Long-term Outcomes of Pandemic 2009 Influenza A(H1N1)-Associated Severe ARDS
Identifieur interne : 001912 ( PascalFrancis/Curation ); précédent : 001911; suivant : 001913Long-term Outcomes of Pandemic 2009 Influenza A(H1N1)-Associated Severe ARDS
Auteurs : Charles-Edauard Luyt [France] ; Alain Combes [France] ; Marie-Hélène Becquemin [France] ; Catherine Beigelman-Aubry [France] ; Stéphane Hatem [France] ; Anne-Laure Brun [France] ; Nizar Zraik [France] ; Fabrice Carrat [France] ; Philippe A. Grenier [France] ; Jean-Chilstophe M. Richard [France] ; Alain Mercat [France] ; Laurent Brochard [Suisse] ; Christian Brun-Buisson [France] ; Jean Chastre [France]Source :
- Chest : (American College of Chest Physicians) [ 0012-3692 ] ; 2012.
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- Pascal (Inist)
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Abstract
Background: No data on long-term outcomes of survivors of 2009 influenza A(H1N1) (A[H1N1])-associated ARDS are available. The objective of this study was to compare the 1-year outcomes of survivors of A(H1N1)-associated ARDS, according to use or no use of extracorporeal lung assist (ECLA), using its need as an ARDS severity surrogate. Methods: Survivors of ARDS (12 with ECLA use vs 25 without, corresponding to 75% and 54% of the eligible patients for each group, respectively) selected from the Réseau Européen de Ventilation Artificielle (REVA) registry had previously been healthy, with only pregnancy and/or moderate obesity (BMI ≤ 35 kg/m2) as known risk factors for A(H1N1) infection. Lung function and morphology, health-related quality of life (HRQoL), and psychologic impairment were evaluated. Results: At 1 year post-ICU discharge for the ECLA and no-ECLA groups, respectively, 50% and 40% reported significant exertion dyspnea, 83% and 64% had returned to work, and 75% and 64% had decreased diffusion capacity across the blood-gas barrier, despite their near-normal and similar lung function test results. For both groups, exercise test results showed diminished but comparable exercise capacities, with similar alveolar-arterial oxygen gradients at peak exercise, and CT scans showed minor abnormal findings. HRQoL assessed by the 36-Item Short-Form Health Survey was poorer for both groups than for a sex- and age-matched general population group, but without between-group differences. ECLA and no-ECLA group patients, respectively, had symptoms of anxiety (50% and 56%) and depression (28% and 28%) and were at risk for post-traumatic stress disorder (41% and 44%). Conclusions: One year post-ICU discharge, a majority of survivors of A(H1N1)-associated ARDS had minor lung disabilities with diminished diffusion capacities across the blood-gas barrier, and most had psychologic impairment and poorer HRQoL than a sex- and age-matched general population group. ECLA and no-ECLA group patients had comparable outcomes.
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Grenier</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Service de Radiologie, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique- Hôpitaux de Paris et Université Paris 6-Pierre-et-Marie-Curie</s1><s2>Paris</s2><s3>FRA</s3><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Richard, Jean Chilstophe M" sort="Richard, Jean Chilstophe M" uniqKey="Richard J" first="Jean-Chilstophe M." last="Richard">Jean-Chilstophe M. Richard</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Service de Réanimation Médicale Centre Hospitalier Universitaire de Rouen</s1><s2>Rouen</s2><s3>FRA</s3><sZ>10 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Mercat, Alain" sort="Mercat, Alain" uniqKey="Mercat A" first="Alain" last="Mercat">Alain Mercat</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Service de Réanimation Médicale Centre Hospitalier Universitaire d'Angers</s1><s2>Angers</s2><s3>FRA</s3><sZ>11 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Brochard, Laurent" sort="Brochard, Laurent" uniqKey="Brochard L" first="Laurent" last="Brochard">Laurent Brochard</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Intensive Care Unit Hôpitaux Universitaires de Genève</s1><s2>Genève</s2><s3>CHE</s3><sZ>12 aut.