the substantia nigra correlates with the presence of iron and corresponds anatomically to the subthalamic nucleus. It can therefore be used as a landmark for electrode implantation in patients with Parkinson's disease. It should, however, be emphasized that although hypointensity was always present in the anterior half of the subthalamic nucleus, the posterior part of the nucleus was not visible in most cases. |
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| A30 | 01 | 1 | ENG | @1 Annual Meeting of the American Society of Neuroradiology @2 41 @3 Washington, DC USA @4 2003-05 |
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Le document en format XML
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</publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Is the subthalamic nucleus hypointense on T2-weighted images? A correlation study using MR imaging and stereotactic atlas data</title>
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<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neuroradiology, Pitié-Salpêtrière Hospital</s1>
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<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14><country>France</country>
</affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>UPR 640 CNRS LENA, Pitié-Salpêtrière Hospital</s1>
<s2> Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14><country>France</country>
</affiliation><author><name sortKey="Ricciardi, Kenneth G" sort="Ricciardi, Kenneth G" uniqKey="Ricciardi K" first="Kenneth G." last="Ricciardi">Kenneth G. Ricciardi</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neuroradiology, Pitié-Salpêtrière Hospital</s1>
<s2>Paris</s2>
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</inist:fA14><country>France</country>
</affiliation><author><name sortKey="Tande, Dominique" sort="Tande, Dominique" uniqKey="Tande D" first="Dominique" last="Tande">Dominique Tande</name>
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<s2> Paris</s2>
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<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14><country>France</country>
</affiliation><author><name sortKey="Parain, Karine" sort="Parain, Karine" uniqKey="Parain K" first="Karine" last="Parain">Karine Parain</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>INSERM U289, Pitié-Salpêtrière Hospital</s1>
<s2> Paris</s2>
<s3>FRA</s3>
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<sZ>10 aut.</sZ>
</inist:fA14><country>France</country>
</affiliation><author><name sortKey="Menuel, Carole" sort="Menuel, Carole" uniqKey="Menuel C" first="Carole" last="Menuel">Carole Menuel</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>UPR 640 CNRS LENA, Pitié-Salpêtrière Hospital</s1>
<s2> Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14><country>France</country>
</affiliation><author><name sortKey="Galanaud, Damien" sort="Galanaud, Damien" uniqKey="Galanaud D" first="Damien" last="Galanaud">Damien Galanaud</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neuroradiology, Pitié-Salpêtrière Hospital</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14><country>France</country>
</affiliation><author><name sortKey="Navarro, Soledad" sort="Navarro, Soledad" uniqKey="Navarro S" first="Soledad" last="Navarro">Soledad Navarro</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Neurosurgery, Pitié-Salpêtrière Hospital</s1>
<s2> Paris</s2>
<s3>FRA</s3>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14><country>France</country>
</affiliation><author><name sortKey="Cornu, Philippe" sort="Cornu, Philippe" uniqKey="Cornu P" first="Philippe" last="Cornu">Philippe Cornu</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Neurosurgery, Pitié-Salpêtrière Hospital</s1>
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</affiliation><author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1> Department ofNeurology, Pitié-Salpêtrière Hospital</s1>
<s2> Paris</s2>
<s3>FRA</s3>
<sZ>9 aut.</sZ>
</inist:fA14><country>France</country>
</affiliation><author><name sortKey="Yelnik, Jerome" sort="Yelnik, Jerome" uniqKey="Yelnik J" first="Jérome" last="Yelnik">Jérome Yelnik</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>INSERM U289, Pitié-Salpêtrière Hospital</s1>
<s2> Paris</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14><country>France</country>
</affiliation><series><title level="j" type="main">American journal of neuroradiology</title>
<title level="j" type="abbreviated">Am. j. neuroradiol.</title>
<idno type="ISSN">0195-6108</idno>
<imprint><date when="2004">2004</date>
</imprint><seriesStmt><title level="j" type="main">American journal of neuroradiology</title>
<title level="j" type="abbreviated">Am. j. neuroradiol.</title>
<idno type="ISSN">0195-6108</idno>
</seriesStmt><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Atlas</term>
<term>Nervous system diseases</term>
<term>Nuclear magnetic resonance imaging</term>
<term>Radiodiagnosis</term>
<term>Stereotaxia</term>
<term>Subthalamic nucleus</term>
</keywords><keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term>
<term>Radiodiagnostic</term>
<term>Noyau sousthalamique</term>
<term>Imagerie RMN</term>
<term>Stéréotaxie</term>
<term>Atlas</term>
</keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Atlas</term>
</keywords><front><div type="abstract" xml:lang="en">BACKGROUND AND PURPOSE: Although the subthalamic nucleus is the most frequently used target for surgical treatment of Parkinson's disease, the criteria on which it can be identified on T2-weighted images have never been clearly defined. This study was conducted to characterize the precise anatomic distribution of T2-weighted hyposignal in the subthalamic region and to correlate this hyposignal with iron content in the subthalamic nucleus. METHODS: The T2-weighted MR imaging acquisitions of 15 patients with Parkinson's disease were fused with a digitized version of the Schaltenbrand and Wahren anatomic atlas. The MR signal intensity within the anatomic limits of the subthalamic nucleus was evaluated. An anatomic specimen obtained at autopsy was used to evaluate iron content. RESULTS: In all patients, the subthalamic nucleus was hypointense on both sides in the anterior half of the nucleus. At more posterior levels of the nucleus, hypointensity was less frequently observed (20-80%). Hypointensity was never observed at the most posterior pole. Iron was present in the anteromedial part of the nucleus but absent at the most posterior levels. CONCLUSION: The hypointense signal intensity located lateral to the red nucleus and dorsolateral to the substantia nigra correlates with the presence of iron and corresponds anatomically to the subthalamic nucleus. It can therefore be used as a landmark for electrode implantation in patients with Parkinson's disease. It should, however, be emphasized that although hypointensity was always present in the anterior half of the subthalamic nucleus, the posterior part of the nucleus was not visible in most cases.</div>
</front><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0195-6108</s0>
</fA01><fA02 i1="01"><s0>AAJNDL</s0>
</fA02><fA03 i2="1"><s0>Am. j. neuroradiol.</s0>
</fA03><fA08 i1="01" i2="1" l="ENG"><s1>Is the subthalamic nucleus hypointense on T2-weighted images? A correlation study using MR imaging and stereotactic atlas data</s1>
</fA08><fA11 i1="01" i2="1"><s1>DORMONT (Didier)</s1>
</fA11><fA11 i1="02" i2="1"><s1>RICCIARDI (Kenneth G.)</s1>
</fA11><fA11 i1="03" i2="1"><s1>TANDE (Dominique)</s1>
</fA11><fA11 i1="04" i2="1"><s1>PARAIN (Karine)</s1>
</fA11><fA11 i1="05" i2="1"><s1>MENUEL (Carole)</s1>
</fA11><fA11 i1="06" i2="1"><s1>GALANAUD (Damien)</s1>
</fA11><fA11 i1="07" i2="1"><s1>NAVARRO (Soledad)</s1>
</fA11><fA11 i1="08" i2="1"><s1>CORNU (Philippe)</s1>
</fA11><fA11 i1="09" i2="1"><s1>AGID (Yves)</s1>
</fA11><fA11 i1="10" i2="1"><s1>YELNIK (Jérome)</s1>
</fA11><fA14 i1="01"><s1>Department of Neuroradiology, Pitié-Salpêtrière Hospital</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
</fA14><fA14 i1="02"><s1>UPR 640 CNRS LENA, Pitié-Salpêtrière Hospital</s1>
<s2> Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
</fA14><fA14 i1="03"><s1>INSERM U289, Pitié-Salpêtrière Hospital</s1>
<s2> Paris</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
</fA14><fA14 i1="04"><s1>Department of Neurosurgery, Pitié-Salpêtrière Hospital</s1>
<s2> Paris</s2>
<s3>FRA</s3>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</fA14><fA14 i1="05"><s1> Department ofNeurology, Pitié-Salpêtrière Hospital</s1>
<s2> Paris</s2>
<s3>FRA</s3>
<sZ>9 aut.</sZ>
</fA14><fA20><s1>1516-1523</s1>
</fA20><fA21><s1>2004</s1>
</fA21><fA23 i1="01"><s0>ENG</s0>
</fA23><fA43 i1="01"><s1>INIST</s1>
<s2>19668</s2>
<s5>354000122447040130</s5>
</fA43><fA44><s0>0000</s0>
<s1>© 2004 INIST-CNRS. All rights reserved.</s1>
</fA44><fA45><s0>42 ref.</s0>
</fA45><fA47 i1="01" i2="1"><s0>04-0588707</s0>
</fA47><fA60><s1>P</s1>
<s2>C</s2>
</fA60><fA64 i1="01" i2="1"><s0>American journal of neuroradiology</s0>
</fA64><fA66 i1="01"><s0>USA</s0>
</fA66><fC01 i1="01" l="ENG"><s0>BACKGROUND AND PURPOSE: Although the subthalamic nucleus is the most frequently used target for surgical treatment of Parkinson's disease, the criteria on which it can be identified on T2-weighted images have never been clearly defined. This study was conducted to characterize the precise anatomic distribution of T2-weighted hyposignal in the subthalamic region and to correlate this hyposignal with iron content in the subthalamic nucleus. METHODS: The T2-weighted MR imaging acquisitions of 15 patients with Parkinson's disease were fused with a digitized version of the Schaltenbrand and Wahren anatomic atlas. The MR signal intensity within the anatomic limits of the subthalamic nucleus was evaluated. An anatomic specimen obtained at autopsy was used to evaluate iron content. RESULTS: In all patients, the subthalamic nucleus was hypointense on both sides in the anterior half of the nucleus. At more posterior levels of the nucleus, hypointensity was less frequently observed (20-80%). Hypointensity was never observed at the most posterior pole. Iron was present in the anteromedial part of the nucleus but absent at the most posterior levels. CONCLUSION: The hypointense signal intensity located lateral to the red nucleus and dorsolateral to the substantia nigra correlates with the presence of iron and corresponds anatomically to the subthalamic nucleus. It can therefore be used as a landmark for electrode implantation in patients with Parkinson's disease. It should, however, be emphasized that although hypointensity was always present in the anterior half of the subthalamic nucleus, the posterior part of the nucleus was not visible in most cases.</s0>
</fC01><fC02 i1="01" i2="X"><s0>002B24A06</s0>
</fC02><fC02 i1="02" i2="X"><s0>002B24A10</s0>
</fC02><fC02 i1="03" i2="X"><s0>002B24D02</s0>
</fC02><fC03 i1="01" i2="X" l="FRE"><s0>Système nerveux pathologie</s0>
<s5>01</s5>
</fC03><fC03 i1="01" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>01</s5>
</fC03><fC03 i1="01" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>01</s5>
</fC03><fC03 i1="02" i2="X" l="FRE"><s0>Radiodiagnostic</s0>
<s5>02</s5>
</fC03><fC03 i1="02" i2="X" l="ENG"><s0>Radiodiagnosis</s0>
<s5>02</s5>
</fC03><fC03 i1="02" i2="X" l="SPA"><s0>Radiodiagnóstico</s0>
<s5>02</s5>
</fC03><fC03 i1="03" i2="X" l="FRE"><s0>Noyau sousthalamique</s0>
<s5>03</s5>
</fC03><fC03 i1="03" i2="X" l="ENG"><s0>Subthalamic nucleus</s0>
<s5>03</s5>
</fC03><fC03 i1="03" i2="X" l="SPA"><s0>Núcleo subtalámico</s0>
<s5>03</s5>
</fC03><fC03 i1="04" i2="X" l="FRE"><s0>Imagerie RMN</s0>
<s5>05</s5>
</fC03><fC03 i1="04" i2="X" l="ENG"><s0>Nuclear magnetic resonance imaging</s0>
<s5>05</s5>
</fC03><fC03 i1="04" i2="X" l="SPA"><s0>Imaginería RMN</s0>
<s5>05</s5>
</fC03><fC03 i1="05" i2="X" l="FRE"><s0>Stéréotaxie</s0>
<s5>06</s5>
</fC03><fC03 i1="05" i2="X" l="ENG"><s0>Stereotaxia</s0>
<s5>06</s5>
</fC03><fC03 i1="05" i2="X" l="SPA"><s0>Estereotaxia</s0>
<s5>06</s5>
</fC03><fC03 i1="06" i2="X" l="FRE"><s0>Atlas</s0>
<s5>08</s5>
</fC03><fC03 i1="06" i2="X" l="ENG"><s0>Atlas</s0>
<s5>08</s5>
</fC03><fC03 i1="06" i2="X" l="SPA"><s0>Atlas</s0>
<s5>08</s5>
</fC03><fC07 i1="01" i2="X" l="FRE"><s0>Encéphale</s0>
<s5>37</s5>
</fC07><fC07 i1="01" i2="X" l="ENG"><s0>Encephalon</s0>
<s5>37</s5>
</fC07><fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo</s0>
<s5>37</s5>
</fC07><fC07 i1="02" i2="X" l="FRE"><s0>Système nerveux central</s0>
<s5>38</s5>
</fC07><fC07 i1="02" i2="X" l="ENG"><s0>Central nervous system</s0>
<s5>38</s5>
</fC07><fC07 i1="02" i2="X" l="SPA"><s0>Sistema nervioso central</s0>
<s5>38</s5>
</fC07><fN21><s1>341</s1>
</fN21><fN44 i1="01"><s1>OTO</s1>
</fN44><fN82><s1>OTO</s1>
</fN82><pR><fA30 i1="01" i2="1" l="ENG"><s1>Annual Meeting of the American Society of Neuroradiology</s1>
<s2>41</s2>
<s3>Washington, DC USA</s3>
<s4>2003-05</s4>
</fA30>
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