Is the subthalamic nucleus hypointense on T2-weighted images? A correlation study using MR imaging and stereotactic atlas data
Identifieur interne : 000D50 ( PascalFrancis/Corpus ); précédent : 000D49; suivant : 000D51Is the subthalamic nucleus hypointense on T2-weighted images? A correlation study using MR imaging and stereotactic atlas data
Auteurs : Didier Dormont ; Kenneth G. Ricciardi ; Dominique Tande ; Karine Parain ; Carole Menuel ; Damien Galanaud ; Soledad Navarro ; Philippe Cornu ; Yves Agid ; Jérome YelnikSource :
- American journal of neuroradiology [ 0195-6108 ] ; 2004.
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- Pascal (Inist)
English descriptors
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Abstract
BACKGROUND AND PURPOSE: Although the subthalamic nucleus is the most frequently used target for surgical treatment of Parkinson's disease, the criteria on which it can be identified on T2-weighted images have never been clearly defined. This study was conducted to characterize the precise anatomic distribution of T2-weighted hyposignal in the subthalamic region and to correlate this hyposignal with iron content in the subthalamic nucleus. METHODS: The T2-weighted MR imaging acquisitions of 15 patients with Parkinson's disease were fused with a digitized version of the Schaltenbrand and Wahren anatomic atlas. The MR signal intensity within the anatomic limits of the subthalamic nucleus was evaluated. An anatomic specimen obtained at autopsy was used to evaluate iron content. RESULTS: In all patients, the subthalamic nucleus was hypointense on both sides in the anterior half of the nucleus. At more posterior levels of the nucleus, hypointensity was less frequently observed (20-80%). Hypointensity was never observed at the most posterior pole. Iron was present in the anteromedial part of the nucleus but absent at the most posterior levels. CONCLUSION: The hypointense signal intensity located lateral to the red nucleus and dorsolateral to the substantia nigra correlates with the presence of iron and corresponds anatomically to the subthalamic nucleus. It can therefore be used as a landmark for electrode implantation in patients with Parkinson's disease. It should, however, be emphasized that although hypointensity was always present in the anterior half of the subthalamic nucleus, the posterior part of the nucleus was not visible in most cases.
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NO : | PASCAL 04-0588707 INIST |
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ET : | Is the subthalamic nucleus hypointense on T2-weighted images? A correlation study using MR imaging and stereotactic atlas data |
AU : | DORMONT (Didier); RICCIARDI (Kenneth G.); TANDE (Dominique); PARAIN (Karine); MENUEL (Carole); GALANAUD (Damien); NAVARRO (Soledad); CORNU (Philippe); AGID (Yves); YELNIK (Jérome) |
AF : | Department of Neuroradiology, Pitié-Salpêtrière Hospital/Paris/France (1 aut., 2 aut., 6 aut.); UPR 640 CNRS LENA, Pitié-Salpêtrière Hospital/ Paris/France (1 aut., 5 aut.); INSERM U289, Pitié-Salpêtrière Hospital/ Paris/France (3 aut., 4 aut., 10 aut.); Department of Neurosurgery, Pitié-Salpêtrière Hospital/ Paris/France (7 aut., 8 aut.); Department ofNeurology, Pitié-Salpêtrière Hospital/ Paris/France (9 aut.) |
DT : | Publication en série; Congrès; Niveau analytique |
SO : | American journal of neuroradiology; ISSN 0195-6108; Coden AAJNDL; Etats-Unis; Da. 2004; Vol. 25; No. 9; Pp. 1516-1523; Bibl. 42 ref. |
LA : | Anglais |
EA : | BACKGROUND AND PURPOSE: Although the subthalamic nucleus is the most frequently used target for surgical treatment of Parkinson's disease, the criteria on which it can be identified on T2-weighted images have never been clearly defined. This study was conducted to characterize the precise anatomic distribution of T2-weighted hyposignal in the subthalamic region and to correlate this hyposignal with iron content in the subthalamic nucleus. METHODS: The T2-weighted MR imaging acquisitions of 15 patients with Parkinson's disease were fused with a digitized version of the Schaltenbrand and Wahren anatomic atlas. The MR signal intensity within the anatomic limits of the subthalamic nucleus was evaluated. An anatomic specimen obtained at autopsy was used to evaluate iron content. RESULTS: In all patients, the subthalamic nucleus was hypointense on both sides in the anterior half of the nucleus. At more posterior levels of the nucleus, hypointensity was less frequently observed (20-80%). Hypointensity was never observed at the most posterior pole. Iron was present in the anteromedial part of the nucleus but absent at the most posterior levels. CONCLUSION: The hypointense signal intensity located lateral to the red nucleus and dorsolateral to the substantia nigra correlates with the presence of iron and corresponds anatomically to the subthalamic nucleus. It can therefore be used as a landmark for electrode implantation in patients with Parkinson's disease. It should, however, be emphasized that although hypointensity was always present in the anterior half of the subthalamic nucleus, the posterior part of the nucleus was not visible in most cases. |
CC : | 002B24A06; 002B24A10; 002B24D02 |
FD : | Système nerveux pathologie; Radiodiagnostic; Noyau sousthalamique; Imagerie RMN; Stéréotaxie; Atlas |
FG : | Encéphale; Système nerveux central |
ED : | Nervous system diseases; Radiodiagnosis; Subthalamic nucleus; Nuclear magnetic resonance imaging; Stereotaxia; Atlas |
EG : | Encephalon; Central nervous system |
SD : | Sistema nervioso patología; Radiodiagnóstico; Núcleo subtalámico; Imaginería RMN; Estereotaxia; Atlas |
LO : | INIST-19668.354000122447040130 |
ID : | 04-0588707 |
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<front><div type="abstract" xml:lang="en">BACKGROUND AND PURPOSE: Although the subthalamic nucleus is the most frequently used target for surgical treatment of Parkinson's disease, the criteria on which it can be identified on T2-weighted images have never been clearly defined. This study was conducted to characterize the precise anatomic distribution of T2-weighted hyposignal in the subthalamic region and to correlate this hyposignal with iron content in the subthalamic nucleus. METHODS: The T2-weighted MR imaging acquisitions of 15 patients with Parkinson's disease were fused with a digitized version of the Schaltenbrand and Wahren anatomic atlas. The MR signal intensity within the anatomic limits of the subthalamic nucleus was evaluated. An anatomic specimen obtained at autopsy was used to evaluate iron content. RESULTS: In all patients, the subthalamic nucleus was hypointense on both sides in the anterior half of the nucleus. At more posterior levels of the nucleus, hypointensity was less frequently observed (20-80%). Hypointensity was never observed at the most posterior pole. Iron was present in the anteromedial part of the nucleus but absent at the most posterior levels. CONCLUSION: The hypointense signal intensity located lateral to the red nucleus and dorsolateral to the substantia nigra correlates with the presence of iron and corresponds anatomically to the subthalamic nucleus. It can therefore be used as a landmark for electrode implantation in patients with Parkinson's disease. It should, however, be emphasized that although hypointensity was always present in the anterior half of the subthalamic nucleus, the posterior part of the nucleus was not visible in most cases.</div>
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<fC01 i1="01" l="ENG"><s0>BACKGROUND AND PURPOSE: Although the subthalamic nucleus is the most frequently used target for surgical treatment of Parkinson's disease, the criteria on which it can be identified on T2-weighted images have never been clearly defined. This study was conducted to characterize the precise anatomic distribution of T2-weighted hyposignal in the subthalamic region and to correlate this hyposignal with iron content in the subthalamic nucleus. METHODS: The T2-weighted MR imaging acquisitions of 15 patients with Parkinson's disease were fused with a digitized version of the Schaltenbrand and Wahren anatomic atlas. The MR signal intensity within the anatomic limits of the subthalamic nucleus was evaluated. An anatomic specimen obtained at autopsy was used to evaluate iron content. RESULTS: In all patients, the subthalamic nucleus was hypointense on both sides in the anterior half of the nucleus. At more posterior levels of the nucleus, hypointensity was less frequently observed (20-80%). Hypointensity was never observed at the most posterior pole. Iron was present in the anteromedial part of the nucleus but absent at the most posterior levels. CONCLUSION: The hypointense signal intensity located lateral to the red nucleus and dorsolateral to the substantia nigra correlates with the presence of iron and corresponds anatomically to the subthalamic nucleus. It can therefore be used as a landmark for electrode implantation in patients with Parkinson's disease. It should, however, be emphasized that although hypointensity was always present in the anterior half of the subthalamic nucleus, the posterior part of the nucleus was not visible in most cases.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B24A06</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B24A10</s0>
</fC02>
<fC02 i1="03" i2="X"><s0>002B24D02</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Système nerveux pathologie</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Radiodiagnostic</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Radiodiagnosis</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Radiodiagnóstico</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Noyau sousthalamique</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Subthalamic nucleus</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Núcleo subtalámico</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Imagerie RMN</s0>
