Early vaccine availability represents an important public health advance for the control of pandemic influenza
Identifieur interne : 001A26 ( Ncbi/Merge ); précédent : 001A25; suivant : 001A27Early vaccine availability represents an important public health advance for the control of pandemic influenza
Auteurs : Amy L. GreerSource :
- BMC Research Notes [ 1756-0500 ] ; 2015.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Canada (épidémiologie), Enfant, Enfant d'âge préscolaire, Grippe humaine (), Grippe humaine (immunologie), Grippe humaine (épidémiologie), Humains, Jeune adulte, Modèles biologiques, Nourrisson, Nouveau-né, Pandémies (), Plantes, Résultat thérapeutique, Saisons, Santé publique, Sujet âgé, Vaccination, Vaccins antigrippaux (immunologie).
- MESH :
- immunologie : Grippe humaine, Vaccins antigrippaux.
- épidémiologie : Canada, Grippe humaine.
- Adolescent, Adulte, Adulte d'âge moyen, Enfant, Enfant d'âge préscolaire, Grippe humaine, Humains, Jeune adulte, Modèles biologiques, Nourrisson, Nouveau-né, Pandémies, Plantes, Résultat thérapeutique, Saisons, Santé publique, Sujet âgé, Vaccination.
- Wicri :
- geographic : Canada.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Canada (epidemiology), Child, Child, Preschool, Humans, Infant, Infant, Newborn, Influenza Vaccines (immunology), Influenza, Human (epidemiology), Influenza, Human (immunology), Influenza, Human (prevention & control), Middle Aged, Models, Biological, Pandemics (prevention & control), Plants, Public Health, Seasons, Treatment Outcome, Vaccination, Young Adult.
- MESH :
- chemical , immunology : Influenza Vaccines.
- geographic , epidemiology : Canada.
- epidemiology : Influenza, Human.
- immunology : Influenza, Human.
- prevention & control : Influenza, Human, Pandemics.
- Adolescent, Adult, Aged, Child, Child, Preschool, Humans, Infant, Infant, Newborn, Middle Aged, Models, Biological, Plants, Public Health, Seasons, Treatment Outcome, Vaccination, Young Adult.
Abstract
Traditional processes for the production of pandemic influenza vaccines are not capable of producing a vaccine that could be deployed sooner than 5–6 months after strain identification. Plant-based vaccine technologies are of public health interest because they represent an opportunity to begin vaccinating earlier.
We used an age- and risk- structured disease transmission model for Canada to evaluate the potential impact of a plant-produced vaccine available for rapid deployment (within 1–3 months) compared to an egg-based vaccine timeline.
We found that in the case of a mildly transmissible virus (
Pandemic influenza vaccines produced by plants, change the timeline of pandemic vaccine availability in a way that could significantly mitigate the impact of the next influenza pandemic.
Url:
DOI: 10.1186/s13104-015-1157-1
PubMed: 25953076
PubMed Central: 4427977
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PMC:4427977Le document en format XML
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Greer</name><affiliation><nlm:aff id="Aff1">Department of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1 Canada</nlm:aff><wicri:noCountry code="subfield">ON N1G 2W1 Canada</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25953076</idno><idno type="pmc">4427977</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427977</idno><idno type="RBID">PMC:4427977</idno><idno type="doi">10.1186/s13104-015-1157-1</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000221</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000221</idno><idno type="wicri:Area/Pmc/Curation">000221</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000221</idno><idno type="wicri:Area/Pmc/Checkpoint">000391</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000391</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:25953076</idno><idno type="wicri:Area/PubMed/Corpus">000660</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000660</idno><idno type="wicri:Area/PubMed/Curation">000660</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000660</idno><idno type="wicri:Area/PubMed/Checkpoint">000661</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000661</idno><idno type="wicri:Area/Ncbi/Merge">001A26</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Early vaccine availability represents an important public health advance for the control of pandemic influenza</title><author><name sortKey="Greer, Amy L" sort="Greer, Amy L" uniqKey="Greer A" first="Amy L" last="Greer">Amy L. Greer</name><affiliation><nlm:aff id="Aff1">Department of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1 Canada</nlm:aff><wicri:noCountry code="subfield">ON N1G 2W1 Canada</wicri:noCountry></affiliation></author></analytic><series><title level="j">BMC Research Notes</title><idno type="eISSN">1756-0500</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Canada (epidemiology)</term><term>Child</term><term>Child, Preschool</term><term>Humans</term><term>Infant</term><term>Infant, Newborn</term><term>Influenza Vaccines (immunology)</term><term>Influenza, Human (epidemiology)</term><term>Influenza, Human (immunology)</term><term>Influenza, Human (prevention & control)</term><term>Middle Aged</term><term>Models, Biological</term><term>Pandemics (prevention & control)</term><term>Plants</term><term>Public Health</term><term>Seasons</term><term>Treatment Outcome</term><term>Vaccination</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Canada (épidémiologie)</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Grippe humaine ()</term><term>Grippe humaine (immunologie)</term><term>Grippe humaine (épidémiologie)</term><term>Humains</term><term>Jeune adulte</term><term>Modèles biologiques</term><term>Nourrisson</term><term>Nouveau-né</term><term>Pandémies ()</term><term>Plantes</term><term>Résultat thérapeutique</term><term>Saisons</term><term>Santé publique</term><term>Sujet âgé</term><term>Vaccination</term><term>Vaccins antigrippaux (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Canada</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Grippe humaine</term><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Influenza, Human</term><term>Pandemics</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Canada</term><term>Grippe humaine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Child</term><term>Child, Preschool</term><term>Humans</term><term>Infant</term><term>Infant, Newborn</term><term>Middle Aged</term><term>Models, Biological</term><term>Plants</term><term>Public Health</term><term>Seasons</term><term>Treatment Outcome</term><term>Vaccination</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Grippe humaine</term><term>Humains</term><term>Jeune adulte</term><term>Modèles biologiques</term><term>Nourrisson</term><term>Nouveau-né</term><term>Pandémies</term><term>Plantes</term><term>Résultat thérapeutique</term><term>Saisons</term><term>Santé publique</term><term>Sujet âgé</term><term>Vaccination</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Canada</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Traditional processes for the production of pandemic influenza vaccines are not capable of producing a vaccine that could be deployed sooner than 5–6 months after strain identification. Plant-based vaccine technologies are of public health interest because they represent an opportunity to begin vaccinating earlier.</p></sec><sec><title>Methods</title><p>We used an age- and risk- structured disease transmission model for Canada to evaluate the potential impact of a plant-produced vaccine available for rapid deployment (within 1–3 months) compared to an egg-based vaccine timeline.</p></sec><sec><title>Results</title><p>We found that in the case of a mildly transmissible virus (<italic>R0</italic> = 1.3), depending on the amount of plant-based vaccine produced per week, severe clinical outcomes could be decreased by 60–100 % if vaccine was available within 3 months of strain identification. However, in the case of a highly transmissible virus (<italic>R0</italic> = 2.0), a delay of 3 months does not change clinical outcomes regardless of the level of weekly vaccine availability. If transmissibility is high, the only strategy that can impact clinical outcomes occurs if vaccine production is high and available within 2 months.