Liver involvement during influenza infection: perspective on the 2009 influenza pandemic
Identifieur interne : 000058 ( Pmc/Curation ); précédent : 000057; suivant : 000059Liver involvement during influenza infection: perspective on the 2009 influenza pandemic
Auteurs : Neven Papic ; Ana Pangercic ; Martina Vargovic ; Bruno Barsic ; Adriana Vince ; Ilija KuzmanSource :
- Influenza and Other Respiratory Viruses [ 1750-2640 ] ; 2011.
Abstract
Elevation of liver transaminase levels is a frequent observation during systemic infections. The aim of our study was to investigate liver damage during pandemic 2009 influenza A/H1N1 infection in comparison with seasonal influenza. Serum levels of aspartate aminotransferase, alanine aminotransferase, and gamma‐glutamyl transpeptidase (GGT) were significantly higher in patients with pandemic influenza compared to seasonal influenza, which was strongly correlated with hypoxia. Moreover, a positive correlation between C‐reactive protein and serum GGT, alkaline phosphatase, and lactate dehydrogenase was noticed. Our findings support the hypothesis that the pandemic 2009 influenza A/H1N1 is an illness with a significant immune response to infection leading to hepatocellular injury.
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DOI: 10.1111/j.1750-2659.2011.00287.x
PubMed: 21951624
PubMed Central: 4941665
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Liver involvement during influenza infection: perspective on the 2009 influenza pandemic</title><author><name sortKey="Papic, Neven" sort="Papic, Neven" uniqKey="Papic N" first="Neven" last="Papic">Neven Papic</name><affiliation><nlm:aff id="a1"></nlm:aff></affiliation></author><author><name sortKey="Pangercic, Ana" sort="Pangercic, Ana" uniqKey="Pangercic A" first="Ana" last="Pangercic">Ana Pangercic</name><affiliation><nlm:aff id="a2"></nlm:aff></affiliation></author><author><name sortKey="Vargovic, Martina" sort="Vargovic, Martina" uniqKey="Vargovic M" first="Martina" last="Vargovic">Martina Vargovic</name><affiliation><nlm:aff id="a3"></nlm:aff></affiliation></author><author><name sortKey="Barsic, Bruno" sort="Barsic, Bruno" uniqKey="Barsic B" first="Bruno" last="Barsic">Bruno Barsic</name><affiliation><nlm:aff id="a2"></nlm:aff></affiliation></author><author><name sortKey="Vince, Adriana" sort="Vince, Adriana" uniqKey="Vince A" first="Adriana" last="Vince">Adriana Vince</name><affiliation><nlm:aff id="a1"></nlm:aff></affiliation></author><author><name sortKey="Kuzman, Ilija" sort="Kuzman, Ilija" uniqKey="Kuzman I" first="Ilija" last="Kuzman">Ilija Kuzman</name><affiliation><nlm:aff id="a4"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21951624</idno><idno type="pmc">4941665</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941665</idno><idno type="RBID">PMC:4941665</idno><idno type="doi">10.1111/j.1750-2659.2011.00287.x</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">000058</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000058</idno><idno type="wicri:Area/Pmc/Curation">000058</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000058</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Liver involvement during influenza infection: perspective on the 2009 influenza pandemic</title><author><name sortKey="Papic, Neven" sort="Papic, Neven" uniqKey="Papic N" first="Neven" last="Papic">Neven Papic</name><affiliation><nlm:aff id="a1"></nlm:aff></affiliation></author><author><name sortKey="Pangercic, Ana" sort="Pangercic, Ana" uniqKey="Pangercic A" first="Ana" last="Pangercic">Ana Pangercic</name><affiliation><nlm:aff id="a2"></nlm:aff></affiliation></author><author><name sortKey="Vargovic, Martina" sort="Vargovic, Martina" uniqKey="Vargovic M" first="Martina" last="Vargovic">Martina Vargovic</name><affiliation><nlm:aff id="a3"></nlm:aff></affiliation></author><author><name