Long-term Outcomes of Pandemic 2009 Influenza A(H1N1)-Associated Severe ARDS
Identifieur interne : 000526 ( PascalFrancis/Corpus ); précédent : 000525; suivant : 000527Long-term Outcomes of Pandemic 2009 Influenza A(H1N1)-Associated Severe ARDS
Auteurs : Charles-Edauard Luyt ; Alain Combes ; Marie-Hélène Becquemin ; Catherine Beigelman-Aubry ; Stéphane Hatem ; Anne-Laure Brun ; Nizar Zraik ; Fabrice Carrat ; Philippe A. Grenier ; Jean-Chilstophe M. Richard ; Alain Mercat ; Laurent Brochard ; Christian Brun-Buisson ; Jean ChastreSource :
- Chest : (American College of Chest Physicians) [ 0012-3692 ] ; 2012.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Background: No data on long-term outcomes of survivors of 2009 influenza A(H1N1) (A[H1N1])-associated ARDS are available. The objective of this study was to compare the 1-year outcomes of survivors of A(H1N1)-associated ARDS, according to use or no use of extracorporeal lung assist (ECLA), using its need as an ARDS severity surrogate. Methods: Survivors of ARDS (12 with ECLA use vs 25 without, corresponding to 75% and 54% of the eligible patients for each group, respectively) selected from the Réseau Européen de Ventilation Artificielle (REVA) registry had previously been healthy, with only pregnancy and/or moderate obesity (BMI ≤ 35 kg/m2) as known risk factors for A(H1N1) infection. Lung function and morphology, health-related quality of life (HRQoL), and psychologic impairment were evaluated. Results: At 1 year post-ICU discharge for the ECLA and no-ECLA groups, respectively, 50% and 40% reported significant exertion dyspnea, 83% and 64% had returned to work, and 75% and 64% had decreased diffusion capacity across the blood-gas barrier, despite their near-normal and similar lung function test results. For both groups, exercise test results showed diminished but comparable exercise capacities, with similar alveolar-arterial oxygen gradients at peak exercise, and CT scans showed minor abnormal findings. HRQoL assessed by the 36-Item Short-Form Health Survey was poorer for both groups than for a sex- and age-matched general population group, but without between-group differences. ECLA and no-ECLA group patients, respectively, had symptoms of anxiety (50% and 56%) and depression (28% and 28%) and were at risk for post-traumatic stress disorder (41% and 44%). Conclusions: One year post-ICU discharge, a majority of survivors of A(H1N1)-associated ARDS had minor lung disabilities with diminished diffusion capacities across the blood-gas barrier, and most had psychologic impairment and poorer HRQoL than a sex- and age-matched general population group. ECLA and no-ECLA group patients had comparable outcomes.
Notice en format standard (ISO 2709)
Pour connaître la documentation sur le format Inist Standard.
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Format Inist (serveur)
NO : | PASCAL 12-0371302 INIST |
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ET : | Long-term Outcomes of Pandemic 2009 Influenza A(H1N1)-Associated Severe ARDS |
AU : | LUYT (Charles-Edauard); COMBES (Alain); BECQUEMIN (Marie-Hélène); BEIGELMAN-AUBRY (Catherine); HATEM (Stéphane); BRUN (Anne-Laure); ZRAIK (Nizar); CARRAT (Fabrice); GRENIER (Philippe A.); RICHARD (Jean-Chilstophe M.); MERCAT (Alain); BROCHARD (Laurent); BRUN-BUISSON (Christian); CHASTRE (Jean) |
AF : | Service de Reanimation Médicale, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique- Hôpitaux de Paris et Université Paris 6-Pierre-et-Marie-Curie/Paris/France (1 aut., 2 aut., 14 aut.); Service d'Explorations Fonctionnelles, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique- Hôpitaux de Paris et Université Paris 6-Pierre-et-Marie-Curie/Paris/France (3 aut., 7 aut.); Service de Radiologie, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique- Hôpitaux de Paris et Université Paris 6-Pierre-et-Marie-Curie/Paris/France (4 aut., 6 aut., 9 aut.); Service d'explorations fonctionnelles cardio-vasculaires, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique- Hôpitaux de Paris et Université Paris 6-Pierre-et-Marie-Curie/Paris/France (5 aut.); Service de Santé Publique, Hôpital Saint-Antoine Assistance Publique-Hôpitaux de Paris, Unité Mixte de Recherche-S 707, Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris 6-Pierre-et-Marie-Curie/Paris/France (8 aut.); Service de Réanimation Médicale Centre Hospitalier Universitaire de Rouen/Rouen/France (10 aut.); Service de Réanimation Médicale Centre Hospitalier Universitaire d'Angers/Angers/France (11 aut.); Intensive Care Unit Hôpitaux Universitaires de Genève/Genève/Suisse (12 aut.); Service de Réanimation Médicale Hôpital Henri-Mondor, Assistance Publique-Hôpitaux de Paris, Université Paris 12/Créteil/France (13 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Chest : (American College of Chest Physicians); ISSN 0012-3692; Coden CHETBF; Etats-Unis; Da. 2012; Vol. 142; No. 3; Pp. 583-592; Bibl. 35 ref. |
LA : | Anglais |
EA : | Background: No data on long-term outcomes of survivors of 2009 influenza A(H1N1) (A[H1N1])-associated ARDS are available. The objective of this study was to compare the 1-year outcomes of survivors of A(H1N1)-associated ARDS, according to use or no use of extracorporeal lung assist (ECLA), using its need as an ARDS severity surrogate. Methods: Survivors of ARDS (12 with ECLA use vs 25 without, corresponding to 75% and 54% of the eligible patients for each group, respectively) selected from the Réseau Européen de Ventilation Artificielle (REVA) registry had previously been healthy, with only pregnancy and/or moderate obesity (BMI ≤ 35 kg/m2) as known risk factors for A(H1N1) infection. Lung function and morphology, health-related quality of life (HRQoL), and psychologic impairment were evaluated. Results: At 1 year post-ICU discharge for the ECLA and no-ECLA groups, respectively, 50% and 40% reported significant exertion dyspnea, 83% and 64% had returned to work, and 75% and 64% had decreased diffusion capacity across the blood-gas barrier, despite their near-normal and similar lung function test results. For both groups, exercise test results showed diminished but comparable exercise capacities, with similar alveolar-arterial oxygen gradients at peak exercise, and CT scans showed minor abnormal findings. HRQoL assessed by the 36-Item Short-Form Health Survey was poorer for both groups than for a sex- and age-matched general population group, but without between-group differences. ECLA and no-ECLA group patients, respectively, had symptoms of anxiety (50% and 56%) and depression (28% and 28%) and were at risk for post-traumatic stress disorder (41% and 44%). Conclusions: One year post-ICU discharge, a majority of survivors of A(H1N1)-associated ARDS had minor lung disabilities with diminished diffusion capacities across the blood-gas barrier, and most had psychologic impairment and poorer HRQoL than a sex- and age-matched general population group. ECLA and no-ECLA group patients had comparable outcomes. |
CC : | 002B11; 002B12; 002B05C02C |
FD : | Long terme; Pronostic; Grave; Anesthésie; Appareil circulatoire; Cardiologie; Forme grave; Grippe H1N1; Virus grippal A(H1N1) |
FG : | Pathologie de l'appareil respiratoire; Virose; Infection |
ED : | Long term; Prognosis; Severe; Anesthesia; Circulatory system; Cardiology; H1N1 influenza; Influenza A (H1N1) |
EG : | Respiratory disease; Viral disease; Infection |
SD : | Largo plazo; Pronóstico; Grave; Anestesia; Aparato circulatorio; Cardiología; Gripe H1N1 |
LO : | INIST-7627.354000509501540100 |
ID : | 12-0371302 |
Links to Exploration step
Pascal:12-0371302Le document en format XML
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anesthesia</term>
<term>Cardiology</term>
<term>Circulatory system</term>
<term>H1N1 influenza</term>
<term>Influenza A (H1N1)</term>
<term>Long term</term>
<term>Prognosis</term>
<term>Severe</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Long terme</term>
<term>Pronostic</term>
<term>Grave</term>
<term>Anesthésie</term>
<term>Appareil circulatoire</term>
<term>Cardiologie</term>
<term>Forme grave</term>
<term>Grippe H1N1</term>
<term>Virus grippal A(H1N1)</term>
</keywords>
</textClass>
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</teiHeader>
<front><div type="abstract" xml:lang="en">Background: No data on long-term outcomes of survivors of 2009 influenza A(H1N1) (A[H1N1])-associated ARDS are available. The objective of this study was to compare the 1-year outcomes of survivors of A(H1N1)-associated ARDS, according to use or no use of extracorporeal lung assist (ECLA), using its need as an ARDS severity surrogate. Methods: Survivors of ARDS (12 with ECLA use vs 25 without, corresponding to 75% and 54% of the eligible patients for each group, respectively) selected from the Réseau Européen de Ventilation Artificielle (REVA) registry had previously been healthy, with only pregnancy and/or moderate obesity (BMI ≤ 35 kg/m<sup>2</sup>
) as known risk factors for A(H1N1) infection. Lung function and morphology, health-related quality of life (HRQoL), and psychologic impairment were evaluated. Results: At 1 year post-ICU discharge for the ECLA and no-ECLA groups, respectively, 50% and 40% reported significant exertion dyspnea, 83% and 64% had returned to work, and 75% and 64% had decreased diffusion capacity across the blood-gas barrier, despite their near-normal and similar lung function test results. For both groups, exercise test results showed diminished but comparable exercise capacities, with similar alveolar-arterial oxygen gradients at peak exercise, and CT scans showed minor abnormal findings. HRQoL assessed by the 36-Item Short-Form Health Survey was poorer for both groups than for a sex- and age-matched general population group, but without between-group differences. ECLA and no-ECLA group patients, respectively, had symptoms of anxiety (50% and 56%) and depression (28% and 28%) and were at risk for post-traumatic stress disorder (41% and 44%). Conclusions: One year post-ICU discharge, a majority of survivors of A(H1N1)-associated ARDS had minor lung disabilities with diminished diffusion capacities across the blood-gas barrier, and most had psychologic impairment and poorer HRQoL than a sex- and age-matched general population group. ECLA and no-ECLA group patients had comparable outcomes.</div>
</front>
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<fA08 i1="01" i2="1" l="ENG"><s1>Long-term Outcomes of Pandemic 2009 Influenza A(H1N1)-Associated Severe ARDS</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>LUYT (Charles-Edauard)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>COMBES (Alain)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>BECQUEMIN (Marie-Hélène)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>BEIGELMAN-AUBRY (Catherine)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>HATEM (Stéphane)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>BRUN (Anne-Laure)</s1>
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<fA11 i1="07" i2="1"><s1>ZRAIK (Nizar)</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>CARRAT (Fabrice)</s1>
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<fA11 i1="09" i2="1"><s1>GRENIER (Philippe A.)</s1>
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<fA11 i1="10" i2="1"><s1>RICHARD (Jean-Chilstophe M.)</s1>
</fA11>
<fA11 i1="11" i2="1"><s1>MERCAT (Alain)</s1>
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<fA11 i1="12" i2="1"><s1>BROCHARD (Laurent)</s1>
</fA11>
<fA11 i1="13" i2="1"><s1>BRUN-BUISSON (Christian)</s1>
</fA11>
<fA11 i1="14" i2="1"><s1>CHASTRE (Jean)</s1>
</fA11>
<fA14 i1="01"><s1>Service de Reanimation Médicale, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique- Hôpitaux de Paris et Université Paris 6-Pierre-et-Marie-Curie</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>14 aut.</sZ>
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<fA14 i1="02"><s1>Service d'Explorations Fonctionnelles, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique- Hôpitaux de Paris et Université Paris 6-Pierre-et-Marie-Curie</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Service de Radiologie, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique- Hôpitaux de Paris et Université Paris 6-Pierre-et-Marie-Curie</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Service d'explorations fonctionnelles cardio-vasculaires, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique- Hôpitaux de Paris et Université Paris 6-Pierre-et-Marie-Curie</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Service de Santé Publique, Hôpital Saint-Antoine Assistance Publique-Hôpitaux de Paris, Unité Mixte de Recherche-S 707, Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris 6-Pierre-et-Marie-Curie</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>8 aut.</sZ>
</fA14>
<fA14 i1="06"><s1>Service de Réanimation Médicale Centre Hospitalier Universitaire de Rouen</s1>
<s2>Rouen</s2>
<s3>FRA</s3>
<sZ>10 aut.</sZ>
</fA14>
<fA14 i1="07"><s1>Service de Réanimation Médicale Centre Hospitalier Universitaire d'Angers</s1>
<s2>Angers</s2>
<s3>FRA</s3>
<sZ>11 aut.</sZ>
</fA14>
<fA14 i1="08"><s1>Intensive Care Unit Hôpitaux Universitaires de Genève</s1>
<s2>Genève</s2>
<s3>CHE</s3>
<sZ>12 aut.</sZ>
</fA14>
<fA14 i1="09"><s1>Service de Réanimation Médicale Hôpital Henri-Mondor, Assistance Publique-Hôpitaux de Paris, Université Paris 12</s1>
<s2>Créteil</s2>
<s3>FRA</s3>
<sZ>13 aut.</sZ>
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<fA20><s1>583-592</s1>
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</fA66>
<fC01 i1="01" l="ENG"><s0>Background: No data on long-term outcomes of survivors of 2009 influenza A(H1N1) (A[H1N1])-associated ARDS are available. The objective of this study was to compare the 1-year outcomes of survivors of A(H1N1)-associated ARDS, according to use or no use of extracorporeal lung assist (ECLA), using its need as an ARDS severity surrogate. Methods: Survivors of ARDS (12 with ECLA use vs 25 without, corresponding to 75% and 54% of the eligible patients for each group, respectively) selected from the Réseau Européen de Ventilation Artificielle (REVA) registry had previously been healthy, with only pregnancy and/or moderate obesity (BMI ≤ 35 kg/m<sup>2</sup>
) as known risk factors for A(H1N1) infection. Lung function and morphology, health-related quality of life (HRQoL), and psychologic impairment were evaluated. Results: At 1 year post-ICU discharge for the ECLA and no-ECLA groups, respectively, 50% and 40% reported significant exertion dyspnea, 83% and 64% had returned to work, and 75% and 64% had decreased diffusion capacity across the blood-gas barrier, despite their near-normal and similar lung function test results. For both groups, exercise test results showed diminished but comparable exercise capacities, with similar alveolar-arterial oxygen gradients at peak exercise, and CT scans showed minor abnormal findings. HRQoL assessed by the 36-Item Short-Form Health Survey was poorer for both groups than for a sex- and age-matched general population group, but without between-group differences. ECLA and no-ECLA group patients, respectively, had symptoms of anxiety (50% and 56%) and depression (28% and 28%) and were at risk for post-traumatic stress disorder (41% and 44%). Conclusions: One year post-ICU discharge, a majority of survivors of A(H1N1)-associated ARDS had minor lung disabilities with diminished diffusion capacities across the blood-gas barrier, and most had psychologic impairment and poorer HRQoL than a sex- and age-matched general population group. ECLA and no-ECLA group patients had comparable outcomes.</s0>
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<s5>12</s5>
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<s5>12</s5>
</fC03>
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<s5>13</s5>
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<s5>14</s5>
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<s5>14</s5>
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<s5>86</s5>
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<s4>CD</s4>
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</fC03>
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<s4>CD</s4>
<s5>96</s5>
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<s5>38</s5>
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<s5>38</s5>
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<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Infection</s0>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Infection</s0>
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</fN21>
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<server><NO>PASCAL 12-0371302 INIST</NO>
<ET>Long-term Outcomes of Pandemic 2009 Influenza A(H1N1)-Associated Severe ARDS</ET>
<AU>LUYT (Charles-Edauard); COMBES (Alain); BECQUEMIN (Marie-Hélène); BEIGELMAN-AUBRY (Catherine); HATEM (Stéphane); BRUN (Anne-Laure); ZRAIK (Nizar); CARRAT (Fabrice); GRENIER (Philippe A.); RICHARD (Jean-Chilstophe M.); MERCAT (Alain); BROCHARD (Laurent); BRUN-BUISSON (Christian); CHASTRE (Jean)</AU>
<AF>Service de Reanimation Médicale, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique- Hôpitaux de Paris et Université Paris 6-Pierre-et-Marie-Curie/Paris/France (1 aut., 2 aut., 14 aut.); Service d'Explorations Fonctionnelles, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique- Hôpitaux de Paris et Université Paris 6-Pierre-et-Marie-Curie/Paris/France (3 aut., 7 aut.); Service de Radiologie, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique- Hôpitaux de Paris et Université Paris 6-Pierre-et-Marie-Curie/Paris/France (4 aut., 6 aut., 9 aut.); Service d'explorations fonctionnelles cardio-vasculaires, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique- Hôpitaux de Paris et Université Paris 6-Pierre-et-Marie-Curie/Paris/France (5 aut.); Service de Santé Publique, Hôpital Saint-Antoine Assistance Publique-Hôpitaux de Paris, Unité Mixte de Recherche-S 707, Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris 6-Pierre-et-Marie-Curie/Paris/France (8 aut.); Service de Réanimation Médicale Centre Hospitalier Universitaire de Rouen/Rouen/France (10 aut.); Service de Réanimation Médicale Centre Hospitalier Universitaire d'Angers/Angers/France (11 aut.); Intensive Care Unit Hôpitaux Universitaires de Genève/Genève/Suisse (12 aut.); Service de Réanimation Médicale Hôpital Henri-Mondor, Assistance Publique-Hôpitaux de Paris, Université Paris 12/Créteil/France (13 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Chest : (American College of Chest Physicians); ISSN 0012-3692; Coden CHETBF; Etats-Unis; Da. 2012; Vol. 142; No. 3; Pp. 583-592; Bibl. 35 ref.</SO>
<LA>Anglais</LA>
<EA>Background: No data on long-term outcomes of survivors of 2009 influenza A(H1N1) (A[H1N1])-associated ARDS are available. The objective of this study was to compare the 1-year outcomes of survivors of A(H1N1)-associated ARDS, according to use or no use of extracorporeal lung assist (ECLA), using its need as an ARDS severity surrogate. Methods: Survivors of ARDS (12 with ECLA use vs 25 without, corresponding to 75% and 54% of the eligible patients for each group, respectively) selected from the Réseau Européen de Ventilation Artificielle (REVA) registry had previously been healthy, with only pregnancy and/or moderate obesity (BMI ≤ 35 kg/m<sup>2</sup>
) as known risk factors for A(H1N1) infection. Lung function and morphology, health-related quality of life (HRQoL), and psychologic impairment were evaluated. Results: At 1 year post-ICU discharge for the ECLA and no-ECLA groups, respectively, 50% and 40% reported significant exertion dyspnea, 83% and 64% had returned to work, and 75% and 64% had decreased diffusion capacity across the blood-gas barrier, despite their near-normal and similar lung function test results. For both groups, exercise test results showed diminished but comparable exercise capacities, with similar alveolar-arterial oxygen gradients at peak exercise, and CT scans showed minor abnormal findings. HRQoL assessed by the 36-Item Short-Form Health Survey was poorer for both groups than for a sex- and age-matched general population group, but without between-group differences. ECLA and no-ECLA group patients, respectively, had symptoms of anxiety (50% and 56%) and depression (28% and 28%) and were at risk for post-traumatic stress disorder (41% and 44%). Conclusions: One year post-ICU discharge, a majority of survivors of A(H1N1)-associated ARDS had minor lung disabilities with diminished diffusion capacities across the blood-gas barrier, and most had psychologic impairment and poorer HRQoL than a sex- and age-matched general population group. ECLA and no-ECLA group patients had comparable outcomes.</EA>
<CC>002B11; 002B12; 002B05C02C</CC>
<FD>Long terme; Pronostic; Grave; Anesthésie; Appareil circulatoire; Cardiologie; Forme grave; Grippe H1N1; Virus grippal A(H1N1)</FD>
<FG>Pathologie de l'appareil respiratoire; Virose; Infection</FG>
<ED>Long term; Prognosis; Severe; Anesthesia; Circulatory system; Cardiology; H1N1 influenza; Influenza A (H1N1)</ED>
<EG>Respiratory disease; Viral disease; Infection</EG>
<SD>Largo plazo; Pronóstico; Grave; Anestesia; Aparato circulatorio; Cardiología; Gripe H1N1</SD>
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