</sZ></inist:fA14><country>Suisse</country></affiliation></author><author><name sortKey="Brun Buisson, Christian" sort="Brun Buisson, Christian" uniqKey="Brun Buisson C" first="Christian" last="Brun-Buisson">Christian Brun-Buisson</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Service de Réanimation Médicale Hôpital Henri-Mondor, Assistance Publique-Hôpitaux de Paris, Université Paris 12</s1><s2>Créteil</s2><s3>FRA</s3><sZ>13 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Chastre, Jean" sort="Chastre, Jean" uniqKey="Chastre J" first="Jean" last="Chastre">Jean Chastre</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Service de Reanimation Médicale, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique- Hôpitaux de Paris et Université Paris 6-Pierre-et-Marie-Curie</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">12-0371302</idno><date when="2012">2012</date><idno type="stanalyst">PASCAL 12-0371302 INIST</idno><idno type="RBID">Pascal:12-0371302</idno><idno type="wicri:Area/PascalFrancis/Corpus">000526</idno><idno type="wicri:Area/PascalFrancis/Curation">001912</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Long-term Outcomes of Pandemic 2009 Influenza A(H1N1)-Associated Severe ARDS</title><author><name sortKey="Luyt, Charles Edauard" sort="Luyt, Charles Edauard" uniqKey="Luyt C" first="Charles-Edauard" last="Luyt">Charles-Edauard Luyt</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Service de Reanimation Médicale, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique- Hôpitaux de Paris et Université Paris 6-Pierre-et-Marie-Curie</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Combes, Alain" sort="Combes, Alain" uniqKey="Combes A" first="Alain" last="Combes">Alain Combes</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Service de Reanimation Médicale, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique- Hôpitaux de Paris et Université Paris 6-Pierre-et-Marie-Curie</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Becquemin, Marie Helene" sort="Becquemin, Marie Helene" uniqKey="Becquemin M" first="Marie-Hélène" last="Becquemin">Marie-Hélène Becquemin</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Service d'Explorations Fonctionnelles, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique- Hôpitaux de Paris et Université Paris 6-Pierre-et-Marie-Curie</s1><s2>Paris</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Beigelman Aubry, Catherine" sort="Beigelman Aubry, Catherine" uniqKey="Beigelman Aubry C" first="Catherine" last="Beigelman-Aubry">Catherine Beigelman-Aubry</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Service de Radiologie, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique- Hôpitaux de Paris et Université Paris 6-Pierre-et-Marie-Curie</s1><s2>Paris</s2><s3>FRA</s3><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Hatem, Stephane" sort="Hatem, Stephane" uniqKey="Hatem S" first="Stéphane" last="Hatem">Stéphane Hatem</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Service d'explorations fonctionnelles cardio-vasculaires, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique- Hôpitaux de Paris et Université Paris 6-Pierre-et-Marie-Curie</s1><s2>Paris</s2><s3>FRA</s3><sZ>5 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Brun, Anne Laure" sort="Brun, Anne Laure" uniqKey="Brun A" first="Anne-Laure" last="Brun">Anne-Laure Brun</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Service de Radiologie, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique- Hôpitaux de Paris et Université Paris 6-Pierre-et-Marie-Curie</s1><s2>Paris</s2><s3>FRA</s3><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Zraik, Nizar" sort="Zraik, Nizar" uniqKey="Zraik N" first="Nizar" last="Zraik">Nizar Zraik</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Service d'Explorations Fonctionnelles, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique- Hôpitaux de Paris et Université Paris 6-Pierre-et-Marie-Curie</s1><s2>Paris</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Carrat, Fabrice" sort="Carrat, Fabrice" uniqKey="Carrat F" first="Fabrice" last="Carrat">Fabrice Carrat</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Service de Santé Publique, Hôpital Saint-Antoine Assistance Publique-Hôpitaux de Paris, Unité Mixte de Recherche-S 707, Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris 6-Pierre-et-Marie-Curie</s1><s2>Paris</s2><s3>FRA</s3><sZ>8 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Grenier, Philippe A" sort="Grenier, Philippe A" uniqKey="Grenier P" first="Philippe A." last="Grenier">Philippe A. Grenier</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Service de Radiologie, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique- Hôpitaux