Liver involvement during influenza infection: perspective on the 2009 influenza pandemic.
Identifieur interne : 000E80 ( PubMed/Corpus ); précédent : 000E79; suivant : 000E81Liver involvement during influenza infection: perspective on the 2009 influenza pandemic.
Auteurs : Neven Papic ; Ana Pangercic ; Martina Vargovic ; Bruno Barsic ; Adriana Vince ; Ilija KuzmanSource :
- Influenza and other respiratory viruses [ 1750-2659 ] ; 2012.
English descriptors
- KwdEn :
- Adolescent, Adult, Alanine Transaminase (blood), Aspartate Aminotransferases (blood), C-Reactive Protein (metabolism), Child, Croatia (epidemiology), Female, Humans, Influenza A Virus, H1N1 Subtype (genetics), Influenza A Virus, H1N1 Subtype (isolation & purification), Influenza, Human (complications), Influenza, Human (enzymology), Influenza, Human (virology), L-Lactate Dehydrogenase (blood), Liver (enzymology), Liver (injuries), Liver Diseases (enzymology), Liver Diseases (etiology), Male, Middle Aged, Pandemics, Retrospective Studies, Young Adult, gamma-Glutamyltransferase (blood).
- MESH :
- chemical , blood : Alanine Transaminase, Aspartate Aminotransferases, L-Lactate Dehydrogenase, gamma-Glutamyltransferase.
- chemical , metabolism : C-Reactive Protein.
- geographic , epidemiology : Croatia.
- complications : Influenza, Human.
- enzymology : Influenza, Human, Liver, Liver Diseases.
- etiology : Liver Diseases.
- genetics : Influenza A Virus, H1N1 Subtype.
- injuries : Liver.
- isolation & purification : Influenza A Virus, H1N1 Subtype.
- virology : Influenza, Human.
- Adolescent, Adult, Child, Female, Humans, Male, Middle Aged, Pandemics, Retrospective Studies, Young Adult.
Abstract
Elevation of liver transaminase levels is a frequent observation during systemic infections. The aim of our study was to investigate liver damage during pandemic 2009 influenza A/H1N1 infection in comparison with seasonal influenza. Serum levels of aspartate aminotransferase, alanine aminotransferase, and gamma-glutamyl transpeptidase (GGT) were significantly higher in patients with pandemic influenza compared to seasonal influenza, which was strongly correlated with hypoxia. Moreover, a positive correlation between C-reactive protein and serum GGT, alkaline phosphatase, and lactate dehydrogenase was noticed. Our findings support the hypothesis that the pandemic 2009 influenza A/H1N1 is an illness with a significant immune response to infection leading to hepatocellular injury.
DOI: 10.1111/j.1750-2659.2011.00287.x
PubMed: 21951624
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pubmed:21951624Le document en format XML
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last="Vince">Adriana Vince</name></author><author><name sortKey="Kuzman, Ilija" sort="Kuzman, Ilija" uniqKey="Kuzman I" first="Ilija" last="Kuzman">Ilija Kuzman</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="RBID">pubmed:21951624</idno><idno type="pmid">21951624</idno><idno type="doi">10.1111/j.1750-2659.2011.00287.x</idno><idno type="wicri:Area/PubMed/Corpus">000E80</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000E80</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Liver involvement during influenza infection: perspective on the 2009 influenza pandemic.</title><author><name sortKey="Papic, Neven" sort="Papic, Neven" uniqKey="Papic N" first="Neven" last="Papic">Neven Papic</name><affiliation><nlm:affiliation>Department of Viral Hepatitis, University Hospital for Infectious Diseases, Zagreb, Croatia. npapic@bfm.hr</nlm:affiliation></affiliation></author><author><name sortKey="Pangercic, Ana" sort="Pangercic, Ana" uniqKey="Pangercic A" first="Ana" last="Pangercic">Ana Pangercic</name></author><author><name sortKey="Vargovic, Martina" sort="Vargovic, Martina" uniqKey="Vargovic M" first="Martina" last="Vargovic">Martina Vargovic</name></author><author><name sortKey="Barsic, Bruno" sort="Barsic, Bruno" uniqKey="Barsic B" first="Bruno" last="Barsic">Bruno Barsic</name></author><author><name sortKey="Vince, Adriana" sort="Vince, Adriana" uniqKey="Vince A" first="Adriana" last="Vince">Adriana Vince</name></author><author><name sortKey="Kuzman, Ilija" sort="Kuzman, Ilija" uniqKey="Kuzman I" first="Ilija" last="Kuzman">Ilija Kuzman</name></author></analytic><series><title level="j">Influenza and other respiratory viruses</title><idno type="eISSN">1750-2659</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Alanine Transaminase (blood)</term><term>Aspartate Aminotransferases (blood)</term><term>C-Reactive Protein (metabolism)</term><term>Child</term><term>Croatia (epidemiology)</term><term>Female</term><term>Humans</term><term>Influenza A Virus, H1N1 Subtype (genetics)</term><term>Influenza A Virus, H1N1 Subtype (isolation & purification)</term><term>Influenza, Human (complications)</term><term>Influenza, Human (enzymology)</term><term>Influenza, Human (virology)</term><term>L-Lactate Dehydrogenase (blood)</term><term>Liver (enzymology)</term><term>Liver (injuries)</term><term>Liver Diseases (enzymology)</term><term>Liver Diseases (etiology)</term><term>Male</term><term>Middle Aged</term><term>Pandemics</term><term>Retrospective Studies</term><term>Young Adult</term><term>gamma-Glutamyltransferase (blood)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Alanine Transaminase</term><term>Aspartate Aminotransferases</term><term>L-Lactate Dehydrogenase</term><term>gamma-Glutamyltransferase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>C-Reactive Protein</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Croatia</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Influenza, Human</term><term>Liver</term><term>Liver Diseases</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Liver Diseases</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="injuries" xml:lang="en"><term>Liver</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Child</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Pandemics</term><term>Retrospective Studies</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Elevation of liver transaminase levels is a frequent observation during systemic infections. The aim of our study was to investigate liver damage during pandemic 2009 influenza A/H1N1 infection in comparison with seasonal influenza. Serum levels of aspartate aminotransferase, alanine aminotransferase, and gamma-glutamyl transpeptidase (GGT) were significantly higher in patients with pandemic influenza compared to seasonal influenza, which was strongly correlated with hypoxia. Moreover, a positive correlation between C-reactive protein and serum GGT, alkaline phosphatase, and lactate dehydrogenase was noticed. Our findings support the hypothesis that the pandemic 2009 influenza A/H1N1 is an illness with a significant immune response to infection leading to hepatocellular injury.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21951624</PMID><DateCompleted><Year>2012</Year><Month>07</Month><Day>30</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1750-2659</ISSN><JournalIssue CitedMedium="Internet"><Volume>6</Volume><Issue>3</Issue><PubDate><Year>2012</Year><Month>May</Month></PubDate></JournalIssue><Title>Influenza and other respiratory viruses</Title><ISOAbbreviation>Influenza Other Respir Viruses</ISOAbbreviation></Journal><ArticleTitle>Liver involvement during influenza infection: perspective on the 2009 influenza pandemic.</ArticleTitle><Pagination><MedlinePgn>e2-5</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/j.1750-2659.2011.00287.x</ELocationID><Abstract><AbstractText>Elevation of liver transaminase levels is a frequent observation during systemic infections. The aim of our study was to investigate liver damage during pandemic 2009 influenza A/H1N1 infection in comparison with seasonal influenza. Serum levels of aspartate aminotransferase, alanine aminotransferase, and gamma-glutamyl transpeptidase (GGT) were significantly higher in patients with pandemic influenza compared to seasonal influenza, which was strongly correlated with hypoxia. Moreover, a positive correlation between C-reactive protein and serum GGT, alkaline phosphatase, and lactate dehydrogenase was noticed. Our findings support the hypothesis that the pandemic 2009 influenza A/H1N1 is an illness with a significant immune response to infection leading to hepatocellular injury.</AbstractText><CopyrightInformation>© 2011 Blackwell Publishing Ltd.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Papic</LastName><ForeName>Neven</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Viral Hepatitis, University Hospital for Infectious Diseases, Zagreb, Croatia. npapic@bfm.hr</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pangercic</LastName><ForeName>Ana</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Vargovic</LastName><ForeName>Martina</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Barsic</LastName><ForeName>Bruno</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Vince</LastName><ForeName>Adriana</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Kuzman</LastName><ForeName>Ilija</ForeName><Initials>I</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2011</Year><Month>09</Month><Day>23</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Influenza Other Respir Viruses</MedlineTA><NlmUniqueID>101304007</NlmUniqueID><ISSNLinking>1750-2640</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>9007-41-4</RegistryNumber><NameOfSubstance UI="D002097">C-Reactive Protein</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.1.1.27</RegistryNumber><NameOfSubstance UI="D007770">L-Lactate Dehydrogenase</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.3.2.2</RegistryNumber><NameOfSubstance UI="D005723">gamma-Glutamyltransferase</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.6.1.1</RegistryNumber><NameOfSubstance UI="D001219">Aspartate Aminotransferases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.6.1.2</RegistryNumber><NameOfSubstance UI="D000410">Alanine Transaminase</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000410" MajorTopicYN="N">Alanine Transaminase</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001219" MajorTopicYN="N">Aspartate Aminotransferases</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002097" MajorTopicYN="N">C-Reactive Protein</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017523" MajorTopicYN="N" Type="Geographic">Croatia</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053118" MajorTopicYN="N">Influenza A Virus, H1N1 Subtype</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007770" MajorTopicYN="N">L-Lactate Dehydrogenase</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008099" MajorTopicYN="N">Liver</DescriptorName><QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName><QualifierName UI="Q000293" MajorTopicYN="Y">injuries</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008107" MajorTopicYN="N">Liver Diseases</DescriptorName><QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName><QualifierName UI="Q000209" 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IdType="pubmed">15694941</ArticleId></ArticleIdList></Reference><Reference><Citation>Hepatology. 1999 Feb;29(2):427-33</Citation><ArticleIdList><ArticleId IdType="pubmed">9918919</ArticleId></ArticleIdList></Reference><Reference><Citation>Intern Med. 2008;47(2):77-82</Citation><ArticleIdList><ArticleId IdType="pubmed">18195495</ArticleId></ArticleIdList></Reference><Reference><Citation>Z Gastroenterol. 2007 Jan;45(1):63-70</Citation><ArticleIdList><ArticleId IdType="pubmed">17236122</ArticleId></ArticleIdList></Reference><Reference><Citation>Ann Hepatol. 2010 Jan-Mar;9(1):107-11</Citation><ArticleIdList><ArticleId IdType="pubmed">20308733</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Pathol. 2006 Apr;168(4):1169-78; quiz 1404-5</Citation><ArticleIdList><ArticleId IdType="pubmed">16565492</ArticleId></ArticleIdList></Reference><Reference><Citation>Arterioscler Thromb Vasc Biol. 2005 Jan;25(1):193-7</Citation><ArticleIdList><ArticleId IdType="pubmed">15499043</ArticleId></ArticleIdList></Reference><Reference><Citation>Crit Care. 2009;13(6):R201</Citation><ArticleIdList><ArticleId IdType="pubmed">20003352</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2009 Nov 12;361(20):1945-52</Citation><ArticleIdList><ArticleId IdType="pubmed">19745214</ArticleId></ArticleIdList></Reference><Reference><Citation>World J Gastroenterol. 2005 Dec 7;11(45):7109-17</Citation><ArticleIdList><ArticleId IdType="pubmed">16437656</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2009 Aug 13;361(7):674-9</Citation><ArticleIdList><ArticleId IdType="pubmed">19564633</ArticleId></ArticleIdList></Reference><Reference><Citation>Arch Virol. 2009;154(3):409-19</Citation><ArticleIdList><ArticleId IdType="pubmed">19189197</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2010 May 6;362(18):1708-19</Citation><ArticleIdList><ArticleId 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