Paleopathological description and diagnosis of metastatic carcinoma in an Early Bronze Age (4588+34 Cal. BP) forager from the Cis-Baikal region of Eastern Siberia.
Identifieur interne : 000149 ( PubMed/Corpus ); précédent : 000148; suivant : 000150Paleopathological description and diagnosis of metastatic carcinoma in an Early Bronze Age (4588+34 Cal. BP) forager from the Cis-Baikal region of Eastern Siberia.
Auteurs : Angela R. Lieverse ; Daniel H. Temple ; Vladimir I. BazaliiskiiSource :
- PloS one [ 1932-6203 ] ; 2014.
English descriptors
- KwdEn :
- MESH :
- geographic : Siberia.
- diagnosis : Carcinoma.
- methods : Paleopathology.
- pathology : Bone and Bones, Osteoblasts, Osteolysis, Essential.
- secondary : Carcinoma.
- Adult, Cemeteries, Fossils, Geography, Humans, Male, Middle Aged.
Abstract
Extensive osteolytic and osteoblastic lesions were observed on the skeletal remains of an adult male excavated from an Early Bronze Age cemetery dated to 4556+32 years BP, located in the Cis-Baikal region of Siberia (Russian Federation). Lytic lesions ranged in size from several mm to over 60 mm in diameter and had irregular, moth-eaten borders. Many of these lesions destroyed trabecular bone, though a hollowed shell of cortical bone often remained observable. Radiographic analysis revealed numerous lytic lesions within trabecular bone that had not yet affected the cortex. Blastic lesions were identified as spiculated lines, bands, or nodules of mostly immature (woven) bone formed at irregular intervals. Anatomical elements with the greatest involvement included those of the axial skeleton (skull, vertebrae, sacrum, ribs, and sternum) as well as proximal appendicular elements (ossa coxae, proximal femora, clavicles, scapulae, and proximal humeri). Osteocoalescence of destructive foci was observed on the ilium and frontal bone, with the largest lesion found on the right ilium. Differential diagnoses include metastatic carcinoma, mycotic infections, tuberculosis, Langerhan's cell histiocytosis, and multiple myeloma. Based on lesion appearance and distribution, age and sex of the individual, as well as pathogen endemism, the most likely diagnostic option for this set of lesions is metastatic carcinoma. The age and sex of this individual and appearance of the lesions may reflect carcinoma of the lung or, possibly, prostate. This represents one of the earliest cases of metastatic carcinoma worldwide and the oldest case documented thus far from Northeast Asia.
DOI: 10.1371/journal.pone.0113919
PubMed: 25470373
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pubmed:25470373Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Paleopathological description and diagnosis of metastatic carcinoma in an Early Bronze Age (4588+34 Cal. BP) forager from the Cis-Baikal region of Eastern Siberia.</title><author><name sortKey="Lieverse, Angela R" sort="Lieverse, Angela R" uniqKey="Lieverse A" first="Angela R" last="Lieverse">Angela R. Lieverse</name><affiliation><nlm:affiliation>Department of Archaeology and Anthropology, University of Saskatchewan, Saskatoon, SK, S7N 5B1, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Temple, Daniel H" sort="Temple, Daniel H" uniqKey="Temple D" first="Daniel H" last="Temple">Daniel H. Temple</name><affiliation><nlm:affiliation>Department of Sociology and Anthropology, George Mason University, Fairfax, Virginia, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Bazaliiskii, Vladimir I" sort="Bazaliiskii, Vladimir I" uniqKey="Bazaliiskii V" first="Vladimir I" last="Bazaliiskii">Vladimir I. Bazaliiskii</name><affiliation><nlm:affiliation>Department of Archaeology and Ethnography, Irkutsk State University, Irkutsk, 664003, Russian Federation.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:25470373</idno><idno type="pmid">25470373</idno><idno type="doi">10.1371/journal.pone.0113919</idno><idno type="wicri:Area/PubMed/Corpus">000149</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000149</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Paleopathological description and diagnosis of metastatic carcinoma in an Early Bronze Age (4588+34 Cal. BP) forager from the Cis-Baikal region of Eastern Siberia.