Quantification of t cells reactive to pf155/RESA peptides in plasmodium falciparum -exposed individuals
Identifieur interne : 000911 ( Istex/Corpus ); précédent : 000910; suivant : 000912Quantification of t cells reactive to pf155/RESA peptides in plasmodium falciparum -exposed individuals
Auteurs : C. Chougnet ; D. Henzel ; L. Diakhate ; P. Imbert ; O. Bouchaud ; P. DeloronSource :
- Research in Immunology [ 0923-2494 ] ; 1994.
English descriptors
Abstract
Summary: This study was designed to estimate, among T lymphocytes circulating in the peripheral blood of donors exposed to malaria parasites, the frequencies of those responding to Plasmodium falciparum antigens, and more specifically to Pf155/RESA peptides. The values of peptide-reactive T-cell frequencies were dispersed and rather low, ranging from 1:24,000 to undetectable (superior to 1:300,000). Subjects presented with different past exposure to parasites : either they had been repetitively exposed to malaria parasite infestation or they were recovering from a recent treated malaria attack. However, they had similar frequencies of T cells reactive to Pf155/RESA peptides. With cells from a minority of patients, “saw-tooth curves” were obtained, suggesting the existence of suppressor mechanisms operating in vitro in our limiting dilution assay.
Url:
DOI: 10.1016/S0923-2494(94)80014-6
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ISTEX:059AAF24F717D019AE4EFA9900464BD51883CD32Le document en format XML
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Diakhate</name><affiliation><mods:affiliation>Centre National de Transfusion Sanguine, Dakar-Fann, Sénégal,Paris,France</mods:affiliation></affiliation></author><author><name sortKey="Imbert, P" sort="Imbert, P" uniqKey="Imbert P" first="P." last="Imbert">P. Imbert</name><affiliation><mods:affiliation>Service de Pathologie infectieuse et tropicale, Hôpital d'Instruction des armées ≪ A. Laveran ≫, Marseille, France</mods:affiliation></affiliation></author><author><name sortKey="Bouchaud, O" sort="Bouchaud, O" uniqKey="Bouchaud O" first="O." last="Bouchaud">O. Bouchaud</name><affiliation><mods:affiliation>Service des maladies infectieuses et tropicales, Hôpital Bichat-Claude Bernard, Paris,France</mods:affiliation></affiliation></author><author><name sortKey="Deloron, P" sort="Deloron, P" uniqKey="Deloron P" first="P." last="Deloron">P. Deloron</name><affiliation><mods:affiliation>INSERM U13/IMEA, Paris,France</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:059AAF24F717D019AE4EFA9900464BD51883CD32</idno><date when="1994" year="1994">1994</date><idno type="doi">10.1016/S0923-2494(94)80014-6</idno><idno type="url">https://api.istex.fr/document/059AAF24F717D019AE4EFA9900464BD51883CD32/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000911</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000911</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Quantification of t cells reactive to pf155/RESA peptides in plasmodium falciparum -exposed individuals</title><author><name sortKey="Chougnet, C" sort="Chougnet, C" uniqKey="Chougnet C" first="C." last="Chougnet">C. Chougnet</name><affiliation><mods:affiliation>INSERM U13/IMEA, Paris,France</mods:affiliation></affiliation><affiliation><mods:affiliation>Correspondence to C. Chougnet, INSERM U13, 190 boulevard MacDonald, 75019 Paris, France.</mods:affiliation></affiliation></author><author><name sortKey="Henzel, D" sort="Henzel, D" uniqKey="Henzel D" first="D." last="Henzel">D. Henzel</name><affiliation><mods:affiliation>INSERM U13/IMEA, Paris,France</mods:affiliation></affiliation></author><author><name sortKey="Diakhate, L" sort="Diakhate, L" uniqKey="Diakhate L" first="L." last="Diakhate">L. Diakhate</name><affiliation><mods:affiliation>Centre National de Transfusion Sanguine, Dakar-Fann, Sénégal,Paris,France</mods:affiliation></affiliation></author><author><name sortKey="Imbert, P" sort="Imbert, P" uniqKey="Imbert P" first="P." last="Imbert">P. Imbert</name><affiliation><mods:affiliation>Service de Pathologie infectieuse et tropicale, Hôpital d'Instruction des armées ≪ A. Laveran ≫, Marseille, France</mods:affiliation></affiliation></author><author><name sortKey="Bouchaud, O" sort="Bouchaud, O" uniqKey="Bouchaud O" first="O." last="Bouchaud">O. Bouchaud</name><affiliation><mods:affiliation>Service des maladies infectieuses et tropicales, Hôpital Bichat-Claude Bernard, Paris,France</mods:affiliation></affiliation></author><author><name sortKey="Deloron, P" sort="Deloron, P" uniqKey="Deloron P" first="P." last="Deloron">P. Deloron</name><affiliation><mods:affiliation>INSERM U13/IMEA, Paris,France</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Research in Immunology</title><title level="j" type="abbrev">X83</title><idno type="ISSN">0923-2494</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1994">1994</date><biblScope unit="volume">145</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="257">257</biblScope><biblScope unit="page" to="266">266</biblScope></imprint><idno type="ISSN">0923-2494</idno></series><idno type="istex">059AAF24F717D019AE4EFA9900464BD51883CD32</idno><idno type="DOI">10.1016/S0923-2494(94)80014-6</idno><idno type="PII">S0923-2494(94)80014-6</idno><idno type="ArticleID">94800146</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0923-2494</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cellular immunity</term><term>Pf155/RESA peptide</term><term>Plasmodium falciparum, Malaria, T lymphocyte</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: This study was designed to estimate, among T lymphocytes circulating in the peripheral blood of donors exposed to malaria parasites, the frequencies of those responding to Plasmodium falciparum antigens, and more specifically to Pf155/RESA peptides. The values of peptide-reactive T-cell frequencies were dispersed and rather low, ranging from 1:24,000 to undetectable (superior to 1:300,000). Subjects presented with different past exposure to parasites : either they had been repetitively exposed to malaria parasite infestation or they were recovering from a recent treated malaria attack. However, they had similar frequencies of T cells reactive to Pf155/RESA peptides. With cells from a minority of patients, “saw-tooth curves” were obtained, suggesting the existence of suppressor mechanisms operating in vitro in our limiting dilution assay.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>C. Chougnet</name><affiliations><json:string>INSERM U13/IMEA, Paris,France</json:string><json:string>Correspondence to C. Chougnet, INSERM U13, 190 boulevard MacDonald, 75019 Paris, France.</json:string></affiliations></json:item><json:item><name>D. Henzel</name><affiliations><json:string>INSERM U13/IMEA, Paris,France</json:string></affiliations></json:item><json:item><name>L. Diakhate</name><affiliations><json:string>Centre National de Transfusion Sanguine, Dakar-Fann, Sénégal,Paris,France</json:string></affiliations></json:item><json:item><name>P. Imbert</name><affiliations><json:string>Service de Pathologie infectieuse et tropicale, Hôpital d'Instruction des armées ≪ A. Laveran ≫, Marseille, France</json:string></affiliations></json:item><json:item><name>O. Bouchaud</name><affiliations><json:string>Service des maladies infectieuses et tropicales, Hôpital Bichat-Claude Bernard, Paris,France</json:string></affiliations></json:item><json:item><name>P. Deloron</name><affiliations><json:string>INSERM U13/IMEA, Paris,France</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Plasmodium falciparum, Malaria, T lymphocyte</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Pf155/RESA peptide</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Cellular immunity</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Lymphocytes T, Plasmodium falciparum, Paludisme</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Immunité cellulaire, Antigène Pf155/RESA</value></json:item></subject><articleId><json:string>94800146</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Summary: This study was designed to estimate, among T lymphocytes circulating in the peripheral blood of donors exposed to malaria parasites, the frequencies of those responding to Plasmodium falciparum antigens, and more specifically to Pf155/RESA peptides. The values of peptide-reactive T-cell frequencies were dispersed and rather low, ranging from 1:24,000 to undetectable (superior to 1:300,000). Subjects presented with different past exposure to parasites : either they had been repetitively exposed to malaria parasite infestation or they were recovering from a recent treated malaria attack. However, they had similar frequencies of T cells reactive to Pf155/RESA peptides. With cells from a minority of patients, “saw-tooth curves” were obtained, suggesting the existence of suppressor mechanisms operating in vitro in our limiting dilution assay.</abstract><qualityIndicators><score>5</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612.28 x 792 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>5</keywordCount><abstractCharCount>858</abstractCharCount><pdfWordCount>3548</pdfWordCount><pdfCharCount>26150</pdfCharCount><pdfPageCount>10</pdfPageCount><abstractWordCount>121</abstractWordCount></qualityIndicators><title>Quantification of t cells reactive to pf155/RESA peptides in plasmodium falciparum -exposed individuals</title><pii><json:string>S0923-2494(94)80014-6</json:string></pii><refBibs><json:item><author><json:item><name>S.J. Brett</name></json:item><json:item><name>A.E. Kingston</name></json:item><json:item><name>M.J. 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Immunol</title></host><title>High frequency of malaria-specific T cells in non-exposed humans</title></json:item></refBibs><genre><json:string>research-article</json:string></genre><serie><volume>85</volume><pages><last>5663</last><first>5659</first></pages><language><json:string>unknown</json:string></language><title>USA</title></serie><host><volume>145</volume><pii><json:string>S0923-2494(00)X0028-4</json:string></pii><pages><last>266</last><first>257</first></pages><issn><json:string>0923-2494</json:string></issn><issue>4</issue><genre><json:string>journal</json:string></genre><language><json:string>unknown</json:string></language><title>Research in Immunology</title><publicationDate>1994</publicationDate></host><categories><wos></wos><scienceMetrix><json:string>health sciences</json:string><json:string>clinical medicine</json:string><json:string>immunology</json:string></scienceMetrix></categories><publicationDate>1994</publicationDate><copyrightDate>1994</copyrightDate><doi><json:string>10.1016/S0923-2494(94)80014-6</json:string></doi><id>059AAF24F717D019AE4EFA9900464BD51883CD32</id><score>0.17656769</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/059AAF24F717D019AE4EFA9900464BD51883CD32/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/059AAF24F717D019AE4EFA9900464BD51883CD32/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/059AAF24F717D019AE4EFA9900464BD51883CD32/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Quantification of t cells reactive to pf155/RESA peptides in plasmodium falciparum -exposed individuals</title><title level="a" type="alt" xml:lang="fr">Quantification des cellules t réactives au peptide Pf155/RESA chez des individus exposés à plasmodium falciparum</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>©1994 Institut Pasteur/Elsevier</p></availability><date>1994</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Quantification of t cells reactive to pf155/RESA peptides in plasmodium falciparum -exposed individuals</title><title level="a" type="alt" xml:lang="fr">Quantification des cellules t réactives au peptide Pf155/RESA chez des individus exposés à plasmodium falciparum</title><author xml:id="author-1"><persName><forename type="first">C.</forename><surname>Chougnet</surname></persName><affiliation>INSERM U13/IMEA, Paris,France</affiliation><affiliation>Correspondence to C. Chougnet, INSERM U13, 190 boulevard MacDonald, 75019 Paris, France.</affiliation></author><author xml:id="author-2"><persName><forename type="first">D.</forename><surname>Henzel</surname></persName><affiliation>INSERM U13/IMEA, Paris,France</affiliation></author><author xml:id="author-3"><persName><forename type="first">L.</forename><surname>Diakhate</surname></persName><affiliation>Centre National de Transfusion Sanguine, Dakar-Fann, Sénégal,Paris,France</affiliation></author><author xml:id="author-4"><persName><forename type="first">P.</forename><surname>Imbert</surname></persName><affiliation>Service de Pathologie infectieuse et tropicale, Hôpital d'Instruction des armées ≪ A. Laveran ≫, Marseille, France</affiliation></author><author xml:id="author-5"><persName><forename type="first">O.</forename><surname>Bouchaud</surname></persName><affiliation>Service des maladies infectieuses et tropicales, Hôpital Bichat-Claude Bernard, Paris,France</affiliation></author><author xml:id="author-6"><persName><forename type="first">P.</forename><surname>Deloron</surname></persName><affiliation>INSERM U13/IMEA, Paris,France</affiliation></author></analytic><monogr><title level="j">Research in Immunology</title><title level="j" type="abbrev">X83</title><idno type="pISSN">0923-2494</idno><idno type="PII">S0923-2494(00)X0028-4</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1994"></date><biblScope unit="volume">145</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="257">257</biblScope><biblScope unit="page" to="266">266</biblScope></imprint></monogr><idno type="istex">059AAF24F717D019AE4EFA9900464BD51883CD32</idno><idno type="DOI">10.1016/S0923-2494(94)80014-6</idno><idno type="PII">S0923-2494(94)80014-6</idno><idno type="ArticleID">94800146</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1994</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Summary: This study was designed to estimate, among T lymphocytes circulating in the peripheral blood of donors exposed to malaria parasites, the frequencies of those responding to Plasmodium falciparum antigens, and more specifically to Pf155/RESA peptides. The values of peptide-reactive T-cell frequencies were dispersed and rather low, ranging from 1:24,000 to undetectable (superior to 1:300,000). Subjects presented with different past exposure to parasites : either they had been repetitively exposed to malaria parasite infestation or they were recovering from a recent treated malaria attack. However, they had similar frequencies of T cells reactive to Pf155/RESA peptides. With cells from a minority of patients, “saw-tooth curves” were obtained, suggesting the existence of suppressor mechanisms operating in vitro in our limiting dilution assay.</p></abstract><abstract xml:lang="fr"><p>Nous avons voulu estimer, parmi les lympho- cytes T circulant dans le sang périphérique de don- neurs exposés aux hématozoaires du paludisme, la fréquence de ceux correspondant aux antigènes de Plasmodium falciparum et plus particulièrement à des peptides de l'antigène Pf155/RESA. Les valeurs des fréquences des cellules T réactives sont dispersées et plutôt faibles, s'échelonnant entre 1/24.000 et des valeurs indétectables (au-delà de 1/300.000). Les sujets avaient un passé d'exposition parasitaire variable: soit ils avaient été exposés à l'infestation de façon répétée, soit ils venaient juste de récupérer d'une crise de malaria traitée. Toutefois les fréquences détectées de cellules T réactives aux peptides de l'antigène Pf155/RESA sont semblables. Pour une minorité de sujets, des courbes de fréquence «en dents de scie ont été obtenues, suggérant l'existence de mécanismes suppresseurs intervenant in vitro dans nos analyses en dilution limitante.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><item><term>Plasmodium falciparum, Malaria, T lymphocyte</term></item><item><term>Pf155/RESA peptide</term></item><item><term>Cellular immunity</term></item></list></keywords></textClass><textClass xml:lang="fr"><keywords scheme="keyword"><list><head>Mots-clés</head><item><term>Lymphocytes T, Plasmodium falciparum, Paludisme</term></item><item><term>Immunité cellulaire, Antigène Pf155/RESA</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1994">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/059AAF24F717D019AE4EFA9900464BD51883CD32/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier doc found" wicri:toSee="Elsevier, no converted or simple article"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 5.0.1//EN//XML" URI="art501.dtd" name="istex:docType"></istex:docType><istex:document><article version="5.0" xml:lang="en" docsubtype="fla"><item-info><jid>X83</jid><aid>94800146</aid><ce:pii>S0923-2494(94)80014-6</ce:pii><ce:doi>10.1016/S0923-2494(94)80014-6</ce:doi><ce:copyright type="unknown" year="1994">Institut Pasteur/Elsevier</ce:copyright></item-info><head><ce:title>Quantification of t cells reactive to pf155/RESA peptides in <ce:italic>plasmodium falciparum</ce:italic>-exposed individuals</ce:title><ce:alt-title xml:lang="fr">Quantification des cellules t réactives au peptide Pf155/RESA chez des individus exposés à <ce:italic>plasmodium falciparum</ce:italic></ce:alt-title><ce:author-group><ce:author><ce:given-name>C.</ce:given-name><ce:surname>Chougnet</ce:surname><ce:cross-ref refid="aff1"><ce:sup>1</ce:sup></ce:cross-ref><ce:cross-ref refid="cor1"><ce:sup>*</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>D.</ce:given-name><ce:surname>Henzel</ce:surname><ce:cross-ref refid="aff1"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>L.</ce:given-name><ce:surname>Diakhate</ce:surname><ce:cross-ref refid="aff2"><ce:sup>2</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>P.</ce:given-name><ce:surname>Imbert</ce:surname><ce:cross-ref refid="aff3"><ce:sup>3</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>O.</ce:given-name><ce:surname>Bouchaud</ce:surname><ce:cross-ref refid="aff4"><ce:sup>4</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>P.</ce:given-name><ce:surname>Deloron</ce:surname><ce:cross-ref refid="aff1"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="aff1"><ce:label>1</ce:label><ce:textfn>INSERM U13/IMEA, Paris,France</ce:textfn></ce:affiliation><ce:affiliation id="aff2"><ce:label>2</ce:label><ce:textfn>Centre National de Transfusion Sanguine, Dakar-Fann, Sénégal,Paris,France</ce:textfn></ce:affiliation><ce:affiliation id="aff3"><ce:label>3</ce:label><ce:textfn>Service de Pathologie infectieuse et tropicale, Hôpital d'Instruction des armées ≪ A. Laveran ≫, Marseille, France</ce:textfn></ce:affiliation><ce:affiliation id="aff4"><ce:label>4</ce:label><ce:textfn>Service des maladies infectieuses et tropicales, Hôpital Bichat-Claude Bernard, Paris,France</ce:textfn></ce:affiliation><ce:correspondence id="cor1"><ce:label>*</ce:label><ce:text>Correspondence to C. Chougnet, INSERM U13, 190 boulevard MacDonald, 75019 Paris, France.</ce:text></ce:correspondence></ce:author-group><ce:date-received day="16" month="5" year="1994"></ce:date-received><ce:date-accepted day="24" month="6" year="1994"></ce:date-accepted><ce:abstract id="ab1" class="author" xml:lang="en"><ce:section-title>Summary</ce:section-title><ce:abstract-sec><ce:simple-para>This study was designed to estimate, among T lymphocytes circulating in the peripheral blood of donors exposed to malaria parasites, the frequencies of those responding to <ce:italic>Plasmodium falciparum</ce:italic> antigens, and more specifically to Pf155/RESA peptides. The values of peptide-reactive T-cell frequencies were dispersed and rather low, ranging from 1:24,000 to undetectable (superior to 1:300,000). Subjects presented with different past exposure to parasites : either they had been repetitively exposed to malaria parasite infestation or they were recovering from a recent treated malaria attack. However, they had similar frequencies of T cells reactive to Pf155/RESA peptides. With cells from a minority of patients, “saw-tooth curves” were obtained, suggesting the existence of suppressor mechanisms operating <ce:italic>in vitro</ce:italic> in our limiting dilution assay.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:abstract id="ab2" class="author" xml:lang="fr"><ce:abstract-sec><ce:simple-para>Nous avons voulu estimer, parmi les lympho- cytes T circulant dans le sang périphérique de don- neurs exposés aux hématozoaires du paludisme, la fréquence de ceux correspondant aux antigènes de <ce:italic>Plasmodium falciparum</ce:italic> et plus particulièrement à des peptides de l'antigène Pf155/RESA. Les valeurs des fréquences des cellules T réactives sont dispersées et plutôt faibles, s'échelonnant entre 1/24.000 et des valeurs indétectables (au-delà de 1/300.000). Les sujets avaient un passé d'exposition parasitaire variable: soit ils avaient été exposés à l'infestation de façon répétée, soit ils venaient juste de récupérer d'une crise de malaria traitée. Toutefois les fréquences détectées de cellules T réactives aux peptides de l'antigène Pf155/RESA sont semblables. Pour une minorité de sujets, des courbes de fréquence «en dents de scie ont été obtenues, suggérant l'existence de mécanismes suppresseurs intervenant <ce:italic>in vitro</ce:italic> dans nos analyses en dilution limitante.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords class="keyword" xml:lang="en"><ce:keyword><ce:text><ce:italic>Plasmodium falciparum</ce:italic>, Malaria, T lymphocyte</ce:text></ce:keyword><ce:keyword><ce:text>Pf155/RESA peptide</ce:text></ce:keyword><ce:keyword><ce:text>Cellular immunity</ce:text></ce:keyword></ce:keywords><ce:keywords class="keyword" xml:lang="fr"><ce:section-title>Mots-clés</ce:section-title><ce:keyword><ce:text>Lymphocytes T, <ce:italic>Plasmodium falciparum</ce:italic>, Paludisme</ce:text></ce:keyword><ce:keyword><ce:text>Immunité cellulaire, Antigène Pf155/RESA</ce:text></ce:keyword></ce:keywords></head><tail><ce:bibliography><ce:section-title>Reference</ce:section-title><ce:bibliography-sec><ce:bib-reference id="bib1"><ce:label>Brett, et al, 1987</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Brett</ce:surname><ce:given-name>S.J.</ce:given-name></sb:author><sb:author><ce:surname>Kingston</ce:surname><ce:given-name>A.E.</ce:given-name></sb:author><sb:author><ce:surname>Colston</ce:surname><ce:given-name>M.J.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Limiting dilution analysis of the human T cell response to mycobacterial antigens from BCG vaccinated individuals and leprosy patients</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Clin. 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Immunol</sb:maintitle></sb:title><sb:volume-nr>22</sb:volume-nr></sb:series><sb:date>1992</sb:date></sb:issue><sb:pages><sb:first-page>689</sb:first-page><sb:last-page>696</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference></ce:bibliography-sec></ce:bibliography></tail></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Quantification of t cells reactive to pf155/RESA peptides in plasmodium falciparum -exposed individuals</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Quantification of t cells reactive to pf155/RESA peptides in</title></titleInfo><titleInfo type="translated" lang="fr"><title>Quantification des cellules t réactives au peptide Pf155/RESA chez des individus exposés à plasmodium falciparum</title></titleInfo><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Chougnet</namePart><affiliation>INSERM U13/IMEA, Paris,France</affiliation><affiliation>Correspondence to C. Chougnet, INSERM U13, 190 boulevard MacDonald, 75019 Paris, France.