T cell epitope engineering: an avian H7N9 influenza vaccine strategy for pandemic preparedness and response
Identifieur interne : 001E15 ( Ncbi/Curation ); précédent : 001E14; suivant : 001E16T cell epitope engineering: an avian H7N9 influenza vaccine strategy for pandemic preparedness and response
Auteurs : Leonard Moise [États-Unis] ; Bethany M. Biron [États-Unis] ; Christine M. Boyle [États-Unis] ; Nese Kurt Yilmaz [États-Unis] ; Hyesun Jang [États-Unis] ; Celia Schiffer [États-Unis] ; Ted M. Ross [États-Unis] ; William D. Martin [États-Unis] ; Anne S. De Groot [États-Unis]Source :
- Human Vaccines & Immunotherapeutics [ 2164-5515 ] ; 2018.
Descripteurs français
- KwdFr :
- Animaux, Biologie informatique, Déterminants antigéniques des lymphocytes T (), Déterminants antigéniques des lymphocytes T (génétique), Déterminants antigéniques des lymphocytes T (immunologie), Glycoprotéine hémagglutinine du virus influenza (), Glycoprotéine hémagglutinine du virus influenza (génétique), Glycoprotéine hémagglutinine du virus influenza (immunologie), Humains, Lymphocytes T CD4+ (immunologie), Modèles biologiques, Modèles moléculaires, Sous-type H7N9 du virus de la grippe A (génétique), Sous-type H7N9 du virus de la grippe A (immunologie), Vaccins antigrippaux (administration et posologie), Vaccins antigrippaux (génétique), Vaccins antigrippaux (immunologie), Vaccins synthétiques (administration et posologie), Vaccins synthétiques (génétique), Vaccins synthétiques (immunologie).
- MESH :
- administration et posologie : Vaccins antigrippaux, Vaccins synthétiques.
- génétique : Déterminants antigéniques des lymphocytes T, Glycoprotéine hémagglutinine du virus influenza, Sous-type H7N9 du virus de la grippe A, Vaccins antigrippaux, Vaccins synthétiques.
- immunologie : Déterminants antigéniques des lymphocytes T, Glycoprotéine hémagglutinine du virus influenza, Lymphocytes T CD4+, Sous-type H7N9 du virus de la grippe A, Vaccins antigrippaux, Vaccins synthétiques.
- Animaux, Biologie informatique, Déterminants antigéniques des lymphocytes T, Glycoprotéine hémagglutinine du virus influenza, Humains, Modèles biologiques, Modèles moléculaires.
English descriptors
- KwdEn :
- Animals, CD4-Positive T-Lymphocytes (immunology), Computational Biology, Epitopes, T-Lymphocyte (chemistry), Epitopes, T-Lymphocyte (genetics), Epitopes, T-Lymphocyte (immunology), Hemagglutinin Glycoproteins, Influenza Virus (chemistry), Hemagglutinin Glycoproteins, Influenza Virus (genetics), Hemagglutinin Glycoproteins, Influenza Virus (immunology), Humans, Influenza A Virus, H7N9 Subtype (genetics), Influenza A Virus, H7N9 Subtype (immunology), Influenza Vaccines (administration & dosage), Influenza Vaccines (genetics), Influenza Vaccines (immunology), Models, Biological, Models, Molecular, Vaccines, Synthetic (administration & dosage), Vaccines, Synthetic (genetics), Vaccines, Synthetic (immunology).
- MESH :
- chemical , administration & dosage : Influenza Vaccines, Vaccines, Synthetic.
- chemical , chemistry : Epitopes, T-Lymphocyte, Hemagglutinin Glycoproteins, Influenza Virus.
- chemical , genetics : Epitopes, T-Lymphocyte, Hemagglutinin Glycoproteins, Influenza Virus, Influenza Vaccines, Vaccines, Synthetic.
- genetics : Influenza A Virus, H7N9 Subtype.
- immunology : CD4-Positive T-Lymphocytes, Epitopes, T-Lymphocyte, Hemagglutinin Glycoproteins, Influenza Virus, Influenza A Virus, H7N9 Subtype, Influenza Vaccines, Vaccines, Synthetic.
- Animals, Computational Biology, Humans, Models, Biological, Models, Molecular.
Abstract
The delayed availability of vaccine during the 2009 H1N1 influenza pandemic created a sense of urgency to better prepare for the next influenza pandemic. Advancements in manufacturing technology, speed and capacity have been achieved but vaccine effectiveness remains a significant challenge. Here, we describe a novel vaccine design strategy called immune engineering in the context of H7N9 influenza vaccine development. The approach combines immunoinformatic and structure modeling methods to promote protective antibody responses against H7N9 hemagglutinin (HA) by engineering whole antigens to carry seasonal influenza HA memory CD4+ T cell epitopes – without perturbing native antigen structure – by galvanizing HA-specific memory helper T cells that support sustained antibody development against the native target HA. The premise for this vaccine concept rests on (i) the significance of CD4+ T cell memory to influenza immunity, (ii) the essential role CD4+ T cells play in development of neutralizing antibodies, (iii) linked specificity of HA-derived CD4+ T cell epitopes to antibody responses, (iv) the structural plasticity of HA and (v) an illustration of improved antibody response to a prototype engineered recombinant H7-HA vaccine. Immune engineering can be applied to development of vaccines against pandemic concerns, including avian influenza, as well as other difficult targets.
Url:
DOI: 10.1080/21645515.2018.1495303
PubMed: 30015562
PubMed Central: 6183197
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PMC:6183197Le document en format XML
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Biron">Bethany M. Biron</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>EpiVax, Inc</institution>., Providence, RI,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Boyle, Christine M" sort="Boyle, Christine M" uniqKey="Boyle C" first="Christine M." last="Boyle">Christine M. 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Ross">Ted M. Ross</name><affiliation wicri:level="1"><nlm:aff id="AFF0005"><institution>Center for Vaccines and Immunology, University of Georgia</institution>, Athens, GA,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AFF0006"><institution>Department of Infectious Diseases, University of Georgia</institution>, Athens, GA,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Martin, William D" sort="Martin, William D" uniqKey="Martin W" first="William D." last="Martin">William D. Martin</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>EpiVax, Inc</institution>., Providence, RI,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="De Groot, Anne S" sort="De Groot, Anne S" uniqKey="De Groot A" first="Anne S." last="De Groot">Anne S. De Groot</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>EpiVax, Inc</institution>., Providence, RI,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AFF0002"><institution>Institute for Immunology and Informatics, University of Rhode Island</institution>, Providence, RI,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AFF0003"><institution>Department of Cell and Molecular Biology, University of Rhode Island</institution>, Providence, RI,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Human Vaccines & Immunotherapeutics</title><idno type="ISSN">2164-5515</idno><idno type="eISSN">2164-554X</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>CD4-Positive T-Lymphocytes (immunology)</term><term>Computational Biology</term><term>Epitopes, T-Lymphocyte (chemistry)</term><term>Epitopes, T-Lymphocyte (genetics)</term><term>Epitopes, T-Lymphocyte (immunology)</term><term>Hemagglutinin Glycoproteins, Influenza Virus (chemistry)</term><term>Hemagglutinin Glycoproteins, Influenza Virus (genetics)</term><term>Hemagglutinin Glycoproteins, Influenza Virus (immunology)</term><term>Humans</term><term>Influenza A Virus, H7N9 Subtype (genetics)</term><term>Influenza A Virus, H7N9 Subtype (immunology)</term><term>Influenza Vaccines (administration & dosage)</term><term>Influenza Vaccines (genetics)</term><term>Influenza Vaccines (immunology)</term><term>Models, Biological</term><term>Models, Molecular</term><term>Vaccines, Synthetic (administration & dosage)</term><term>Vaccines, Synthetic (genetics)</term><term>Vaccines, Synthetic (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Biologie informatique</term><term>Déterminants antigéniques des lymphocytes T ()</term><term>Déterminants antigéniques des lymphocytes T (génétique)</term><term>Déterminants antigéniques des lymphocytes T (immunologie)</term><term>Glycoprotéine hémagglutinine du virus influenza ()</term><term>Glycoprotéine hémagglutinine du virus influenza (génétique)</term><term>Glycoprotéine hémagglutinine du virus influenza (immunologie)</term><term>Humains</term><term>Lymphocytes T CD4+ (immunologie)</term><term>Modèles biologiques</term><term>Modèles moléculaires</term><term>Sous-type H7N9 du virus de la grippe A (génétique)</term><term>Sous-type H7N9 du virus de la grippe A (immunologie)</term><term>Vaccins antigrippaux (administration et posologie)</term><term>Vaccins antigrippaux (génétique)</term><term>Vaccins antigrippaux (immunologie)</term><term>Vaccins synthétiques (administration et posologie)</term><term>Vaccins synthétiques (génétique)</term><term>Vaccins synthétiques (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Influenza Vaccines</term><term>Vaccines, Synthetic</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Epitopes, T-Lymphocyte</term><term>Hemagglutinin Glycoproteins, Influenza Virus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Epitopes, T-Lymphocyte</term><term>Hemagglutinin Glycoproteins, Influenza Virus</term><term>Influenza Vaccines</term><term>Vaccines, Synthetic</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Vaccins antigrippaux</term><term>Vaccins synthétiques</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A Virus, H7N9 Subtype</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Déterminants antigéniques des lymphocytes T</term><term>Glycoprotéine hémagglutinine du virus influenza</term><term>Sous-type H7N9 du virus de la grippe A</term><term>Vaccins antigrippaux</term><term>Vaccins synthétiques</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Déterminants antigéniques des lymphocytes T</term><term>Glycoprotéine hémagglutinine du virus influenza</term><term>Lymphocytes T CD4+</term><term>Sous-type H7N9 du virus de la grippe A</term><term>Vaccins antigrippaux</term><term>Vaccins synthétiques</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>CD4-Positive T-Lymphocytes</term><term>Epitopes, T-Lymphocyte</term><term>Hemagglutinin Glycoproteins, Influenza Virus</term><term>Influenza A Virus, H7N9 Subtype</term><term>Influenza Vaccines</term><term>Vaccines, Synthetic</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Computational Biology</term><term>Humans</term><term>Models, Biological</term><term>Models, Molecular</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Biologie informatique</term><term>Déterminants antigéniques des lymphocytes T</term><term>Glycoprotéine hémagglutinine du virus influenza</term><term>Humains</term><term>Modèles biologiques</term><term>Modèles moléculaires</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>ABSTRACT</title><p>The delayed availability of vaccine during the 2009 H1N1 influenza pandemic created a sense of urgency to better prepare for the next influenza pandemic. Advancements in manufacturing technology, speed and capacity have been achieved but vaccine effectiveness remains a significant challenge. Here, we describe a novel vaccine design strategy called immune engineering in the context of H7N9 influenza vaccine development. The approach combines immunoinformatic and structure modeling methods to promote protective antibody responses against H7N9 hemagglutinin (HA) by engineering whole antigens to carry seasonal influenza HA memory CD4<sup>+</sup> T cell epitopes – without perturbing native antigen structure – by galvanizing HA-specific memory helper T cells that support sustained antibody development against the native target HA. The premise for this vaccine concept rests on (i) the significance of CD4<sup>+</sup> T cell memory to influenza immunity, (ii) the essential role CD4<sup>+</sup> T cells play in development of neutralizing antibodies, (iii) linked specificity of HA-derived CD4<sup>+</sup> T cell epitopes to antibody responses, (iv) the structural plasticity of HA and (v) an illustration of improved antibody response to a prototype engineered recombinant H7-HA vaccine. Immune engineering can be applied to development of vaccines against pandemic concerns, including avian influenza, as well as other difficult targets.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Gao, H N" uniqKey="Gao H">H-N Gao</name></author><author><name sortKey="Lu, H Z" uniqKey="Lu H">H-Z Lu</name></author><author><name sortKey="Cao, B" uniqKey="Cao B">B Cao</name></author><author><name sortKey="Du, B" uniqKey="Du B">B Du</name></author><author><name sortKey="Shang, H" uniqKey="Shang H">H Shang</name></author><author><name sortKey="Gan, J H" uniqKey="Gan J">J-H Gan</name></author><author><name sortKey="Lu, S H" uniqKey="Lu S">S-H Lu</name></author><author><name sortKey="Yang, Y D" uniqKey="Yang Y">Y-D Yang</name></author><author><name sortKey="Fang, Q" uniqKey="Fang Q">Q Fang</name></author><author><name sortKey="Shen, Y Z" uniqKey="Shen Y">Y-Z Shen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gao, R" uniqKey="Gao R">R Gao</name></author><author><name sortKey="Cao, B" uniqKey="Cao B">B Cao</name></author><author><name sortKey="Hu, Y" uniqKey="Hu Y">Y Hu</name></author><author><name sortKey="Feng, Z" uniqKey="Feng Z">Z Feng</name></author><author><name sortKey="Wang, D" uniqKey="Wang D">D Wang</name></author><author><name sortKey="Hu, W" uniqKey="Hu W">W Hu</name></author><author><name sortKey="Chen, J" uniqKey="Chen J">J Chen</name></author><author><name sortKey="Jie, Z" uniqKey="Jie Z">Z Jie</name></author><author><name sortKey="Qiu, H" uniqKey="Qiu H">H Qiu</name></author><author><name sortKey="Xu, K" uniqKey="Xu K">K Xu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Su, S" uniqKey="Su S">S Su</name></author><author><name sortKey="Gu, M" uniqKey="Gu M">M Gu</name></author><author><name sortKey="Liu, D" uniqKey="Liu D">D Liu</name></author><author><name sortKey="Cui, J" uniqKey="Cui J">J Cui</name></author><author><name sortKey="Gao, Gf" uniqKey="Gao G">GF Gao</name></author><author><name sortKey="Zhou, J" uniqKey="Zhou J">J Zhou</name></author><author><name sortKey="Liu, X" uniqKey="Liu X">X. 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