<s5>05</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Nuclear magnetic resonance imaging</s0>
<s5>05</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Imaginería RMN</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Stéréotaxie</s0>
<s5>06</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Stereotaxia</s0>
<s5>06</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Estereotaxia</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Atlas</s0>
<s5>08</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Atlas</s0>
<s5>08</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Atlas</s0>
<s5>08</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Encéphale</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Encephalon</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Système nerveux central</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Central nervous system</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Sistema nervioso central</s0>
<s5>38</s5>
</fC07>
<fN21><s1>341</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
<pR><fA30 i1="01" i2="1" l="ENG"><s1>Annual Meeting of the American Society of Neuroradiology</s1>
<s2>41</s2>
<s3>Washington, DC USA</s3>
<s4>2003-05</s4>
</fA30>
</pR>
</standard>
<server><NO>PASCAL 04-0588707 INIST</NO>
<ET>Is the subthalamic nucleus hypointense on T2-weighted images? A correlation study using MR imaging and stereotactic atlas data</ET>
<AU>DORMONT (Didier); RICCIARDI (Kenneth G.); TANDE (Dominique); PARAIN (Karine); MENUEL (Carole); GALANAUD (Damien); NAVARRO (Soledad); CORNU (Philippe); AGID (Yves); YELNIK (Jérome)</AU>
<AF>Department of Neuroradiology, Pitié-Salpêtrière Hospital/Paris/France (1 aut., 2 aut., 6 aut.); UPR 640 CNRS LENA, Pitié-Salpêtrière Hospital/ Paris/France (1 aut., 5 aut.); INSERM U289, Pitié-Salpêtrière Hospital/ Paris/France (3 aut., 4 aut., 10 aut.); Department of Neurosurgery, Pitié-Salpêtrière Hospital/ Paris/France (7 aut., 8 aut.); Department ofNeurology, Pitié-Salpêtrière Hospital/ Paris/France (9 aut.)</AF>
<DT>Publication en série; Congrès; Niveau analytique</DT>
<SO>American journal of neuroradiology; ISSN 0195-6108; Coden AAJNDL; Etats-Unis; Da. 2004; Vol. 25; No. 9; Pp. 1516-1523; Bibl. 42 ref.</SO>
<LA>Anglais</LA>
<EA>BACKGROUND AND PURPOSE: Although the subthalamic nucleus is the most frequently used target for surgical treatment of Parkinson's disease, the criteria on which it can be identified on T2-weighted images have never been clearly defined. This study was conducted to characterize the precise anatomic distribution of T2-weighted hyposignal in the subthalamic region and to correlate this hyposignal with iron content in the subthalamic nucleus. METHODS: The T2-weighted MR imaging acquisitions of 15 patients with Parkinson's disease were fused with a digitized version of the Schaltenbrand and Wahren anatomic atlas. The MR signal intensity within the anatomic limits of the subthalamic nucleus was evaluated. An anatomic specimen obtained at autopsy was used to evaluate iron content. RESULTS: In all patients, the subthalamic nucleus was hypointense on both sides in the anterior half of the nucleus. At more posterior levels of the nucleus, hypointensity was less frequently observed (20-80%). Hypointensity was never observed at the most posterior pole. Iron was present in the anteromedial part of the nucleus but absent at the most posterior levels. CONCLUSION: The hypointense signal intensity located lateral to the red nucleus and dorsolateral to the substantia nigra correlates with the presence of iron and corresponds anatomically to the subthalamic nucleus. It can therefore be used as a landmark for electrode implantation in patients with Parkinson's disease. It should, however, be emphasized that although hypointensity was always present in the anterior half of the subthalamic nucleus, the posterior part of the nucleus was not visible in most cases.</EA>
<CC>002B24A06; 002B24A10; 002B24D02</CC>
<FD>Système nerveux pathologie; Radiodiagnostic; Noyau sousthalamique; Imagerie RMN; Stéréotaxie; Atlas</FD>
<FG>Encéphale; Système nerveux central</FG>
<ED>Nervous system diseases; Radiodiagnosis; Subthalamic nucleus; Nuclear magnetic resonance imaging; Stereotaxia; Atlas</ED>
<EG>Encephalon; Central nervous system</EG>
<SD>Sistema nervioso patología; Radiodiagnóstico; Núcleo subtalámico; Imaginería RMN; Estereotaxia; Atlas</SD>
<LO>INIST-19668.354000122447040130</LO>
<ID>04-0588707</ID>
</server>
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