Determining the Mutation Bias of Favipiravir in Influenza Virus Using Next-Generation Sequencing
Identifieur interne : 000355 ( Main/Exploration ); précédent : 000354; suivant : 000356Determining the Mutation Bias of Favipiravir in Influenza Virus Using Next-Generation Sequencing
Auteurs : Daniel H. Goldhill [Royaume-Uni] ; Pinky Langat [Royaume-Uni] ; Hongyao Xie [Royaume-Uni] ; Monica Galiano [Royaume-Uni] ; Shahjahan Miah [Royaume-Uni] ; Paul Kellam [Royaume-Uni] ; Maria Zambon [Royaume-Uni] ; Angie Lackenby [Royaume-Uni] ; Wendy S. Barclay [Royaume-Uni]Source :
- Journal of Virology [ 0022-538X ] ; 2019.
Descripteurs français
- KwdFr :
- MESH :
- génétique : Amorces ADN, Virus de la grippe A.
- pharmacologie : Amides, Pyrazines.
- Analyse de séquence d'ARN, Animaux, Cellules HEK293, Cellules rénales canines Madin-Darby, Chiens, Humains, Mutation, Séquençage nucléotidique à haut débit, Virus de la grippe A.
English descriptors
- KwdEn :
- Amides (pharmacology), Animals, Bias, DNA Primers (genetics), Dogs, HEK293 Cells, High-Throughput Nucleotide Sequencing (methods), Humans, Influenza A virus (drug effects), Influenza A virus (genetics), Madin Darby Canine Kidney Cells, Mutation, Pyrazines (pharmacology), Sequence Analysis, RNA, Whole Genome Sequencing.
- MESH :
- chemical , genetics : DNA Primers.
- chemical , pharmacology : Amides, Pyrazines.
- drug effects : Influenza A virus.
- genetics : Influenza A virus.
- methods : High-Throughput Nucleotide Sequencing.
- Animals, Bias, Dogs, HEK293 Cells, Humans, Madin Darby Canine Kidney Cells, Mutation, Sequence Analysis, RNA, Whole Genome Sequencing.
Abstract
New antiviral drugs are needed as a first line of defense in the event of a novel influenza pandemic. Favipiravir is a broad-spectrum antiviral which is effective against influenza. The exact mechanism of how favipiravir works to inhibit influenza is still unclear. We used next-generation sequencing (NGS) to demonstrate that favipiravir causes mutations in influenza RNA. The greater depth of NGS sequence information over traditional sequencing methods allowed us to precisely determine the bias of particular mutations caused by favipiravir. NGS can also be used in a standard diagnostic pipeline to show that favipiravir is acting on the virus by revealing the mutation bias pattern typical to the drug. Our work will aid in testing whether viruses are resistant to favipiravir and may help demonstrate the effect of favipiravir on viruses in a clinical setting. This will be important if favipiravir is used during a future influenza pandemic.
Url:
DOI: 10.1128/JVI.01217-18
PubMed: 30381482
PubMed Central: 6321902
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000B53
- to stream Pmc, to step Curation: 000B53
- to stream Pmc, to step Checkpoint: 000080
- to stream PubMed, to step Corpus: 000205
- to stream PubMed, to step Curation: 000205
- to stream PubMed, to step Checkpoint: 000156
- to stream Ncbi, to step Merge: 001E87
- to stream Ncbi, to step Curation: 001E87
- to stream Ncbi, to step Checkpoint: 001E87
- to stream Main, to step Merge: 000354
- to stream Main, to step Curation: 000355
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Determining the Mutation Bias of Favipiravir in Influenza Virus Using Next-Generation Sequencing</title><author><name sortKey="Goldhill, Daniel H" sort="Goldhill, Daniel H" uniqKey="Goldhill D" first="Daniel H." last="Goldhill">Daniel H. Goldhill</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Public Health England, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Public Health England, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Department of Virology, Faculty of Medicine, Imperial College, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Virology, Faculty of Medicine, Imperial College, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Langat, Pinky" sort="Langat, Pinky" uniqKey="Langat P" first="Pinky" last="Langat">Pinky Langat</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Department of Virology, Faculty of Medicine, Imperial College, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Virology, Faculty of Medicine, Imperial College, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Xie, Hongyao" sort="Xie, Hongyao" uniqKey="Xie H" first="Hongyao" last="Xie">Hongyao Xie</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Department of Virology, Faculty of Medicine, Imperial College, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Virology, Faculty of Medicine, Imperial College, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Galiano, Monica" sort="Galiano, Monica" uniqKey="Galiano M" first="Monica" last="Galiano">Monica Galiano</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Public Health England, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Public Health England, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Miah, Shahjahan" sort="Miah, Shahjahan" uniqKey="Miah S" first="Shahjahan" last="Miah">Shahjahan Miah</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Public Health England, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Public Health England, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Kellam, Paul" sort="Kellam, Paul" uniqKey="Kellam P" first="Paul" last="Kellam">Paul Kellam</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Department of Virology, Faculty of Medicine, Imperial College, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Virology, Faculty of Medicine, Imperial College, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Zambon, Maria" sort="Zambon, Maria" uniqKey="Zambon M" first="Maria" last="Zambon">Maria Zambon</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Public Health England, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Public Health England, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Lackenby, Angie" sort="Lackenby, Angie" uniqKey="Lackenby A" first="Angie" last="Lackenby">Angie Lackenby</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Public Health England, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Public Health England, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Barclay, Wendy S" sort="Barclay, Wendy S" uniqKey="Barclay W" first="Wendy S." last="Barclay">Wendy S. Barclay</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Department of Virology, Faculty of Medicine, Imperial College, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Virology, Faculty of