de Paris et Université Paris 6-Pierre-et-Marie-Curie</s1><s2>Paris</s2><s3>FRA</s3><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Richard, Jean Chilstophe M" sort="Richard, Jean Chilstophe M" uniqKey="Richard J" first="Jean-Chilstophe M." last="Richard">Jean-Chilstophe M. Richard</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Service de Réanimation Médicale Centre Hospitalier Universitaire de Rouen</s1><s2>Rouen</s2><s3>FRA</s3><sZ>10 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Mercat, Alain" sort="Mercat, Alain" uniqKey="Mercat A" first="Alain" last="Mercat">Alain Mercat</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Service de Réanimation Médicale Centre Hospitalier Universitaire d'Angers</s1><s2>Angers</s2><s3>FRA</s3><sZ>11 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Brochard, Laurent" sort="Brochard, Laurent" uniqKey="Brochard L" first="Laurent" last="Brochard">Laurent Brochard</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Intensive Care Unit Hôpitaux Universitaires de Genève</s1><s2>Genève</s2><s3>CHE</s3><sZ>12 aut.</sZ></inist:fA14><country>Suisse</country></affiliation></author><author><name sortKey="Brun Buisson, Christian" sort="Brun Buisson, Christian" uniqKey="Brun Buisson C" first="Christian" last="Brun-Buisson">Christian Brun-Buisson</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Service de Réanimation Médicale Hôpital Henri-Mondor, Assistance Publique-Hôpitaux de Paris, Université Paris 12</s1><s2>Créteil</s2><s3>FRA</s3><sZ>13 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Chastre, Jean" sort="Chastre, Jean" uniqKey="Chastre J" first="Jean" last="Chastre">Jean Chastre</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Service de Reanimation Médicale, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique- Hôpitaux de Paris et Université Paris 6-Pierre-et-Marie-Curie</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country></affiliation></author></analytic><series><title level="j" type="main">Chest : (American College of Chest Physicians)</title><title level="j" type="abbreviated">Chest : (Amer. Coll. Chest Phys.)</title><idno type="ISSN">0012-3692</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Chest : (American College of Chest Physicians)</title><title level="j" type="abbreviated">Chest : (Amer. Coll. Chest Phys.)</title><idno type="ISSN">0012-3692</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anesthesia</term><term>Cardiology</term><term>Circulatory system</term><term>H1N1 influenza</term><term>Influenza A (H1N1)</term><term>Long term</term><term>Prognosis</term><term>Severe</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Long terme</term><term>Pronostic</term><term>Grave</term><term>Anesthésie</term><term>Appareil circulatoire</term><term>Cardiologie</term><term>Forme grave</term><term>Grippe H1N1</term><term>Virus grippal A(H1N1)</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: No data on long-term outcomes of survivors of 2009 influenza A(H1N1) (A[H1N1])-associated ARDS are available. The objective of this study was to compare the 1-year outcomes of survivors of A(H1N1)-associated ARDS, according to use or no use of extracorporeal lung assist (ECLA), using its need as an ARDS severity surrogate. Methods: Survivors of ARDS (12 with ECLA use vs 25 without, corresponding to 75% and 54% of the eligible patients for each group, respectively) selected from the Réseau Européen de Ventilation Artificielle (REVA) registry had previously been healthy, with only pregnancy and/or moderate obesity (BMI ≤ 35 kg/m<sup>2</sup>) as known risk factors for A(H1N1) infection. Lung function and morphology, health-related quality of life (HRQoL), and psychologic impairment were evaluated. Results: At 1 year post-ICU discharge for the ECLA and no-ECLA groups, respectively, 50% and 40% reported significant exertion dyspnea, 83% and 64% had returned to work, and 75% and 64% had decreased diffusion capacity across the blood-gas barrier, despite their near-normal and similar lung function test results. For both groups, exercise test results showed diminished but comparable exercise capacities, with similar alveolar-arterial oxygen gradients at peak exercise, and CT scans showed minor abnormal findings. HRQoL assessed by the 36-Item Short-Form Health Survey was poorer for both groups than for a sex- and age-matched general population group, but without between-group differences. ECLA and no-ECLA group patients, respectively, had symptoms of anxiety (50% and 56%) and depression (28% and 28%) and were at risk for post-traumatic stress disorder (41% and 44%). Conclusions: One year post-ICU discharge, a majority of survivors of A(H1N1)-associated ARDS had minor lung disabilities with diminished diffusion capacities across the blood-gas barrier, and most had psychologic impairment and poorer HRQoL than a sex- and age-matched general population group. ECLA and no-ECLA group patients had comparable outcomes.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0012-3692</s0></fA01><fA02 i1="01"><s0>CHETBF</s0></fA02><fA03 i2="1"><s0>Chest : (Amer. Coll. Chest Phys.)</s0></fA03><fA05><s2>142</s2></fA05><fA06><s2>3</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Long-term Outcomes of Pandemic 2009 Influenza A(H1N1)-Associated Severe ARDS</s1></fA08><fA11 i1="01" i2="1"><s1>LUYT (Charles-Edauard)</s1></fA11><fA11 i1="02" i2="1"><s1>COMBES (Alain)</s1></fA11><fA11 i1="03" i2="1"><s1>BECQUEMIN (Marie-Hélène)</s1></fA11><fA11 i1="04" i2="1"><s1>BEIGELMAN-AUBRY (Catherine)</s1></fA11><fA11 i1="05" i2="1"><s1>HATEM (Stéphane)</s1></fA11><fA11 i1="06" i2="1"><s1>BRUN (Anne-Laure)</s1></fA11><fA11 i1="07" i2="1"><s1>ZRAIK (Nizar)</s1></fA11><fA11 i1="08" i2="1"><s1>CARRAT (Fabrice)</s1></fA11><fA11 i1="09" i2="1"><s1>GRENIER (Philippe A.)</s1></fA11><fA11 i1="10" i2="1"><s1>RICHARD (Jean-Chilstophe M.)</s1></fA11><fA11 i1="11" i2="1"><s1>MERCAT (Alain)</s1></fA11><fA11 i1="12" i2="1"><s1>BROCHARD (Laurent)</s1></fA11><fA11 i1="13" i2="1"><s1>BRUN-BUISSON (Christian)</s1></fA11><fA11 i1="14" i2="1"><s1>CHASTRE (Jean)</s1></fA11><fA14 i1="01"><s1>Service de Reanimation Médicale, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique- Hôpitaux de Paris et Université Paris 6-Pierre-et-Marie-Curie</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>14 aut.</sZ></fA14><fA14 i1="02"><s1>Service d'Explorations Fonctionnelles, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique- Hôpitaux de Paris et Université Paris 6-Pierre-et-Marie-Curie</s1><s2>Paris</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ></fA14><fA14 i1="03"><s1>Service de Radiologie, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique- Hôpitaux de Paris et Université Paris 6-Pierre-et-Marie-Curie</s1><s2>Paris</s2><s3>FRA</s3><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ></fA14><fA14 i1="04"><s1>Service d'explorations fonctionnelles cardio-vasculaires, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique- Hôpitaux de Paris et Université Paris 6-Pierre-et-Marie-Curie</s1><s2>Paris</s2><s3>FRA</s3><sZ>5 aut.</sZ></fA14><fA14 i1="05"><s1>Service de Santé Publique, Hôpital Saint-Antoine Assistance Publique-Hôpitaux de Paris, Unité Mixte de Recherche-S 707, Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris 6-Pierre-et-Marie-Curie</s1><s2>Paris</s2><s3>FRA</s3><sZ>8 aut.</sZ></fA14><fA14 i1="06"><s1>Service de Réanimation Médicale Centre Hospitalier Universitaire de Rouen</s1><s2>Rouen</s2><s3>FRA</s3><sZ>10 aut.</sZ></fA14><fA14 i1="07"><s1>Service de Réanimation Médicale Centre Hospitalier Universitaire d'Angers</s1><s2>Angers</s2><s3>FRA</s3><sZ>11 aut.</sZ></fA14><fA14 i1="08"><s1>Intensive Care Unit Hôpitaux Universitaires de Genève</s1><s2>Genève</s2><s3>CHE</s3><sZ>12 aut.</sZ></fA14><fA14 i1="09"><s1>Service de Réanimation Médicale Hôpital Henri-Mondor, Assistance Publique-Hôpitaux de Paris, Université Paris 12</s1><s2>Créteil</s2><s3>FRA</s3><sZ>13 aut.</sZ></fA14><fA17 i1="01" i2="1"><s1>REVA Study Group</s1><s3>INC</s3></fA17><fA20><s1>583-592</s1></fA20><fA21><s1>2012</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>7627</s2><s5>354000509501540100</s5></fA43><fA44><s0>0000</s0><s1>© 2012 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>35 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>12-0371302</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Chest : (American College of Chest Physicians)</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Background: No data on long-term outcomes of survivors of 2009 influenza A(H1N1) (A[H1N1])-associated ARDS are available. The objective of this study was to compare the 1-year outcomes of survivors of A(H1N1)-associated ARDS, according to use or no use of extracorporeal lung assist (ECLA), using its need as an ARDS severity surrogate. Methods: Survivors of ARDS (12 with ECLA use vs 25 without, corresponding to 75% and 54% of the eligible patients