Paleopathological Description and Diagnosis of Metastatic Carcinoma in an Early Bronze Age (4588+34 Cal. BP) Forager from the Cis-Baikal Region of Eastern Siberia
Identifieur interne : 000218 ( Main/Exploration ); précédent : 000217; suivant : 000219Paleopathological Description and Diagnosis of Metastatic Carcinoma in an Early Bronze Age (4588+34 Cal. BP) Forager from the Cis-Baikal Region of Eastern Siberia
Auteurs : Angela R. Lieverse [Canada] ; Daniel H. Temple [États-Unis] ; Vladimir I. Bazaliiskii [Russie]Source :
- PLoS ONE [ 1932-6203 ] ; 2014.
English descriptors
- KwdEn :
- MESH :
- geographic : Siberia.
- diagnosis : Carcinoma.
- methods : Paleopathology.
- pathology : Bone and Bones, Osteoblasts, Osteolysis, Essential.
- secondary : Carcinoma.
- Adult, Cemeteries, Fossils, Geography, Humans, Male, Middle Aged.
Abstract
Extensive osteolytic and osteoblastic lesions were observed on the skeletal remains of an adult male excavated from an Early Bronze Age cemetery dated to 4556+32 years BP, located in the Cis-Baikal region of Siberia (Russian Federation). Lytic lesions ranged in size from several mm to over 60 mm in diameter and had irregular, moth-eaten borders. Many of these lesions destroyed trabecular bone, though a hollowed shell of cortical bone often remained observable. Radiographic analysis revealed numerous lytic lesions within trabecular bone that had not yet affected the cortex. Blastic lesions were identified as spiculated lines, bands, or nodules of mostly immature (woven) bone formed at irregular intervals. Anatomical elements with the greatest involvement included those of the axial skeleton (skull, vertebrae, sacrum, ribs, and sternum) as well as proximal appendicular elements (ossa coxae, proximal femora, clavicles, scapulae, and proximal humeri). Osteocoalescence of destructive foci was observed on the ilium and frontal bone, with the largest lesion found on the right ilium. Differential diagnoses include metastatic carcinoma, mycotic infections, tuberculosis, Langerhan's cell histiocytosis, and multiple myeloma. Based on lesion appearance and distribution, age and sex of the individual, as well as pathogen endemism, the most likely diagnostic option for this set of lesions is metastatic carcinoma. The age and sex of this individual and appearance of the lesions may reflect carcinoma of the lung or, possibly, prostate. This represents one of the earliest cases of metastatic carcinoma worldwide and the oldest case documented thus far from Northeast Asia.
Url:
DOI: 10.1371/journal.pone.0113919
PubMed: 25470373
PubMed Central: 4254749
Affiliations:
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BP) Forager from the Cis-Baikal Region of Eastern Siberia</title><author><name sortKey="Lieverse, Angela R" sort="Lieverse, Angela R" uniqKey="Lieverse A" first="Angela R." last="Lieverse">Angela R. Lieverse</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Archaeology and Anthropology, University of Saskatchewan, Saskatoon, SK, S7N 5B1, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Archaeology and Anthropology, University of Saskatchewan, Saskatoon, SK, S7N 5B1</wicri:regionArea><wicri:noRegion>S7N 5B1</wicri:noRegion></affiliation></author><author><name sortKey="Temple, Daniel H" sort="Temple, Daniel H" uniqKey="Temple D" first="Daniel H." last="Temple">Daniel H. Temple</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Department of Sociology and Anthropology, George Mason University, Fairfax, Virginia, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Sociology and Anthropology, George Mason University, Fairfax, Virginia</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author><author><name sortKey="Bazaliiskii, Vladimir I" sort="Bazaliiskii, Vladimir I" uniqKey="Bazaliiskii V" first="Vladimir I." last="Bazaliiskii">Vladimir I. Bazaliiskii</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Archaeology and Ethnography, Irkutsk State University, Irkutsk, 664003, Russian Federation</addr-line></nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea>Department of Archaeology and Ethnography, Irkutsk State University, Irkutsk, 664003</wicri:regionArea><wicri:noRegion>664003</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Bone and Bones (pathology)</term><term>Carcinoma (diagnosis)</term><term>Carcinoma (secondary)</term><term>Cemeteries</term><term>Fossils</term><term>Geography</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Osteoblasts (pathology)</term><term>Osteolysis, Essential (pathology)</term><term>Paleopathology (methods)</term><term>Siberia</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Siberia</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Carcinoma</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Paleopathology</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Bone and Bones</term><term>Osteoblasts</term><term>Osteolysis, Essential</term></keywords><keywords scheme="MESH" qualifier="secondary" xml:lang="en"><term>Carcinoma</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Cemeteries</term><term>Fossils</term><term>Geography</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Extensive osteolytic and osteoblastic lesions were observed on the skeletal remains of an adult male excavated from an Early Bronze Age cemetery dated to 4556+32 years BP, located in the Cis-Baikal region of Siberia (Russian Federation). Lytic lesions ranged in size from several mm to over 60 mm in diameter and had irregular, moth-eaten borders. Many of these lesions destroyed trabecular bone, though a hollowed shell of cortical bone often remained observable. Radiographic analysis revealed numerous lytic lesions within trabecular bone that had not yet affected the cortex. Blastic lesions were identified as spiculated lines, bands, or nodules of mostly immature (woven) bone formed at irregular intervals. Anatomical elements with the greatest involvement included those of the axial skeleton (skull, vertebrae, sacrum, ribs, and sternum) as well as proximal appendicular elements (ossa coxae, proximal femora, clavicles, scapulae, and proximal humeri). Osteocoalescence of destructive foci was observed on the ilium and frontal bone, with the largest lesion found on the right ilium. Differential diagnoses include metastatic carcinoma, mycotic infections, tuberculosis, Langerhan's cell histiocytosis, and multiple myeloma. Based on lesion appearance and distribution, age and sex of the individual, as well as pathogen endemism, the most likely diagnostic option for this set of lesions is metastatic carcinoma. The age and sex of this individual and appearance of the lesions may reflect carcinoma of the lung or, possibly, prostate. This represents one of the earliest cases of metastatic carcinoma worldwide and the oldest case documented thus far from Northeast Asia.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Alt, Kw" uniqKey="Alt K">KW Alt</name></author><author><name sortKey="Adler, Cp" uniqKey="Adler C">CP Adler</name></author><author><name sortKey="Buitrago Tellez, Ch" uniqKey="Buitrago Tellez C">CH Buitrago-Téllez</name></author><author><name sortKey="Lohrke, B" uniqKey="Lohrke B">B Lohrke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Assis, S" uniqKey="Assis S">S Assis</name></author><author><name sortKey="Codinha, S" uniqKey="Codinha S">S Codinha</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Binder, M" uniqKey="Binder M">M Binder</name></author><author><name sortKey="Roberts, C" uniqKey="Roberts C">C Roberts</name></author><author><name sortKey="Spencer, N" 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uniqKey="Jemal A">A Jemal</name></author><author><name sortKey="Murray, T" uniqKey="Murray T">T Murray</name></author><author><name sortKey="Ward, E" uniqKey="Ward E">E Ward</name></author><author><name sortKey="Samuels, A" uniqKey="Samuels A">A Samuels</name></author><author><name sortKey="Tiwari, Rc" uniqKey="Tiwari R">RC Tiwari</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bubendorf, L" uniqKey="Bubendorf L">L Bubendorf</name></author><author><name sortKey="Schopfer, A" uniqKey="Schopfer A">A Schöpfer</name></author><author><name sortKey="Wagner, U" uniqKey="Wagner U">U Wagner</name></author><author><name sortKey="Sauter, G" uniqKey="Sauter G">G Sauter</name></author><author><name sortKey="Moch, H" uniqKey="Moch H">H Moch</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Weber, Aw" uniqKey="Weber A">AW Weber</name></author><author><name sortKey="Beukens, Rp" uniqKey="Beukens R">RP Beukens</name></author><author><name sortKey="Bazaliiskii, Vi" uniqKey="Bazaliiskii V">VI Bazaliiskii</name></author><author><name sortKey="Goriunova, Oi" uniqKey="Goriunova O">OI Goriunova</name></author><author><name sortKey="Savel Ev, Na" uniqKey="Savel Ev N">NA Savel'ev</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Suzuki, T" uniqKey="Suzuki T">T Suzuki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wakely, J" uniqKey="Wakely J">J Wakely</name></author><author><name sortKey="Anderson, T" uniqKey="Anderson T">T Anderson</name></author><author><name sortKey="Carter, A" uniqKey="Carter A">A Carter</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Nagaoka, T" uniqKey="Nagaoka T">T Nagaoka</name></author><author><name sortKey="Sawada, J" uniqKey="Sawada J">J Sawada</name></author><author><name sortKey="Hirata, K" uniqKey="Hirata K">K Hirata</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nagaoka, T" uniqKey="Nagaoka T">T Nagaoka</name></author><author><name sortKey="Ishida, H" uniqKey="Ishida H">H Ishida</name></author><author><name sortKey="Shimoda, Y" uniqKey="Shimoda Y">Y Shimoda</name></author><author><name sortKey="Sunagawa, M" uniqKey="Sunagawa M">M Sunagawa</name></author><author><name sortKey="Amano, T" uniqKey="Amano T">T Amano</name></author></analytic></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Canada</li><li>Russie</li><li>États-Unis</li></country><region><li>Virginie</li></region></list><tree><country name="Canada"><noRegion><name sortKey="Lieverse, Angela R" sort="Lieverse, Angela R" uniqKey="Lieverse A" first="Angela R." last="Lieverse">Angela R. Lieverse</name></noRegion></country><country name="États-Unis"><region name="Virginie"><name sortKey="Temple, Daniel H" sort="Temple, Daniel H" uniqKey="Temple D" first="Daniel H." last="Temple">Daniel H. Temple</name></region></country><country name="Russie"><noRegion><name sortKey="Bazaliiskii, Vladimir I" sort="Bazaliiskii, Vladimir I" uniqKey="Bazaliiskii V" first="Vladimir I." last="Bazaliiskii">Vladimir I. Bazaliiskii</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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