ParkinsonFranceV1, PascalFrancis, Corpus, bibRecord, 000D50

Is the subthalamic nucleus hypointense on T2-weighted images? A correlation study using MR imaging and stereotactic atlas data

Identifieur interne : 000D50 ( PascalFrancis/Corpus ); précédent : 000D49; suivant : 000D51

Is the subthalamic nucleus hypointense on T2-weighted images? A correlation study using MR imaging and stereotactic atlas data

Auteurs : Didier Dormont ; Kenneth G. Ricciardi ; Dominique Tande ; Karine Parain ; Carole Menuel ; Damien Galanaud ; Soledad Navarro ; Philippe Cornu ; Yves Agid ; Jérome Yelnik

Source :

American journal of neuroradiology [ 0195-6108 ] ; 2004.

RBID : Pascal:04-0588707

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Radiodiagnostic, Noyau sousthalamique, Imagerie RMN, Stéréotaxie, Atlas.

English descriptors

KwdEn :
- Atlas, Nervous system diseases, Nuclear magnetic resonance imaging, Radiodiagnosis, Stereotaxia, Subthalamic nucleus.

Abstract

BACKGROUND AND PURPOSE: Although the subthalamic nucleus is the most frequently used target for surgical treatment of Parkinson's disease, the criteria on which it can be identified on T2-weighted images have never been clearly defined. This study was conducted to characterize the precise anatomic distribution of T2-weighted hyposignal in the subthalamic region and to correlate this hyposignal with iron content in the subthalamic nucleus. METHODS: The T2-weighted MR imaging acquisitions of 15 patients with Parkinson's disease were fused with a digitized version of the Schaltenbrand and Wahren anatomic atlas. The MR signal intensity within the anatomic limits of the subthalamic nucleus was evaluated. An anatomic specimen obtained at autopsy was used to evaluate iron content. RESULTS: In all patients, the subthalamic nucleus was hypointense on both sides in the anterior half of the nucleus. At more posterior levels of the nucleus, hypointensity was less frequently observed (20-80%). Hypointensity was never observed at the most posterior pole. Iron was present in the anteromedial part of the nucleus but absent at the most posterior levels. CONCLUSION: The hypointense signal intensity located lateral to the red nucleus and dorsolateral to the substantia nigra correlates with the presence of iron and corresponds anatomically to the subthalamic nucleus. It can therefore be used as a landmark for electrode implantation in patients with Parkinson's disease. It should, however, be emphasized that although hypointensity was always present in the anterior half of the subthalamic nucleus, the posterior part of the nucleus was not visible in most cases.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A08	`01`	`1`	`ENG`	`@1 Is the subthalamic nucleus hypointense on T2-weighted images? A correlation study using MR imaging and stereotactic atlas data`
A11	`01`	`1`		`@1 DORMONT (Didier)`
A11	`02`	`1`		`@1 RICCIARDI (Kenneth G.)`
A11	`03`	`1`		`@1 TANDE (Dominique)`
A11	`04`	`1`		`@1 PARAIN (Karine)`
A11	`05`	`1`		`@1 MENUEL (Carole)`
A11	`06`	`1`		`@1 GALANAUD (Damien)`
A11	`07`	`1`		`@1 NAVARRO (Soledad)`
A11	`08`	`1`		`@1 CORNU (Philippe)`
A11	`09`	`1`		`@1 AGID (Yves)`
A11	`10`	`1`		`@1 YELNIK (Jérome)`
