ParkinsonFranceV1, Hal, Corpus, bibRecord, 000321

Does neuronal expression of GDNF effectively protect dopaminergic neurons in a rat model of Parkinson's disease?

Identifieur interne : 000321 ( Hal/Corpus ); précédent : 000320; suivant : 000322

Does neuronal expression of GDNF effectively protect dopaminergic neurons in a rat model of Parkinson's disease?

Auteurs : N. A. Do Thi ; P. Saillour ; L. Ferrero ; T. Paunio ; J. Mallet

Source :

Gene Therapy [ 0969-7128 ] ; 2007-03.

RBID : Hal:hal-00166656

Abstract

The transfer of the Glial cell line-derived neurotrophic factor (GDNF) gene to the central nervous system by a recombinant adenoviral vector (Ad) was studied. We constructed the adenovirus vector Ad-NSE-GDNF from which the E1, E3/E4 regions of Ad5 have been deleted and in which the GDNF gene was under the control of a neuron-specific enolase (NSE) promoter. The vector was injected into the striatum of a rat model of Parkinson's disease. We found that (i) the NSE promoter can restrict transgene expression in neurons; (ii) Ad-NSE-GDNF significantly protected dopaminergic (DA) neurons in the substantia nigra (SN) but did not reverse the impairments of amphetamine-induced rotational behavior in lesioned rats.

Url:

https://hal.archives-ouvertes.fr/hal-00166656

DOI: 10.1038/sj.gt.3302844

Links to Exploration step

Hal:hal-00166656

Le document en format XML

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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

Does neuronal expression of GDNF effectively protect dopaminergic neurons in a rat model of Parkinson's disease?

Does neuronal expression of GDNF effectively protect dopaminergic neurons in a rat model of Parkinson's disease?

Source :

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri