PandemieGrippaleV1, Main, Exploration, bibRecord, 001011

Summary of knowledge gaps related to quality and efficacy of current influenza vaccines

Identifieur interne : 001011 ( Main/Exploration ); précédent : 001010; suivant : 001012

Summary of knowledge gaps related to quality and efficacy of current influenza vaccines

Auteurs : Michael Pfleiderer [Allemagne] ; Jean-Hugues Trouvin [France] ; Daniel Brasseur [Belgique] ; Marta Gr Nstrom [Suède] ; Ragini Shivji [Royaume-Uni] ; Manuela Mura [Royaume-Uni] ; Marco Cavaleri [Royaume-Uni]

Source :

Vaccine [ 0264-410X ] ; 2014.

RBID : Pascal:14-0190716

Descripteurs français

Pascal (Inist)
- Efficacité, Vaccin, Vaccination, Sérologie, Grippe.
Wicri :
- topic : Vaccin, Vaccination.

English descriptors

KwdEn :
- Efficiency, Influenza, Serology, Vaccination, Vaccine.

Abstract

Influenza viruses are a public health threat, as they are pathogenic, highly transmissible and prone to genetic changes. For decades vaccination strategies have been based on trivalent inactivated vaccines, which are regulated by specific guidelines. The progress in scientific knowledge and the lessons learned from the A(H1N1)2009 pandemic have highlighted further the need to improve current guidelines, including the immunogenicity criteria set by the CHMP in 1997, and to promote the discussion on the shortcomings encountered, e.g. the evaluation of vaccine efficacy in the paediatric and elderly populations, the measurement of the naivety of a population, the impact of prior immunity on subsequent vaccinations, and the technical issues with the serological assays for detection of immunity and immunogenicity. The authors attempted to summarise and tackle key gaps in the existing evidence concerning quality and efficacy of influenza vaccines, aiming at favouring a common understanding and a coordinated approach across stakeholders.

Affiliations:

Allemagne, Belgique, France, Royaume-Uni, Suède
Svealand, Vienne (Autriche), Île-de-France
Paris, Stockholm, Vienne (Autriche)

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000064
to stream PascalFrancis, to step Curation: 001D55
to stream PascalFrancis, to step Checkpoint: 000018
to stream Main, to step Merge: 001019
to stream Main, to step Curation: 001011

Le document en format XML

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<front><div type="abstract" xml:lang="en">Influenza viruses are a public health threat, as they are pathogenic, highly transmissible and prone to genetic changes. For decades vaccination strategies have been based on trivalent inactivated vaccines, which are regulated by specific guidelines. The progress in scientific knowledge and the lessons learned from the A(H1N1)2009 pandemic have highlighted further the need to improve current guidelines, including the immunogenicity criteria set by the CHMP in 1997, and to promote the discussion on the shortcomings encountered, e.g. the evaluation of vaccine efficacy in the paediatric and elderly populations, the measurement of the naivety of a population, the impact of prior immunity on subsequent vaccinations, and the technical issues with the serological assays for detection of immunity and immunogenicity. The authors attempted to summarise and tackle key gaps in the existing evidence concerning quality and efficacy of influenza vaccines, aiming at favouring a common understanding and a coordinated approach across stakeholders.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Belgique</li>
<li>France</li>
<li>Royaume-Uni</li>
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<li>Vienne (Autriche)</li>
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<tree><country name="Allemagne"><noRegion><name sortKey="Pfleiderer, Michael" sort="Pfleiderer, Michael" uniqKey="Pfleiderer M" first="Michael" last="Pfleiderer">Michael Pfleiderer</name>
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<country name="France"><region name="Île-de-France"><name sortKey="Trouvin, Jean Hugues" sort="Trouvin, Jean Hugues" uniqKey="Trouvin J" first="Jean-Hugues" last="Trouvin">Jean-Hugues Trouvin</name>
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<country name="Belgique"><region name="Vienne (Autriche)"><name sortKey="Brasseur, Daniel" sort="Brasseur, Daniel" uniqKey="Brasseur D" first="Daniel" last="Brasseur">Daniel Brasseur</name>
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<country name="Suède"><region name="Svealand"><name sortKey="Gr Nstrom, Marta" sort="Gr Nstrom, Marta" uniqKey="Gr Nstrom M" first="Marta" last="Gr Nstrom">Marta Gr Nstrom</name>
</region>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Shivji, Ragini" sort="Shivji, Ragini" uniqKey="Shivji R" first="Ragini" last="Shivji">Ragini Shivji</name>
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<name sortKey="Cavaleri, Marco" sort="Cavaleri, Marco" uniqKey="Cavaleri M" first="Marco" last="Cavaleri">Marco Cavaleri</name>
<name sortKey="Mura, Manuela" sort="Mura, Manuela" uniqKey="Mura M" first="Manuela" last="Mura">Manuela Mura</name>
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</record>

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Summary of knowledge gaps related to quality and efficacy of current influenza vaccines

Summary of knowledge gaps related to quality and efficacy of current influenza vaccines

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri