Identification and Characterization of a Novel Human Methyltransferase Modulating Hsp70 Protein Function through Lysine Methylation*
Identifieur interne : 000D04 ( Main/Curation ); précédent : 000D03; suivant : 000D05Identification and Characterization of a Novel Human Methyltransferase Modulating Hsp70 Protein Function through Lysine Methylation*
Auteurs : Magnus E. Jakobsson ; Anders Moen ; Luc Bousset ; Wolfgang Egge-Jacobsen ; Stefan Kernstock ; Ronald Melki ; P L FalnesSource :
- The Journal of Biological Chemistry [ 0021-9258 ] ; 2013.
Abstract
Url:
DOI: 10.1074/jbc.M113.483248
PubMed: 23921388
PubMed Central: 3784692
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PMC:3784692Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Identification and Characterization of a Novel Human Methyltransferase Modulating Hsp70 Protein Function through Lysine Methylation<xref ref-type="fn" rid="FN1">*</xref>
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<front><div type="abstract" xml:lang="en"><p><bold>Background:</bold>
The function of many proteins is regulated through post-translational methylation.</p>
<p><bold>Results:</bold>
METTL21A was identified as a human protein methyltransferase targeting Hsp70 proteins, thereby altering their ability to interact with client proteins.</p>
<p><bold>Conclusion:</bold>
METTL21A is a specific methyltransferase modulating the function of Hsp70 proteins.</p>
<p><bold>Significance:</bold>
The activity of a human protein-modifying enzyme is unraveled, and the modification is demonstrated to have functional consequences.</p>
</div>
</front>
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