ParkinsonFranceV1, Hal, Checkpoint, bibRecord, 000582

Rewiring the brain with cell transplantation in Parkinson's disease.

Identifieur interne : 000582 ( Hal/Checkpoint ); précédent : 000581; suivant : 000583

Rewiring the brain with cell transplantation in Parkinson's disease.

Auteurs : Afsaneh Gaillard [France] ; Mohamed Jaber [France]

Source :

Trends in Neurosciences [ 0166-2236 ] ; 2011-03.

RBID : Hal:hal-00582383

Abstract

Cell replacement therapy has been proposed as a means to replace lost dopaminergic neurons in Parkinson's disease (PD). In most studies, the transplanted cells have been placed within the target site, the striatum, and not within the lesioned site, the substantia nigra, as the adult nigrostriatal pathway was thought to constitute a non-permissive environment for long distance axonal outgrowth of transplanted neuroblasts. Here, we discuss recent findings showing that intranigral transplanted dopaminergic neuroblasts can form axonal projections to the striatum, resulting in increased striatal dopamine levels and ameliorating behavioral deficits in animal models of PD. Such findings have raised new hopes and opened new avenues for cell replacement therapy in patients with PD.

Url:

https://hal.archives-ouvertes.fr/hal-00582383

DOI: 10.1016/j.tins.2011.01.003

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Hal:hal-00582383

Le document en format XML

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{{Explor lien
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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

Rewiring the brain with cell transplantation in Parkinson's disease.

Rewiring the brain with cell transplantation in Parkinson's disease.

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri