ParkinsonFranceV1, Hal, Corpus, bibRecord, 000322

Does subthalamic nucleus stimulation affect the frontal limbic areas? A single-photon emission computed tomography study using a manual anatomical segmentation method.

Identifieur interne : 000322 ( Hal/Corpus ); précédent : 000321; suivant : 000323

Does subthalamic nucleus stimulation affect the frontal limbic areas? A single-photon emission computed tomography study using a manual anatomical segmentation method.

Auteurs : Claire Haegelen ; Marc Verin ; Bérangère Aubert Broche ; François Prigent ; Pierre Jannin ; Bernard Gibaud ; Xavier Morandi

Source :

Surgical and Radiologic Anatomy [ 0930-1038 ] ; 2005-12.

RBID : Hal:inserm-00330529

Abstract

Among the basal ganglia nuclei, the subthalamic nucleus (STN) is considered to play a major role in output modulation. The STN represents a relay of the motor cortico-basal ganglia-thalamo-cortical circuit and has become the standard surgical target for treating Parkinson's patients with long-term motor fluctuations and dyskinesia. But chronic bilateral stimulation of the STN produces cognitive effects. According to animal and clinical studies, the STN also appears to have direct or indirect connections with the frontal associative and limbic areas. This prospective study was conducted to analyse regional cerebral blood flow changes in single-photon emission computed tomography imaging of six Parkinson's patients before and after STN stimulation. We particularly focused on the dorsolateral prefrontal cortex and the frontal limbic areas using a manual anatomical MRI segmentation method. We defined nine regions of interest, segmenting each MR slice to quantify the regional cerebral blood flow on pre- and postoperative SPECT images. We normalised the region-of-interest-based measurements to the entire brain volume. The patients showed increased activation during STN stimulation in the dorsolateral prefrontal cortex bilaterally and no change in the anterior cingulate and orbito-frontal cortices. In our study, STN stimulation induced activation of premotor and associative frontal areas. Further studies are needed to underline involvement of the STN with the so-called limbic system.

Url:

http://www.hal.inserm.fr/inserm-00330529

DOI: 10.1007/s00276-005-0021-8

Links to Exploration step

Hal:inserm-00330529

Le document en format XML

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<front><div type="abstract" xml:lang="en">Among the basal ganglia nuclei, the subthalamic nucleus (STN) is considered to play a major role in output modulation. The STN represents a relay of the motor cortico-basal ganglia-thalamo-cortical circuit and has become the standard surgical target for treating Parkinson's patients with long-term motor fluctuations and dyskinesia. But chronic bilateral stimulation of the STN produces cognitive effects. According to animal and clinical studies, the STN also appears to have direct or indirect connections with the frontal associative and limbic areas. This prospective study was conducted to analyse regional cerebral blood flow changes in single-photon emission computed tomography imaging of six Parkinson's patients before and after STN stimulation. We particularly focused on the dorsolateral prefrontal cortex and the frontal limbic areas using a manual anatomical MRI segmentation method. We defined nine regions of interest, segmenting each MR slice to quantify the regional cerebral blood flow on pre- and postoperative SPECT images. We normalised the region-of-interest-based measurements to the entire brain volume. The patients showed increased activation during STN stimulation in the dorsolateral prefrontal cortex bilaterally and no change in the anterior cingulate and orbito-frontal cortices. In our study, STN stimulation induced activation of premotor and associative frontal areas. Further studies are needed to underline involvement of the STN with the so-called limbic system.</div>
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            <author role="aut">              <persName>                <forename type="first">François</forename>
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              <idno type="halauthorid">360349</idno>
              <affiliation ref="#struct-15218"></affiliation>
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            <author role="aut">              <persName>                <forename type="first">Pierre</forename>
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            <author role="aut">              <persName>                <forename type="first">Bernard</forename>
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              <date type="whenProduced">2005-12</date>
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            <idno type="halRefHtml">Surgical and Radiologic Anatomy, Springer Verlag (Germany), 2005, 27 (5), pp.389-94. <10.1007/s00276-005-0021-8></idno>
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            <idno type="stamp" n="UNIV-UBS">Université de Bretagne Sud</idno>
            <idno type="stamp" n="UNIV-RENNES1">Université de Rennes 1</idno>
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            <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
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                <author role="aut">                  <persName>                    <forename type="first">Claire</forename>
                    <surname>Haegelen</surname>
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                  <affiliation ref="#struct-33545"></affiliation>
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                <author role="aut">                  <persName>                    <forename type="first">Marc</forename>
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                <author role="aut">                  <persName>                    <forename type="first">Bérangère</forename>
                    <surname>Aubert Broche</surname>
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                  <idno type="halauthorid">360348</idno>
                  <affiliation ref="#struct-32594"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">François</forename>
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                  <idno type="halauthorid">360349</idno>
                  <affiliation ref="#struct-15218"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Pierre</forename>
                    <surname>Jannin</surname>
                  </persName>
                  <idno type="halauthorid">140493</idno>
                  <affiliation ref="#struct-32594"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Bernard</forename>
                    <surname>Gibaud</surname>
                  </persName>
                  <idno type="halauthorid">169839</idno>
                  <affiliation ref="#struct-32594"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Xavier</forename>
                    <surname>Morandi</surname>
                  </persName>
                  <idno type="halauthorid">140492</idno>
                  <affiliation ref="#struct-32594"></affiliation>
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                <idno type="issn">0930-1038</idno>
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                <title level="j">Surgical and Radiologic Anatomy</title>
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                  <biblScope unit="volume">27</biblScope>
                  <biblScope unit="issue">5</biblScope>
                  <biblScope unit="pp">389-94</biblScope>
                  <date type="datePub">2005-12</date>
                  <date type="dateEpub">2005-09-14</date>
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              <idno type="doi">10.1007/s00276-005-0021-8</idno>
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            <textClass>              <classCode scheme="mesh">Cerebrovascular Circulation</classCode>
              <classCode scheme="mesh">Levodopa</classCode>
              <classCode scheme="mesh">Limbic System</classCode>
              <classCode scheme="mesh">Magnetic Resonance Imaging</classCode>
              <classCode scheme="mesh">Male</classCode>
              <classCode scheme="mesh">Middle Aged</classCode>
              <classCode scheme="mesh">Neural Pathways</classCode>
              <classCode scheme="mesh">Parkinson Disease</classCode>
              <classCode scheme="mesh">Prefrontal Cortex</classCode>
              <classCode scheme="mesh">Prospective Studies</classCode>
              <classCode scheme="mesh">Subthalamic Nucleus</classCode>
              <classCode scheme="mesh">Cognition</classCode>
              <classCode scheme="mesh">Tomography, Emission-Computed, Single-Photon</classCode>
              <classCode scheme="mesh">Antiparkinson Agents</classCode>
              <classCode scheme="mesh">Deep Brain Stimulation</classCode>
              <classCode scheme="mesh">Female</classCode>
              <classCode scheme="mesh">Frontal Lobe</classCode>
              <classCode scheme="mesh">Gyrus Cinguli</classCode>
              <classCode scheme="mesh">Humans</classCode>
              <classCode scheme="mesh">Image Processing, Computer-Assisted</classCode>
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            <abstract xml:lang="en">Among the basal ganglia nuclei, the subthalamic nucleus (STN) is considered to play a major role in output modulation. The STN represents a relay of the motor cortico-basal ganglia-thalamo-cortical circuit and has become the standard surgical target for treating Parkinson's patients with long-term motor fluctuations and dyskinesia. But chronic bilateral stimulation of the STN produces cognitive effects. According to animal and clinical studies, the STN also appears to have direct or indirect connections with the frontal associative and limbic areas. This prospective study was conducted to analyse regional cerebral blood flow changes in single-photon emission computed tomography imaging of six Parkinson's patients before and after STN stimulation. We particularly focused on the dorsolateral prefrontal cortex and the frontal limbic areas using a manual anatomical MRI segmentation method. We defined nine regions of interest, segmenting each MR slice to quantify the regional cerebral blood flow on pre- and postoperative SPECT images. We normalised the region-of-interest-based measurements to the entire brain volume. The patients showed increased activation during STN stimulation in the dorsolateral prefrontal cortex bilaterally and no change in the anterior cingulate and orbito-frontal cortices. In our study, STN stimulation induced activation of premotor and associative frontal areas. Further studies are needed to underline involvement of the STN with the so-called limbic system.</abstract>
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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

Does subthalamic nucleus stimulation affect the frontal limbic areas? A single-photon emission computed tomography study using a manual anatomical segmentation method.

Does subthalamic nucleus stimulation affect the frontal limbic areas? A single-photon emission computed tomography study using a manual anatomical segmentation method.

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