Proton magnetic resonance spectroscopy in Steele-Richardson-Olszewski syndrome.
Identifieur interne : 004591 ( PubMed/Checkpoint ); précédent : 004590; suivant : 004592Proton magnetic resonance spectroscopy in Steele-Richardson-Olszewski syndrome.
Auteurs : C A Davie [Royaume-Uni] ; G J Barker ; C. Machado ; D H Miller ; A J LeesSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1997.
English descriptors
- KwdEn :
- Adult, Aged, Aspartic Acid (analogs & derivatives), Aspartic Acid (analysis), Basal Ganglia (chemistry), Basal Ganglia (pathology), Case-Control Studies, Choline (analysis), Creatine (analysis), Diagnosis, Differential, Globus Pallidus (pathology), Humans, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Middle Aged, Supranuclear Palsy, Progressive (diagnosis).
- MESH :
- chemical , analogs & derivatives : Aspartic Acid.
- chemical , analysis : Aspartic Acid, Choline, Creatine.
- chemistry : Basal Ganglia.
- diagnosis : Supranuclear Palsy, Progressive.
- pathology : Basal Ganglia, Globus Pallidus.
- Adult, Aged, Case-Control Studies, Diagnosis, Differential, Humans, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Middle Aged.
Abstract
Proton magnetic resonance spectroscopy, localized to the lentiform nucleus, was carried out in nine patients with a clinical diagnosis of Steele-Richardson-Olszewski syndrome (SRO) and in eight healthy age-matched controls. Three of the nine SRO patients had a so-called "eye of the tiger sign" with high signal in the globus pallidus surrounded by a ring of low signal on T2 weighted magnetic resonance imaging previously only reported in Hallervorden-Spatz disease. One of these patients had pathologically proven SRO at postmortem. The SRO group showed a significant reduction in the median concentration from N-acetyl groups (median, 6.87 mM; range, 4.92-10.59 mM; p < 0.015) compared with the control group (median, 9.85 mM; range, 9.26-11.0 mM). The N-acetylaspartate concentration was significantly reduced in seven of the nine patients studied. The reduction of the N-acetylaspartate-creatine ratio from the lentiform nucleus in the SRO group may reflect neuronal loss, occurring predominantly in the globus pallidus. Proton magnetic resonance spectroscopy may be a useful, noninvasive technique to help differentiate the various parkinsonian syndromes.
DOI: 10.1002/mds.870120525
PubMed: 9380064
Affiliations:
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<author><name sortKey="Barker, G J" sort="Barker, G J" uniqKey="Barker G" first="G J" last="Barker">G J Barker</name>
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<author><name sortKey="Machado, C" sort="Machado, C" uniqKey="Machado C" first="C" last="Machado">C. Machado</name>
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<author><name sortKey="Miller, D H" sort="Miller, D H" uniqKey="Miller D" first="D H" last="Miller">D H Miller</name>
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<author><name sortKey="Lees, A J" sort="Lees, A J" uniqKey="Lees A" first="A J" last="Lees">A J Lees</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Proton magnetic resonance spectroscopy in Steele-Richardson-Olszewski syndrome.</title>
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<term>Basal Ganglia (chemistry)</term>
<term>Basal Ganglia (pathology)</term>
<term>Case-Control Studies</term>
<term>Choline (analysis)</term>
<term>Creatine (analysis)</term>
<term>Diagnosis, Differential</term>
<term>Globus Pallidus (pathology)</term>
<term>Humans</term>
<term>Magnetic Resonance Imaging</term>
<term>Magnetic Resonance Spectroscopy</term>
<term>Middle Aged</term>
<term>Supranuclear Palsy, Progressive (diagnosis)</term>
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<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Aspartic Acid</term>
<term>Choline</term>
<term>Creatine</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Basal Ganglia</term>
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<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Supranuclear Palsy, Progressive</term>
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<term>Case-Control Studies</term>
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<front><div type="abstract" xml:lang="en">Proton magnetic resonance spectroscopy, localized to the lentiform nucleus, was carried out in nine patients with a clinical diagnosis of Steele-Richardson-Olszewski syndrome (SRO) and in eight healthy age-matched controls. Three of the nine SRO patients had a so-called "eye of the tiger sign" with high signal in the globus pallidus surrounded by a ring of low signal on T2 weighted magnetic resonance imaging previously only reported in Hallervorden-Spatz disease. One of these patients had pathologically proven SRO at postmortem. The SRO group showed a significant reduction in the median concentration from N-acetyl groups (median, 6.87 mM; range, 4.92-10.59 mM; p < 0.015) compared with the control group (median, 9.85 mM; range, 9.26-11.0 mM). The N-acetylaspartate concentration was significantly reduced in seven of the nine patients studied. The reduction of the N-acetylaspartate-creatine ratio from the lentiform nucleus in the SRO group may reflect neuronal loss, occurring predominantly in the globus pallidus. Proton magnetic resonance spectroscopy may be a useful, noninvasive technique to help differentiate the various parkinsonian syndromes.</div>
</front>
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<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
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<ArticleTitle>Proton magnetic resonance spectroscopy in Steele-Richardson-Olszewski syndrome.</ArticleTitle>
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<Abstract><AbstractText>Proton magnetic resonance spectroscopy, localized to the lentiform nucleus, was carried out in nine patients with a clinical diagnosis of Steele-Richardson-Olszewski syndrome (SRO) and in eight healthy age-matched controls. Three of the nine SRO patients had a so-called "eye of the tiger sign" with high signal in the globus pallidus surrounded by a ring of low signal on T2 weighted magnetic resonance imaging previously only reported in Hallervorden-Spatz disease. One of these patients had pathologically proven SRO at postmortem. The SRO group showed a significant reduction in the median concentration from N-acetyl groups (median, 6.87 mM; range, 4.92-10.59 mM; p < 0.015) compared with the control group (median, 9.85 mM; range, 9.26-11.0 mM). The N-acetylaspartate concentration was significantly reduced in seven of the nine patients studied. The reduction of the N-acetylaspartate-creatine ratio from the lentiform nucleus in the SRO group may reflect neuronal loss, occurring predominantly in the globus pallidus. Proton magnetic resonance spectroscopy may be a useful, noninvasive technique to help differentiate the various parkinsonian syndromes.</AbstractText>
</Abstract>
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<tree><noCountry><name sortKey="Barker, G J" sort="Barker, G J" uniqKey="Barker G" first="G J" last="Barker">G J Barker</name>
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<name sortKey="Machado, C" sort="Machado, C" uniqKey="Machado C" first="C" last="Machado">C. Machado</name>
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