sortKey="Barsic, Bruno" sort="Barsic, Bruno" uniqKey="Barsic B" first="Bruno" last="Barsic">Bruno Barsic</name><affiliation><nlm:aff id="a2"></nlm:aff></affiliation></author><author><name sortKey="Vince, Adriana" sort="Vince, Adriana" uniqKey="Vince A" first="Adriana" last="Vince">Adriana Vince</name><affiliation><nlm:aff id="a1"></nlm:aff></affiliation></author><author><name sortKey="Kuzman, Ilija" sort="Kuzman, Ilija" uniqKey="Kuzman I" first="Ilija" last="Kuzman">Ilija Kuzman</name><affiliation><nlm:aff id="a4"></nlm:aff></affiliation></author></analytic><series><title level="j">Influenza and Other Respiratory Viruses</title><idno type="ISSN">1750-2640</idno><idno type="eISSN">1750-2659</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><italic>Please cite this paper as:</italic> Papic <italic>et al.</italic> (2011) Liver involvement during influenza infection: perspective on the 2009 influenza pandemic. Influenza and Other Respiratory Viruses 6(3), e2–e5.</p><p>Elevation of liver transaminase levels is a frequent observation during systemic infections. The aim of our study was to investigate liver damage during pandemic 2009 influenza A/H1N1 infection in comparison with seasonal influenza. Serum levels of aspartate aminotransferase, alanine aminotransferase, and gamma‐glutamyl transpeptidase (GGT) were significantly higher in patients with pandemic influenza compared to seasonal influenza, which was strongly correlated with hypoxia. Moreover, a positive correlation between C‐reactive protein and serum GGT, alkaline phosphatase, and lactate dehydrogenase was noticed. Our findings support the hypothesis that the pandemic 2009 influenza A/H1N1 is an illness with a significant immune response to infection leading to hepatocellular injury.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="brief-report"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Influenza Other Respir Viruses</journal-id><journal-id journal-id-type="iso-abbrev">Influenza Other Respir Viruses</journal-id><journal-id journal-id-type="doi">10.1111/(ISSN)1750-2659</journal-id><journal-id journal-id-type="publisher-id">IRV</journal-id><journal-title-group><journal-title>Influenza and Other Respiratory Viruses</journal-title></journal-title-group><issn pub-type="ppub">1750-2640</issn><issn pub-type="epub">1750-2659</issn><publisher><publisher-name>Blackwell Publishing Ltd</publisher-name><publisher-loc>Oxford, UK</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">21951624</article-id><article-id pub-id-type="pmc">4941665</article-id><article-id pub-id-type="doi">10.1111/j.1750-2659.2011.00287.x</article-id><article-id pub-id-type="publisher-id">IRV287</article-id><article-categories><subj-group subj-group-type="heading"><subject>Part 2 (E‐only)</subject><subj-group subj-group-type="heading"><subject>Short Articles</subject></subj-group></subj-group><subj-group subj-group-type="overline"><subject>Short Article</subject></subj-group></article-categories><title-group><article-title>Liver involvement during influenza infection: perspective on the 2009 influenza pandemic</article-title><alt-title alt-title-type="left-running-head">Papic <italic>et al.</italic></alt-title><alt-title alt-title-type="right-running-head">Liver involvement during influenza infection</alt-title></title-group><contrib-group><contrib id="cr1" contrib-type="author"><name><surname>Papic</surname><given-names>Neven</given-names></name><xref ref-type="aff" rid="a1"><sup>1</sup></xref></contrib><contrib id="cr2" contrib-type="author"><name><surname>Pangercic</surname><given-names>Ana</given-names></name><xref ref-type="aff" rid="a2"><sup>2</sup></xref></contrib><contrib id="cr3" contrib-type="author"><name><surname>Vargovic</surname><given-names>Martina</given-names></name><xref ref-type="aff" rid="a3"><sup>3</sup></xref></contrib><contrib id="cr4" contrib-type="author"><name><surname>Barsic</surname><given-names>Bruno</given-names></name><xref ref-type="aff" rid="a2"><sup>2</sup></xref></contrib><contrib id="cr5" contrib-type="author"><name><surname>Vince</surname><given-names>Adriana</given-names></name><xref ref-type="aff" rid="a1"><sup>1</sup></xref></contrib><contrib id="cr6" contrib-type="author"><name><surname>Kuzman</surname><given-names>Ilija</given-names></name><xref ref-type="aff" rid="a4"><sup>4</sup></xref></contrib></contrib-group><aff id="a1"><label><sup>1</sup></label>Department of Viral Hepatitis, University Hospital for Infectious Diseases, Zagreb, Croatia</aff><aff id="a2"><label><sup>2</sup></label>Department of Adult Intensive Care and Neuroinfection, University Hospital for Infectious Diseases, Zagreb, Croatia</aff><aff id="a3"><label><sup>3</sup></label>Department of Urinary Tract Infections, University Hospital for Infectious Diseases, Zagreb, Croatia</aff><aff id="a4"><label><sup>4</sup></label>Department of Acute Respiratory Infections, University Hospital for Infectious Diseases, Zagreb, Croatia.</aff><author-notes><corresp id="correspondenceTo">Neven Papic, Department of Viral Hepatitis, University Hospital for Infectious Diseases, Mirogojska 8, 10 000 Zagreb, Croatia. E‐mail: <email>npapic@bfm.hr</email></corresp></author-notes><pub-date pub-type="epub"><day>23</day><month>9</month><year>2011</year></pub-date><pub-date pub-type="ppub"><month>5</month><year>2012</year></pub-date><volume>6</volume><issue>3</issue><issue-id pub-id-type="doi">10.1111/irv.2012.6.issue-3</issue-id><fpage>e2</fpage><lpage>e5</lpage><history>Accepted 23 July 2011. Published Online 23 September 2011.</history><permissions><copyright-statement content-type="article-copyright">© 2011 Blackwell Publishing Ltd</copyright-statement></permissions><self-uri content-type="pdf" xlink:type="simple" xlink:href="file:IRV-6-0e2.pdf"></self-uri><abstract><p><italic>Please cite this paper as:</italic> Papic <italic>et al.</italic> (2011) Liver involvement during influenza infection: perspective on the 2009 influenza pandemic. Influenza and Other Respiratory Viruses 6(3), e2–e5.</p><p>Elevation of liver transaminase levels is a frequent observation during systemic infections. The aim of our study was to investigate liver damage during pandemic 2009 influenza A/H1N1 infection in comparison with seasonal influenza. Serum levels of aspartate aminotransferase, alanine aminotransferase, and gamma‐glutamyl transpeptidase (GGT) were significantly higher in patients with pandemic influenza compared to seasonal influenza, which was strongly correlated with hypoxia. Moreover, a positive correlation between C‐reactive protein and serum GGT, alkaline phosphatase, and lactate dehydrogenase was noticed. Our findings support the hypothesis that the pandemic 2009 influenza A/H1N1 is an illness with a significant immune response to infection leading to hepatocellular injury.</p></abstract><kwd-group><kwd id="k1">Alanine aminotransferase</kwd><kwd id="k2">H1N1</kwd><kwd id="k3">hypoxia</kwd><kwd id="k4">influenza</kwd><kwd id="k5">liver</kwd><kwd id="k6">systemic inflammatory response</kwd></kwd-group><counts><fig-count count="1"></fig-count><table-count count="1"></table-count><page-count count="4"></page-count></counts><custom-meta-group><custom-meta><meta-name>source-schema-version-number</meta-name><meta-value>2.0</meta-value></custom-meta><custom-meta><meta-name>cover-date</meta-name><meta-value>May 2012</meta-value></custom-meta><custom-meta><meta-name>details-of-publishers-convertor</meta-name><meta-value>Converter:WILEY_ML3GV2_TO_NLMPMC version:4.6.9 mode:remove_FC converted:04.11.2015</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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