Medicine, Imperial College, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">30381482</idno><idno type="pmc">6321902</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321902</idno><idno type="RBID">PMC:6321902</idno><idno type="doi">10.1128/JVI.01217-18</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000B53</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000B53</idno><idno type="wicri:Area/Pmc/Curation">000B53</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000B53</idno><idno type="wicri:Area/Pmc/Checkpoint">000080</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000080</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:30381482</idno><idno type="wicri:Area/PubMed/Corpus">000205</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000205</idno><idno type="wicri:Area/PubMed/Curation">000205</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000205</idno><idno type="wicri:Area/PubMed/Checkpoint">000156</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000156</idno><idno type="wicri:Area/Ncbi/Merge">001E87</idno><idno type="wicri:Area/Ncbi/Curation">001E87</idno><idno type="wicri:Area/Ncbi/Checkpoint">001E87</idno><idno type="wicri:doubleKey">0022-538X:2019:Goldhill D:determining:the:mutation</idno><idno type="wicri:Area/Main/Merge">000354</idno><idno type="wicri:Area/Main/Curation">000355</idno><idno type="wicri:Area/Main/Exploration">000355</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Determining the Mutation Bias of Favipiravir in Influenza Virus Using Next-Generation Sequencing</title><author><name sortKey="Goldhill, Daniel H" sort="Goldhill, Daniel H" uniqKey="Goldhill D" first="Daniel H." last="Goldhill">Daniel H. Goldhill</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Public Health England, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Public Health England, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Department of Virology, Faculty of Medicine, Imperial College, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Virology, Faculty of Medicine, Imperial College, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Langat, Pinky" sort="Langat, Pinky" uniqKey="Langat P" first="Pinky" last="Langat">Pinky Langat</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Department of Virology, Faculty of Medicine, Imperial College, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Virology, Faculty of Medicine, Imperial College, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Xie, Hongyao" sort="Xie, Hongyao" uniqKey="Xie H" first="Hongyao" last="Xie">Hongyao Xie</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Department of Virology, Faculty of Medicine, Imperial College, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Virology, Faculty of Medicine, Imperial College, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Galiano, Monica" sort="Galiano, Monica" uniqKey="Galiano M" first="Monica" last="Galiano">Monica Galiano</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Public Health England, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Public Health England, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Miah, Shahjahan" sort="Miah, Shahjahan" uniqKey="Miah S" first="Shahjahan" last="Miah">Shahjahan Miah</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Public Health England, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Public Health England, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Kellam, Paul" sort="Kellam, Paul" uniqKey="Kellam P" first="Paul" last="Kellam">Paul Kellam</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Department of Virology, Faculty of Medicine, Imperial College, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Virology, Faculty of Medicine, Imperial College, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Zambon, Maria" sort="Zambon, Maria" uniqKey="Zambon M" first="Maria" last="Zambon">Maria Zambon</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Public Health England, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Public Health England, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Lackenby, Angie" sort="Lackenby, Angie" uniqKey="Lackenby A" first="Angie" last="Lackenby">Angie Lackenby</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Public Health England, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Public Health England, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Barclay, Wendy S" sort="Barclay, Wendy S" uniqKey="Barclay W" first="Wendy S." last="Barclay">Wendy S. Barclay</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Department of Virology, Faculty of Medicine, Imperial College, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Virology, Faculty of Medicine, Imperial College, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><series><title level="j">Journal of Virology</title><idno type="ISSN">0022-538X</idno><idno type="eISSN">1098-5514</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amides (pharmacology)</term><term>Animals</term><term>Bias</term><term>DNA Primers (genetics)</term><term>Dogs</term><term>HEK293 Cells</term><term>High-Throughput Nucleotide Sequencing (methods)</term><term>Humans</term><term>Influenza A virus (drug effects)</term><term>Influenza A virus (genetics)</term><term>Madin Darby Canine Kidney Cells</term><term>Mutation</term><term>Pyrazines (pharmacology)</term><term>Sequence Analysis, RNA</term><term>Whole Genome Sequencing</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Amides (pharmacologie)</term><term>Amorces ADN (génétique)</term><term>Analyse de séquence d'ARN</term><term>Animaux</term><term>Cellules HEK293</term><term>Cellules rénales canines Madin-Darby</term><term>Chiens</term><term>Humains</term><term>Mutation</term><term>Pyrazines (pharmacologie)</term><term>Séquençage nucléotidique à haut débit ()</term><term>Virus de la grippe A ()</term><term>Virus de la grippe A (génétique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>DNA Primers</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Amides</term><term>Pyrazines</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Amorces ADN</term><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>High-Throughput Nucleotide Sequencing</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Amides</term><term>Pyrazines</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Bias</term><term>Dogs</term><term>HEK293 Cells</term><term>Humans</term><term>Madin Darby Canine Kidney Cells</term><term>Mutation</term><term>Sequence Analysis, RNA</term><term>Whole Genome Sequencing</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Analyse de séquence d'ARN</term><term>Animaux</term><term>Cellules HEK293</term><term>Cellules rénales canines Madin-Darby</term><term>Chiens</term><term>Humains</term><term>Mutation</term><term>Séquençage nucléotidique à haut débit</term><term>Virus de la grippe A</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>New antiviral drugs are needed as a first line of defense in the event of a novel influenza pandemic. Favipiravir is a broad-spectrum antiviral which is effective against influenza. The exact mechanism of how favipiravir works to inhibit influenza is still unclear. We used next-generation sequencing (NGS) to demonstrate that favipiravir causes mutations in influenza RNA. The greater depth of NGS sequence information over traditional sequencing methods allowed us to precisely determine the bias of particular mutations caused by favipiravir. NGS can also be used in a standard diagnostic pipeline to show that favipiravir is acting on the virus by revealing the mutation bias pattern typical to the drug. Our work will aid in testing whether viruses are resistant to favipiravir and may help demonstrate the effect of favipiravir on viruses in a clinical setting. This will be important if favipiravir is used during a future influenza pandemic.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Ferguson, Nm" uniqKey="Ferguson N">NM Ferguson</name></author><author><name sortKey="Cummings, Dat" uniqKey="Cummings D">DAT Cummings</name></author><author><name sortKey="Fraser, C" uniqKey="Fraser C">C Fraser</name></author><author><name sortKey="Cajka, Jc" uniqKey="Cajka J">JC Cajka</name></author><author><name sortKey="Cooley, Pc" uniqKey="Cooley P">PC Cooley</name></author><author><name sortKey="Burke, Ds" uniqKey="Burke D">DS Burke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fauci, As" uniqKey="Fauci A">AS Fauci</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Deyde, Vm" uniqKey="Deyde V">VM Deyde</name></author><author><name sortKey="Xu, X" uniqKey="Xu X">X Xu</name></author><author><name sortKey="Bright, Ra" uniqKey="Bright R">RA Bright</name></author><author><name sortKey="Shaw, M" uniqKey="Shaw M">M Shaw</name></author><author><name sortKey="Smith, Cb" uniqKey="Smith C">CB Smith</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author><author><name sortKey="Shu, Y" uniqKey="Shu Y">Y Shu</name></author><author><name sortKey="Gubareva, Lv" uniqKey="Gubareva L">LV Gubareva</name></author><author><name sortKey="Cox, Nj" uniqKey="Cox N">NJ Cox</name></author><author><name sortKey="Klimov, Ai" uniqKey="Klimov A">AI Klimov</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hurt, Ac" uniqKey="Hurt A">AC Hurt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moscona, A" uniqKey="Moscona A">A Moscona</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Watanabe, T" uniqKey="Watanabe T">T Watanabe</name></author><author><name sortKey="Kiso, M" uniqKey="Kiso M">M Kiso</name></author><author><name sortKey="Fukuyama, S" uniqKey="Fukuyama S">S Fukuyama</name></author><author><name sortKey="Nakajima, N" uniqKey="Nakajima N">N Nakajima</name></author><author><name sortKey="Imai, M" uniqKey="Imai M">M Imai</name></author><author><name sortKey="Yamada, S" uniqKey="Yamada S">S Yamada</name></author><author><name sortKey="Murakami, S" uniqKey="Murakami S">S Murakami</name></author><author><name sortKey="Yamayoshi, S" uniqKey="Yamayoshi S">S Yamayoshi</name></author><author><name sortKey="Iwatsuki Horimoto, K" uniqKey="Iwatsuki Horimoto K">K Iwatsuki-Horimoto</name></author><author><name sortKey="Sakoda, Y" uniqKey="Sakoda Y">Y Sakoda</name></author><author><name sortKey="Takashita, E" uniqKey="Takashita E">E Takashita</name></author><author><name sortKey="Mcbride, R" uniqKey="Mcbride R">R McBride</name></author><author><name sortKey="Noda, T" uniqKey="Noda T">T Noda</name></author><author><name sortKey="Hatta, M" uniqKey="Hatta M">M Hatta</name></author><author><name sortKey="Imai, H" uniqKey="Imai H">H Imai</name></author><author><name sortKey="Zhao, D" uniqKey="Zhao D">D Zhao</name></author><author><name sortKey="Kishida, N" uniqKey="Kishida N">N Kishida</name></author><author><name sortKey="Shirakura, M" uniqKey="Shirakura M">M Shirakura</name></author><author><name sortKey="De Vries, Rp" uniqKey="De Vries R">RP de Vries</name></author><author><name sortKey="Shichinohe, S" uniqKey="Shichinohe S">S Shichinohe</name></author><author><name sortKey="Okamatsu, M" uniqKey="Okamatsu M">M Okamatsu</name></author><author><name sortKey="Tamura, T" uniqKey="Tamura T">T Tamura</name></author><author><name sortKey="Tomita, Y" uniqKey="Tomita Y">Y Tomita</name></author><author><name sortKey="Fujimoto, N" uniqKey="Fujimoto N">N Fujimoto</name></author><author><name sortKey="Goto, K" uniqKey="Goto K">K Goto</name></author><author><name sortKey="Katsura, H" uniqKey="Katsura H">H Katsura</name></author><author><name sortKey="Kawakami, E" uniqKey="Kawakami E">E Kawakami</name></author><author><name sortKey="Ishikawa, I" uniqKey="Ishikawa I">I Ishikawa</name></author><author><name sortKey="Watanabe, S" uniqKey="Watanabe S">S Watanabe</name></author><author><name sortKey="Ito, M" uniqKey="Ito M">M Ito</name></author><author><name sortKey="Sakai Tagawa, Y" uniqKey="Sakai Tagawa Y">Y Sakai-Tagawa</name></author><author><name sortKey="Sugita, Y" uniqKey="Sugita Y">Y Sugita</name></author><author><name sortKey="Uraki, R" uniqKey="Uraki R">R Uraki</name></author><author><name sortKey="Yamaji, R" uniqKey="Yamaji R">R Yamaji</name></author><author><name sortKey="Eisfeld, Aj" uniqKey="Eisfeld A">AJ Eisfeld</name></author><author><name sortKey="Zhong, G" uniqKey="Zhong G">G Zhong</name></author><author><name sortKey="Fan, S" uniqKey="Fan S">S Fan</name></author><author><name sortKey="Ping, J" uniqKey="Ping J">J Ping</name></author><author><name sortKey="Maher, Ea" uniqKey="Maher E">EA Maher</name></author><author><name sortKey="Hanson, A" uniqKey="Hanson A">A Hanson</name></author><author><name sortKey="Uchida, Y" uniqKey="Uchida Y">Y Uchida</name></author><author><name sortKey="Saito, T" uniqKey="Saito T">T Saito</name></author><author><name sortKey="Ozawa, M" uniqKey="Ozawa M">M Ozawa</name></author><author><name sortKey="Neumann, G" uniqKey="Neumann G">G Neumann</name></author><author><name sortKey="Kida, H" uniqKey="Kida H">H Kida</name></author><author><name sortKey="Odagiri, T" uniqKey="Odagiri T">T Odagiri</name></author><author><name sortKey="Paulson, Jc" uniqKey="Paulson J">JC Paulson</name></author><author><name sortKey="Hasegawa, H" uniqKey="Hasegawa H">H Hasegawa</name></author><author><name sortKey="Tashiro, M" uniqKey="Tashiro M">M Tashiro</name></author><author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y Kawaoka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhu, H" uniqKey="Zhu H">H Zhu</name></author><author><name sortKey="Wang, D" uniqKey="Wang D">D Wang</name></author><author><name sortKey="Kelvin, Dj" uniqKey="Kelvin D">DJ Kelvin</name></author><author><name sortKey="Li, L" uniqKey="Li L">L Li</name></author><author><name sortKey="Zheng, Z" uniqKey="Zheng Z">Z Zheng</name></author><author><name sortKey="Yoon, S W" uniqKey="Yoon S">S-W Yoon</name></author><author><name sortKey="Wong, S S" uniqKey="Wong S">S-S Wong</name></author><author><name sortKey="Farooqui, A" uniqKey="Farooqui A">A Farooqui</name></author><author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name></author><author><name sortKey="Banner, D" uniqKey="Banner D">D Banner</name></author><author><name sortKey="Chen, R" uniqKey="Chen R">R Chen</name></author><author><name sortKey="Zheng, R" uniqKey="Zheng R">R Zheng</name></author><author><name sortKey="Zhou, J" uniqKey="Zhou J">J Zhou</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author><author><name sortKey="Hong, W" uniqKey="Hong W">W Hong</name></author><author><name sortKey="Dong, W" uniqKey="Dong W">W Dong</name></author><author><name sortKey="Cai, Q" uniqKey="Cai Q">Q Cai</name></author><author><name sortKey="Roehrl, Mha" uniqKey="Roehrl M">MHA Roehrl</name></author><author><name sortKey="Huang, Ssh" uniqKey="Huang S">SSH Huang</name></author><author><name sortKey="Kelvin, Aa" uniqKey="Kelvin A">AA Kelvin</name></author><author><name sortKey="Yao, T" uniqKey="Yao T">T Yao</name></author><author><name sortKey="Zhou, B" uniqKey="Zhou B">B Zhou</name></author><author><name sortKey="Chen, X" uniqKey="Chen X">X Chen</name></author><author><name sortKey="Leung, Gm" uniqKey="Leung G">GM Leung</name></author><author><name sortKey="Poon, Llm" uniqKey="Poon L">LLM Poon</name></author><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name></author><author><name sortKey="Webby, Rj" uniqKey="Webby R">RJ Webby</name></author><author><name sortKey="Peiris, Jsm" uniqKey="Peiris J">JSM Peiris</name></author><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name></author><author><name sortKey="Shu, Y" uniqKey="Shu Y">Y Shu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Imai, M" uniqKey="Imai M">M Imai</name></author><author><name sortKey="Watanabe, T" uniqKey="Watanabe T">T Watanabe</name></author><author><name sortKey="Kiso, M" uniqKey="Kiso M">M Kiso</name></author><author><name sortKey="Nakajima, N" uniqKey="Nakajima N">N Nakajima</name></author><author><name sortKey="Yamayoshi, S" uniqKey="Yamayoshi S">S Yamayoshi</name></author><author><name sortKey="Iwatsuki Horimoto, K" uniqKey="Iwatsuki Horimoto K">K Iwatsuki-Horimoto</name></author><author><name sortKey="Hatta, M" uniqKey="Hatta M">M Hatta</name></author><author><name sortKey="Yamada, S" uniqKey="Yamada S">S Yamada</name></author><author><name sortKey="Ito, M" uniqKey="Ito M">M Ito</name></author><author><name sortKey="Sakai Tagawa, Y" uniqKey="Sakai Tagawa Y">Y Sakai-Tagawa</name></author><author><name sortKey="Shirakura, M" uniqKey="Shirakura M">M Shirakura</name></author><author><name sortKey="Takashita, E" uniqKey="Takashita E">E Takashita</name></author><author><name sortKey="Fujisaki, S" uniqKey="Fujisaki S">S Fujisaki</name></author><author><name sortKey="Mcbride, R" uniqKey="Mcbride R">R McBride</name></author><author><name sortKey="Thompson, Aj" uniqKey="Thompson A">AJ Thompson</name></author><author><name sortKey="Takahashi, K" uniqKey="Takahashi K">K Takahashi</name></author><author><name sortKey="Maemura, T" uniqKey="Maemura T">T Maemura</name></author><author><name sortKey="Mitake, H" uniqKey="Mitake H">H Mitake</name></author><author><name sortKey="Chiba, S" uniqKey="Chiba S">S Chiba</name></author><author><name sortKey="Zhong, G" uniqKey="Zhong G">G Zhong</name></author><author><name sortKey="Fan, S" uniqKey="Fan S">S Fan</name></author><author><name sortKey="Oishi, K" uniqKey="Oishi K">K Oishi</name></author><author><name sortKey="Yasuhara, A" uniqKey="Yasuhara A">A Yasuhara</name></author><author><name sortKey="Takada, K" uniqKey="Takada K">K Takada</name></author><author><name sortKey="Nakao, T" uniqKey="Nakao T">T Nakao</name></author><author><name sortKey="Fukuyama, S" uniqKey="Fukuyama S">S Fukuyama</name></author><author><name sortKey="Yamashita, M" uniqKey="Yamashita M">M Yamashita</name></author><author><name sortKey="Lopes, Tjs" uniqKey="Lopes T">TJS Lopes</name></author><author><name sortKey="Neumann, G" uniqKey="Neumann G">G Neumann</name></author><author><name sortKey="Odagiri, T" uniqKey="Odagiri T">T Odagiri</name></author><author><name sortKey="Watanabe, S" uniqKey="Watanabe S">S Watanabe</name></author><author><name sortKey="Shu, Y" uniqKey="Shu Y">Y Shu</name></author><author><name sortKey="Paulson, Jc" uniqKey="Paulson J">JC Paulson</name></author><author><name sortKey="Hasegawa, H" uniqKey="Hasegawa H">H Hasegawa</name></author><author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y Kawaoka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koszalka, P" uniqKey="Koszalka P">P Koszalka</name></author><author><name sortKey="Tilmanis, D" uniqKey="Tilmanis D">D Tilmanis</name></author><author><name sortKey="Hurt, Ac" uniqKey="Hurt A">AC Hurt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Clercq, E" uniqKey="De Clercq E">E De Clercq</name></author><author><name sortKey="Li, G" uniqKey="Li G">G Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Furuta, Y" uniqKey="Furuta Y">Y Furuta</name></author><author><name sortKey="Takahashi, K" uniqKey="Takahashi K">K Takahashi</name></author><author><name sortKey="Fukuda, Y" uniqKey="Fukuda Y">Y Fukuda</name></author><author><name sortKey="Kuno, M" uniqKey="Kuno M">M Kuno</name></author><author><name sortKey="Kamiyama, T" uniqKey="Kamiyama T">T Kamiyama</name></author><author><name sortKey="Kozaki, K" uniqKey="Kozaki K">K Kozaki</name></author><author><name sortKey="Nomura, N" uniqKey="Nomura N">N Nomura</name></author><author><name sortKey="Egawa, H" uniqKey="Egawa H">H