PET evidence of central GABAergic changes in stiff-person syndrome.
Identifieur interne : 002631 ( PubMed/Curation ); précédent : 002630; suivant : 002632PET evidence of central GABAergic changes in stiff-person syndrome.
Auteurs : Daniela Perani [Italie] ; Valentina Garibotto ; Andrea Panzacchi ; Rosa Maria Moresco ; Paola Ortelli ; Massimo Corbo ; Ferruccio Fazio ; Franco FolliSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : gamma-Aminobutyric Acid.
- metabolism : Stiff-Person Syndrome.
- physiopathology : Stiff-Person Syndrome.
- radionuclide imaging : Stiff-Person Syndrome.
- Female, Humans, Male, Middle Aged, Neuropsychological Tests, Positron-Emission Tomography.
Abstract
We measured expression of central nervous system GABA-A receptors with (11)C-flumazenil ((11)C-FMZ) and PET in two subjects with stiff person syndrome (SPS). We found reduced (11)C-FMZ binding potential (BP) in motor-premotor cortex, and increased (11)C-FMZ BP in the cerebellar nuclei. This is the first in vivo PET evidence of central GABA-A receptors dysfunction in SPS, possibly concurring to the motor symptoms.
PubMed: 17575583
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Rosa Maria" uniqKey="Moresco R" first="Rosa Maria" last="Moresco">Rosa Maria Moresco</name></author><author><name sortKey="Ortelli, Paola" sort="Ortelli, Paola" uniqKey="Ortelli P" first="Paola" last="Ortelli">Paola Ortelli</name></author><author><name sortKey="Corbo, Massimo" sort="Corbo, Massimo" uniqKey="Corbo M" first="Massimo" last="Corbo">Massimo Corbo</name></author><author><name sortKey="Fazio, Ferruccio" sort="Fazio, Ferruccio" uniqKey="Fazio F" first="Ferruccio" last="Fazio">Ferruccio Fazio</name></author><author><name sortKey="Folli, Franco" sort="Folli, Franco" uniqKey="Folli F" first="Franco" last="Folli">Franco Folli</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="RBID">pubmed:17575583</idno><idno type="pmid">17575583</idno><idno type="wicri:Area/PubMed/Corpus">002631</idno><idno type="wicri:Area/PubMed/Curation">002631</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">PET evidence of central GABAergic changes in stiff-person syndrome.</title><author><name sortKey="Perani, Daniela" sort="Perani, Daniela" uniqKey="Perani D" first="Daniela" last="Perani">Daniela Perani</name><affiliation wicri:level="1"><nlm:affiliation>Istituto Nazionale di Neuroscienze, Vita-Salute San Raffaele University, Milan, Italy. daniela.perani@hsr.it</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto Nazionale di Neuroscienze, Vita-Salute San Raffaele University, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Garibotto, Valentina" sort="Garibotto, Valentina" uniqKey="Garibotto V" first="Valentina" last="Garibotto">Valentina Garibotto</name></author><author><name sortKey="Panzacchi, Andrea" sort="Panzacchi, Andrea" uniqKey="Panzacchi A" first="Andrea" last="Panzacchi">Andrea Panzacchi</name></author><author><name sortKey="Moresco, Rosa Maria" sort="Moresco, Rosa Maria" uniqKey="Moresco R" first="Rosa Maria" last="Moresco">Rosa Maria Moresco</name></author><author><name sortKey="Ortelli, Paola" sort="Ortelli, Paola" uniqKey="Ortelli P" first="Paola" last="Ortelli">Paola Ortelli</name></author><author><name sortKey="Corbo, Massimo" sort="Corbo, Massimo" uniqKey="Corbo M" first="Massimo" last="Corbo">Massimo Corbo</name></author><author><name sortKey="Fazio, Ferruccio" sort="Fazio, Ferruccio" uniqKey="Fazio F" first="Ferruccio" last="Fazio">Ferruccio Fazio</name></author><author><name sortKey="Folli, Franco" sort="Folli, Franco" uniqKey="Folli F" first="Franco" last="Folli">Franco Folli</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Female</term><term>Humans</term><term>Male</term><term>Middle 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Tomography</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We measured expression of central nervous system GABA-A receptors with (11)C-flumazenil ((11)C-FMZ) and PET in two subjects with stiff person syndrome (SPS). We found reduced (11)C-FMZ binding potential (BP) in motor-premotor cortex, and increased (11)C-FMZ BP in the cerebellar nuclei. This is the first in vivo PET evidence of central GABA-A receptors dysfunction in SPS, possibly concurring to the motor symptoms.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">17575583</PMID><DateCreated><Year>2007</Year><Month>06</Month><Day>15</Day></DateCreated><DateCompleted><Year>2007</Year><Month>08</Month><Day>03</Day></DateCompleted><DateRevised><Year>2014</Year><Month>03</Month><Day>11</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>22</Volume><Issue>7</Issue><PubDate><Year>2007</Year><Month>May</Month><Day>15</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>PET evidence of central GABAergic changes in stiff-person syndrome.</ArticleTitle><Pagination><MedlinePgn>1030-3</MedlinePgn></Pagination><Abstract><AbstractText>We measured expression of central nervous system GABA-A receptors with (11)C-flumazenil ((11)C-FMZ) and PET in two subjects with stiff person syndrome (SPS). We found reduced (11)C-FMZ binding potential (BP) in motor-premotor cortex, and increased (11)C-FMZ BP in the cerebellar nuclei. This is the first in vivo PET evidence of central GABA-A receptors dysfunction in SPS, possibly concurring to the motor symptoms.</AbstractText><CopyrightInformation>(c) 2007 Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Perani</LastName><ForeName>Daniela</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Istituto Nazionale di Neuroscienze, Vita-Salute San Raffaele University, Milan, Italy. daniela.perani@hsr.it</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Garibotto</LastName><ForeName>Valentina</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Panzacchi</LastName><ForeName>Andrea</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Moresco</LastName><ForeName>Rosa Maria</ForeName><Initials>RM</Initials></Author><Author ValidYN="Y"><LastName>Ortelli</LastName><ForeName>Paola</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Corbo</LastName><ForeName>Massimo</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Fazio</LastName><ForeName>Ferruccio</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Folli</LastName><ForeName>Franco</ForeName><Initials>F</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>56-12-2</RegistryNumber><NameOfSubstance UI="D005680">gamma-Aminobutyric Acid</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009483">Neuropsychological Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D049268">Positron-Emission Tomography</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D016750">Stiff-Person Syndrome</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000531">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005680">gamma-Aminobutyric Acid</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2007</Year><Month>6</Month><Day>19</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2007</Year><Month>8</Month><Day>4</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2007</Year><Month>6</Month><Day>19</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">17575583</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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