ParkinsonFranceV1, Hal, Curation, bibRecord, 000967

Subthalamic nucleus influences spatial orientation in extra-personal space.

Identifieur interne : 000967 ( Hal/Curation ); précédent : 000966; suivant : 000968

Subthalamic nucleus influences spatial orientation in extra-personal space.

Auteurs : Karsten Witt [Allemagne] ; Florian Kopper [Allemagne] ; Günther Deuschl [Allemagne] ; Paul Krack [France]

Source :

Movement Disorders [ 0885-3185 ] ; 2006-03.

RBID : Hal:inserm-00391639

Abstract

While the role of frontal and parietal cortex in spatial orientation has been studied extensively, the contribution of the basal ganglia and especially the subthalamic nucleus to spatial orientation remains less clear. Here we use subthalamic nucleus (STN) deep brain stimulation (DBS) in Parkinson's disease (PD) as a reversible model of functional lesioning to evaluate the influence of the STN in extra-personal space orientation. To this end, 12 PD patients were examined 1 year after implantation of DBS electrodes in the STN after overnight withdrawal of L-dopa. Patients were tested in a pseudo-randomized order while both stimulators, the right only, the left only, or no stimulator, were switched on. Patients performed line bisection and a reaction time task responding to stimuli of the middle, the left, and the right extra-personal space. A separate assessment of the right and left hand responding to visual stimuli in each hemispace made it possible to distinguish hemi-spatial and hemi-motor impairments. No asymmetries in space orientation were found when both stimulators were switched OFF, when both stimulators were switched ON, and when only the right stimulator was switched ON. When only the left subthalamic stimulation was switched ON, the reaction times of both hands to visual stimuli in the left extra-personal hemispace increased significantly and the line bisection test showed a significant orientation to the right. These results lead to the conclusion that the STN and its cortical projections influence the network involved in visuospatial orientation. These patterns of symptoms of neglect demonstrate the influence of the STN on the attentional system of the nondominant hemisphere.

Url:

http://www.hal.inserm.fr/inserm-00391639

DOI: 10.1002/mds.20728

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000A60

Links to Exploration step

Hal:inserm-00391639

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Subthalamic nucleus influences spatial orientation in extra-personal space.</title>
<author><name sortKey="Witt, Karsten" sort="Witt, Karsten" uniqKey="Witt K" first="Karsten" last="Witt">Karsten Witt</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-95774" status="INCOMING">  <orgName>Department of Neurology</orgName>
  <desc>    <address>      <addrLine>Kie</addrLine>
      <country key="DE"></country>
    </address>
  </desc>
  <listRelation>    <relation active="#struct-323430" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-323430" type="direct"><org type="institution" xml:id="struct-323430" status="INCOMING"><orgName>University Schleswig-Holstein</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Allemagne</country>
</affiliation>
</author>
<author><name sortKey="Kopper, Florian" sort="Kopper, Florian" uniqKey="Kopper F" first="Florian" last="Kopper">Florian Kopper</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-95774" status="INCOMING">  <orgName>Department of Neurology</orgName>
  <desc>    <address>      <addrLine>Kie</addrLine>
      <country key="DE"></country>
    </address>
  </desc>
  <listRelation>    <relation active="#struct-323430" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-323430" type="direct"><org type="institution" xml:id="struct-323430" status="INCOMING"><orgName>University Schleswig-Holstein</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Allemagne</country>
</affiliation>
</author>
<author><name sortKey="Deuschl, Gunther" sort="Deuschl, Gunther" uniqKey="Deuschl G" first="Günther" last="Deuschl">Günther Deuschl</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-95774" status="INCOMING">  <orgName>Department of Neurology</orgName>
  <desc>    <address>      <addrLine>Kie</addrLine>
      <country key="DE"></country>
    </address>
  </desc>
  <listRelation>    <relation active="#struct-323430" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-323430" type="direct"><org type="institution" xml:id="struct-323430" status="INCOMING"><orgName>University Schleswig-Holstein</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Allemagne</country>
</affiliation>
</author>
<author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-14242" status="VALID"><orgName>Département de neurologie</orgName>
<desc><address><addrLine>Grenoble</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation><relation active="#struct-300071" type="direct"></relation>
<relation active="#struct-51016" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-300071" type="direct"><org type="institution" xml:id="struct-300071" status="VALID">  <orgName>CHU Grenoble</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
</org>
</tutelle>
<tutelle active="#struct-51016" type="direct"><org type="institution" xml:id="struct-51016" status="OLD">  <idno type="IdRef">026404796</idno>
  <orgName>Université Joseph Fourier - Grenoble 1</orgName>
  <orgName type="acronym">UJF</orgName>
  <date type="end">2015-12-31</date>
  <desc>    <address>      <addrLine>BP 53 - 38041 Grenoble Cedex 9</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.ujf-grenoble.fr/</ref>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Grenoble</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
<orgName type="university">Université Joseph Fourier</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Grenoble</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">HAL</idno>
<idno type="RBID">Hal:inserm-00391639</idno>
<idno type="halId">inserm-00391639</idno>
<idno type="halUri">http://www.hal.inserm.fr/inserm-00391639</idno>
<idno type="url">http://www.hal.inserm.fr/inserm-00391639</idno>
<idno type="doi">10.1002/mds.20728</idno>
<date when="2006-03">2006-03</date>
<idno type="wicri:Area/Hal/Corpus">000A60</idno>
<idno type="wicri:Area/Hal/Curation">000A60</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Subthalamic nucleus influences spatial orientation in extra-personal space.</title>
<author><name sortKey="Witt, Karsten" sort="Witt, Karsten" uniqKey="Witt K" first="Karsten" last="Witt">Karsten Witt</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-95774" status="INCOMING">  <orgName>Department of Neurology</orgName>
  <desc>    <address>      <addrLine>Kie</addrLine>
      <country key="DE"></country>
    </address>
  </desc>
  <listRelation>    <relation active="#struct-323430" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-323430" type="direct"><org type="institution" xml:id="struct-323430" status="INCOMING"><orgName>University Schleswig-Holstein</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Allemagne</country>
</affiliation>
</author>
<author><name sortKey="Kopper, Florian" sort="Kopper, Florian" uniqKey="Kopper F" first="Florian" last="Kopper">Florian Kopper</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-95774" status="INCOMING">  <orgName>Department of Neurology</orgName>
  <desc>    <address>      <addrLine>Kie</addrLine>
      <country key="DE"></country>
    </address>
  </desc>
  <listRelation>    <relation active="#struct-323430" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-323430" type="direct"><org type="institution" xml:id="struct-323430" status="INCOMING"><orgName>University Schleswig-Holstein</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Allemagne</country>
</affiliation>
</author>
<author><name sortKey="Deuschl, Gunther" sort="Deuschl, Gunther" uniqKey="Deuschl G" first="Günther" last="Deuschl">Günther Deuschl</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-95774" status="INCOMING">  <orgName>Department of Neurology</orgName>
  <desc>    <address>      <addrLine>Kie</addrLine>
      <country key="DE"></country>
    </address>
  </desc>
  <listRelation>    <relation active="#struct-323430" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-323430" type="direct"><org type="institution" xml:id="struct-323430" status="INCOMING"><orgName>University Schleswig-Holstein</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Allemagne</country>
</affiliation>
</author>
<author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-14242" status="VALID"><orgName>Département de neurologie</orgName>
<desc><address><addrLine>Grenoble</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation><relation active="#struct-300071" type="direct"></relation>
<relation active="#struct-51016" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-300071" type="direct"><org type="institution" xml:id="struct-300071" status="VALID">  <orgName>CHU Grenoble</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
</org>
</tutelle>
<tutelle active="#struct-51016" type="direct"><org type="institution" xml:id="struct-51016" status="OLD">  <idno type="IdRef">026404796</idno>
  <orgName>Université Joseph Fourier - Grenoble 1</orgName>
  <orgName type="acronym">UJF</orgName>
  <date type="end">2015-12-31</date>
  <desc>    <address>      <addrLine>BP 53 - 38041 Grenoble Cedex 9</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.ujf-grenoble.fr/</ref>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Grenoble</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
<orgName type="university">Université Joseph Fourier</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Grenoble</orgName>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1002/mds.20728</idno>
<series><title level="j">Movement Disorders</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date type="datePub">2006-03</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">While the role of frontal and parietal cortex in spatial orientation has been studied extensively, the contribution of the basal ganglia and especially the subthalamic nucleus to spatial orientation remains less clear. Here we use subthalamic nucleus (STN) deep brain stimulation (DBS) in Parkinson's disease (PD) as a reversible model of functional lesioning to evaluate the influence of the STN in extra-personal space orientation. To this end, 12 PD patients were examined 1 year after implantation of DBS electrodes in the STN after overnight withdrawal of L-dopa. Patients were tested in a pseudo-randomized order while both stimulators, the right only, the left only, or no stimulator, were switched on. Patients performed line bisection and a reaction time task responding to stimuli of the middle, the left, and the right extra-personal space. A separate assessment of the right and left hand responding to visual stimuli in each hemispace made it possible to distinguish hemi-spatial and hemi-motor impairments. No asymmetries in space orientation were found when both stimulators were switched OFF, when both stimulators were switched ON, and when only the right stimulator was switched ON. When only the left subthalamic stimulation was switched ON, the reaction times of both hands to visual stimuli in the left extra-personal hemispace increased significantly and the line bisection test showed a significant orientation to the right. These results lead to the conclusion that the STN and its cortical projections influence the network involved in visuospatial orientation. These patterns of symptoms of neglect demonstrate the influence of the STN on the attentional system of the nondominant hemisphere.</div>
</front>
</TEI>
<hal api="V3">          <titleStmt>            <title xml:lang="en">Subthalamic nucleus influences spatial orientation in extra-personal space.</title>
            <author role="aut">              <persName>                <forename type="first">Karsten</forename>
                <surname>Witt</surname>
              </persName>
              <idno type="halauthorid">410337</idno>
              <affiliation ref="#struct-95774"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Florian</forename>
                <surname>Kopper</surname>
              </persName>
              <idno type="halauthorid">410451</idno>
              <affiliation ref="#struct-95774"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Günther</forename>
                <surname>Deuschl</surname>
              </persName>
              <idno type="halauthorid">410353</idno>
              <affiliation ref="#struct-95774"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Paul</forename>
                <surname>Krack</surname>
              </persName>
              <idno type="halauthorid">296412</idno>
              <affiliation ref="#struct-14242"></affiliation>
            </author>
            <editor role="depositor">              <persName>                <forename>Marc</forename>
                <surname>Savasta</surname>
              </persName>
              <email type="md5">17a3ed21e3dd17a996152da3d29e00bb</email>
              <email type="domain">ujf-grenoble.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>            <edition n="v1" type="current">              <date type="whenSubmitted">2009-06-04 12:09:59</date>
              <date type="whenModified">2009-06-11 15:22:58</date>
              <date type="whenReleased">2009-06-11 15:22:58</date>
              <date type="whenProduced">2006-03</date>
            </edition>
            <respStmt>              <resp>contributor</resp>
              <name key="140382">                <persName>                  <forename>Marc</forename>
                  <surname>Savasta</surname>
                </persName>
                <email type="md5">17a3ed21e3dd17a996152da3d29e00bb</email>
                <email type="domain">ujf-grenoble.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>            <distributor>CCSD</distributor>
            <idno type="halId">inserm-00391639</idno>
            <idno type="halUri">http://www.hal.inserm.fr/inserm-00391639</idno>
            <idno type="halBibtex">witt:inserm-00391639</idno>
            <idno type="halRefHtml">Movement Disorders, Wiley, 2006, 21 (3), pp.354-61. <10.1002/mds.20728></idno>
            <idno type="halRef">Movement Disorders, Wiley, 2006, 21 (3), pp.354-61. <10.1002/mds.20728></idno>