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Henzel</namePart><affiliation>INSERM U13/IMEA, Paris,France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Diakhate</namePart><affiliation>Centre National de Transfusion Sanguine, Dakar-Fann, Sénégal,Paris,France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Imbert</namePart><affiliation>Service de Pathologie infectieuse et tropicale, Hôpital d'Instruction des armées ≪ A. Laveran ≫, Marseille, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">O.</namePart><namePart type="family">Bouchaud</namePart><affiliation>Service des maladies infectieuses et tropicales, Hôpital Bichat-Claude Bernard, Paris,France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Deloron</namePart><affiliation>INSERM U13/IMEA, Paris,France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1994</dateIssued><copyrightDate encoding="w3cdtf">1994</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Summary: This study was designed to estimate, among T lymphocytes circulating in the peripheral blood of donors exposed to malaria parasites, the frequencies of those responding to Plasmodium falciparum antigens, and more specifically to Pf155/RESA peptides. The values of peptide-reactive T-cell frequencies were dispersed and rather low, ranging from 1:24,000 to undetectable (superior to 1:300,000). Subjects presented with different past exposure to parasites : either they had been repetitively exposed to malaria parasite infestation or they were recovering from a recent treated malaria attack. However, they had similar frequencies of T cells reactive to Pf155/RESA peptides. With cells from a minority of patients, “saw-tooth curves” were obtained, suggesting the existence of suppressor mechanisms operating in vitro in our limiting dilution assay.</abstract><abstract lang="fr">Nous avons voulu estimer, parmi les lympho- cytes T circulant dans le sang périphérique de don- neurs exposés aux hématozoaires du paludisme, la fréquence de ceux correspondant aux antigènes de Plasmodium falciparum et plus particulièrement à des peptides de l'antigène Pf155/RESA. Les valeurs des fréquences des cellules T réactives sont dispersées et plutôt faibles, s'échelonnant entre 1/24.000 et des valeurs indétectables (au-delà de 1/300.000). Les sujets avaient un passé d'exposition parasitaire variable: soit ils avaient été exposés à l'infestation de façon répétée, soit ils venaient juste de récupérer d'une crise de malaria traitée. Toutefois les fréquences détectées de cellules T réactives aux peptides de l'antigène Pf155/RESA sont semblables. Pour une minorité de sujets, des courbes de fréquence «en dents de scie ont été obtenues, suggérant l'existence de mécanismes suppresseurs intervenant in vitro dans nos analyses en dilution limitante.</abstract><subject lang="en"><topic>Plasmodium falciparum, Malaria, T lymphocyte</topic><topic>Pf155/RESA peptide</topic><topic>Cellular immunity</topic></subject><subject lang="fr"><genre>Mots-clés</genre><topic>Lymphocytes T, Plasmodium falciparum, Paludisme</topic><topic>Immunité cellulaire, Antigène Pf155/RESA</topic></subject><relatedItem type="host"><titleInfo><title>Research in Immunology</title></titleInfo><titleInfo type="abbreviated"><title>X83</title></titleInfo><genre type="journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">1994</dateIssued></originInfo><identifier type="ISSN">0923-2494</identifier><identifier type="PII">S0923-2494(00)X0028-4</identifier><part><date>1994</date><detail type="volume"><number>145</number><caption>vol.</caption></detail><detail type="issue"><number>4</number><caption>no.</caption></detail><extent unit="issue pages"><start>257</start><end>317</end></extent><extent unit="pages"><start>257</start><end>266</end></extent></part></relatedItem><identifier type="istex">059AAF24F717D019AE4EFA9900464BD51883CD32</identifier><identifier type="DOI">10.1016/S0923-2494(94)80014-6</identifier><identifier type="PII">S0923-2494(94)80014-6</identifier><identifier type="ArticleID">94800146</identifier><accessCondition type="use and reproduction" contentType="copyright">©1994 Institut Pasteur/Elsevier</accessCondition><recordInfo><recordContentSource>ELSEVIER</recordContentSource><recordOrigin>Institut Pasteur/Elsevier, ©1994</recordOrigin></recordInfo></mods></metadata></istex></record>Pour manipuler ce document sous Unix (Dilib)
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