</p></sec><sec><title>Conclusions</title><p>Pandemic influenza vaccines produced by plants, change the timeline of pandemic vaccine availability in a way that could significantly mitigate the impact of the next influenza pandemic.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Funk, Dj" uniqKey="Funk D">DJ Funk</name></author><author><name sortKey="Siddiqui, F" uniqKey="Siddiqui F">F Siddiqui</name></author><author><name sortKey="Wiebe, K" uniqKey="Wiebe K">K Wiebe</name></author><author><name sortKey="Miller, Rr" uniqKey="Miller R">RR Miller</name></author><author><name sortKey="Bautista, E" uniqKey="Bautista E">E Bautista</name></author><author><name sortKey="Jimenez, E" uniqKey="Jimenez E">E Jimenez</name></author></analytic></biblStruct><biblStruct><analytic><author><name 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uniqKey="Zhong W">W Zhong</name></author><author><name sortKey="Butler, En" uniqKey="Butler E">EN Butler</name></author><author><name sortKey="Sun, H" uniqKey="Sun H">H Sun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Longini, Im" uniqKey="Longini I">IM Longini</name></author><author><name sortKey="Halloran, Me" uniqKey="Halloran M">ME Halloran</name></author><author><name sortKey="Nizam, A" uniqKey="Nizam A">A Nizam</name></author><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y Yang</name></author></analytic></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><double pmid="25953076"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Early vaccine availability represents an important public health advance for the control of pandemic influenza</title><author><name sortKey="Greer, Amy L" sort="Greer, Amy L" uniqKey="Greer A" first="Amy L" last="Greer">Amy L. Greer</name><affiliation><nlm:aff id="Aff1">Department of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1 Canada</nlm:aff><wicri:noCountry code="subfield">ON N1G 2W1 Canada</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25953076</idno><idno type="pmc">4427977</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427977</idno><idno type="RBID">PMC:4427977</idno><idno type="doi">10.1186/s13104-015-1157-1</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000221</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000221</idno><idno type="wicri:Area/Pmc/Curation">000221</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000221</idno><idno type="wicri:Area/Pmc/Checkpoint">000391</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000391</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Early vaccine availability represents an important public health advance for the control of pandemic influenza</title><author><name sortKey="Greer, Amy L" sort="Greer, Amy L" uniqKey="Greer A" first="Amy L" last="Greer">Amy L. Greer</name><affiliation><nlm:aff id="Aff1">Department of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1 Canada</nlm:aff><wicri:noCountry code="subfield">ON N1G 2W1 Canada</wicri:noCountry></affiliation></author></analytic><series><title level="j">BMC Research Notes</title><idno type="eISSN">1756-0500</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Traditional processes for the production of pandemic influenza vaccines are not capable of producing a vaccine that could be deployed sooner than 5–6 months after strain identification. Plant-based vaccine technologies are of public health interest because they represent an opportunity to begin vaccinating earlier.</p></sec><sec><title>Methods</title><p>We used an age- and risk- structured disease transmission model for Canada to evaluate the potential impact of a plant-produced vaccine available for rapid deployment (within 1–3 months) compared to an egg-based vaccine timeline.</p></sec><sec><title>Results</title><p>We found that in the case of a mildly transmissible virus (<italic>R0</italic> = 1.3), depending on the amount of plant-based vaccine produced per week, severe clinical outcomes could be decreased by 60–100 % if vaccine was available within 3 months of strain identification. However, in the case of a highly transmissible virus (<italic>R0</italic> = 2.0), a delay of 3 months does not change clinical outcomes regardless of the level of weekly vaccine availability. If transmissibility is high, the only strategy that can impact clinical outcomes occurs if vaccine production is high and available within 2 months.</p></sec><sec><title>Conclusions</title><p>Pandemic influenza vaccines produced by plants, change the timeline of pandemic vaccine availability in a way that could significantly mitigate the impact of the next influenza pandemic.