          </publicationStmt>
          <seriesStmt>            <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
            <idno type="stamp" n="UNIV-GRENOBLE1" p="UGA">Université Joseph Fourier - Grenoble I</idno>
            <idno type="stamp" n="UGA">HAL Grenoble Alpes</idno>
          </seriesStmt>
          <notesStmt>            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>            <biblStruct>              <analytic>                <title xml:lang="en">Subthalamic nucleus influences spatial orientation in extra-personal space.</title>
                <author role="aut">                  <persName>                    <forename type="first">Karsten</forename>
                    <surname>Witt</surname>
                  </persName>
                  <idno type="halauthorid">410337</idno>
                  <affiliation ref="#struct-95774"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Florian</forename>
                    <surname>Kopper</surname>
                  </persName>
                  <idno type="halauthorid">410451</idno>
                  <affiliation ref="#struct-95774"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Günther</forename>
                    <surname>Deuschl</surname>
                  </persName>
                  <idno type="halauthorid">410353</idno>
                  <affiliation ref="#struct-95774"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Paul</forename>
                    <surname>Krack</surname>
                  </persName>
                  <idno type="halauthorid">296412</idno>
                  <affiliation ref="#struct-14242"></affiliation>
                </author>
              </analytic>
              <monogr>                <idno type="halJournalId" status="VALID">17211</idno>
                <idno type="issn">0885-3185</idno>
                <idno type="eissn">1531-8257</idno>
                <title level="j">Movement Disorders</title>
                <imprint>                  <publisher>Wiley</publisher>
                  <biblScope unit="volume">21</biblScope>
                  <biblScope unit="issue">3</biblScope>
                  <biblScope unit="pp">354-61</biblScope>
                  <date type="datePub">2006-03</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1002/mds.20728</idno>
              <idno type="pubmed">16211596</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>            <langUsage>              <language ident="en">English</language>
            </langUsage>
            <textClass>              <classCode scheme="mesh">Attention</classCode>
              <classCode scheme="mesh">Deep Brain Stimulation</classCode>
              <classCode scheme="mesh">Visual Perception</classCode>
              <classCode scheme="mesh">Female</classCode>
              <classCode scheme="mesh">Humans</classCode>
              <classCode scheme="mesh">Male</classCode>
              <classCode scheme="mesh">Middle Aged</classCode>
              <classCode scheme="mesh">Parkinson Disease</classCode>
              <classCode scheme="mesh">Reaction Time</classCode>
              <classCode scheme="mesh">Space Perception</classCode>
              <classCode scheme="mesh">Subthalamic Nucleus</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">While the role of frontal and parietal cortex in spatial orientation has been studied extensively, the contribution of the basal ganglia and especially the subthalamic nucleus to spatial orientation remains less clear. Here we use subthalamic nucleus (STN) deep brain stimulation (DBS) in Parkinson's disease (PD) as a reversible model of functional lesioning to evaluate the influence of the STN in extra-personal space orientation. To this end, 12 PD patients were examined 1 year after implantation of DBS electrodes in the STN after overnight withdrawal of L-dopa. Patients were tested in a pseudo-randomized order while both stimulators, the right only, the left only, or no stimulator, were switched on. Patients performed line bisection and a reaction time task responding to stimuli of the middle, the left, and the right extra-personal space. A separate assessment of the right and left hand responding to visual stimuli in each hemispace made it possible to distinguish hemi-spatial and hemi-motor impairments. No asymmetries in space orientation were found when both stimulators were switched OFF, when both stimulators were switched ON, and when only the right stimulator was switched ON. When only the left subthalamic stimulation was switched ON, the reaction times of both hands to visual stimuli in the left extra-personal hemispace increased significantly and the line bisection test showed a significant orientation to the right. These results lead to the conclusion that the STN and its cortical projections influence the network involved in visuospatial orientation. These patterns of symptoms of neglect demonstrate the influence of the STN on the attentional system of the nondominant hemisphere.</abstract>
            <particDesc>              <org type="consortium">Collaboration</org>
            </particDesc>
          </profileDesc>
        </hal>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Hal/Curation

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000967 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Hal/Curation/biblio.hfd -nk 000967 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    ParkinsonFranceV1
   |flux=    Hal
   |étape=   Curation
   |type=    RBID
   |clé=     Hal:inserm-00391639
   |texte=   Subthalamic nucleus influences spatial orientation in extra-personal space.
}}

This area was generated with Dilib version V0.6.29.
Data generation: Wed May 17 19:46:39 2017. Site generation: Mon Mar 4 15:48:15 2024

	La maladie de Parkinson en France (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson en France (serveur d'exploration)

Subthalamic nucleus influences spatial orientation in extra-personal space.

Subthalamic nucleus influences spatial orientation in extra-personal space.

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri