Obesity as a risk factor for severe influenza-like illness
Identifieur interne : 000562 ( Pmc/Checkpoint ); précédent : 000561; suivant : 000563Obesity as a risk factor for severe influenza-like illness
Auteurs : Noelle M. Cocoros [États-Unis] ; Timothy L. Lash [États-Unis] ; Alfred Demaria [États-Unis] ; Michael Klompas [États-Unis]Source :
- Influenza and Other Respiratory Viruses [ 1750-2640 ] ; 2013.
Abstract
Obesity was recognized as in independent risk factor for influenza during the 2009 H1N1 influenza pandemic.
We evaluated the association between body mass index (BMI) and influenza-like illness (ILI) during two non-pandemic influenza seasons (2003–2004 and 2004–2005) and during the spring and fall waves of the 2009 H1N1 pandemic.
Adults with severe (inpatient) and mild (outpatient) ILI were compared to those without ILI using a case-cohort design. The study was nested among those insured by a single health insurance company, receiving care from a large multispecialty practice. Data were collected from insurance claims and the electronic health record. The primary exposure was obesity (BMI ≥ 30·0 kg/m2).
Across three seasons, the crude and adjusted ORs for obesity and severe ILI were 1·65 (95% CI 1·31, 2·08) and 1·23 (95% CI 0·97, 1·57), respectively. An association was observed for those aged 20–59 years (adjusted OR 1·92, 95% CI 1·26, 2·90), but not for those 60 and older (adjusted OR 1·08, 95% CI 0·80, 1·46). The adjusted ORs for obesity and severe ILI in 2003–2004, 2004–2005, and during H1N1 were 1·14 (95% CI 0·80, 1·64), 1·24 (95% CI 0·86, 1·79), and 1·76 (95% CI 0·91, 3·42), respectively. Among those with a Charlson Comorbidity Index score of zero, the adjusted ORs for 2003–2004, 2004–2005, and H1N1 were 1·60 (95% CI 0·93, 2·76), 1·43 (95% CI 0·80, 2·56), and 1·90 (95% CI 0·68, 5·27), respectively.
Our results suggest a small to moderate association between obesity and hospitalized ILI among adults.
Url:
DOI: 10.1111/irv.12156
PubMed: 23957732
PubMed Central: 4177795
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Lash</name><affiliation wicri:level="2"><nlm:aff id="au2"><institution>Department of Epidemiology, Rollins School of Public Health, Emory University</institution><addr-line>Atlanta, GA, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Atlanta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Demaria, Alfred" sort="Demaria, Alfred" uniqKey="Demaria A" first="Alfred" last="Demaria">Alfred Demaria</name><affiliation wicri:level="2"><nlm:aff id="au1"><institution>Bureau of Infectious Disease, Massachusetts Department of Public Health</institution><addr-line>Jamaica Plain, MA, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Jamaica Plain, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Klompas, Michael" sort="Klompas, Michael" uniqKey="Klompas M" first="Michael" last="Klompas">Michael Klompas</name><affiliation wicri:level="2"><nlm:aff id="au3"><institution>Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute</institution><addr-line>Boston, MA, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23957732</idno><idno type="pmc">4177795</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177795</idno><idno type="RBID">PMC:4177795</idno><idno type="doi">10.1111/irv.12156</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000A89</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000A89</idno><idno type="wicri:Area/Pmc/Curation">000A89</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000A89</idno><idno type="wicri:Area/Pmc/Checkpoint">000562</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000562</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Obesity as a risk factor for severe influenza-like illness</title><author><name sortKey="Cocoros, Noelle M" sort="Cocoros, Noelle M" uniqKey="Cocoros N" first="Noelle M" last="Cocoros">Noelle M. Cocoros</name><affiliation wicri:level="2"><nlm:aff id="au1"><institution>Bureau of Infectious Disease, Massachusetts Department of Public Health</institution><addr-line>Jamaica Plain, MA, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Jamaica Plain, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Lash, Timothy L" sort="Lash, Timothy L" uniqKey="Lash T" first="Timothy L" last="Lash">Timothy L. Lash</name><affiliation wicri:level="2"><nlm:aff id="au2"><institution>Department of Epidemiology, Rollins School of Public Health, Emory University</institution><addr-line>Atlanta, GA, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Atlanta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Demaria, Alfred" sort="Demaria, Alfred" uniqKey="Demaria A" first="Alfred" last="Demaria">Alfred Demaria</name><affiliation wicri:level="2"><nlm:aff id="au1"><institution>Bureau of Infectious Disease, Massachusetts Department of Public Health</institution><addr-line>Jamaica Plain, MA, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Jamaica Plain, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Klompas, Michael" sort="Klompas, Michael" uniqKey="Klompas M" first="Michael" last="Klompas">Michael Klompas</name><affiliation wicri:level="2"><nlm:aff id="au3"><institution>Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute</institution><addr-line>Boston, MA, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></analytic><series><title level="j">Influenza and Other Respiratory Viruses</title><idno type="ISSN">1750-2640</idno><idno type="eISSN">1750-2659</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Obesity was recognized as in independent risk factor for influenza during the 2009 H1N1 influenza pandemic.</p></sec><sec><title>Objectives</title><p>We evaluated the association between body mass index (BMI) and influenza-like illness (ILI) during two non-pandemic influenza seasons (2003–2004 and 2004–2005) and during the spring and fall waves of the 2009 H1N1 pandemic.</p></sec><sec><title>Methods</title><p>Adults with severe (inpatient) and mild (outpatient) ILI were compared to those without ILI using a case-cohort design. The study was nested among those insured by a single health insurance company, receiving care from a large multispecialty practice. Data were collected from insurance claims and the electronic health record. The primary exposure was obesity (BMI ≥ 30·0 kg/m<sup>2</sup>).</p></sec><sec><title>Results</title><p>Across three seasons, the crude and adjusted ORs for obesity and severe ILI were 1·65 (95% CI 1·31, 2·08) and 1·23 (95% CI 0·97, 1·57), respectively. An association was observed for those aged 20–59 years (adjusted OR 1·92, 95% CI 1·26, 2·90), but not for those 60 and older (adjusted OR 1·08, 95% CI 0·80, 1·46). The adjusted ORs for obesity and severe ILI in 2003–2004, 2004–2005, and during H1N1 were 1·14 (95% CI 0·80, 1·64), 1·24 (95% CI 0·86, 1·79), and 1·76 (95% CI 0·91, 3·42), respectively. Among those with a Charlson Comorbidity Index score of zero, the adjusted ORs for 2003–2004, 2004–2005, and H1N1 were 1·60 (95% CI 0·93, 2·76), 1·43 (95% CI 0·80, 2·56), and 1·90 (95% CI 0·68, 5·27), respectively.</p></sec><sec><title>Conclusions</title><p>Our results suggest a small to moderate association between obesity and hospitalized ILI among adults.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Kumar, A" uniqKey="Kumar A">A Kumar</name></author><author><name sortKey="Zarychanski, R" uniqKey="Zarychanski R">R Zarychanski</name></author><author><name sortKey="Pinto, R" uniqKey="Pinto R">R Pinto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Louie, Jk" uniqKey="Louie J">JK Louie</name></author><author><name sortKey="Acosta, M" uniqKey="Acosta M">M Acosta</name></author><author><name sortKey="Winter, K" uniqKey="Winter K">K Winter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Napolitano, Lm" uniqKey="Napolitano L">LM Napolitano</name></author><author><name sortKey="Park, Pk" uniqKey="Park P">PK Park</name></author><author><name sortKey="Sihler, Kc" uniqKey="Sihler K">KC Sihler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Slopen, Me" uniqKey="Slopen M">ME Slopen</name></author><author><name sortKey="Mosquera, Mc" uniqKey="Mosquera M">MC Mosquera</name></author><author><name sortKey="Balter, S" uniqKey="Balter S">S Balter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ugarte, S" uniqKey="Ugarte S">S Ugarte</name></author><author><name sortKey="Arancibia, F" uniqKey="Arancibia F">F Arancibia</name></author><author><name sortKey="Soto, R" uniqKey="Soto R">R Soto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vaillant, L" uniqKey="Vaillant L">L Vaillant</name></author><author><name sortKey="La Ruche, G" uniqKey="La Ruche G">G La