Liver involvement during influenza infection: perspective on the 2009 influenza pandemic
Identifieur interne : 001183 ( Ncbi/Merge ); précédent : 001182; suivant : 001184Liver involvement during influenza infection: perspective on the 2009 influenza pandemic
Auteurs : Neven Papic ; Ana Pangercic ; Martina Vargovic ; Bruno Barsic ; Adriana Vince ; Ilija KuzmanSource :
- Influenza and Other Respiratory Viruses [ 1750-2640 ] ; 2011.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Alanine transaminase (sang), Aspartate aminotransferases (sang), Croatie (épidémiologie), Enfant, Femelle, Foie (enzymologie), Foie (traumatismes), Grippe humaine (), Grippe humaine (enzymologie), Grippe humaine (virologie), Humains, Jeune adulte, L-Lactate dehydrogenase (sang), Maladies du foie (enzymologie), Maladies du foie (étiologie), Mâle, Pandémies, Protéine C-réactive (métabolisme), Sous-type H1N1 du virus de la grippe A (génétique), Sous-type H1N1 du virus de la grippe A (isolement et purification), gamma-Glutamyltransferase (sang), Études rétrospectives.
- MESH :
- enzymologie : Foie, Grippe humaine, Maladies du foie.
- génétique : Sous-type H1N1 du virus de la grippe A.
- isolement et purification : Sous-type H1N1 du virus de la grippe A.
- métabolisme : Protéine C-réactive.
- sang : Alanine transaminase, Aspartate aminotransferases, L-Lactate dehydrogenase, gamma-Glutamyltransferase.
- traumatismes : Foie.
- virologie : Grippe humaine.
- épidémiologie : Croatie.
- étiologie : Maladies du foie.
- Adolescent, Adulte, Adulte d'âge moyen, Enfant, Femelle, Grippe humaine, Humains, Jeune adulte, Mâle, Pandémies, Études rétrospectives.
- Wicri :
- geographic : Croatie.
English descriptors
- KwdEn :
- Adolescent, Adult, Alanine Transaminase (blood), Aspartate Aminotransferases (blood), C-Reactive Protein (metabolism), Child, Croatia (epidemiology), Female, Humans, Influenza A Virus, H1N1 Subtype (genetics), Influenza A Virus, H1N1 Subtype (isolation & purification), Influenza, Human (complications), Influenza, Human (enzymology), Influenza, Human (virology), L-Lactate Dehydrogenase (blood), Liver (enzymology), Liver (injuries), Liver Diseases (enzymology), Liver Diseases (etiology), Male, Middle Aged, Pandemics, Retrospective Studies, Young Adult, gamma-Glutamyltransferase (blood).
- MESH :
- chemical , blood : Alanine Transaminase, Aspartate Aminotransferases, L-Lactate Dehydrogenase, gamma-Glutamyltransferase.
- chemical , metabolism : C-Reactive Protein.
- geographic , epidemiology : Croatia.
- complications : Influenza, Human.
- enzymology : Influenza, Human, Liver, Liver Diseases.
- etiology : Liver Diseases.
- genetics : Influenza A Virus, H1N1 Subtype.
- injuries : Liver.
- isolation & purification : Influenza A Virus, H1N1 Subtype.
- virology : Influenza, Human.
- Adolescent, Adult, Child, Female, Humans, Male, Middle Aged, Pandemics, Retrospective Studies, Young Adult.
Abstract
Elevation of liver transaminase levels is a frequent observation during systemic infections. The aim of our study was to investigate liver damage during pandemic 2009 influenza A/H1N1 infection in comparison with seasonal influenza. Serum levels of aspartate aminotransferase, alanine aminotransferase, and gamma‐glutamyl transpeptidase (GGT) were significantly higher in patients with pandemic influenza compared to seasonal influenza, which was strongly correlated with hypoxia. Moreover, a positive correlation between C‐reactive protein and serum GGT, alkaline phosphatase, and lactate dehydrogenase was noticed. Our findings support the hypothesis that the pandemic 2009 influenza A/H1N1 is an illness with a significant immune response to infection leading to hepatocellular injury.
Url:
DOI: 10.1111/j.1750-2659.2011.00287.x
PubMed: 21951624
PubMed Central: 4941665
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PMC:4941665Le document en format XML
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Human</term><term>Liver</term><term>Liver Diseases</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Liver Diseases</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="injuries" xml:lang="en"><term>Liver</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Protéine C-réactive</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Alanine transaminase</term><term>Aspartate aminotransferases</term><term>L-Lactate dehydrogenase</term><term>gamma-Glutamyltransferase</term></keywords><keywords scheme="MESH" qualifier="traumatismes" xml:lang="fr"><term>Foie</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Croatie</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Maladies du foie</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Child</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Pandemics</term><term>Retrospective Studies</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Enfant</term><term>Femelle</term><term>Grippe humaine</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Pandémies</term><term>Études rétrospectives</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Croatie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><italic>Please cite this paper as:</italic> Papic <italic>et al.</italic> (2011) Liver involvement during influenza infection: perspective on the 2009 influenza pandemic. Influenza and Other Respiratory Viruses 6(3), e2–e5.</p><p>Elevation of liver transaminase levels is a frequent observation during systemic infections. The aim of our study was to investigate liver damage during pandemic 2009 influenza A/H1N1 infection in comparison with seasonal influenza. Serum levels of aspartate aminotransferase, alanine aminotransferase, and gamma‐glutamyl transpeptidase (GGT) were significantly higher in patients with pandemic influenza compared to seasonal influenza, which was strongly correlated with hypoxia. Moreover, a positive correlation between C‐reactive protein and serum GGT, alkaline phosphatase, and lactate dehydrogenase was noticed. Our findings support the hypothesis that the pandemic 2009 influenza A/H1N1 is an illness with a significant immune response to infection leading to hepatocellular injury.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><double pmid="21951624"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Liver involvement during influenza infection: perspective on the 2009 influenza pandemic</title><author><name sortKey="Papic, Neven" sort="Papic, Neven" uniqKey="Papic N" first="Neven" last="Papic">Neven Papic</name><affiliation><nlm:aff id="a1"></nlm:aff></affiliation></author><author><name sortKey="Pangercic, Ana" sort="Pangercic, Ana" uniqKey="Pangercic A" first="Ana" last="Pangercic">Ana Pangercic</name><affiliation><nlm:aff id="a2"></nlm:aff></affiliation></author><author><name sortKey="Vargovic, Martina" sort="Vargovic, Martina" uniqKey="Vargovic M" first="Martina" last="Vargovic">Martina Vargovic</name><affiliation><nlm:aff id="a3"></nlm:aff></affiliation></author><author><name sortKey="Barsic, Bruno" sort="Barsic, Bruno" uniqKey="Barsic B" first="Bruno" last="Barsic">Bruno Barsic</name><affiliation><nlm:aff id="a2"></nlm:aff></affiliation></author><author><name sortKey="Vince, Adriana" sort="Vince, Adriana" uniqKey="Vince A" first="Adriana" last="Vince">Adriana Vince</name><affiliation><nlm:aff id="a1"></nlm:aff></affiliation></author><author><name sortKey="Kuzman, Ilija" sort="Kuzman, Ilija" uniqKey="Kuzman I" first="Ilija" last="Kuzman">Ilija Kuzman</name><affiliation><nlm:aff id="a4"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21951624</idno><idno type="pmc">4941665</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941665</idno><idno type="RBID">PMC:4941665</idno><idno type="doi">10.1111/j.1750-2659.2011.00287.x</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">000058</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000058</idno><idno type="wicri:Area/Pmc/Curation">000058</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000058</idno><idno type="wicri:Area/Pmc/Checkpoint">000859</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000859</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Liver involvement during influenza infection: perspective on the 2009 influenza pandemic</title><author><name sortKey="Papic, Neven" sort="Papic, Neven" uniqKey="Papic N" first="Neven" last="Papic">Neven Papic</name><affiliation><nlm:aff id="a1"></nlm:aff></affiliation></author><author><name sortKey="Pangercic, Ana" sort="Pangercic, Ana" uniqKey="Pangercic A" first="Ana" last="Pangercic">Ana Pangercic</name><affiliation><nlm:aff id="a2"></nlm:aff></affiliation></author><author><name sortKey="Vargovic, Martina" sort="Vargovic, Martina" uniqKey="Vargovic M" first="Martina" last="Vargovic">Martina Vargovic</name><affiliation><nlm:aff id="a3"></nlm:aff></affiliation></author><author><name sortKey="Barsic, Bruno" sort="Barsic, Bruno" uniqKey="Barsic B" first="Bruno" last="Barsic">Bruno Barsic</name><affiliation><nlm:aff id="a2"></nlm:aff></affiliation></author><author><name sortKey="Vince, Adriana" sort="Vince, Adriana" uniqKey="Vince A" first="Adriana" last="Vince">Adriana Vince</name><affiliation><nlm:aff id="a1"></nlm:aff></affiliation></author><author><name sortKey="Kuzman, Ilija" sort="Kuzman, Ilija" uniqKey="Kuzman I" first="Ilija" last="Kuzman">Ilija Kuzman</name><affiliation><nlm:aff id="a4"></nlm:aff></affiliation></author></analytic><series><title level="j">Influenza and Other Respiratory Viruses</title><idno type="ISSN">1750-2640</idno><idno type="eISSN">1750-2659</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><italic>Please cite this paper as:</italic> Papic <italic>et al.</italic> (2011) Liver involvement during influenza infection: perspective on the 2009 influenza pandemic. Influenza and Other Respiratory Viruses 6(3), e2–e5.</p><p>Elevation of liver transaminase levels is a frequent observation during systemic infections. The aim of our study was to investigate liver damage during pandemic 2009 influenza A/H1N1 infection in comparison with seasonal influenza. Serum levels of aspartate aminotransferase, alanine aminotransferase, and gamma‐glutamyl transpeptidase (GGT) were significantly higher in patients with pandemic influenza compared to seasonal influenza, which was strongly correlated with hypoxia. Moreover, a positive correlation between C‐reactive protein and serum GGT, alkaline phosphatase, and lactate dehydrogenase was noticed. Our findings support the hypothesis that the pandemic 2009 influenza A/H1N1 is an illness with a significant immune response to infection leading to hepatocellular injury.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI></pmc><pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Liver involvement during influenza infection: perspective on the 2009 influenza pandemic.</title><author><name sortKey="Papic, Neven" sort="Papic, Neven" uniqKey="Papic N" first="Neven" last="Papic">Neven Papic</name><affiliation wicri:level="1"><nlm:affiliation>Department of Viral Hepatitis, University Hospital for Infectious Diseases, Zagreb, Croatia. npapic@bfm.hr</nlm:affiliation><country xml:lang="fr">Croatie</country><wicri:regionArea>Department of Viral Hepatitis, University Hospital for Infectious Diseases, Zagreb</wicri:regionArea><wicri:noRegion>Zagreb</wicri:noRegion></affiliation></author><author><name sortKey="Pangercic, Ana" sort="Pangercic, Ana" uniqKey="Pangercic A" first="Ana" last="Pangercic">Ana Pangercic</name></author><author><name sortKey="Vargovic, Martina" sort="Vargovic, Martina" uniqKey="Vargovic M" first="Martina" last="Vargovic">Martina Vargovic</name></author><author><name sortKey="Barsic, Bruno" sort="Barsic, Bruno" uniqKey="Barsic B" first="Bruno" last="Barsic">Bruno Barsic</name></author><author><name sortKey="Vince, Adriana" sort="Vince, Adriana" uniqKey="Vince A" first="Adriana" last="Vince">Adriana Vince</name></author><author><name sortKey="Kuzman, Ilija" sort="Kuzman, Ilija" uniqKey="Kuzman I" first="Ilija" last="Kuzman">Ilija Kuzman</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="RBID">pubmed:21951624</idno><idno type="pmid">21951624</idno><idno type="doi">10.1111/j.1750-2659.2011.00287.x</idno><idno type="wicri:Area/PubMed/Corpus">000E80</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000E80</idno><idno type="wicri:Area/PubMed/Curation">000E80</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000E80</idno><idno type="wicri:Area/PubMed/Checkpoint">000C18</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000C18</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Liver involvement during influenza infection: perspective on the 2009 influenza pandemic.</title><author><name sortKey="Papic, Neven" sort="Papic, Neven" uniqKey="Papic N" first="Neven" last="Papic">Neven Papic</name><affiliation wicri:level="1"><nlm:affiliation>Department of Viral Hepatitis, University Hospital for Infectious Diseases, Zagreb, Croatia. npapic@bfm.hr</nlm:affiliation><country xml:lang="fr">Croatie</country><wicri:regionArea>Department of Viral Hepatitis, University Hospital for Infectious Diseases, Zagreb</wicri:regionArea><wicri:noRegion>Zagreb</wicri:noRegion></affiliation></author><author><name sortKey="Pangercic, Ana" sort="Pangercic, Ana" uniqKey="Pangercic A" first="Ana" last="Pangercic">Ana Pangercic</name></author><author><name sortKey="Vargovic, Martina" sort="Vargovic, Martina" uniqKey="Vargovic M" first="Martina" last="Vargovic">Martina