High protection by grape seed proanthocyanidins (GSPC) of polyunsaturated fatty acids against UV-C induced peroxidation
Identifieur interne : 000555 ( Istex/Curation ); précédent : 000554; suivant : 000556High protection by grape seed proanthocyanidins (GSPC) of polyunsaturated fatty acids against UV-C induced peroxidation
Auteurs : Rachid Bouhamidi [France] ; Virginie Prévost [France] ; André Nouvelot [France]Source :
- Comptes Rendus de l'Academie des Sciences Series III Sciences de la Vie [ 0764-4469 ] ; 1998.
English descriptors
Abstract
Abstract: The antioxidative effects of grape seed proanthocyanidins (GSPC) were studied in three in-vitro models in which polyunsaturated fatty acids (PUFAs) in aqueous solution and mice liver or brain microsomes were used as oxidative substrates, and UVC irradiation as the pro-oxidant system. Analysis of UV-C induced lipid peroxidation was carried out by two methods: gas liquid chromatography of residual PUFAs and release of thiobarbituric acid-reactive substances (TBARs) measured by TBA reaction. Results indicate that PUFAs are more radiosensitive when incorporated in single component micelles than in mixed component micelles or microsomes. In every case, PUFA peroxidation was inhibited by low concentrations of GSPC (2 rng/L) while epigallocatecin (EGC) and epigallocatechin gallate (EGCG) monomers, at an equivalent level of epicatechin, exhibited no efficacy in our experimental conditions. This latter effect might be explained by a synergistic action of flavan-3-ol monomers, dimers and oligomers contained in the grape seed extract.
Url:
DOI: 10.1016/S0764-4469(97)89623-0
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000555
Links to Exploration step
ISTEX:3792FB74D0E7B6FA8A00C137A0997A0C6F9618BCLe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">High protection by grape seed proanthocyanidins (GSPC) of polyunsaturated fatty acids against UV-C induced peroxidation</title>
<author><name sortKey="Bouhamidi, Rachid" sort="Bouhamidi, Rachid" uniqKey="Bouhamidi R" first="Rachid" last="Bouhamidi">Rachid Bouhamidi</name>
<affiliation wicri:level="1"><mods:affiliation>Laboratoire de neurosciences, UMR 6551 du CNRS, université de Caen, bd H.-Becquerel, BP 5229, 14074 Caen cedex, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire de neurosciences, UMR 6551 du CNRS, université de Caen, bd H.-Becquerel, BP 5229, 14074 Caen cedex</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Prevost, Virginie" sort="Prevost, Virginie" uniqKey="Prevost V" first="Virginie" last="Prévost">Virginie Prévost</name>
<affiliation wicri:level="1"><mods:affiliation>Laboratoire de neurosciences, UMR 6551 du CNRS, université de Caen, bd H.-Becquerel, BP 5229, 14074 Caen cedex, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire de neurosciences, UMR 6551 du CNRS, université de Caen, bd H.-Becquerel, BP 5229, 14074 Caen cedex</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nouvelot, Andre" sort="Nouvelot, Andre" uniqKey="Nouvelot A" first="André" last="Nouvelot">André Nouvelot</name>
<affiliation wicri:level="1"><mods:affiliation>Laboratoire de neurosciences, UMR 6551 du CNRS, université de Caen, bd H.-Becquerel, BP 5229, 14074 Caen cedex, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire de neurosciences, UMR 6551 du CNRS, université de Caen, bd H.-Becquerel, BP 5229, 14074 Caen cedex</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:3792FB74D0E7B6FA8A00C137A0997A0C6F9618BC</idno>
<date when="1998" year="1998">1998</date>
<idno type="doi">10.1016/S0764-4469(97)89623-0</idno>
<idno type="url">https://api.istex.fr/document/3792FB74D0E7B6FA8A00C137A0997A0C6F9618BC/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000555</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000555</idno>
<idno type="wicri:Area/Istex/Curation">000555</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">High protection by grape seed proanthocyanidins (GSPC) of polyunsaturated fatty acids against UV-C induced peroxidation</title>
<author><name sortKey="Bouhamidi, Rachid" sort="Bouhamidi, Rachid" uniqKey="Bouhamidi R" first="Rachid" last="Bouhamidi">Rachid Bouhamidi</name>
<affiliation wicri:level="1"><mods:affiliation>Laboratoire de neurosciences, UMR 6551 du CNRS, université de Caen, bd H.-Becquerel, BP 5229, 14074 Caen cedex, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire de neurosciences, UMR 6551 du CNRS, université de Caen, bd H.-Becquerel, BP 5229, 14074 Caen cedex</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Prevost, Virginie" sort="Prevost, Virginie" uniqKey="Prevost V" first="Virginie" last="Prévost">Virginie Prévost</name>
<affiliation wicri:level="1"><mods:affiliation>Laboratoire de neurosciences, UMR 6551 du CNRS, université de Caen, bd H.-Becquerel, BP 5229, 14074 Caen cedex, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire de neurosciences, UMR 6551 du CNRS, université de Caen, bd H.-Becquerel, BP 5229, 14074 Caen cedex</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nouvelot, Andre" sort="Nouvelot, Andre" uniqKey="Nouvelot A" first="André" last="Nouvelot">André Nouvelot</name>
<affiliation wicri:level="1"><mods:affiliation>Laboratoire de neurosciences, UMR 6551 du CNRS, université de Caen, bd H.-Becquerel, BP 5229, 14074 Caen cedex, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire de neurosciences, UMR 6551 du CNRS, université de Caen, bd H.-Becquerel, BP 5229, 14074 Caen cedex</wicri:regionArea>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Comptes Rendus de l'Academie des Sciences Series III Sciences de la Vie</title>
<title level="j" type="abbrev">PXVOLD</title>
<idno type="ISSN">0764-4469</idno>
<imprint><publisher>ELSEVIER</publisher>
<date type="published" when="1998">1998</date>
<biblScope unit="volume">321</biblScope>
<biblScope unit="issue">1</biblScope>
<biblScope unit="page" from="31">31</biblScope>
<biblScope unit="page" to="38">38</biblScope>
</imprint>
<idno type="ISSN">0764-4469</idno>
</series>
<idno type="istex">3792FB74D0E7B6FA8A00C137A0997A0C6F9618BC</idno>
<idno type="DOI">10.1016/S0764-4469(97)89623-0</idno>
<idno type="PII">S0764-4469(97)89623-0</idno>
<idno type="ArticleID">97896230</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0764-4469</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>UV-C rays</term>
<term>grape seeds</term>
<term>lipoperoxidation</term>
<term>polyunsaturated fatty acids</term>
<term>proanthocyanidins</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Abstract: The antioxidative effects of grape seed proanthocyanidins (GSPC) were studied in three in-vitro models in which polyunsaturated fatty acids (PUFAs) in aqueous solution and mice liver or brain microsomes were used as oxidative substrates, and UVC irradiation as the pro-oxidant system. Analysis of UV-C induced lipid peroxidation was carried out by two methods: gas liquid chromatography of residual PUFAs and release of thiobarbituric acid-reactive substances (TBARs) measured by TBA reaction. Results indicate that PUFAs are more radiosensitive when incorporated in single component micelles than in mixed component micelles or microsomes. In every case, PUFA peroxidation was inhibited by low concentrations of GSPC (2 rng/L) while epigallocatecin (EGC) and epigallocatechin gallate (EGCG) monomers, at an equivalent level of epicatechin, exhibited no efficacy in our experimental conditions. This latter effect might be explained by a synergistic action of flavan-3-ol monomers, dimers and oligomers contained in the grape seed extract.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Istex/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000555 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Curation/biblio.hfd -nk 000555 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonFranceV1 |flux= Istex |étape= Curation |type= RBID |clé= ISTEX:3792FB74D0E7B6FA8A00C137A0997A0C6F9618BC |texte= High protection by grape seed proanthocyanidins (GSPC) of polyunsaturated fatty acids against UV-C induced peroxidation }}
This area was generated with Dilib version V0.6.29. |