Ruche</name></author><author><name sortKey="Tarantola, A" uniqKey="Tarantola A">A Tarantola</name></author><author><name sortKey="Barboza, P" uniqKey="Barboza P">P Barboza</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fuhrman, C" uniqKey="Fuhrman C">C Fuhrman</name></author><author><name sortKey="Bonmarin, I" uniqKey="Bonmarin I">I Bonmarin</name></author><author><name sortKey="Bitar, D" uniqKey="Bitar D">D Bitar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Louie, Jk" uniqKey="Louie J">JK Louie</name></author><author><name sortKey="Acosta, M" uniqKey="Acosta M">M Acosta</name></author><author><name sortKey="Samuel, Mc" uniqKey="Samuel M">MC Samuel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morgan, Ow" uniqKey="Morgan O">OW Morgan</name></author><author><name sortKey="Bramley, A" uniqKey="Bramley A">A Bramley</name></author><author><name sortKey="Fowlkes, A" uniqKey="Fowlkes A">A Fowlkes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Coleman, La" uniqKey="Coleman L">LA Coleman</name></author><author><name sortKey="Waring, Sc" uniqKey="Waring S">SC Waring</name></author><author><name sortKey="Irving, Sa" uniqKey="Irving S">SA Irving</name></author><author><name sortKey="Vandermause, M" uniqKey="Vandermause M">M Vandermause</name></author><author><name sortKey="Shay, Dk" uniqKey="Shay D">DK Shay</name></author><author><name sortKey="Belongia, Ea" uniqKey="Belongia E">EA Belongia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kwong, Jc" uniqKey="Kwong J">JC Kwong</name></author><author><name sortKey="Campitelli, Ma" uniqKey="Campitelli M">MA Campitelli</name></author><author><name sortKey="Rosella, Lc" uniqKey="Rosella L">LC Rosella</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rothman, Kj" uniqKey="Rothman K">KJ Rothman</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Yih, Wk" uniqKey="Yih W">WK Yih</name></author><author><name sortKey="Caldwell, B" uniqKey="Caldwell B">B Caldwell</name></author><author><name sortKey="Harmon, R" uniqKey="Harmon R">R Harmon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yih, Wk" uniqKey="Yih W">WK Yih</name></author><author><name sortKey="Deshpande, S" uniqKey="Deshpande S">S Deshpande</name></author><author><name sortKey="Fuller, C" uniqKey="Fuller C">C Fuller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Greene, Sk" uniqKey="Greene S">SK Greene</name></author><author><name sortKey="Kulldorff, M" uniqKey="Kulldorff M">M Kulldorff</name></author><author><name sortKey="Huang, J" uniqKey="Huang J">J Huang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Charlson, Me" uniqKey="Charlson M">ME Charlson</name></author><author><name sortKey="Pompei, P" uniqKey="Pompei P">P Pompei</name></author><author><name sortKey="Ales, Kl" uniqKey="Ales K">KL Ales</name></author><author><name sortKey="Mackenzie, Cr" uniqKey="Mackenzie C">CR MacKenzie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey=" Stbye, T" uniqKey=" Stbye T">T Østbye</name></author><author><name sortKey="Taylor, Dh" uniqKey="Taylor D">DH Taylor</name></author><author><name sortKey="Yancy, Ws" uniqKey="Yancy W">WS Yancy</name></author><author><name sortKey="Krause, Km" uniqKey="Krause K">KM Krause</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Influenza Other Respir Viruses</journal-id><journal-id journal-id-type="iso-abbrev">Influenza Other Respir Viruses</journal-id><journal-id journal-id-type="publisher-id">irv</journal-id><journal-title-group><journal-title>Influenza and Other Respiratory Viruses</journal-title></journal-title-group><issn pub-type="ppub">1750-2640</issn><issn pub-type="epub">1750-2659</issn><publisher><publisher-name>Blackwell Publishing Ltd</publisher-name><publisher-loc>Oxford, UK</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23957732</article-id><article-id pub-id-type="pmc">4177795</article-id><article-id pub-id-type="doi">10.1111/irv.12156</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Articles</subject></subj-group></article-categories><title-group><article-title>Obesity as a risk factor for severe influenza-like illness</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Cocoros</surname><given-names>Noelle M</given-names></name><xref ref-type="aff" rid="au1">a</xref></contrib><contrib contrib-type="author"><name><surname>Lash</surname><given-names>Timothy