Liver involvement during influenza infection: perspective on the 2009 influenza pandemic.
Identifieur interne : 000E80 ( PubMed/Corpus ); précédent : 000E79; suivant : 000E81Liver involvement during influenza infection: perspective on the 2009 influenza pandemic.
Auteurs : Neven Papic ; Ana Pangercic ; Martina Vargovic ; Bruno Barsic ; Adriana Vince ; Ilija KuzmanSource :
- Influenza and other respiratory viruses [ 1750-2659 ] ; 2012.
English descriptors
- KwdEn :
- Adolescent, Adult, Alanine Transaminase (blood), Aspartate Aminotransferases (blood), C-Reactive Protein (metabolism), Child, Croatia (epidemiology), Female, Humans, Influenza A Virus, H1N1 Subtype (genetics), Influenza A Virus, H1N1 Subtype (isolation & purification), Influenza, Human (complications), Influenza, Human (enzymology), Influenza, Human (virology), L-Lactate Dehydrogenase (blood), Liver (enzymology), Liver (injuries), Liver Diseases (enzymology), Liver Diseases (etiology), Male, Middle Aged, Pandemics, Retrospective Studies, Young Adult, gamma-Glutamyltransferase (blood).
- MESH :
- chemical , blood : Alanine Transaminase, Aspartate Aminotransferases, L-Lactate Dehydrogenase, gamma-Glutamyltransferase.
- chemical , metabolism : C-Reactive Protein.
- geographic , epidemiology : Croatia.
- complications : Influenza, Human.
- enzymology : Influenza, Human, Liver, Liver Diseases.
- etiology : Liver Diseases.
- genetics : Influenza A Virus, H1N1 Subtype.
- injuries : Liver.
- isolation & purification : Influenza A Virus, H1N1 Subtype.
- virology : Influenza, Human.
- Adolescent, Adult, Child, Female, Humans, Male, Middle Aged, Pandemics, Retrospective Studies, Young Adult.
Abstract
Elevation of liver transaminase levels is a frequent observation during systemic infections. The aim of our study was to investigate liver damage during pandemic 2009 influenza A/H1N1 infection in comparison with seasonal influenza. Serum levels of aspartate aminotransferase, alanine aminotransferase, and gamma-glutamyl transpeptidase (GGT) were significantly higher in patients with pandemic influenza compared to seasonal influenza, which was strongly correlated with hypoxia. Moreover, a positive correlation between C-reactive protein and serum GGT, alkaline phosphatase, and lactate dehydrogenase was noticed. Our findings support the hypothesis that the pandemic 2009 influenza A/H1N1 is an illness with a significant immune response to infection leading to hepatocellular injury.
DOI: 10.1111/j.1750-2659.2011.00287.x
PubMed: 21951624
Links to Exploration step
pubmed:21951624Le document en format XML
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<author><name sortKey="Papic, Neven" sort="Papic, Neven" uniqKey="Papic N" first="Neven" last="Papic">Neven Papic</name>
<affiliation><nlm:affiliation>Department of Viral Hepatitis, University Hospital for Infectious Diseases, Zagreb, Croatia. npapic@bfm.hr</nlm:affiliation>
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<author><name sortKey="Pangercic, Ana" sort="Pangercic, Ana" uniqKey="Pangercic A" first="Ana" last="Pangercic">Ana Pangercic</name>
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<author><name sortKey="Vargovic, Martina" sort="Vargovic, Martina" uniqKey="Vargovic M" first="Martina" last="Vargovic">Martina Vargovic</name>
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<author><name sortKey="Barsic, Bruno" sort="Barsic, Bruno" uniqKey="Barsic B" first="Bruno" last="Barsic">Bruno Barsic</name>
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<author><name sortKey="Vince, Adriana" sort="Vince, Adriana" uniqKey="Vince A" first="Adriana" last="Vince">Adriana Vince</name>
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<author><name sortKey="Kuzman, Ilija" sort="Kuzman, Ilija" uniqKey="Kuzman I" first="Ilija" last="Kuzman">Ilija Kuzman</name>
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<term>Adult</term>
<term>Alanine Transaminase (blood)</term>
<term>Aspartate Aminotransferases (blood)</term>
<term>C-Reactive Protein (metabolism)</term>
<term>Child</term>
<term>Croatia (epidemiology)</term>
<term>Female</term>
<term>Humans</term>
<term>Influenza A Virus, H1N1 Subtype (genetics)</term>
<term>Influenza A Virus, H1N1 Subtype (isolation & purification)</term>
<term>Influenza, Human (complications)</term>
<term>Influenza, Human (enzymology)</term>
<term>Influenza, Human (virology)</term>
<term>L-Lactate Dehydrogenase (blood)</term>
<term>Liver (enzymology)</term>
<term>Liver (injuries)</term>
<term>Liver Diseases (enzymology)</term>
<term>Liver Diseases (etiology)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Pandemics</term>
<term>Retrospective Studies</term>
<term>Young Adult</term>
<term>gamma-Glutamyltransferase (blood)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Alanine Transaminase</term>
<term>Aspartate Aminotransferases</term>
<term>L-Lactate Dehydrogenase</term>
<term>gamma-Glutamyltransferase</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>C-Reactive Protein</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Croatia</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Influenza, Human</term>
<term>Liver</term>
<term>Liver Diseases</term>
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<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Liver Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term>
</keywords>
<keywords scheme="MESH" qualifier="injuries" xml:lang="en"><term>Liver</term>
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<term>Adult</term>
<term>Child</term>
<term>Female</term>
<term>Humans</term>
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<term>Pandemics</term>
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<front><div type="abstract" xml:lang="en">Elevation of liver transaminase levels is a frequent observation during systemic infections. The aim of our study was to investigate liver damage during pandemic 2009 influenza A/H1N1 infection in comparison with seasonal influenza. Serum levels of aspartate aminotransferase, alanine aminotransferase, and gamma-glutamyl transpeptidase (GGT) were significantly higher in patients with pandemic influenza compared to seasonal influenza, which was strongly correlated with hypoxia. Moreover, a positive correlation between C-reactive protein and serum GGT, alkaline phosphatase, and lactate dehydrogenase was noticed. Our findings support the hypothesis that the pandemic 2009 influenza A/H1N1 is an illness with a significant immune response to infection leading to hepatocellular injury.</div>
</front>
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<Title>Influenza and other respiratory viruses</Title>
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<Abstract><AbstractText>Elevation of liver transaminase levels is a frequent observation during systemic infections. The aim of our study was to investigate liver damage during pandemic 2009 influenza A/H1N1 infection in comparison with seasonal influenza. Serum levels of aspartate aminotransferase, alanine aminotransferase, and gamma-glutamyl transpeptidase (GGT) were significantly higher in patients with pandemic influenza compared to seasonal influenza, which was strongly correlated with hypoxia. Moreover, a positive correlation between C-reactive protein and serum GGT, alkaline phosphatase, and lactate dehydrogenase was noticed. Our findings support the hypothesis that the pandemic 2009 influenza A/H1N1 is an illness with a significant immune response to infection leading to hepatocellular injury.</AbstractText>
<CopyrightInformation>© 2011 Blackwell Publishing Ltd.</CopyrightInformation>
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<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Papic</LastName>
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