Humoral Antibody Response After Receipt of Inactivated Seasonal Influenza Vaccinations One Year Apart in Children
Identifieur interne : 001911 ( PascalFrancis/Curation ); précédent : 001910; suivant : 001912Humoral Antibody Response After Receipt of Inactivated Seasonal Influenza Vaccinations One Year Apart in Children
Auteurs : Sophia Ng [Hong Kong] ; Vicky J. Fang ; Dennis K. M. Ip ; Susan S. Chiu ; Gabriel M. Leung ; J. S. Malik Peiris ; D. Phil ; Benjamin J. CowlingSource :
- The Pediatric infectious disease journal [ 0891-3668 ] ; 2012.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Enfant, Vaccination, Pédiatrie.
English descriptors
- KwdEn :
Abstract
Background: Annual vaccination against seasonal influenza viruses is recommended for school-age children in some countries. There are limited data on the immunogenicity and efficacy of repeated influenza vaccinations. Methods: In a randomized controlled trial, we administered seasonal trivalent inactivated influenza vaccine (TIV) or placebo to 64 children 6-15 years of age in two consecutive years and explored their humoral antibody responses. Results: Receipt of TIV in the first year was associated with lower antibody titer rises in the second year to seasonal influenza A(H1N1) and A(H3N2) strains for which the vaccine strains remained unchanged. Antibody response to a different influenza B strain in the second year was unaffected by receipt ofTIV in the first year. Children who received TIV in both years showed higher antibody titers against pandemic A(H IN 1) which was not included in either TIV. Conclusions: Results from our study suggest that humoral antibody response to TIV may be lower in children receiving repeated vaccination, but receipt of TIV induced seroprotection in most subjects. Our study was underpowered to explore whether differences in immunogenicity translated to differences in vaccine efficacy.
pA |
|
---|
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000527
Links to Exploration step
Pascal:12-0369112Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Humoral Antibody Response After Receipt of Inactivated Seasonal Influenza Vaccinations One Year Apart in Children</title>
<author><name sortKey="Ng, Sophia" sort="Ng, Sophia" uniqKey="Ng S" first="Sophia" last="Ng">Sophia Ng</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>School of Public Health</s1>
<s3>HKG</s3>
</inist:fA14>
<country>Hong Kong</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Pediatrics and Adolescent Medicine</s1>
<s3>HKG</s3>
</inist:fA14>
<country>Hong Kong</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Centre for Influenza Research, Li Ka Shing Faculty of Medicine, the University of Hong Kong,</s1>
<s2>Hong Kong</s2>
<s3>HKG</s3>
</inist:fA14>
<country>Hong Kong</country>
</affiliation>
</author>
<author><name sortKey="Fang, Vicky J" sort="Fang, Vicky J" uniqKey="Fang V" first="Vicky J." last="Fang">Vicky J. Fang</name>
</author>
<author><name sortKey="Ip, Dennis K M" sort="Ip, Dennis K M" uniqKey="Ip D" first="Dennis K. M." last="Ip">Dennis K. M. Ip</name>
</author>
<author><name sortKey="Chiu, Susan S" sort="Chiu, Susan S" uniqKey="Chiu S" first="Susan S." last="Chiu">Susan S. Chiu</name>
</author>
<author><name sortKey="Leung, Gabriel M" sort="Leung, Gabriel M" uniqKey="Leung G" first="Gabriel M." last="Leung">Gabriel M. Leung</name>
</author>
<author><name sortKey="Malik Peiris, J S" sort="Malik Peiris, J S" uniqKey="Malik Peiris J" first="J. S." last="Malik Peiris">J. S. Malik Peiris</name>
</author>
<author><name sortKey="Phil, D" sort="Phil, D" uniqKey="Phil D" first="D." last="Phil">D. Phil</name>
</author>
<author><name sortKey="Cowling, Benjamin J" sort="Cowling, Benjamin J" uniqKey="Cowling B" first="Benjamin J." last="Cowling">Benjamin J. Cowling</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">12-0369112</idno>
<date when="2012">2012</date>
<idno type="stanalyst">PASCAL 12-0369112 INIST</idno>
<idno type="RBID">Pascal:12-0369112</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000527</idno>
<idno type="wicri:Area/PascalFrancis/Curation">001911</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Humoral Antibody Response After Receipt of Inactivated Seasonal Influenza Vaccinations One Year Apart in Children</title>
<author><name sortKey="Ng, Sophia" sort="Ng, Sophia" uniqKey="Ng S" first="Sophia" last="Ng">Sophia Ng</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>School of Public Health</s1>
<s3>HKG</s3>
</inist:fA14>
<country>Hong Kong</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Pediatrics and Adolescent Medicine</s1>
<s3>HKG</s3>
</inist:fA14>
<country>Hong Kong</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Centre for Influenza Research, Li Ka Shing Faculty of Medicine, the University of Hong Kong,</s1>
<s2>Hong Kong</s2>
<s3>HKG</s3>
</inist:fA14>
<country>Hong Kong</country>
</affiliation>
</author>
<author><name sortKey="Fang, Vicky J" sort="Fang, Vicky J" uniqKey="Fang V" first="Vicky J." last="Fang">Vicky J. Fang</name>
</author>
<author><name sortKey="Ip, Dennis K M" sort="Ip, Dennis K M" uniqKey="Ip D" first="Dennis K. M." last="Ip">Dennis K. M. Ip</name>
</author>
<author><name sortKey="Chiu, Susan S" sort="Chiu, Susan S" uniqKey="Chiu S" first="Susan S." last="Chiu">Susan S. Chiu</name>
</author>
<author><name sortKey="Leung, Gabriel M" sort="Leung, Gabriel M" uniqKey="Leung G" first="Gabriel M." last="Leung">Gabriel M. Leung</name>
</author>
<author><name sortKey="Malik Peiris, J S" sort="Malik Peiris, J S" uniqKey="Malik Peiris J" first="J. S." last="Malik Peiris">J. S. Malik Peiris</name>
</author>
<author><name sortKey="Phil, D" sort="Phil, D" uniqKey="Phil D" first="D." last="Phil">D. Phil</name>
</author>
<author><name sortKey="Cowling, Benjamin J" sort="Cowling, Benjamin J" uniqKey="Cowling B" first="Benjamin J." last="Cowling">Benjamin J. Cowling</name>
</author>
</analytic>
<series><title level="j" type="main">The Pediatric infectious disease journal</title>
<title level="j" type="abbreviated">Pediatr. infect. dis. j.</title>
<idno type="ISSN">0891-3668</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">The Pediatric infectious disease journal</title>
<title level="j" type="abbreviated">Pediatr. infect. dis. j.</title>
<idno type="ISSN">0891-3668</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antibody</term>
<term>Child</term>
<term>Humoral immunity</term>
<term>Immunoprophylaxis</term>
<term>Influenza</term>
<term>Pediatrics</term>
<term>Seasonal variation</term>
<term>Vaccination</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Grippe</term>
<term>Immunoprophylaxie</term>
<term>Immunité humorale</term>
<term>Anticorps</term>
<term>Variation saisonnière</term>
<term>Enfant</term>
<term>Vaccination</term>
<term>Pédiatrie</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Enfant</term>
<term>Vaccination</term>
<term>Pédiatrie</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Background: Annual vaccination against seasonal influenza viruses is recommended for school-age children in some countries. There are limited data on the immunogenicity and efficacy of repeated influenza vaccinations. Methods: In a randomized controlled trial, we administered seasonal trivalent inactivated influenza vaccine (TIV) or placebo to 64 children 6-15 years of age in two consecutive years and explored their humoral antibody responses. Results: Receipt of TIV in the first year was associated with lower antibody titer rises in the second year to seasonal influenza A(H1N1) and A(H3N2) strains for which the vaccine strains remained unchanged. Antibody response to a different influenza B strain in the second year was unaffected by receipt ofTIV in the first year. Children who received TIV in both years showed higher antibody titers against pandemic A(H IN 1) which was not included in either TIV. Conclusions: Results from our study suggest that humoral antibody response to TIV may be lower in children receiving repeated vaccination, but receipt of TIV induced seroprotection in most subjects. Our study was underpowered to explore whether differences in immunogenicity translated to differences in vaccine efficacy.</div>
</front>
</TEI>
<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0891-3668</s0>
</fA01>
<fA02 i1="01"><s0>PIDJEV</s0>
</fA02>
<fA03 i2="1"><s0>Pediatr. infect. dis. j.</s0>
</fA03>
<fA05><s2>31</s2>
</fA05>
<fA06><s2>9</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>Humoral Antibody Response After Receipt of Inactivated Seasonal Influenza Vaccinations One Year Apart in Children</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>NG (Sophia)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>FANG (Vicky J.)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>IP (Dennis K. M.)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>CHIU (Susan S.)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>LEUNG (Gabriel M.)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>MALIK PEIRIS (J. S.)</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>PHIL (D.)</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>COWLING (Benjamin J.)</s1>
</fA11>
<fA14 i1="01"><s1>School of Public Health</s1>
<s3>HKG</s3>
</fA14>
<fA14 i1="02"><s1>Department of Pediatrics and Adolescent Medicine</s1>
<s3>HKG</s3>
</fA14>
<fA14 i1="03"><s1>Centre for Influenza Research, Li Ka Shing Faculty of Medicine, the University of Hong Kong,</s1>
<s2>Hong Kong</s2>
<s3>HKG</s3>
</fA14>
<fA20><s1>964-969</s1>
</fA20>
<fA21><s1>2012</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>20356</s2>
<s5>354000504481590170</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2012 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>13 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>12-0369112</s0>
</fA47>
<fA60><s1>P</s1>
<s3>C</s3>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>The Pediatric infectious disease journal</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Background: Annual vaccination against seasonal influenza viruses is recommended for school-age children in some countries. There are limited data on the immunogenicity and efficacy of repeated influenza vaccinations. Methods: In a randomized controlled trial, we administered seasonal trivalent inactivated influenza vaccine (TIV) or placebo to 64 children 6-15 years of age in two consecutive years and explored their humoral antibody responses. Results: Receipt of TIV in the first year was associated with lower antibody titer rises in the second year to seasonal influenza A(H1N1) and A(H3N2) strains for which the vaccine strains remained unchanged. Antibody response to a different influenza B strain in the second year was unaffected by receipt ofTIV in the first year. Children who received TIV in both years showed higher antibody titers against pandemic A(H IN 1) which was not included in either TIV. Conclusions: Results from our study suggest that humoral antibody response to TIV may be lower in children receiving repeated vaccination, but receipt of TIV induced seroprotection in most subjects. Our study was underpowered to explore whether differences in immunogenicity translated to differences in vaccine efficacy.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B05C02C</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Grippe</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Influenza</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Gripe</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Immunoprophylaxie</s0>
<s5>04</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Immunoprophylaxis</s0>
<s5>04</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Inmunoprofilaxia</s0>
<s5>04</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Immunité humorale</s0>
<s5>07</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Humoral immunity</s0>
<s5>07</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Inmunidad humoral</s0>
<s5>07</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Anticorps</s0>
<s5>08</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Antibody</s0>
<s5>08</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Anticuerpo</s0>
<s5>08</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Variation saisonnière</s0>
<s5>09</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Seasonal variation</s0>
<s5>09</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Variación estacional</s0>
<s5>09</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Enfant</s0>
<s5>10</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Child</s0>
<s5>10</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Niño</s0>
<s5>10</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Vaccination</s0>
<s5>13</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Vaccination</s0>
<s5>13</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Vacunación</s0>
<s5>13</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Pédiatrie</s0>
<s5>15</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Pediatrics</s0>
<s5>15</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Pediatría</s0>
<s5>15</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Virose</s0>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Viral disease</s0>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Virosis</s0>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Infection</s0>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Infection</s0>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Infección</s0>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Homme</s0>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Human</s0>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Hombre</s0>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Epidémiologie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Epidemiology</s0>
<s5>37</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Epidemiología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Prévention</s0>
<s5>38</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Prevention</s0>
<s5>38</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Prevención</s0>
<s5>38</s5>
</fC07>
<fN21><s1>289</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/PandemieGrippaleV1/Data/PascalFrancis/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001911 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PascalFrancis/Curation/biblio.hfd -nk 001911 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= PandemieGrippaleV1 |flux= PascalFrancis |étape= Curation |type= RBID |clé= Pascal:12-0369112 |texte= Humoral Antibody Response After Receipt of Inactivated Seasonal Influenza Vaccinations One Year Apart in Children }}
![]() | This area was generated with Dilib version V0.6.34. | ![]() |