L</given-names></name><xref ref-type="aff" rid="au2">b</xref></contrib><contrib contrib-type="author"><name><surname>DeMaria</surname><given-names>Alfred</given-names></name><xref ref-type="aff" rid="au1">a</xref></contrib><contrib contrib-type="author"><name><surname>Klompas</surname><given-names>Michael</given-names></name><xref ref-type="aff" rid="au3">c</xref></contrib><aff id="au1"><label>a</label><institution>Bureau of Infectious Disease, Massachusetts Department of Public Health</institution><addr-line>Jamaica Plain, MA, USA</addr-line></aff><aff id="au2"><label>b</label><institution>Department of Epidemiology, Rollins School of Public Health, Emory University</institution><addr-line>Atlanta, GA, USA</addr-line></aff><aff id="au3"><label>c</label><institution>Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute</institution><addr-line>Boston, MA, USA</addr-line></aff></contrib-group><author-notes><corresp id="cor1">Noelle M. Cocoros, Massachusetts Department of Public Health, 305 South Street, Jamaica Plain, MA 02130, USA. E-mail: <email>noelle.cocoros@state.ma.us</email></corresp></author-notes><pub-date pub-type="ppub"><month>1</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>20</day><month>8</month><year>2013</year></pub-date><volume>8</volume><issue>1</issue><fpage>25</fpage><lpage>32</lpage><history><date date-type="accepted"><day>24</day><month>7</month><year>2013</year></date></history><permissions><copyright-statement>© 2013 The Authors. <italic>Influenza and Other Respiratory Viruses</italic> Published by John Wiley & Sons Ltd.</copyright-statement><copyright-year>2013</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/3.0/"><license-p>This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><sec><title>Background</title><p>Obesity was recognized as in independent risk factor for influenza during the 2009 H1N1 influenza pandemic.</p></sec><sec><title>Objectives</title><p>We evaluated the association between body mass index (BMI) and influenza-like illness (ILI) during two non-pandemic influenza seasons (2003–2004 and 2004–2005) and during the spring and fall waves of the 2009 H1N1 pandemic.</p></sec><sec><title>Methods</title><p>Adults with severe (inpatient) and mild (outpatient) ILI were compared to those without ILI using a case-cohort design. The study was nested among those insured by a single health insurance company, receiving care from a large multispecialty practice. Data were collected from insurance claims and the electronic health record. The primary exposure was obesity (BMI ≥ 30·0 kg/m<sup>2</sup>).</p></sec><sec><title>Results</title><p>Across three seasons, the crude and adjusted ORs for obesity and severe ILI were 1·65 (95% CI 1·31, 2·08) and 1·23 (95% CI 0·97, 1·57), respectively. An association was observed for those aged 20–59 years (adjusted OR 1·92, 95% CI 1·26, 2·90), but not for those 60 and older (adjusted OR 1·08, 95% CI 0·80, 1·46). The adjusted ORs for obesity and severe ILI in 2003–2004, 2004–2005, and during H1N1 were 1·14 (95% CI 0·80, 1·64), 1·24 (95% CI 0·86, 1·79), and 1·76 (95% CI 0·91, 3·42), respectively. Among those with a Charlson Comorbidity Index score of zero, the adjusted ORs for 2003–2004, 2004–2005, and H1N1 were 1·60 (95% CI 0·93, 2·76), 1·43 (95% CI 0·80, 2·56), and 1·90 (95% CI 0·68, 5·27), respectively.</p></sec><sec><title>Conclusions</title><p>Our results suggest a small to moderate association between obesity and hospitalized ILI among adults.</p></sec></abstract><kwd-group><kwd>BMI</kwd><kwd>influenza</kwd><kwd>obesity</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li><li>Massachusetts</li></region></list><tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Cocoros, Noelle M" sort="Cocoros, Noelle M" uniqKey="Cocoros N" first="Noelle M" last="Cocoros">Noelle M. Cocoros</name></region><name sortKey="Demaria, Alfred" sort="Demaria, Alfred" uniqKey="Demaria A" first="Alfred" last="Demaria">Alfred Demaria</name><name sortKey="Klompas, Michael" sort="Klompas, Michael" uniqKey="Klompas M" first="Michael" last="Klompas">Michael Klompas</name><name sortKey="Lash, Timothy L" sort="Lash, Timothy L" uniqKey="Lash T" first="Timothy L" last="Lash">Timothy L. Lash</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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