Rewiring the brain with cell transplantation in Parkinson's disease.
Identifieur interne : 001541 ( Main/Curation ); précédent : 001540; suivant : 001542Rewiring the brain with cell transplantation in Parkinson's disease.
Auteurs : Afsaneh Gaillard [France] ; Mohamed JaberSource :
- Trends in neurosciences [ 1878-108X ] ; 2011.
English descriptors
- KwdEn :
- Animals, Brain Tissue Transplantation (methods), Brain Tissue Transplantation (trends), Humans, Neural Stem Cells (cytology), Neural Stem Cells (physiology), Neural Stem Cells (transplantation), Parkinson Disease (physiopathology), Parkinson Disease (surgery), Stem Cell Transplantation (methods), Stem Cell Transplantation (trends).
- MESH :
- cytology : Neural Stem Cells.
- methods : Brain Tissue Transplantation, Stem Cell Transplantation.
- physiology : Neural Stem Cells.
- physiopathology : Parkinson Disease.
- surgery : Parkinson Disease.
- transplantation : Neural Stem Cells.
- trends : Brain Tissue Transplantation, Stem Cell Transplantation.
- Animals, Humans.
Abstract
Cell replacement therapy has been proposed as a means to replace lost dopaminergic neurons in Parkinson's disease (PD). In most studies, the transplanted cells have been placed within the target site, the striatum, and not within the lesioned site, the substantia nigra, as the adult nigrostriatal pathway was thought to constitute a non-permissive environment for long distance axonal outgrowth of transplanted neuroblasts. Here, we discuss recent findings showing that intranigral transplanted dopaminergic neuroblasts can form axonal projections to the striatum, resulting in increased striatal dopamine levels and ameliorating behavioral deficits in animal models of PD. Such findings have raised new hopes and opened new avenues for cell replacement therapy in patients with PD.
Url:
DOI: 10.1016/j.tins.2011.01.003
PubMed: 21316770
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Afsaneh.Gaillard@univ-poitiers.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut de Physiologie et Biologie Cellulaires, Université de Poitiers, Centre National de la Recherche Scientifique (CNRS), 1 rue Georges Bonnet, Poitiers, F-86022</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Poitou-Charentes</region></placeName><orgName type="university">Université de Poitiers</orgName></affiliation></author><author><name sortKey="Jaber, Mohamed" sort="Jaber, Mohamed" uniqKey="Jaber M" first="Mohamed" last="Jaber">Mohamed Jaber</name></author></analytic><series><title level="j">Trends in neurosciences</title><idno type="eISSN">1878-108X</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Brain Tissue Transplantation (methods)</term><term>Brain Tissue Transplantation (trends)</term><term>Humans</term><term>Neural Stem Cells (cytology)</term><term>Neural Stem Cells (physiology)</term><term>Neural Stem Cells (transplantation)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (surgery)</term><term>Stem Cell Transplantation (methods)</term><term>Stem Cell Transplantation (trends)</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Neural Stem Cells</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Brain Tissue Transplantation</term><term>Stem Cell Transplantation</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Neural Stem Cells</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="transplantation" xml:lang="en"><term>Neural Stem Cells</term></keywords><keywords scheme="MESH" qualifier="trends" xml:lang="en"><term>Brain Tissue Transplantation</term><term>Stem Cell Transplantation</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Cell replacement therapy has been proposed as a means to replace lost dopaminergic neurons in Parkinson's disease (PD). 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