for each group, respectively) selected from the Réseau Européen de Ventilation Artificielle (REVA) registry had previously been healthy, with only pregnancy and/or moderate obesity (BMI ≤ 35 kg/m<sup>2</sup>) as known risk factors for A(H1N1) infection. Lung function and morphology, health-related quality of life (HRQoL), and psychologic impairment were evaluated. Results: At 1 year post-ICU discharge for the ECLA and no-ECLA groups, respectively, 50% and 40% reported significant exertion dyspnea, 83% and 64% had returned to work, and 75% and 64% had decreased diffusion capacity across the blood-gas barrier, despite their near-normal and similar lung function test results. For both groups, exercise test results showed diminished but comparable exercise capacities, with similar alveolar-arterial oxygen gradients at peak exercise, and CT scans showed minor abnormal findings. HRQoL assessed by the 36-Item Short-Form Health Survey was poorer for both groups than for a sex- and age-matched general population group, but without between-group differences. ECLA and no-ECLA group patients, respectively, had symptoms of anxiety (50% and 56%) and depression (28% and 28%) and were at risk for post-traumatic stress disorder (41% and 44%). Conclusions: One year post-ICU discharge, a majority of survivors of A(H1N1)-associated ARDS had minor lung disabilities with diminished diffusion capacities across the blood-gas barrier, and most had psychologic impairment and poorer HRQoL than a sex- and age-matched general population group. ECLA and no-ECLA group patients had comparable outcomes.</s0></fC01><fC02 i1="01" i2="X"><s0>002B11</s0></fC02><fC02 i1="02" i2="X"><s0>002B12</s0></fC02><fC02 i1="03" i2="X"><s0>002B05C02C</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Long terme</s0><s5>09</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Long term</s0><s5>09</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Largo plazo</s0><s5>09</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Pronostic</s0><s5>10</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Prognosis</s0><s5>10</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Pronóstico</s0><s5>10</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Grave</s0><s5>11</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Severe</s0><s5>11</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Grave</s0><s5>11</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Anesthésie</s0><s5>12</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Anesthesia</s0><s5>12</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Anestesia</s0><s5>12</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Appareil circulatoire</s0><s5>13</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Circulatory system</s0><s5>13</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Aparato circulatorio</s0><s5>13</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Cardiologie</s0><s5>14</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Cardiology</s0><s5>14</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Cardiología</s0><s5>14</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Forme grave</s0><s4>INC</s4><s5>86</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Grippe H1N1</s0><s4>CD</s4><s5>96</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>H1N1 influenza</s0><s4>CD</s4><s5>96</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Gripe H1N1</s0><s4>CD</s4><s5>96</s5></fC03><fC03 i1="09" i2="X" l="FRE"><s0>Virus grippal A(H1N1)</s0><s4>CD</s4><s5>97</s5></fC03><fC03 i1="09" i2="X" l="ENG"><s0>Influenza A (H1N1)</s0><s4>CD</s4><s5>97</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Pathologie de l'appareil respiratoire</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Respiratory disease</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Aparato respiratorio patología</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Virose</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Viral disease</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Virosis</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Infection</s0></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Infection</s0></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Infección</s0></fC07><fN21><s1>289</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist></record>Pour manipuler ce document sous Unix (Dilib)
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