Vargovic</name></author><author><name sortKey="Barsic, Bruno" sort="Barsic, Bruno" uniqKey="Barsic B" first="Bruno" last="Barsic">Bruno Barsic</name></author><author><name sortKey="Vince, Adriana" sort="Vince, Adriana" uniqKey="Vince A" first="Adriana" last="Vince">Adriana Vince</name></author><author><name sortKey="Kuzman, Ilija" sort="Kuzman, Ilija" uniqKey="Kuzman I" first="Ilija" last="Kuzman">Ilija Kuzman</name></author></analytic><series><title level="j">Influenza and other respiratory viruses</title><idno type="eISSN">1750-2659</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Alanine Transaminase (blood)</term><term>Aspartate Aminotransferases (blood)</term><term>C-Reactive Protein (metabolism)</term><term>Child</term><term>Croatia (epidemiology)</term><term>Female</term><term>Humans</term><term>Influenza A Virus, H1N1 Subtype (genetics)</term><term>Influenza A Virus, H1N1 Subtype (isolation & purification)</term><term>Influenza, Human (complications)</term><term>Influenza, Human (enzymology)</term><term>Influenza, Human (virology)</term><term>L-Lactate Dehydrogenase (blood)</term><term>Liver (enzymology)</term><term>Liver (injuries)</term><term>Liver Diseases (enzymology)</term><term>Liver Diseases (etiology)</term><term>Male</term><term>Middle Aged</term><term>Pandemics</term><term>Retrospective Studies</term><term>Young Adult</term><term>gamma-Glutamyltransferase (blood)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Alanine transaminase (sang)</term><term>Aspartate aminotransferases (sang)</term><term>Croatie (épidémiologie)</term><term>Enfant</term><term>Femelle</term><term>Foie (enzymologie)</term><term>Foie (traumatismes)</term><term>Grippe humaine ()</term><term>Grippe humaine (enzymologie)</term><term>Grippe humaine (virologie)</term><term>Humains</term><term>Jeune adulte</term><term>L-Lactate dehydrogenase (sang)</term><term>Maladies du foie (enzymologie)</term><term>Maladies du foie (étiologie)</term><term>Mâle</term><term>Pandémies</term><term>Protéine C-réactive (métabolisme)</term><term>Sous-type H1N1 du virus de la grippe A (génétique)</term><term>Sous-type H1N1 du virus de la grippe A (isolement et purification)</term><term>gamma-Glutamyltransferase (sang)</term><term>Études rétrospectives</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Alanine Transaminase</term><term>Aspartate Aminotransferases</term><term>L-Lactate Dehydrogenase</term><term>gamma-Glutamyltransferase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>C-Reactive Protein</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Croatia</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Foie</term><term>Grippe humaine</term><term>Maladies du foie</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Influenza, Human</term><term>Liver</term><term>Liver Diseases</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Liver Diseases</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="injuries" xml:lang="en"><term>Liver</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Protéine C-réactive</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Alanine transaminase</term><term>Aspartate aminotransferases</term><term>L-Lactate dehydrogenase</term><term>gamma-Glutamyltransferase</term></keywords><keywords scheme="MESH" qualifier="traumatismes" xml:lang="fr"><term>Foie</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Croatie</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Maladies du foie</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Child</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Pandemics</term><term>Retrospective Studies</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Enfant</term><term>Femelle</term><term>Grippe humaine</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Pandémies</term><term>Études rétrospectives</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Croatie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Elevation of liver transaminase levels is a frequent observation during systemic infections. The aim of our study was to investigate liver damage during pandemic 2009 influenza A/H1N1 infection in comparison with seasonal influenza. Serum levels of aspartate aminotransferase, alanine aminotransferase, and gamma-glutamyl transpeptidase (GGT) were significantly higher in patients with pandemic influenza compared to seasonal influenza, which was strongly correlated with hypoxia. Moreover, a positive correlation between C-reactive protein and serum GGT, alkaline phosphatase, and lactate dehydrogenase was noticed. Our findings support the hypothesis that the pandemic 2009 influenza A/H1N1 is an illness with a significant immune response to infection leading to hepatocellular injury.</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
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