Egawa</name></author><author><name sortKey="Minami, S" uniqKey="Minami S">S Minami</name></author><author><name sortKey="Watanabe, Y" uniqKey="Watanabe Y">Y Watanabe</name></author><author><name sortKey="Narita, H" uniqKey="Narita H">H Narita</name></author><author><name sortKey="Shiraki, K" uniqKey="Shiraki K">K Shiraki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sidwell, Rw" uniqKey="Sidwell R">RW Sidwell</name></author><author><name sortKey="Barnard, Dl" uniqKey="Barnard D">DL Barnard</name></author><author><name sortKey="Day, Cw" uniqKey="Day C">CW Day</name></author><author><name sortKey="Smee, Df" uniqKey="Smee D">DF Smee</name></author><author><name sortKey="Bailey, Kw" uniqKey="Bailey K">KW Bailey</name></author><author><name sortKey="Wong, M H" uniqKey="Wong M">M-H Wong</name></author><author><name sortKey="Morrey, Jd" uniqKey="Morrey J">JD Morrey</name></author><author><name sortKey="Furuta, Y" uniqKey="Furuta Y">Y Furuta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kiso, M" uniqKey="Kiso M">M Kiso</name></author><author><name sortKey="Takahashi, K" uniqKey="Takahashi K">K Takahashi</name></author><author><name sortKey="Sakai Tagawa, Y" uniqKey="Sakai Tagawa Y">Y Sakai-Tagawa</name></author><author><name sortKey="Shinya, K" uniqKey="Shinya K">K Shinya</name></author><author><name sortKey="Sakabe, S" uniqKey="Sakabe S">S Sakabe</name></author><author><name sortKey="Le, Qm" uniqKey="Le Q">QM Le</name></author><author><name sortKey="Ozawa, M" uniqKey="Ozawa M">M Ozawa</name></author><author><name sortKey="Furuta, Y" uniqKey="Furuta Y">Y Furuta</name></author><author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y Kawaoka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Furuta, Y" uniqKey="Furuta Y">Y Furuta</name></author><author><name sortKey="Takahashi, K" uniqKey="Takahashi K">K Takahashi</name></author><author><name sortKey="Shiraki, K" uniqKey="Shiraki K">K Shiraki</name></author><author><name sortKey="Sakamoto, K" uniqKey="Sakamoto K">K Sakamoto</name></author><author><name sortKey="Smee, Df" uniqKey="Smee D">DF Smee</name></author><author><name sortKey="Barnard, Dl" uniqKey="Barnard D">DL Barnard</name></author><author><name sortKey="Gowen, Bb" uniqKey="Gowen B">BB Gowen</name></author><author><name sortKey="Julander, Jg" uniqKey="Julander J">JG Julander</name></author><author><name sortKey="Morrey, Jd" uniqKey="Morrey J">JD Morrey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sleeman, K" uniqKey="Sleeman K">K Sleeman</name></author><author><name sortKey="Mishin, Vp" uniqKey="Mishin V">VP Mishin</name></author><author><name sortKey="Deyde, Vm" uniqKey="Deyde V">VM Deyde</name></author><author><name sortKey="Furuta, Y" uniqKey="Furuta Y">Y Furuta</name></author><author><name sortKey="Klimov, Ai" uniqKey="Klimov A">AI Klimov</name></author><author><name sortKey="Gubareva, Lv" uniqKey="Gubareva L">LV Gubareva</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Furuta, Y" uniqKey="Furuta Y">Y Furuta</name></author><author><name sortKey="Gowen, Bb" uniqKey="Gowen B">BB Gowen</name></author><author><name sortKey="Takahashi, K" uniqKey="Takahashi K">K Takahashi</name></author><author><name sortKey="Shiraki, K" uniqKey="Shiraki K">K Shiraki</name></author><author><name sortKey="Smee, Df" uniqKey="Smee D">DF Smee</name></author><author><name sortKey="Barnard, Dl" uniqKey="Barnard D">DL Barnard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Furuta, Y" uniqKey="Furuta Y">Y Furuta</name></author><author><name sortKey="Komeno, T" uniqKey="Komeno T">T Komeno</name></author><author><name sortKey="Nakamura, T" uniqKey="Nakamura T">T Nakamura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mendenhall, M" uniqKey="Mendenhall M">M Mendenhall</name></author><author><name sortKey="Russell, A" uniqKey="Russell A">A Russell</name></author><author><name sortKey="Juelich, T" uniqKey="Juelich T">T Juelich</name></author><author><name sortKey="Messina, El" uniqKey="Messina E">EL Messina</name></author><author><name sortKey="Smee, Df" uniqKey="Smee D">DF Smee</name></author><author><name sortKey="Freiberg, An" uniqKey="Freiberg A">AN Freiberg</name></author><author><name sortKey="Holbrook, Mr" uniqKey="Holbrook M">MR Holbrook</name></author><author><name sortKey="Furuta, Y" uniqKey="Furuta Y">Y Furuta</name></author><author><name sortKey="De La Torre, J C" uniqKey="De La Torre J">J-C de la Torre</name></author><author><name sortKey="Nunberg, Jh" uniqKey="Nunberg J">JH Nunberg</name></author><author><name sortKey="Gowen, Bb" uniqKey="Gowen B">BB Gowen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mendenhall, M" uniqKey="Mendenhall M">M Mendenhall</name></author><author><name sortKey="Russell, A" uniqKey="Russell A">A Russell</name></author><author><name sortKey="Smee, Df" uniqKey="Smee D">DF Smee</name></author><author><name sortKey="Hall, Jo" uniqKey="Hall J">JO Hall</name></author><author><name sortKey="Skirpstunas, R" uniqKey="Skirpstunas R">R Skirpstunas</name></author><author><name sortKey="Furuta, Y" uniqKey="Furuta Y">Y Furuta</name></author><author><name sortKey="Gowen, Bb" uniqKey="Gowen B">BB Gowen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oestereich, L" uniqKey="Oestereich L">L Oestereich</name></author><author><name sortKey="Ludtke, A" uniqKey="Ludtke A">A Lüdtke</name></author><author><name sortKey="Wurr, S" uniqKey="Wurr S">S Wurr</name></author><author><name sortKey="Rieger, T" uniqKey="Rieger T">T Rieger</name></author><author><name sortKey="Mu Oz Fontela, C" uniqKey="Mu Oz Fontela C">C Muñoz-Fontela</name></author><author><name sortKey="Gunther, S" uniqKey="Gunther S">S Günther</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Safronetz, D" uniqKey="Safronetz D">D Safronetz</name></author><author><name sortKey="Rosenke, K" uniqKey="Rosenke K">K Rosenke</name></author><author><name sortKey="Westover, Jb" uniqKey="Westover J">JB Westover</name></author><author><name sortKey="Martellaro, C" uniqKey="Martellaro C">C Martellaro</name></author><author><name sortKey="Okumura, A" uniqKey="Okumura A">A Okumura</name></author><author><name sortKey="Furuta, Y" uniqKey="Furuta Y">Y Furuta</name></author><author><name sortKey="Geisbert, J" uniqKey="Geisbert J">J Geisbert</name></author><author><name sortKey="Saturday, G" uniqKey="Saturday G">G Saturday</name></author><author><name sortKey="Komeno, T" uniqKey="Komeno T">T Komeno</name></author><author><name sortKey="Geisbert, Tw" uniqKey="Geisbert T">TW Geisbert</name></author><author><name sortKey="Feldmann, H" uniqKey="Feldmann H">H Feldmann</name></author><author><name sortKey="Gowen, Bb" uniqKey="Gowen B">BB Gowen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oestereich, L" uniqKey="Oestereich L">L Oestereich</name></author><author><name sortKey="Rieger, T" uniqKey="Rieger T">T Rieger</name></author><author><name sortKey="Ludtke, A" uniqKey="Ludtke A">A Lüdtke</name></author><author><name sortKey="Ruibal, P" uniqKey="Ruibal P">P Ruibal</name></author><author><name sortKey="Wurr, S" uniqKey="Wurr S">S Wurr</name></author><author><name sortKey="Pallasch, E" uniqKey="Pallasch E">E Pallasch</name></author><author><name sortKey="Bockholt, S" uniqKey="Bockholt S">S Bockholt</name></author><author><name sortKey="Krasemann, S" uniqKey="Krasemann S">S Krasemann</name></author><author><name sortKey="Mu Oz Fontela, C" uniqKey="Mu Oz Fontela C">C Muñoz-Fontela</name></author><author><name sortKey="Gunther, S" uniqKey="Gunther S">S Günther</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tani, H" uniqKey="Tani H">H Tani</name></author><author><name sortKey="Fukuma, A" uniqKey="Fukuma A">A Fukuma</name></author><author><name sortKey="Fukushi, S" uniqKey="Fukushi S">S Fukushi</name></author><author><name sortKey="Taniguchi, S" uniqKey="Taniguchi S">S Taniguchi</name></author><author><name sortKey="Yoshikawa, T" uniqKey="Yoshikawa T">T Yoshikawa</name></author><author><name sortKey="Iwata Yoshikawa, N" uniqKey="Iwata Yoshikawa N">N Iwata-Yoshikawa</name></author><author><name sortKey="Sato, Y" uniqKey="Sato Y">Y Sato</name></author><author><name sortKey="Suzuki, T" uniqKey="Suzuki T">T Suzuki</name></author><author><name sortKey="Nagata, N" uniqKey="Nagata N">N Nagata</name></author><author><name sortKey="Hasegawa, H" uniqKey="Hasegawa H">H Hasegawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Delang, L" uniqKey="Delang L">L Delang</name></author><author><name sortKey="Abdelnabi, R" uniqKey="Abdelnabi R">R Abdelnabi</name></author><author><name sortKey="Neyts, J" uniqKey="Neyts J">J Neyts</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Furuta, Y" uniqKey="Furuta Y">Y Furuta</name></author><author><name sortKey="Takahashi, K" uniqKey="Takahashi K">K Takahashi</name></author><author><name sortKey="Kuno Maekawa, M" uniqKey="Kuno Maekawa M">M Kuno-Maekawa</name></author><author><name sortKey="Sangawa, H" uniqKey="Sangawa H">H Sangawa</name></author><author><name sortKey="Uehara, S" uniqKey="Uehara S">S Uehara</name></author><author><name sortKey="Kozaki, K" uniqKey="Kozaki K">K Kozaki</name></author><author><name sortKey="Nomura, N" uniqKey="Nomura N">N Nomura</name></author><author><name sortKey="Egawa, H" uniqKey="Egawa H">H Egawa</name></author><author><name sortKey="Shiraki, K" uniqKey="Shiraki K">K Shiraki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baranovich, T" uniqKey="Baranovich T">T Baranovich</name></author><author><name sortKey="Wong, S S" uniqKey="Wong S">S-S Wong</name></author><author><name sortKey="Armstrong, J" uniqKey="Armstrong J">J Armstrong</name></author><author><name sortKey="Marjuki, H" uniqKey="Marjuki H">H Marjuki</name></author><author><name sortKey="Webby, Rj" uniqKey="Webby R">RJ Webby</name></author><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name></author><author><name sortKey="Govorkova, Ea" uniqKey="Govorkova E">EA Govorkova</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arias, A" uniqKey="Arias A">A Arias</name></author><author><name sortKey="Thorne, L" uniqKey="Thorne L">L Thorne</name></author><author><name sortKey="Goodfellow, I" uniqKey="Goodfellow I">I Goodfellow</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Vila, Ai" uniqKey="De Vila A">AI de Ávila</name></author><author><name sortKey="Gallego, I" uniqKey="Gallego I">I Gallego</name></author><author><name sortKey="Soria, Me" uniqKey="Soria M">ME Soria</name></author><author><name sortKey="Gregori, J" uniqKey="Gregori J">J Gregori</name></author><author><name sortKey="Quer, J" uniqKey="Quer J">J Quer</name></author><author><name sortKey="Esteban, Ji" uniqKey="Esteban J">JI Esteban</name></author><author><name sortKey="Rice, Cm" uniqKey="Rice C">CM Rice</name></author><author><name sortKey="Domingo, E" uniqKey="Domingo E">E Domingo</name></author><author><name sortKey="Perales, C" uniqKey="Perales C">C Perales</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barauskas, O" uniqKey="Barauskas O">O Barauskas</name></author><author><name sortKey="Xing, W" uniqKey="Xing W">W Xing</name></author><author><name sortKey="Aguayo, E" uniqKey="Aguayo E">E Aguayo</name></author><author><name sortKey="Willkom, M" uniqKey="Willkom M">M Willkom</name></author><author><name sortKey="Sapre, A" uniqKey="Sapre A">A Sapre</name></author><author><name sortKey="Clarke, M" uniqKey="Clarke M">M Clarke</name></author><author><name sortKey="Birkus, G" uniqKey="Birkus G">G Birkus</name></author><author><name sortKey="Schultz, Be" uniqKey="Schultz B">BE Schultz</name></author><author><name sortKey="Sakowicz, R" uniqKey="Sakowicz R">R Sakowicz</name></author><author><name sortKey="Kwon, Hj" uniqKey="Kwon H">HJ Kwon</name></author><author><name sortKey="Feng, Jy" uniqKey="Feng J">JY Feng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vanderlinden, E" uniqKey="Vanderlinden E">E Vanderlinden</name></author><author><name sortKey="Vrancken, B" uniqKey="Vrancken B">B Vrancken</name></author><author><name sortKey="Van Houdt, J" uniqKey="Van Houdt J">J Van Houdt</name></author><author><name sortKey="Rajwanshi, Vk" uniqKey="Rajwanshi V">VK Rajwanshi</name></author><author><name sortKey="Gillemot, S" uniqKey="Gillemot S">S Gillemot</name></author><author><name sortKey="Andrei, G" uniqKey="Andrei G">G Andrei</name></author><author><name sortKey="Lemey, P" uniqKey="Lemey P">P Lemey</name></author><author><name sortKey="Naesens, L" uniqKey="Naesens L">L Naesens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sangawa, H" uniqKey="Sangawa H">H Sangawa</name></author><author><name sortKey="Komeno, T" uniqKey="Komeno T">T Komeno</name></author><author><name sortKey="Nishikawa, H" uniqKey="Nishikawa H">H Nishikawa</name></author><author><name sortKey="Yoshida, A" uniqKey="Yoshida A">A Yoshida</name></author><author><name sortKey="Takahashi, K" uniqKey="Takahashi K">K Takahashi</name></author><author><name sortKey="Nomura, N" uniqKey="Nomura N">N Nomura</name></author><author><name sortKey="Furuta, Y" uniqKey="Furuta Y">Y Furuta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jin, Z" uniqKey="Jin Z">Z Jin</name></author><author><name sortKey="Smith, Lk" uniqKey="Smith L">LK Smith</name></author><author><name sortKey="Rajwanshi, Vk" uniqKey="Rajwanshi V">VK Rajwanshi</name></author><author><name sortKey="Kim, B" uniqKey="Kim B">B Kim</name></author><author><name sortKey="Deval, J" uniqKey="Deval J">J Deval</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jin, Z" uniqKey="Jin Z">Z Jin</name></author><author><name sortKey="Kinkade, A" uniqKey="Kinkade A">A Kinkade</name></author><author><name sortKey="Behera, I" uniqKey="Behera I">I Behera</name></author><author><name sortKey="Chaudhuri, S" uniqKey="Chaudhuri S">S Chaudhuri</name></author><author><name sortKey="Tucker, K" uniqKey="Tucker K">K Tucker</name></author><author><name sortKey="Dyatkina, N" uniqKey="Dyatkina N">N Dyatkina</name></author><author><name sortKey="Rajwanshi, Vk" uniqKey="Rajwanshi V">VK Rajwanshi</name></author><author><name sortKey="Wang, G" uniqKey="Wang G">G Wang</name></author><author><name sortKey="Jekle, A" uniqKey="Jekle A">A Jekle</name></author><author><name sortKey="Smith, Db" uniqKey="Smith D">DB Smith</name></author><author><name sortKey="Beigelman, L" uniqKey="Beigelman L">L Beigelman</name></author><author><name sortKey="Symons, Ja" uniqKey="Symons J">JA Symons</name></author><author><name sortKey="Deval, J" uniqKey="Deval J">J Deval</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marathe, Bm" uniqKey="Marathe B">BM Marathe</name></author><author><name sortKey="Wong, S S" uniqKey="Wong S">S-S Wong</name></author><author><name sortKey="Vogel, P" uniqKey="Vogel P">P Vogel</name></author><author><name sortKey="Garcia Alcalde, F" uniqKey="Garcia Alcalde F">F Garcia-Alcalde</name></author><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name></author><author><name sortKey="Webby, Rj" uniqKey="Webby R">RJ Webby</name></author><author><name sortKey="Najera, I" uniqKey="Najera I">I Najera</name></author><author><name sortKey="Govorkova, Ea" uniqKey="Govorkova E">EA Govorkova</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Delang, L" uniqKey="Delang L">L Delang</name></author><author><name sortKey="Segura Guerrero, N" uniqKey="Segura Guerrero N">N Segura Guerrero</name></author><author><name sortKey="Tas, A" uniqKey="Tas A">A Tas</name></author><author><name sortKey="Querat, G" uniqKey="Querat G">G Quérat</name></author><author><name sortKey="Pastorino, B" uniqKey="Pastorino B">B Pastorino</name></author><author><name sortKey="Froeyen, M" uniqKey="Froeyen M">M Froeyen</name></author><author><name sortKey="Dallmeier, K" uniqKey="Dallmeier K">K Dallmeier</name></author><author><name sortKey="Jochmans, D" uniqKey="Jochmans D">D Jochmans</name></author><author><name sortKey="Herdewijn, P" uniqKey="Herdewijn P">P Herdewijn</name></author><author><name sortKey="Bello, F" uniqKey="Bello F">F Bello</name></author><author><name sortKey="Snijder, Ej" uniqKey="Snijder E">EJ Snijder</name></author><author><name sortKey="De Lamballerie, X" uniqKey="De Lamballerie X">X de Lamballerie</name></author><author><name sortKey="Martina, B" uniqKey="Martina B">B Martina</name></author><author><name sortKey="Neyts, J" uniqKey="Neyts J">J Neyts</name></author><author><name sortKey="Van Hemert, Mj" uniqKey="Van Hemert M">MJ van Hemert</name></author><author><name sortKey="Leyssen, P" uniqKey="Leyssen P">P Leyssen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guedj, J" uniqKey="Guedj J">J Guedj</name></author><author><name sortKey="Piorkowski, G" uniqKey="Piorkowski G">G Piorkowski</name></author><author><name sortKey="Jacquot, F" uniqKey="Jacquot F">F Jacquot</name></author><author><name sortKey="Madelain, V" uniqKey="Madelain V">V Madelain</name></author><author><name sortKey="Nguyen, Tht" uniqKey="Nguyen T">THT Nguyen</name></author><author><name sortKey="Rodallec, A" uniqKey="Rodallec A">A Rodallec</name></author><author><name sortKey="Gunther, S" uniqKey="Gunther S">S Gunther</name></author><author><name sortKey="Carbonnelle, C" uniqKey="Carbonnelle C">C Carbonnelle</name></author><author><name sortKey="Mentre, F" uniqKey="Mentre F">F Mentré</name></author><author><name sortKey="Raoul, H" uniqKey="Raoul H">H Raoul</name></author><author><name sortKey="De Lamballerie, X" uniqKey="De Lamballerie X">X de Lamballerie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jabara, Cb" uniqKey="Jabara C">CB Jabara</name></author><author><name sortKey="Jones, Cd" uniqKey="Jones C">CD Jones</name></author><author><name sortKey="Roach, J" uniqKey="Roach J">J Roach</name></author><author><name sortKey="Anderson, Ja" uniqKey="Anderson J">JA Anderson</name></author><author><name sortKey="Swanstrom, R" uniqKey="Swanstrom R">R Swanstrom</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhou, S" uniqKey="Zhou S">S Zhou</name></author><author><name sortKey="Jones, C" uniqKey="Jones C">C Jones</name></author><author><name sortKey="Mieczkowski, P" uniqKey="Mieczkowski P">P Mieczkowski</name></author><author><name sortKey="Swanstrom, R" uniqKey="Swanstrom R">R Swanstrom</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kosik, I" uniqKey="Kosik I">I Kosik</name></author><author><name sortKey="Ince, Wl" uniqKey="Ince W">WL Ince</name></author><author><name sortKey="Gentles, Le" uniqKey="Gentles L">LE Gentles</name></author><author><name sortKey="Oler, Aj" uniqKey="Oler A">AJ Oler</name></author><author><name sortKey="Kosikova, M" uniqKey="Kosikova M">M Kosikova</name></author><author><name sortKey="Angel, M" uniqKey="Angel M">M Angel</name></author><author><name sortKey="Magadan, Jg" uniqKey="Magadan J">JG Magadán</name></author><author><name sortKey="Xie, H" uniqKey="Xie H">H Xie</name></author><author><name sortKey="Brooke, Cb" uniqKey="Brooke C">CB Brooke</name></author><author><name sortKey="Yewdell, Jw" uniqKey="Yewdell J">JW Yewdell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, Nc" uniqKey="Wu N">NC Wu</name></author><author><name sortKey="Young, Ap" uniqKey="Young A">AP Young</name></author><author><name sortKey="Al Mawsawi, Lq" uniqKey="Al Mawsawi L">LQ Al-Mawsawi</name></author><author><name sortKey="Olson, Ca" uniqKey="Olson C">CA Olson</name></author><author><name sortKey="Feng, J" uniqKey="Feng J">J Feng</name></author><author><name sortKey="Qi, H" uniqKey="Qi H">H Qi</name></author><author><name sortKey="Chen, S H" uniqKey="Chen S">S-H Chen</name></author><author><name sortKey="Lu, I H" uniqKey="Lu I">I-H Lu</name></author><author><name sortKey="Lin, C Y" uniqKey="Lin C">C-Y Lin</name></author><author><name sortKey="Chin, Rg" uniqKey="Chin R">RG Chin</name></author><author><name sortKey="Luan, Hh" uniqKey="Luan H">HH Luan</name></author><author><name sortKey="Nguyen, N" uniqKey="Nguyen N">N Nguyen</name></author><author><name sortKey="Nelson, Sf" uniqKey="Nelson S">SF Nelson</name></author><author><name sortKey="Li, X" uniqKey="Li X">X Li</name></author><author><name sortKey="Wu, T T" uniqKey="Wu T">T-T Wu</name></author><author><name sortKey="Sun, R" uniqKey="Sun R">R Sun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Doud, Mb" uniqKey="Doud M">MB Doud</name></author><author><name sortKey="Bloom, Jd" uniqKey="Bloom J">JD Bloom</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goldhill, Dh" uniqKey="Goldhill D">DH Goldhill</name></author><author><name sortKey="Langat, P" uniqKey="Langat P">P Langat</name></author><author><name sortKey="Xie, H" uniqKey="Xie H">H Xie</name></author><author><name sortKey="Galiano, M" uniqKey="Galiano M">M Galiano</name></author><author><name sortKey="Shahjahan, M" uniqKey="Shahjahan M">M Shahjahan</name></author><author><name sortKey="Kellam, P" uniqKey="Kellam P">P Kellam</name></author><author><name sortKey="Lackenby, A" uniqKey="Lackenby A">A Lackenby</name></author><author><name sortKey="Barclay, W" uniqKey="Barclay W">W Barclay</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pauly, Md" uniqKey="Pauly M">MD Pauly</name></author><author><name sortKey="Procario, M" uniqKey="Procario M">M Procario</name></author><author><name sortKey="Lauring, As" uniqKey="Lauring A">AS Lauring</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Visher, E" uniqKey="Visher E">E Visher</name></author><author><name sortKey="Whitefield, Se" uniqKey="Whitefield S">SE Whitefield</name></author><author><name sortKey="Mccrone, Jt" uniqKey="Mccrone J">JT McCrone</name></author><author><name sortKey="Fitzsimmons, W" uniqKey="Fitzsimmons W">W Fitzsimmons</name></author><author><name sortKey="Lauring, As" uniqKey="Lauring A">AS Lauring</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pauly, Md" uniqKey="Pauly M">MD Pauly</name></author><author><name sortKey="Lauring, As" uniqKey="Lauring A">AS Lauring</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Watson, Sj" uniqKey="Watson S">SJ Watson</name></author><author><name sortKey="Welkers, Mr" uniqKey="Welkers M">MR Welkers</name></author><author><name sortKey="Depledge, Dp" uniqKey="Depledge D">DP Depledge</name></author><author><name sortKey="Coulter, E" uniqKey="Coulter E">E Coulter</name></author><author><name sortKey="Breuer, Jm" uniqKey="Breuer J">JM Breuer</name></author><author><name sortKey="De Jong, Md" uniqKey="De Jong M">MD de Jong</name></author><author><name sortKey="Kellam, P" uniqKey="Kellam P">P Kellam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sheward, Dj" uniqKey="Sheward D">DJ Sheward</name></author><author><name sortKey="Murrell, B" uniqKey="Murrell B">B Murrell</name></author><author><name sortKey="Williamson, C" uniqKey="Williamson C">C Williamson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Long, Js" uniqKey="Long J">JS Long</name></author><author><name sortKey="Giotis, Es" uniqKey="Giotis E">ES Giotis</name></author><author><name sortKey="Moncorge, O" uniqKey="Moncorge O">O Moncorgé</name></author><author><name sortKey="Frise, R" uniqKey="Frise R">R Frise</name></author><author><name sortKey="Mistry, B" uniqKey="Mistry B">B Mistry</name></author><author><name sortKey="James, J" uniqKey="James J">J James</name></author><author><name sortKey="Morisson, M" uniqKey="Morisson M">M Morisson</name></author><author><name sortKey="Iqbal, M" uniqKey="Iqbal M">M Iqbal</name></author><author><name sortKey="Vignal, A" uniqKey="Vignal A">A Vignal</name></author><author><name sortKey="Skinner, Ma" uniqKey="Skinner M">MA Skinner</name></author><author><name sortKey="Barclay, Ws" uniqKey="Barclay W">WS Barclay</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhou, B" uniqKey="Zhou B">B Zhou</name></author><author><name sortKey="Donnelly, Me" uniqKey="Donnelly M">ME Donnelly</name></author><author><name sortKey="Scholes, Dt" uniqKey="Scholes D">DT Scholes</name></author><author><name sortKey="George, Ks" uniqKey="George K">KS George</name></author><author><name sortKey="Hatta, M" uniqKey="Hatta M">M Hatta</name></author><author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y Kawaoka</name></author><author><name sortKey="Wentworth, De" uniqKey="Wentworth D">DE Wentworth</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Goldhill, Daniel H" sort="Goldhill, Daniel H" uniqKey="Goldhill D" first="Daniel H." last="Goldhill">Daniel H. Goldhill</name></region><name sortKey="Barclay, Wendy S" sort="Barclay, Wendy S" uniqKey="Barclay W" first="Wendy S." last="Barclay">Wendy S. Barclay</name><name sortKey="Galiano, Monica" sort="Galiano, Monica" uniqKey="Galiano M" first="Monica" last="Galiano">Monica Galiano</name><name sortKey="Goldhill, Daniel H" sort="Goldhill, Daniel H" uniqKey="Goldhill D" first="Daniel H." last="Goldhill">Daniel H. Goldhill</name><name sortKey="Kellam, Paul" sort="Kellam, Paul" uniqKey="Kellam P" first="Paul" last="Kellam">Paul Kellam</name><name sortKey="Lackenby, Angie" sort="Lackenby, Angie" uniqKey="Lackenby A" first="Angie" last="Lackenby">Angie Lackenby</name><name sortKey="Langat, Pinky" sort="Langat, Pinky" uniqKey="Langat P" first="Pinky" last="Langat">Pinky Langat</name><name sortKey="Miah, Shahjahan" sort="Miah, Shahjahan" uniqKey="Miah S" first="Shahjahan" last="Miah">Shahjahan Miah</name><name sortKey="Xie, Hongyao" sort="Xie, Hongyao" uniqKey="Xie H" first="Hongyao" last="Xie">Hongyao Xie</name><name sortKey="Zambon, Maria" sort="Zambon, Maria" uniqKey="Zambon M" first="Maria" last="Zambon">Maria Zambon</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/PandemieGrippaleV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000355 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000355 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= PandemieGrippaleV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:6321902
|texte= Determining the Mutation Bias of Favipiravir in Influenza Virus Using Next-Generation Sequencing
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:30381482" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a PandemieGrippaleV1
| This area was generated with Dilib version V0.6.34. |  |