</title><author><name sortKey="Lieverse, Angela R" sort="Lieverse, Angela R" uniqKey="Lieverse A" first="Angela R" last="Lieverse">Angela R. Lieverse</name><affiliation><nlm:affiliation>Department of Archaeology and Anthropology, University of Saskatchewan, Saskatoon, SK, S7N 5B1, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Temple, Daniel H" sort="Temple, Daniel H" uniqKey="Temple D" first="Daniel H" last="Temple">Daniel H. Temple</name><affiliation><nlm:affiliation>Department of Sociology and Anthropology, George Mason University, Fairfax, Virginia, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Bazaliiskii, Vladimir I" sort="Bazaliiskii, Vladimir I" uniqKey="Bazaliiskii V" first="Vladimir I" last="Bazaliiskii">Vladimir I. Bazaliiskii</name><affiliation><nlm:affiliation>Department of Archaeology and Ethnography, Irkutsk State University, Irkutsk, 664003, Russian Federation.</nlm:affiliation></affiliation></author></analytic><series><title level="j">PloS one</title><idno type="eISSN">1932-6203</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Bone and Bones (pathology)</term><term>Carcinoma (diagnosis)</term><term>Carcinoma (secondary)</term><term>Cemeteries</term><term>Fossils</term><term>Geography</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Osteoblasts (pathology)</term><term>Osteolysis, Essential (pathology)</term><term>Paleopathology (methods)</term><term>Siberia</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Siberia</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Carcinoma</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Paleopathology</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Bone and Bones</term><term>Osteoblasts</term><term>Osteolysis, Essential</term></keywords><keywords scheme="MESH" qualifier="secondary" xml:lang="en"><term>Carcinoma</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Cemeteries</term><term>Fossils</term><term>Geography</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Extensive osteolytic and osteoblastic lesions were observed on the skeletal remains of an adult male excavated from an Early Bronze Age cemetery dated to 4556+32 years BP, located in the Cis-Baikal region of Siberia (Russian Federation). Lytic lesions ranged in size from several mm to over 60 mm in diameter and had irregular, moth-eaten borders. Many of these lesions destroyed trabecular bone, though a hollowed shell of cortical bone often remained observable. Radiographic analysis revealed numerous lytic lesions within trabecular bone that had not yet affected the cortex. Blastic lesions were identified as spiculated lines, bands, or nodules of mostly immature (woven) bone formed at irregular intervals. Anatomical elements with the greatest involvement included those of the axial skeleton (skull, vertebrae, sacrum, ribs, and sternum) as well as proximal appendicular elements (ossa coxae, proximal femora, clavicles, scapulae, and proximal humeri). Osteocoalescence of destructive foci was observed on the ilium and frontal bone, with the largest lesion found on the right ilium. Differential diagnoses include metastatic carcinoma, mycotic infections, tuberculosis, Langerhan's cell histiocytosis, and multiple myeloma. Based on lesion appearance and distribution, age and sex of the individual, as well as pathogen endemism, the most likely diagnostic option for this set of lesions is metastatic carcinoma. The age and sex of this individual and appearance of the lesions may reflect carcinoma of the lung or, possibly, prostate. This represents one of the earliest cases of metastatic carcinoma worldwide and the oldest case documented thus far from Northeast Asia.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25470373</PMID><DateCreated><Year>2014</Year><Month>12</Month><Day>04</Day></DateCreated><DateCompleted><Year>2015</Year><Month>07</Month><Day>24</Day></DateCompleted><DateRevised><Year>2015</Year><Month>10</Month><Day>28</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN><JournalIssue CitedMedium="Internet"><Volume>9</Volume><Issue>12</Issue><PubDate><Year>2014</Year></PubDate></JournalIssue><Title>PloS one</Title><ISOAbbreviation>PLoS ONE</ISOAbbreviation></Journal><ArticleTitle>Paleopathological description and diagnosis of metastatic carcinoma in an Early Bronze Age (4588+34 Cal. BP) forager from the Cis-Baikal region of Eastern Siberia.</ArticleTitle><Pagination><MedlinePgn>e113919</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0113919</ELocationID><Abstract><AbstractText>Extensive osteolytic and osteoblastic lesions were observed on the skeletal remains of an adult male excavated from an Early Bronze Age cemetery dated to 4556+32 years BP, located in the Cis-Baikal region of Siberia (Russian Federation). Lytic lesions ranged in size from several mm to over 60 mm in diameter and had irregular, moth-eaten borders. Many of these lesions destroyed trabecular bone, though a hollowed shell of cortical bone often remained observable. Radiographic analysis revealed numerous lytic lesions within trabecular bone that had not yet affected the cortex. Blastic lesions were identified as spiculated lines, bands, or nodules of mostly immature (woven) bone formed at irregular intervals. Anatomical elements with the greatest involvement included those of the axial skeleton (skull, vertebrae, sacrum, ribs, and sternum) as well as proximal appendicular elements (ossa coxae, proximal femora, clavicles, scapulae, and proximal humeri). Osteocoalescence of destructive foci was observed on the ilium and frontal bone, with the largest lesion found on the right ilium. Differential diagnoses include metastatic carcinoma, mycotic infections, tuberculosis, Langerhan's cell histiocytosis, and multiple myeloma. Based on lesion appearance and distribution, age and sex of the individual, as well as pathogen endemism, the most likely diagnostic option for this set of lesions is metastatic carcinoma. The age and sex of this individual and appearance of the lesions may reflect carcinoma of the lung or, possibly, prostate. This represents one of the earliest cases of metastatic carcinoma worldwide and the oldest case documented thus far from Northeast Asia.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lieverse</LastName><ForeName>Angela R</ForeName><Initials>AR</Initials><AffiliationInfo><Affiliation>Department of Archaeology and Anthropology, University of Saskatchewan, Saskatoon, SK, S7N 5B1, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Temple</LastName><ForeName>Daniel H</ForeName><Initials>DH</Initials><AffiliationInfo><Affiliation>Department of Sociology and Anthropology, George Mason University, Fairfax, Virginia, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bazaliiskii</LastName><ForeName>Vladimir I</ForeName><Initials>VI</Initials><AffiliationInfo><Affiliation>Department of Archaeology and Ethnography, Irkutsk State University, Irkutsk, 664003, Russian Federation.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>12</Month><Day>03</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>PLoS One</MedlineTA><NlmUniqueID>101285081</NlmUniqueID><ISSNLinking>1932-6203</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>CA Cancer J Clin. 2005 Jan-Feb;55(1):10-30</RefSource><PMID Version="1">15661684</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Rev Cancer. 2002 Aug;2(8):584-93</RefSource><PMID Version="1">12154351</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Int J Cancer. 2007 Dec 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UI="D055699" MajorTopicYN="N">Cemeteries</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005580" MajorTopicYN="N">Fossils</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005843" MajorTopicYN="N">Geography</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010006" MajorTopicYN="N">Osteoblasts</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010015" MajorTopicYN="N">Osteolysis, Essential</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010164" MajorTopicYN="N">Paleopathology</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012800" MajorTopicYN="N" Type="Geographic">Siberia</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC4254749</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>07</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>10</Month><Day>31</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>12</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>12</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>7</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25470373</ArticleId><ArticleId IdType="doi">10.1371/journal.pone.0113919</ArticleId><ArticleId IdType="pii">PONE-D-14-26178</ArticleId><ArticleId IdType="pmc">PMC4254749</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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