Movement Disorders (revue)

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Dopamine levels after repetitive transcranial magnetic stimulation of motor cortex in patients with Parkinson's disease: preliminary results.

Identifieur interne : 002630 ( PubMed/Curation ); précédent : 002629; suivant : 002631

Dopamine levels after repetitive transcranial magnetic stimulation of motor cortex in patients with Parkinson's disease: preliminary results.

Auteurs : Eman M. Khedr [Égypte] ; John C. Rothwell ; Ola A. Shawky ; Mohammed A. Ahmed ; Nageh Foly ; Ahmed Hamdy

Source :

RBID : pubmed:17575584

English descriptors

Abstract

Repeated session of repetitive transcranial magnetic stimulation (rTMS) over motor cortex have been reported to produce significant improvement of motor performance in patients with parkinson's disease (PD). In addition, it is known that a single session of rTMS over motor cortex transiently increases DA in striatum. Here, we test whether repeated sessions of rTMS increase serum dopamine in PD patients and whether this correlates with changes in clinical rating scales.

PubMed: 17575584

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pubmed:17575584

Le document en format XML

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<title xml:lang="en">Dopamine levels after repetitive transcranial magnetic stimulation of motor cortex in patients with Parkinson's disease: preliminary results.</title>
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<name sortKey="Khedr, Eman M" sort="Khedr, Eman M" uniqKey="Khedr E" first="Eman M" last="Khedr">Eman M. Khedr</name>
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<nlm:affiliation>Department of Neurology, Assiut University Hospital, Assiut, Egypt. emankhedr99@yahoo.com</nlm:affiliation>
<country xml:lang="fr">Égypte</country>
<wicri:regionArea>Department of Neurology, Assiut University Hospital, Assiut</wicri:regionArea>
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<name sortKey="Rothwell, John C" sort="Rothwell, John C" uniqKey="Rothwell J" first="John C" last="Rothwell">John C. Rothwell</name>
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<name sortKey="Shawky, Ola A" sort="Shawky, Ola A" uniqKey="Shawky O" first="Ola A" last="Shawky">Ola A. Shawky</name>
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<name sortKey="Ahmed, Mohammed A" sort="Ahmed, Mohammed A" uniqKey="Ahmed M" first="Mohammed A" last="Ahmed">Mohammed A. Ahmed</name>
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<name sortKey="Foly, Nageh" sort="Foly, Nageh" uniqKey="Foly N" first="Nageh" last="Foly">Nageh Foly</name>
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<name sortKey="Hamdy, Ahmed" sort="Hamdy, Ahmed" uniqKey="Hamdy A" first="Ahmed" last="Hamdy">Ahmed Hamdy</name>
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<name sortKey="Rothwell, John C" sort="Rothwell, John C" uniqKey="Rothwell J" first="John C" last="Rothwell">John C. Rothwell</name>
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<name sortKey="Shawky, Ola A" sort="Shawky, Ola A" uniqKey="Shawky O" first="Ola A" last="Shawky">Ola A. Shawky</name>
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<name sortKey="Ahmed, Mohammed A" sort="Ahmed, Mohammed A" uniqKey="Ahmed M" first="Mohammed A" last="Ahmed">Mohammed A. Ahmed</name>
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<name sortKey="Foly, Nageh" sort="Foly, Nageh" uniqKey="Foly N" first="Nageh" last="Foly">Nageh Foly</name>
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<title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
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<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Dopamine (metabolism)</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Motor Cortex (metabolism)</term>
<term>Parkinson Disease (metabolism)</term>
<term>Parkinson Disease (pathology)</term>
<term>Transcranial Magnetic Stimulation</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en">
<term>Dopamine</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en">
<term>Motor Cortex</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en">
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
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<div type="abstract" xml:lang="en">Repeated session of repetitive transcranial magnetic stimulation (rTMS) over motor cortex have been reported to produce significant improvement of motor performance in patients with parkinson's disease (PD). In addition, it is known that a single session of rTMS over motor cortex transiently increases DA in striatum. Here, we test whether repeated sessions of rTMS increase serum dopamine in PD patients and whether this correlates with changes in clinical rating scales.</div>
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<Year>2007</Year>
<Month>06</Month>
<Day>15</Day>
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<DateCompleted>
<Year>2007</Year>
<Month>08</Month>
<Day>03</Day>
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<DateRevised>
<Year>2013</Year>
<Month>11</Month>
<Day>21</Day>
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<ISSN IssnType="Print">0885-3185</ISSN>
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<Volume>22</Volume>
<Issue>7</Issue>
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<Year>2007</Year>
<Month>May</Month>
<Day>15</Day>
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<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
<ISOAbbreviation>Mov. Disord.</ISOAbbreviation>
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<ArticleTitle>Dopamine levels after repetitive transcranial magnetic stimulation of motor cortex in patients with Parkinson's disease: preliminary results.</ArticleTitle>
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<MedlinePgn>1046-50</MedlinePgn>
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<Abstract>
<AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Repeated session of repetitive transcranial magnetic stimulation (rTMS) over motor cortex have been reported to produce significant improvement of motor performance in patients with parkinson's disease (PD). In addition, it is known that a single session of rTMS over motor cortex transiently increases DA in striatum. Here, we test whether repeated sessions of rTMS increase serum dopamine in PD patients and whether this correlates with changes in clinical rating scales.</AbstractText>
<AbstractText Label="MATERIAL AND METHODS" NlmCategory="METHODS">Twenty untreated PD patients with moderate to severe symptoms (Hoehn & Yahr state III-V 1967) were assessed on the Unified Parkinson's Disease Rating Scale (UPDRS), and with an enzyme immunoassay for quantitative determination of plasma dopamine before and after six daily sessions of 25 Hz rTMS with 3,000 stimuli over the right and left hand and leg motor cortex.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">There was significant improvement in UPDRS compared with the baseline. Serum dopamine level also was significantly elevated over the same interval. There was a significant correlation between UPDRS and serum dopamine level before and after treatment.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Improved motor performance in PD after repeated session of rTMS may be related to an elevation of serum dopamine concentration.</AbstractText>
<CopyrightInformation>(c) 2007 Movement Disorder Society.</CopyrightInformation>
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<DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName>
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<QualifierName MajorTopicYN="Y" UI="Q000473">pathology</QualifierName>
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