Summary of knowledge gaps related to quality and efficacy of current influenza vaccines
Identifieur interne : 000064 ( PascalFrancis/Corpus ); précédent : 000063; suivant : 000065Summary of knowledge gaps related to quality and efficacy of current influenza vaccines
Auteurs : Michael Pfleiderer ; Jean-Hugues Trouvin ; Daniel Brasseur ; Marta Gr Nstrom ; Ragini Shivji ; Manuela Mura ; Marco CavaleriSource :
- Vaccine [ 0264-410X ] ; 2014.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Influenza viruses are a public health threat, as they are pathogenic, highly transmissible and prone to genetic changes. For decades vaccination strategies have been based on trivalent inactivated vaccines, which are regulated by specific guidelines. The progress in scientific knowledge and the lessons learned from the A(H1N1)2009 pandemic have highlighted further the need to improve current guidelines, including the immunogenicity criteria set by the CHMP in 1997, and to promote the discussion on the shortcomings encountered, e.g. the evaluation of vaccine efficacy in the paediatric and elderly populations, the measurement of the naivety of a population, the impact of prior immunity on subsequent vaccinations, and the technical issues with the serological assays for detection of immunity and immunogenicity. The authors attempted to summarise and tackle key gaps in the existing evidence concerning quality and efficacy of influenza vaccines, aiming at favouring a common understanding and a coordinated approach across stakeholders.
Notice en format standard (ISO 2709)
Pour connaître la documentation sur le format Inist Standard.
pA |
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Format Inist (serveur)
NO : | PASCAL 14-0190716 INIST |
---|---|
ET : | Summary of knowledge gaps related to quality and efficacy of current influenza vaccines |
AU : | PFLEIDERER (Michael); TROUVIN (Jean-Hugues); BRASSEUR (Daniel); GRÄNSTROM (Marta); SHIVJI (Ragini); MURA (Manuela); CAVALERI (Marco) |
AF : | Vaccine Working Party of the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA)/Europe (1 aut., 3 aut., 4 aut.); Federal Institute for Vaccines and Biomedicines, Paul-Ehrlich-Strasse 51-59/63225 Langen/Allemagne (1 aut.); Paris Descartes University, School of Pharmacy, Health Safety and Public Health Department/Paris/France (2 aut.); Agence Fédérale des Medicaments et des Produits de Santé, Batiment EUROSTATION, bloc 2, place Victor Horta, 40/40/1060 Brussels/Belgique (3 aut.); Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA)/Europe (3 aut.); MTC, Karolinska Institutet/Stockholm/Suède (4 aut.); Paediatric Committee of the European Medicines Agency (EMA)/Europe (4 aut.); European Medicines Agency (EMA), 7 Westferry Circus, Canary Wharf/London E14 4HB/Royaume-Uni (5 aut., 6 aut., 7 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Vaccine; ISSN 0264-410X; Coden VACCDE; Royaume-Uni; Da. 2014; Vol. 32; No. 35; Pp. 4586-4591; Bibl. 24 ref. |
LA : | Anglais |
EA : | Influenza viruses are a public health threat, as they are pathogenic, highly transmissible and prone to genetic changes. For decades vaccination strategies have been based on trivalent inactivated vaccines, which are regulated by specific guidelines. The progress in scientific knowledge and the lessons learned from the A(H1N1)2009 pandemic have highlighted further the need to improve current guidelines, including the immunogenicity criteria set by the CHMP in 1997, and to promote the discussion on the shortcomings encountered, e.g. the evaluation of vaccine efficacy in the paediatric and elderly populations, the measurement of the naivety of a population, the impact of prior immunity on subsequent vaccinations, and the technical issues with the serological assays for detection of immunity and immunogenicity. The authors attempted to summarise and tackle key gaps in the existing evidence concerning quality and efficacy of influenza vaccines, aiming at favouring a common understanding and a coordinated approach across stakeholders. |
CC : | 002A05F04 |
FD : | Efficacité; Vaccin; Vaccination; Sérologie; Grippe |
FG : | Virose; Infection |
ED : | Efficiency; Vaccine; Vaccination; Serology; Influenza |
EG : | Viral disease; Infection |
SD : | Eficacia; Vacuna; Vacunación; Serología; Gripe |
LO : | INIST-20289.354000150336410320 |
ID : | 14-0190716 |
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Pascal:14-0190716Le document en format XML
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<front><div type="abstract" xml:lang="en">Influenza viruses are a public health threat, as they are pathogenic, highly transmissible and prone to genetic changes. For decades vaccination strategies have been based on trivalent inactivated vaccines, which are regulated by specific guidelines. The progress in scientific knowledge and the lessons learned from the A(H1N1)2009 pandemic have highlighted further the need to improve current guidelines, including the immunogenicity criteria set by the CHMP in 1997, and to promote the discussion on the shortcomings encountered, e.g. the evaluation of vaccine efficacy in the paediatric and elderly populations, the measurement of the naivety of a population, the impact of prior immunity on subsequent vaccinations, and the technical issues with the serological assays for detection of immunity and immunogenicity. The authors attempted to summarise and tackle key gaps in the existing evidence concerning quality and efficacy of influenza vaccines, aiming at favouring a common understanding and a coordinated approach across stakeholders.</div>
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<ET>Summary of knowledge gaps related to quality and efficacy of current influenza vaccines</ET>
<AU>PFLEIDERER (Michael); TROUVIN (Jean-Hugues); BRASSEUR (Daniel); GRÄNSTROM (Marta); SHIVJI (Ragini); MURA (Manuela); CAVALERI (Marco)</AU>
<AF>Vaccine Working Party of the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA)/Europe (1 aut., 3 aut., 4 aut.); Federal Institute for Vaccines and Biomedicines, Paul-Ehrlich-Strasse 51-59/63225 Langen/Allemagne (1 aut.); Paris Descartes University, School of Pharmacy, Health Safety and Public Health Department/Paris/France (2 aut.); Agence Fédérale des Medicaments et des Produits de Santé, Batiment EUROSTATION, bloc 2, place Victor Horta, 40/40/1060 Brussels/Belgique (3 aut.); Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA)/Europe (3 aut.); MTC, Karolinska Institutet/Stockholm/Suède (4 aut.); Paediatric Committee of the European Medicines Agency (EMA)/Europe (4 aut.); European Medicines Agency (EMA), 7 Westferry Circus, Canary Wharf/London E14 4HB/Royaume-Uni (5 aut., 6 aut., 7 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Vaccine; ISSN 0264-410X; Coden VACCDE; Royaume-Uni; Da. 2014; Vol. 32; No. 35; Pp. 4586-4591; Bibl. 24 ref.</SO>
<LA>Anglais</LA>
<EA>Influenza viruses are a public health threat, as they are pathogenic, highly transmissible and prone to genetic changes. For decades vaccination strategies have been based on trivalent inactivated vaccines, which are regulated by specific guidelines. The progress in scientific knowledge and the lessons learned from the A(H1N1)2009 pandemic have highlighted further the need to improve current guidelines, including the immunogenicity criteria set by the CHMP in 1997, and to promote the discussion on the shortcomings encountered, e.g. the evaluation of vaccine efficacy in the paediatric and elderly populations, the measurement of the naivety of a population, the impact of prior immunity on subsequent vaccinations, and the technical issues with the serological assays for detection of immunity and immunogenicity. The authors attempted to summarise and tackle key gaps in the existing evidence concerning quality and efficacy of influenza vaccines, aiming at favouring a common understanding and a coordinated approach across stakeholders.</EA>
<CC>002A05F04</CC>
<FD>Efficacité; Vaccin; Vaccination; Sérologie; Grippe</FD>
<FG>Virose; Infection</FG>
<ED>Efficiency; Vaccine; Vaccination; Serology; Influenza</ED>
<EG>Viral disease; Infection</EG>
<SD>Eficacia; Vacuna; Vacunación; Serología; Gripe</SD>
<LO>INIST-20289.354000150336410320</LO>
<ID>14-0190716</ID>
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