Paleopathological Description and Diagnosis of Metastatic Carcinoma in an Early Bronze Age (4588+34 Cal. BP) Forager from the Cis-Baikal Region of Eastern Siberia
Identifieur interne : 000033 ( Pmc/Curation ); précédent : 000032; suivant : 000034Paleopathological Description and Diagnosis of Metastatic Carcinoma in an Early Bronze Age (4588+34 Cal. BP) Forager from the Cis-Baikal Region of Eastern Siberia
Auteurs : Angela R. Lieverse [Canada] ; Daniel H. Temple [États-Unis] ; Vladimir I. Bazaliiskii [Russie]Source :
- PLoS ONE [ 1932-6203 ] ; 2014.
Abstract
Extensive osteolytic and osteoblastic lesions were observed on the skeletal remains of an adult male excavated from an Early Bronze Age cemetery dated to 4556+32 years BP, located in the Cis-Baikal region of Siberia (Russian Federation). Lytic lesions ranged in size from several mm to over 60 mm in diameter and had irregular, moth-eaten borders. Many of these lesions destroyed trabecular bone, though a hollowed shell of cortical bone often remained observable. Radiographic analysis revealed numerous lytic lesions within trabecular bone that had not yet affected the cortex. Blastic lesions were identified as spiculated lines, bands, or nodules of mostly immature (woven) bone formed at irregular intervals. Anatomical elements with the greatest involvement included those of the axial skeleton (skull, vertebrae, sacrum, ribs, and sternum) as well as proximal appendicular elements (ossa coxae, proximal femora, clavicles, scapulae, and proximal humeri). Osteocoalescence of destructive foci was observed on the ilium and frontal bone, with the largest lesion found on the right ilium. Differential diagnoses include metastatic carcinoma, mycotic infections, tuberculosis, Langerhan's cell histiocytosis, and multiple myeloma. Based on lesion appearance and distribution, age and sex of the individual, as well as pathogen endemism, the most likely diagnostic option for this set of lesions is metastatic carcinoma. The age and sex of this individual and appearance of the lesions may reflect carcinoma of the lung or, possibly, prostate. This represents one of the earliest cases of metastatic carcinoma worldwide and the oldest case documented thus far from Northeast Asia.
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DOI: 10.1371/journal.pone.0113919
PubMed: 25470373
PubMed Central: 4254749
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Paleopathological Description and Diagnosis of Metastatic Carcinoma in an Early Bronze Age (4588+34 Cal. BP) Forager from the Cis-Baikal Region of Eastern Siberia</title><author><name sortKey="Lieverse, Angela R" sort="Lieverse, Angela R" uniqKey="Lieverse A" first="Angela R." last="Lieverse">Angela R. Lieverse</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Archaeology and Anthropology, University of Saskatchewan, Saskatoon, SK, S7N 5B1, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Archaeology and Anthropology, University of Saskatchewan, Saskatoon, SK, S7N 5B1</wicri:regionArea></affiliation></author><author><name sortKey="Temple, Daniel H" sort="Temple, Daniel H" uniqKey="Temple D" first="Daniel H." last="Temple">Daniel H. Temple</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Department of Sociology and Anthropology, George Mason University, Fairfax, Virginia, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Sociology and Anthropology, George Mason University, Fairfax, Virginia</wicri:regionArea></affiliation></author><author><name sortKey="Bazaliiskii, Vladimir I" sort="Bazaliiskii, Vladimir I" uniqKey="Bazaliiskii V" first="Vladimir I." last="Bazaliiskii">Vladimir I. 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BP) Forager from the Cis-Baikal Region of Eastern Siberia</title><author><name sortKey="Lieverse, Angela R" sort="Lieverse, Angela R" uniqKey="Lieverse A" first="Angela R." last="Lieverse">Angela R. Lieverse</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Archaeology and Anthropology, University of Saskatchewan, Saskatoon, SK, S7N 5B1, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Archaeology and Anthropology, University of Saskatchewan, Saskatoon, SK, S7N 5B1</wicri:regionArea></affiliation></author><author><name sortKey="Temple, Daniel H" sort="Temple, Daniel H" uniqKey="Temple D" first="Daniel H." last="Temple">Daniel H. Temple</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Department of Sociology and Anthropology, George Mason University, Fairfax, Virginia, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Sociology and Anthropology, George Mason University, Fairfax, Virginia</wicri:regionArea></affiliation></author><author><name sortKey="Bazaliiskii, Vladimir I" sort="Bazaliiskii, Vladimir I" uniqKey="Bazaliiskii V" first="Vladimir I." last="Bazaliiskii">Vladimir I. Bazaliiskii</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Archaeology and Ethnography, Irkutsk State University, Irkutsk, 664003, Russian Federation</addr-line></nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea>Department of Archaeology and Ethnography, Irkutsk State University, Irkutsk, 664003</wicri:regionArea></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Extensive osteolytic and osteoblastic lesions were observed on the skeletal remains of an adult male excavated from an Early Bronze Age cemetery dated to 4556+32 years BP, located in the Cis-Baikal region of Siberia (Russian Federation). Lytic lesions ranged in size from several mm to over 60 mm in diameter and had irregular, moth-eaten borders. Many of these lesions destroyed trabecular bone, though a hollowed shell of cortical bone often remained observable. Radiographic analysis revealed numerous lytic lesions within trabecular bone that had not yet affected the cortex. Blastic lesions were identified as spiculated lines, bands, or nodules of mostly immature (woven) bone formed at irregular intervals. Anatomical elements with the greatest involvement included those of the axial skeleton (skull, vertebrae, sacrum, ribs, and sternum) as well as proximal appendicular elements (ossa coxae, proximal femora, clavicles, scapulae, and proximal humeri). Osteocoalescence of destructive foci was observed on the ilium and frontal bone, with the largest lesion found on the right ilium. Differential diagnoses include metastatic carcinoma, mycotic infections, tuberculosis, Langerhan's cell histiocytosis, and multiple myeloma. Based on lesion appearance and distribution, age and sex of the individual, as well as pathogen endemism, the most likely diagnostic option for this set of lesions is metastatic carcinoma. The age and sex of this individual and appearance of the lesions may reflect carcinoma of the lung or, possibly, prostate. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id><journal-id journal-id-type="iso-abbrev">PLoS ONE</journal-id><journal-id journal-id-type="publisher-id">plos</journal-id><journal-id journal-id-type="pmc">plosone</journal-id><journal-title-group><journal-title>PLoS ONE</journal-title></journal-title-group><issn pub-type="epub">1932-6203</issn><publisher><publisher-name>Public Library of Science</publisher-name><publisher-loc>San Francisco, USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25470373</article-id><article-id pub-id-type="pmc">4254749</article-id><article-id pub-id-type="publisher-id">PONE-D-14-26178</article-id><article-id pub-id-type="doi">10.1371/journal.pone.0113919</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Biology and Life Sciences</subject><subj-group><subject>Paleontology</subject><subj-group><subject>Paleoanthropology</subject></subj-group></subj-group><subj-group><subject>Physical Anthropology</subject></subj-group></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Medicine and Health Sciences</subject><subj-group><subject>Oncology</subject></subj-group></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Social Sciences</subject><subj-group><subject>Anthropology</subject></subj-group><subj-group><subject>Archaeology</subject></subj-group></subj-group></article-categories><title-group><article-title>Paleopathological Description and Diagnosis of Metastatic Carcinoma in an Early Bronze Age (4588+34 Cal. BP) Forager from the Cis-Baikal Region of Eastern Siberia</article-title><alt-title alt-title-type="running-head">Metastatic Carcinoma in an Early Bronze Age Forager from Siberia</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Lieverse</surname><given-names>Angela R.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib><contrib contrib-type="author"><name><surname>Temple</surname><given-names>Daniel H.</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bazaliiskii</surname><given-names>Vladimir I.</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib></contrib-group><aff id="aff1"><label>1</label><addr-line>Department of Archaeology and Anthropology, University of Saskatchewan, Saskatoon, SK, S7N 5B1, Canada</addr-line></aff><aff id="aff2"><label>2</label><addr-line>Department of Sociology and Anthropology, George Mason University, Fairfax, Virginia, United States of America</addr-line></aff><aff id="aff3"><label>3</label><addr-line>Department of Archaeology and Ethnography, Irkutsk State University, Irkutsk, 664003, Russian Federation</addr-line></aff><contrib-group><contrib contrib-type="editor"><name><surname>Caramelli</surname><given-names>David</given-names></name><role>Editor</role><xref ref-type="aff" rid="edit1"></xref></contrib></contrib-group><aff id="edit1"><addr-line>University of Florence, Italy</addr-line></aff><author-notes><corresp id="cor1">* E-mail: <email>angela.lieverse@usask.ca</email></corresp><fn fn-type="conflict"><p><bold>Competing Interests: </bold>The authors have declared that no competing interests exist.</p></fn><fn fn-type="con"><p>Conceived and designed the experiments: ARL DHT VIB. Performed the experiments: ARL DHT VIB. Analyzed the data: ARL DHT. Contributed reagents/materials/analysis tools: ARL DHT VIB. Wrote the paper: ARL DHT.</p></fn></author-notes><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>3</day><month>12</month><year>2014</year></pub-date><volume>9</volume><issue>12</issue><elocation-id>e113919</elocation-id><history><date date-type="received"><day>10</day><month>7</month><year>2014</year></date><date date-type="accepted"><day>31</day><month>10</month><year>2014</year></date></history><permissions><copyright-year>2014</copyright-year><copyright-holder>Lieverse et al</copyright-holder><license><license-p>This is an open-access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</ext-link>, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p></license></permissions><abstract><p>Extensive osteolytic and osteoblastic lesions were observed on the skeletal remains of an adult male excavated from an Early Bronze Age cemetery dated to 4556+32 years BP, located in the Cis-Baikal region of Siberia (Russian Federation). Lytic lesions ranged in size from several mm to over 60 mm in diameter and had irregular, moth-eaten borders. Many of these lesions destroyed trabecular bone, though a hollowed shell of cortical bone often remained observable. Radiographic analysis revealed numerous lytic lesions within trabecular bone that had not yet affected the cortex. Blastic lesions were identified as spiculated lines, bands, or nodules of mostly immature (woven) bone formed at irregular intervals. Anatomical elements with the greatest involvement included those of the axial skeleton (skull, vertebrae, sacrum, ribs, and sternum) as well as proximal appendicular elements (ossa coxae, proximal femora, clavicles, scapulae, and proximal humeri). Osteocoalescence of destructive foci was observed on the ilium and frontal bone, with the largest lesion found on the right ilium. Differential diagnoses include metastatic carcinoma, mycotic infections, tuberculosis, Langerhan's cell histiocytosis, and multiple myeloma. Based on lesion appearance and distribution, age and sex of the individual, as well as pathogen endemism, the most likely diagnostic option for this set of lesions is metastatic carcinoma. The age and sex of this individual and appearance of the lesions may reflect carcinoma of the lung or, possibly, prostate. This represents one of the earliest cases of metastatic carcinoma worldwide and the oldest case documented thus far from Northeast Asia.</p></abstract><funding-group><funding-statement>This research is part of the Baikal-Hokkaido Archaeology Project funded largely by the Social Sciences and Humanities Research Council of Canada (grant #412-2011-1001). Funding was also provided by the University of Saskatchewan and the University of North Carolina Wilmington. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</funding-statement></funding-group><counts><page-count count="25"></page-count></counts><custom-meta-group><custom-meta id="data-availability"><meta-name>Data Availability</meta-name><meta-value>The authors confirm that all data underlying the findings are fully available without restriction. All relevant data are within the paper and its Supporting Information files.</meta-value></custom-meta></custom-meta-group></article-meta><notes><title>Data Availability</title><p>The authors confirm that all data underlying the findings are fully available without restriction. All relevant data are within the paper and its Supporting Information files.</p></notes></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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