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Funk, Dj" uniqKey="Funk D">DJ Funk</name></author><author><name sortKey="Siddiqui, F" uniqKey="Siddiqui F">F Siddiqui</name></author><author><name sortKey="Wiebe, K" uniqKey="Wiebe K">K Wiebe</name></author><author><name sortKey="Miller, Rr" uniqKey="Miller R">RR Miller</name></author><author><name sortKey="Bautista, E" uniqKey="Bautista E">E Bautista</name></author><author><name sortKey="Jimenez, E" uniqKey="Jimenez E">E Jimenez</name></author></analytic></biblStruct><biblStruct><analytic><author><name 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uniqKey="Zhong W">W Zhong</name></author><author><name sortKey="Butler, En" uniqKey="Butler E">EN Butler</name></author><author><name sortKey="Sun, H" uniqKey="Sun H">H Sun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Longini, Im" uniqKey="Longini I">IM Longini</name></author><author><name sortKey="Halloran, Me" uniqKey="Halloran M">ME Halloran</name></author><author><name sortKey="Nizam, A" uniqKey="Nizam A">A Nizam</name></author><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y Yang</name></author></analytic></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI></pmc><pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Early vaccine availability represents an important public health advance for the control of pandemic influenza.</title><author><name sortKey="Greer, Amy L" sort="Greer, Amy L" uniqKey="Greer A" first="Amy L" last="Greer">Amy L. Greer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, ON, N1G 2W1, Canada. agreer@uoguelph.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, ON, N1G 2W1</wicri:regionArea><wicri:noRegion>N1G 2W1</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25953076</idno><idno type="pmid">25953076</idno><idno type="doi">10.1186/s13104-015-1157-1</idno><idno type="wicri:Area/PubMed/Corpus">000660</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000660</idno><idno type="wicri:Area/PubMed/Curation">000660</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000660</idno><idno type="wicri:Area/PubMed/Checkpoint">000661</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000661</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Early vaccine availability represents an important public health advance for the control of pandemic influenza.</title><author><name sortKey="Greer, Amy L" sort="Greer, Amy L" uniqKey="Greer A" first="Amy L" last="Greer">Amy L. Greer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, ON, N1G 2W1, Canada. agreer@uoguelph.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, ON, N1G 2W1</wicri:regionArea><wicri:noRegion>N1G 2W1</wicri:noRegion></affiliation></author></analytic><series><title level="j">BMC research notes</title><idno type="eISSN">1756-0500</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Canada (epidemiology)</term><term>Child</term><term>Child, Preschool</term><term>Humans</term><term>Infant</term><term>Infant, Newborn</term><term>Influenza Vaccines (immunology)</term><term>Influenza, Human (epidemiology)</term><term>Influenza, Human (immunology)</term><term>Influenza, Human (prevention & control)</term><term>Middle Aged</term><term>Models, Biological</term><term>Pandemics (prevention & control)</term><term>Plants</term><term>Public Health</term><term>Seasons</term><term>Treatment Outcome</term><term>Vaccination</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Canada (épidémiologie)</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Grippe humaine ()</term><term>Grippe humaine (immunologie)</term><term>Grippe humaine (épidémiologie)</term><term>Humains</term><term>Jeune adulte</term><term>Modèles biologiques</term><term>Nourrisson</term><term>Nouveau-né</term><term>Pandémies ()</term><term>Plantes</term><term>Résultat thérapeutique</term><term>Saisons</term><term>Santé publique</term><term>Sujet âgé</term><term>Vaccination</term><term>Vaccins antigrippaux (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Canada</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Grippe humaine</term><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Influenza, Human</term><term>Pandemics</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Canada</term><term>Grippe humaine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Child</term><term>Child, Preschool</term><term>Humans</term><term>Infant</term><term>Infant, Newborn</term><term>Middle Aged</term><term>Models, Biological</term><term>Plants</term><term>Public Health</term><term>Seasons</term><term>Treatment Outcome</term><term>Vaccination</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Grippe humaine</term><term>Humains</term><term>Jeune adulte</term><term>Modèles biologiques</term><term>Nourrisson</term><term>Nouveau-né</term><term>Pandémies</term><term>Plantes</term><term>Résultat thérapeutique</term><term>Saisons</term><term>Santé publique</term><term>Sujet âgé</term><term>Vaccination</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Canada</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Traditional processes for the production of pandemic influenza vaccines are not capable of producing a vaccine that could be deployed sooner than 5-6 months after strain identification. Plant-based vaccine technologies are of public health interest because they represent an opportunity to begin vaccinating earlier.</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
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