ParkinsonFranceV1, Hal, Corpus, bibRecord, 000323

Does unilateral basal ganglia activity functionally influence the contralateral side? What we can learn from STN stimulation in patients with Parkinson's disease.

Identifieur interne : 000323 ( Hal/Corpus ); précédent : 000322; suivant : 000324

Does unilateral basal ganglia activity functionally influence the contralateral side? What we can learn from STN stimulation in patients with Parkinson's disease.

Auteurs : Yohann Brun ; Carine Karachi ; Sara Fernandez-Vidal ; Nicolas Jodoin ; David Grabli ; Eric Bardinet ; Luc Mallet ; Yves Agid ; Jerome Yelnik ; Marie-Laure Welter

Source :

Journal of Neurophysiology [ 0022-3077 ] ; 2012-09.

RBID : Hal:hal-00795702

Abstract

In humans, the control of voluntary movement, in which the corticobasal ganglia (BG) circuitry participates, is mainly lateralized. However, several studies have suggested that both the contralateral and ipsilateral BG systems are implicated during unilateral movement. Bilateral improvement of motor signs in patients with Parkinson's disease (PD) has been reported with unilateral lesion or high-frequency stimulation (HFS) of the internal part of the globus pallidus or the subthalamic nucleus (STN-HFS). To decipher the mechanisms of production of ipsilateral movements induced by the modulation of unilateral BG circuitry activity, we recorded left STN neuronal activity during right STN-HFS in PD patients operated for bilateral deep brain stimulation. Left STN single cells were recorded in the operating room during right STN-HFS while patients experienced, or did not experience, right stimulation-induced dyskinesias. Most of the left-side STN neurons (64%) associated with the presence of right dyskinesias were inhibited, with a significant decrease in burst and intraburst frequencies. In contrast, left STN neurons not associated with right dyskinesias were mainly activated (48%), with a predominant increase 4-5 ms after the stimulation pulse and a decrease in oscillatory activity. This suggests that unilateral neuronal STN modulation is associated with changes in the activity of the contralateral STN. The fact that one side of the BG system can influence the functioning of the other could explain the occurrence of bilateral dyskinesias and motor improvement observed in PD patients during unilateral STN-HFS, as a result of a bilateral disruption of the pathological activity in the corticosubcortical circuitry.

Url:

