ParkinsonFranceV1, Ncbi, Curation, bibRecord, 001188

Identification and Characterization of a Novel Human Methyltransferase Modulating Hsp70 Protein Function through Lysine Methylation*

Identifieur interne : 001188 ( Ncbi/Curation ); précédent : 001187; suivant : 001189

Identification and Characterization of a Novel Human Methyltransferase Modulating Hsp70 Protein Function through Lysine Methylation*

Auteurs : Magnus E. Jakobsson ; Anders Moen ; Luc Bousset ; Wolfgang Egge-Jacobsen ; Stefan Kernstock ; Ronald Melki ; P L Falnes

Source :

The Journal of Biological Chemistry [ 0021-9258 ] ; 2013.

RBID : PMC:3784692

Abstract

Background: The function of many proteins is regulated through post-translational methylation.

Results: METTL21A was identified as a human protein methyltransferase targeting Hsp70 proteins, thereby altering their ability to interact with client proteins.

Conclusion: METTL21A is a specific methyltransferase modulating the function of Hsp70 proteins.

Significance: The activity of a human protein-modifying enzyme is unraveled, and the modification is demonstrated to have functional consequences.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784692

DOI: 10.1074/jbc.M113.483248
PubMed: 23921388
PubMed Central: 3784692

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PMC:3784692

Le document en format XML

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<author><name sortKey="Jakobsson, Magnus E" sort="Jakobsson, Magnus E" uniqKey="Jakobsson M" first="Magnus E." last="Jakobsson">Magnus E. Jakobsson</name>
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<author><name sortKey="Moen, Anders" sort="Moen, Anders" uniqKey="Moen A" first="Anders" last="Moen">Anders Moen</name>
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<author><name sortKey="Bousset, Luc" sort="Bousset, Luc" uniqKey="Bousset L" first="Luc" last="Bousset">Luc Bousset</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Identification and Characterization of a Novel Human Methyltransferase Modulating Hsp70 Protein Function through Lysine Methylation<xref ref-type="fn" rid="FN1">*</xref>
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<author><name sortKey="Kernstock, Stefan" sort="Kernstock, Stefan" uniqKey="Kernstock S" first="Stefan" last="Kernstock">Stefan Kernstock</name>
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<author><name sortKey="Melki, Ronald" sort="Melki, Ronald" uniqKey="Melki R" first="Ronald" last="Melki">Ronald Melki</name>
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<author><name sortKey="Falnes, P L" sort="Falnes, P L" uniqKey="Falnes P" first="P L" last="Falnes">P L Falnes</name>
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<series><title level="j">The Journal of Biological Chemistry</title>
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<front><div type="abstract" xml:lang="en"><p><bold>Background:</bold>
 The function of many proteins is regulated through post-translational methylation.</p>
<p><bold>Results:</bold>
 METTL21A was identified as a human protein methyltransferase targeting Hsp70 proteins, thereby altering their ability to interact with client proteins.</p>
<p><bold>Conclusion:</bold>
 METTL21A is a specific methyltransferase modulating the function of Hsp70 proteins.</p>
<p><bold>Significance:</bold>
 The activity of a human protein-modifying enzyme is unraveled, and the modification is demonstrated to have functional consequences.</p>
</div>
</front>
</TEI>
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Identification and Characterization of a Novel Human Methyltransferase Modulating Hsp70 Protein Function through Lysine Methylation*

Identification and Characterization of a Novel Human Methyltransferase Modulating Hsp70 Protein Function through Lysine Methylation*

Source :

Abstract

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Pour générer des pages wiki