A14	`01`			`@1 Department of Neuroradiology, Pitié-Salpêtrière Hospital @2 Paris @3 FRA @Z 1 aut. @Z 2 aut. @Z 6 aut.`
A14	`02`			`@1 UPR 640 CNRS LENA, Pitié-Salpêtrière Hospital @2 Paris @3 FRA @Z 1 aut. @Z 5 aut.`
A14	`03`			`@1 INSERM U289, Pitié-Salpêtrière Hospital @2 Paris @3 FRA @Z 3 aut. @Z 4 aut. @Z 10 aut.`
A14	`04`			`@1 Department of Neurosurgery, Pitié-Salpêtrière Hospital @2 Paris @3 FRA @Z 7 aut. @Z 8 aut.`
A14	`05`			`@1 Department ofNeurology, Pitié-Salpêtrière Hospital @2 Paris @3 FRA @Z 9 aut.`
A20				`@1 1516-1523`
A21				`@1 2004`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 19668 @5 354000122447040130`
A44				`@0 0000 @1 © 2004 INIST-CNRS. All rights reserved.`
A45				`@0 42 ref.`
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A64	`01`	`1`		`@0 American journal of neuroradiology`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 BACKGROUND AND PURPOSE: Although the subthalamic nucleus is the most frequently used target for surgical treatment of Parkinson's disease, the criteria on which it can be identified on T2-weighted images have never been clearly defined. This study was conducted to characterize the precise anatomic distribution of T2-weighted hyposignal in the subthalamic region and to correlate this hyposignal with iron content in the subthalamic nucleus. METHODS: The T2-weighted MR imaging acquisitions of 15 patients with Parkinson's disease were fused with a digitized version of the Schaltenbrand and Wahren anatomic atlas. The MR signal intensity within the anatomic limits of the subthalamic nucleus was evaluated. An anatomic specimen obtained at autopsy was used to evaluate iron content. RESULTS: In all patients, the subthalamic nucleus was hypointense on both sides in the anterior half of the nucleus. At more posterior levels of the nucleus, hypointensity was less frequently observed (20-80%). Hypointensity was never observed at the most posterior pole. Iron was present in the anteromedial part of the nucleus but absent at the most posterior levels. CONCLUSION: The hypointense signal intensity located lateral to the red nucleus and dorsolateral to the substantia nigra correlates with the presence of iron and corresponds anatomically to the subthalamic nucleus. It can therefore be used as a landmark for electrode implantation in patients with Parkinson's disease. It should, however, be emphasized that although hypointensity was always present in the anterior half of the subthalamic nucleus, the posterior part of the nucleus was not visible in most cases.
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C03	`03`	`X`	`FRE`	`@0 Noyau sousthalamique @5 03`
C03	`03`	`X`	`ENG`	`@0 Subthalamic nucleus @5 03`
C03	`03`	`X`	`SPA`	`@0 Núcleo subtalámico @5 03`
C03	`04`	`X`	`FRE`	`@0 Imagerie RMN @5 05`
C03	`04`	`X`	`ENG`	`@0 Nuclear magnetic resonance imaging @5 05`
C03	`04`	`X`	`SPA`	`@0 Imaginería RMN @5 05`
C03	`05`	`X`	`FRE`	`@0 Stéréotaxie @5 06`
C03	`05`	`X`	`ENG`	`@0 Stereotaxia @5 06`
C03	`05`	`X`	`SPA`	`@0 Estereotaxia @5 06`
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A30	`01`	`1`	`ENG`	`@1 Annual Meeting of the American Society of Neuroradiology @2 41 @3 Washington, DC USA @4 2003-05`

Format Inist (serveur)

NO :	PASCAL 04-0588707 INIST
ET :	Is the subthalamic nucleus hypointense on T2-weighted images? A correlation study using MR imaging and stereotactic atlas data
AU :	DORMONT (Didier); RICCIARDI (Kenneth G.); TANDE (Dominique); PARAIN (Karine); MENUEL (Carole); GALANAUD (Damien); NAVARRO (Soledad); CORNU (Philippe); AGID (Yves); YELNIK (Jérome)
AF :	Department of Neuroradiology, Pitié-Salpêtrière Hospital/Paris/France (1 aut., 2 aut., 6 aut.); UPR 640 CNRS LENA, Pitié-Salpêtrière Hospital/ Paris/France (1 aut., 5 aut.); INSERM U289, Pitié-Salpêtrière Hospital/ Paris/France (3 aut., 4 aut., 10 aut.); Department of Neurosurgery, Pitié-Salpêtrière Hospital/ Paris/France (7 aut., 8 aut.); Department ofNeurology, Pitié-Salpêtrière Hospital/ Paris/France (9 aut.)
DT :	Publication en série; Congrès; Niveau analytique
SO :	American journal of neuroradiology; ISSN 0195-6108; Coden AAJNDL; Etats-Unis; Da. 2004; Vol. 25; No. 9; Pp. 1516-1523; Bibl. 42 ref.
LA :	Anglais
EA :	BACKGROUND AND PURPOSE: Although the subthalamic nucleus is the most frequently used target for surgical treatment of Parkinson's disease, the criteria on which it can be identified on T2-weighted images have never been clearly defined. This study was conducted to characterize the precise anatomic distribution of T2-weighted hyposignal in the subthalamic region and to correlate this hyposignal with iron content in the subthalamic nucleus. METHODS: The T2-weighted MR imaging acquisitions of 15 patients with Parkinson's disease were fused with a digitized version of the Schaltenbrand and Wahren anatomic atlas. The MR signal intensity within the anatomic limits of the subthalamic nucleus was evaluated. An anatomic specimen obtained at autopsy was used to evaluate iron content. RESULTS: In all patients, the subthalamic nucleus was hypointense on both sides in the anterior half of the nucleus. At more posterior levels of the nucleus, hypointensity was less frequently observed (20-80%). Hypointensity was never observed at the most posterior pole. Iron was present in the anteromedial part of the nucleus but absent at the most posterior levels. CONCLUSION: The hypointense signal intensity located lateral to the red nucleus and dorsolateral to the substantia nigra correlates with the presence of iron and corresponds anatomically to the subthalamic nucleus. It can therefore be used as a landmark for electrode implantation in patients with Parkinson's disease. It should, however, be emphasized that although hypointensity was always present in the anterior half of the subthalamic nucleus, the posterior part of the nucleus was not visible in most cases.
CC :	002B24A06; 002B24A10; 002B24D02
FD :	Système nerveux pathologie; Radiodiagnostic; Noyau sousthalamique; Imagerie RMN; Stéréotaxie; Atlas
FG :	Encéphale; Système nerveux central
ED :	Nervous system diseases; Radiodiagnosis; Subthalamic nucleus; Nuclear magnetic resonance imaging; Stereotaxia; Atlas
EG :	Encephalon; Central nervous system
SD :	Sistema nervioso patología; Radiodiagnóstico; Núcleo subtalámico; Imaginería RMN; Estereotaxia; Atlas
LO :	INIST-19668.354000122447040130
ID :	04-0588707

Links to Exploration step

Pascal:04-0588707

Le document en format XML

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<front><div type="abstract" xml:lang="en">BACKGROUND AND PURPOSE: Although the subthalamic nucleus is the most frequently used target for surgical treatment of Parkinson's disease, the criteria on which it can be identified on T2-weighted images have never been clearly defined. This study was conducted to characterize the precise anatomic distribution of T2-weighted hyposignal in the subthalamic region and to correlate this hyposignal with iron content in the subthalamic nucleus. METHODS: The T2-weighted MR imaging acquisitions of 15 patients with Parkinson's disease were fused with a digitized version of the Schaltenbrand and Wahren anatomic atlas. The MR signal intensity within the anatomic limits of the subthalamic nucleus was evaluated. An anatomic specimen obtained at autopsy was used to evaluate iron content. RESULTS: In all patients, the subthalamic nucleus was hypointense on both sides in the anterior half of the nucleus. At more posterior levels of the nucleus, hypointensity was less frequently observed (20-80%). Hypointensity was never observed at the most posterior pole. Iron was present in the anteromedial part of the nucleus but absent at the most posterior levels. CONCLUSION: The hypointense signal intensity located lateral to the red nucleus and dorsolateral to the substantia nigra correlates with the presence of iron and corresponds anatomically to the subthalamic nucleus. It can therefore be used as a landmark for electrode implantation in patients with Parkinson's disease. It should, however, be emphasized that although hypointensity was always present in the anterior half of the subthalamic nucleus, the posterior part of the nucleus was not visible in most cases.</div>
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<fA02 i1="01"><s0>AAJNDL</s0>
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<fA03 i2="1"><s0>Am. j. neuroradiol.</s0>
</fA03>
<fA05><s2>25</s2>
</fA05>
<fA06><s2>9</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>Is the subthalamic nucleus hypointense on T2-weighted images? A correlation study using MR imaging and stereotactic atlas data</s1>
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<fA11 i1="01" i2="1"><s1>DORMONT (Didier)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>RICCIARDI (Kenneth G.)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>TANDE (Dominique)</s1>
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<fA11 i1="04" i2="1"><s1>PARAIN (Karine)</s1>
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<fA11 i1="05" i2="1"><s1>MENUEL (Carole)</s1>
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<fA11 i1="06" i2="1"><s1>GALANAUD (Damien)</s1>
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<fA11 i1="07" i2="1"><s1>NAVARRO (Soledad)</s1>
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<fA11 i1="08" i2="1"><s1>CORNU (Philippe)</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>AGID (Yves)</s1>
</fA11>
<fA11 i1="10" i2="1"><s1>YELNIK (Jérome)</s1>
</fA11>
<fA14 i1="01"><s1>Department of Neuroradiology, Pitié-Salpêtrière Hospital</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
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<fA14 i1="02"><s1>UPR 640 CNRS LENA, Pitié-Salpêtrière Hospital</s1>
<s2> Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>INSERM U289, Pitié-Salpêtrière Hospital</s1>
<s2> Paris</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
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<fA14 i1="04"><s1>Department of Neurosurgery, Pitié-Salpêtrière Hospital</s1>
<s2> Paris</s2>
<s3>FRA</s3>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</fA14>
<fA14 i1="05"><s1> Department ofNeurology, Pitié-Salpêtrière Hospital</s1>
<s2> Paris</s2>
<s3>FRA</s3>
<sZ>9 aut.</sZ>
</fA14>
<fA20><s1>1516-1523</s1>
</fA20>
<fA21><s1>2004</s1>
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<fA61><s0>A</s0>
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<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>BACKGROUND AND PURPOSE: Although the subthalamic nucleus is the most frequently used target for surgical treatment of Parkinson's disease, the criteria on which it can be identified on T2-weighted images have never been clearly defined. This study was conducted to characterize the precise anatomic distribution of T2-weighted hyposignal in the subthalamic region and to correlate this hyposignal with iron content in the subthalamic nucleus. METHODS: The T2-weighted MR imaging acquisitions of 15 patients with Parkinson's disease were fused with a digitized version of the Schaltenbrand and Wahren anatomic atlas. The MR signal intensity within the anatomic limits of the subthalamic nucleus was evaluated. An anatomic specimen obtained at autopsy was used to evaluate iron content. RESULTS: In all patients, the subthalamic nucleus was hypointense on both sides in the anterior half of the nucleus. At more posterior levels of the nucleus, hypointensity was less frequently observed (20-80%). Hypointensity was never observed at the most posterior pole. Iron was present in the anteromedial part of the nucleus but absent at the most posterior levels. CONCLUSION: The hypointense signal intensity located lateral to the red nucleus and dorsolateral to the substantia nigra correlates with the presence of iron and corresponds anatomically to the subthalamic nucleus. It can therefore be used as a landmark for electrode implantation in patients with Parkinson's disease. It should, however, be emphasized that although hypointensity was always present in the anterior half of the subthalamic nucleus, the posterior part of the nucleus was not visible in most cases.</s0>
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<fC03 i1="01" i2="X" l="FRE"><s0>Système nerveux pathologie</s0>
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<pR><fA30 i1="01" i2="1" l="ENG"><s1>Annual Meeting of the American Society of Neuroradiology</s1>
<s2>41</s2>
<s3>Washington, DC USA</s3>
<s4>2003-05</s4>
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<server><NO>PASCAL 04-0588707 INIST</NO>
<ET>Is the subthalamic nucleus hypointense on T2-weighted images? A correlation study using MR imaging and stereotactic atlas data</ET>
<AU>DORMONT (Didier); RICCIARDI (Kenneth G.); TANDE (Dominique); PARAIN (Karine); MENUEL (Carole); GALANAUD (Damien); NAVARRO (Soledad); CORNU (Philippe); AGID (Yves); YELNIK (Jérome)</AU>
<AF>Department of Neuroradiology, Pitié-Salpêtrière Hospital/Paris/France (1 aut., 2 aut., 6 aut.); UPR 640 CNRS LENA, Pitié-Salpêtrière Hospital/ Paris/France (1 aut., 5 aut.); INSERM U289, Pitié-Salpêtrière Hospital/ Paris/France (3 aut., 4 aut., 10 aut.); Department of Neurosurgery, Pitié-Salpêtrière Hospital/ Paris/France (7 aut., 8 aut.);  Department ofNeurology, Pitié-Salpêtrière Hospital/ Paris/France (9 aut.)</AF>
<DT>Publication en série; Congrès; Niveau analytique</DT>
<SO>American journal of neuroradiology; ISSN 0195-6108; Coden AAJNDL; Etats-Unis; Da. 2004; Vol. 25; No. 9; Pp. 1516-1523; Bibl. 42 ref.</SO>
<LA>Anglais</LA>
<EA>BACKGROUND AND PURPOSE: Although the subthalamic nucleus is the most frequently used target for surgical treatment of Parkinson's disease, the criteria on which it can be identified on T2-weighted images have never been clearly defined. This study was conducted to characterize the precise anatomic distribution of T2-weighted hyposignal in the subthalamic region and to correlate this hyposignal with iron content in the subthalamic nucleus. METHODS: The T2-weighted MR imaging acquisitions of 15 patients with Parkinson's disease were fused with a digitized version of the Schaltenbrand and Wahren anatomic atlas. The MR signal intensity within the anatomic limits of the subthalamic nucleus was evaluated. An anatomic specimen obtained at autopsy was used to evaluate iron content. RESULTS: In all patients, the subthalamic nucleus was hypointense on both sides in the anterior half of the nucleus. At more posterior levels of the nucleus, hypointensity was less frequently observed (20-80%). Hypointensity was never observed at the most posterior pole. Iron was present in the anteromedial part of the nucleus but absent at the most posterior levels. CONCLUSION: The hypointense signal intensity located lateral to the red nucleus and dorsolateral to the substantia nigra correlates with the presence of iron and corresponds anatomically to the subthalamic nucleus. It can therefore be used as a landmark for electrode implantation in patients with Parkinson's disease. It should, however, be emphasized that although hypointensity was always present in the anterior half of the subthalamic nucleus, the posterior part of the nucleus was not visible in most cases.</EA>
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<FG>Encéphale; Système nerveux central</FG>
<ED>Nervous system diseases; Radiodiagnosis; Subthalamic nucleus; Nuclear magnetic resonance imaging; Stereotaxia; Atlas</ED>
<EG>Encephalon; Central nervous system</EG>
<SD>Sistema nervioso patología; Radiodiagnóstico; Núcleo subtalámico; Imaginería RMN; Estereotaxia; Atlas</SD>
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	La maladie de Parkinson en France (serveur d'exploration)
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Is the subthalamic nucleus hypointense on T2-weighted images? A correlation study using MR imaging and stereotactic atlas data

Is the subthalamic nucleus hypointense on T2-weighted images? A correlation study using MR imaging and stereotactic atlas data

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