https://hal.inria.fr/hal-00795702

DOI: 10.1152/jn.00254.2012

Links to Exploration step

Hal:hal-00795702

Le document en format XML

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<author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name>
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<author><name sortKey="Welter, Marie Laure" sort="Welter, Marie Laure" uniqKey="Welter M" first="Marie-Laure" last="Welter">Marie-Laure Welter</name>
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<idno type="DOI">10.1152/jn.00254.2012</idno>
<series><title level="j">Journal of Neurophysiology</title>
<idno type="ISSN">0022-3077</idno>
<imprint><date type="datePub">2012-09</date>
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<front><div type="abstract" xml:lang="en">In humans, the control of voluntary movement, in which the corticobasal ganglia (BG) circuitry participates, is mainly lateralized. However, several studies have suggested that both the contralateral and ipsilateral BG systems are implicated during unilateral movement. Bilateral improvement of motor signs in patients with Parkinson's disease (PD) has been reported with unilateral lesion or high-frequency stimulation (HFS) of the internal part of the globus pallidus or the subthalamic nucleus (STN-HFS). To decipher the mechanisms of production of ipsilateral movements induced by the modulation of unilateral BG circuitry activity, we recorded left STN neuronal activity during right STN-HFS in PD patients operated for bilateral deep brain stimulation. Left STN single cells were recorded in the operating room during right STN-HFS while patients experienced, or did not experience, right stimulation-induced dyskinesias. Most of the left-side STN neurons (64%) associated with the presence of right dyskinesias were inhibited, with a significant decrease in burst and intraburst frequencies. In contrast, left STN neurons not associated with right dyskinesias were mainly activated (48%), with a predominant increase 4-5 ms after the stimulation pulse and a decrease in oscillatory activity. This suggests that unilateral neuronal STN modulation is associated with changes in the activity of the contralateral STN. The fact that one side of the BG system can influence the functioning of the other could explain the occurrence of bilateral dyskinesias and motor improvement observed in PD patients during unilateral STN-HFS, as a result of a bilateral disruption of the pathological activity in the corticosubcortical circuitry.</div>
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<hal api="V3">          <titleStmt>            <title xml:lang="en">Does unilateral basal ganglia activity functionally influence the contralateral side? What we can learn from STN stimulation in patients with Parkinson's disease.</title>
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                <author role="aut">                  <persName>                    <forename type="first">Yohann</forename>
                    <surname>Brun</surname>
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                  <idno type="halauthorid">822504</idno>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Carine</forename>
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                  <affiliation ref="#struct-81470"></affiliation>
                  <affiliation ref="#struct-106232"></affiliation>
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                <author role="aut">                  <persName>                    <forename type="first">Nicolas</forename>
                    <surname>Jodoin</surname>
                  </persName>
                  <idno type="halauthorid">822505</idno>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">David</forename>
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                  <affiliation ref="#struct-81470"></affiliation>
                  <affiliation ref="#struct-455092"></affiliation>
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                <author role="aut">                  <persName>                    <forename type="first">Eric</forename>
                    <surname>Bardinet</surname>
                  </persName>
                  <idno type="halauthorid">98501</idno>
                  <affiliation ref="#struct-81470"></affiliation>
                  <affiliation ref="#struct-106232"></affiliation>
                  <affiliation ref="#struct-218549"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Luc</forename>
                    <surname>Mallet</surname>
                  </persName>
                  <idno type="halauthorid">214480</idno>
                  <affiliation ref="#struct-81470"></affiliation>
                  <affiliation ref="#struct-2623"></affiliation>
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                <author role="aut">                  <persName>                    <forename type="first">Yves</forename>
                    <surname>Agid</surname>
                  </persName>
                  <idno type="halauthorid">217013</idno>
                  <affiliation ref="#struct-43171"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Jerome</forename>
                    <surname>Yelnik</surname>
                  </persName>
                  <idno type="halauthorid">547687</idno>
                  <affiliation ref="#struct-81470"></affiliation>
                  <affiliation ref="#struct-2623"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Marie-Laure</forename>
                    <surname>Welter</surname>
                  </persName>
                  <idno type="halauthorid">214475</idno>
                  <affiliation ref="#struct-81470"></affiliation>
                  <affiliation ref="#struct-2623"></affiliation>
                  <affiliation ref="#struct-5370"></affiliation>
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                <idno type="issn">0022-3077</idno>
                <idno type="eissn">1522-1598</idno>
                <title level="j">Journal of Neurophysiology</title>
                <imprint>                  <publisher>American Physiological Society</publisher>
                  <biblScope unit="volume">108</biblScope>
                  <biblScope unit="issue">6</biblScope>
                  <biblScope unit="pp">1575-1583</biblScope>
                  <date type="datePub">2012-09</date>
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              <idno type="doi">10.1152/jn.00254.2012</idno>
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            <abstract xml:lang="en">In humans, the control of voluntary movement, in which the corticobasal ganglia (BG) circuitry participates, is mainly lateralized. However, several studies have suggested that both the contralateral and ipsilateral BG systems are implicated during unilateral movement. Bilateral improvement of motor signs in patients with Parkinson's disease (PD) has been reported with unilateral lesion or high-frequency stimulation (HFS) of the internal part of the globus pallidus or the subthalamic nucleus (STN-HFS). To decipher the mechanisms of production of ipsilateral movements induced by the modulation of unilateral BG circuitry activity, we recorded left STN neuronal activity during right STN-HFS in PD patients operated for bilateral deep brain stimulation. Left STN single cells were recorded in the operating room during right STN-HFS while patients experienced, or did not experience, right stimulation-induced dyskinesias. Most of the left-side STN neurons (64%) associated with the presence of right dyskinesias were inhibited, with a significant decrease in burst and intraburst frequencies. In contrast, left STN neurons not associated with right dyskinesias were mainly activated (48%), with a predominant increase 4-5 ms after the stimulation pulse and a decrease in oscillatory activity. This suggests that unilateral neuronal STN modulation is associated with changes in the activity of the contralateral STN. The fact that one side of the BG system can influence the functioning of the other could explain the occurrence of bilateral dyskinesias and motor improvement observed in PD patients during unilateral STN-HFS, as a result of a bilateral disruption of the pathological activity in the corticosubcortical circuitry.</abstract>
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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

Does unilateral basal ganglia activity functionally influence the contralateral side? What we can learn from STN stimulation in patients with Parkinson's disease.

Does unilateral basal ganglia activity functionally influence the contralateral side? What we can learn from STN stimulation in patients with Parkinson's disease.

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