Proton magnetic resonance spectroscopy in Parkinson's disease and atypical parkinsonian disorders.
Identifieur interne : 004592 ( PubMed/Checkpoint ); précédent : 004591; suivant : 004593Proton magnetic resonance spectroscopy in Parkinson's disease and atypical parkinsonian disorders.
Auteurs : F. Federico [Italie] ; I L Simone ; V. Lucivero ; G. Iliceto ; M. De Mari ; P. Giannini ; D M Mezzapesa ; A. Tarantino ; P. LambertiSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1997.
English descriptors
- KwdEn :
- Aged, Antiparkinson Agents (therapeutic use), Aspartic Acid (metabolism), Atrophy (pathology), Cerebral Cortex (pathology), Choline (metabolism), Corpus Striatum (metabolism), Creatinine (metabolism), Female, Globus Pallidus (metabolism), Globus Pallidus (pathology), Humans, Levodopa (therapeutic use), Magnetic Resonance Spectroscopy, Middle Aged, Parkinson Disease (drug therapy), Parkinson Disease (pathology), Parkinson Disease, Secondary (pathology), Phosphocreatine (metabolism), Protons (diagnostic use), Putamen (metabolism), Putamen (pathology), Supranuclear Palsy, Progressive (pathology).
- MESH :
- chemical , diagnostic use : Protons.
- chemical , metabolism : Aspartic Acid, Choline, Creatinine, Phosphocreatine.
- chemical , therapeutic use : Antiparkinson Agents, Levodopa.
- drug therapy : Parkinson Disease.
- metabolism : Corpus Striatum, Globus Pallidus, Putamen.
- pathology : Atrophy, Cerebral Cortex, Globus Pallidus, Parkinson Disease, Parkinson Disease, Secondary, Putamen, Supranuclear Palsy, Progressive.
- Aged, Female, Humans, Magnetic Resonance Spectroscopy, Middle Aged.
Abstract
Proton magnetic resonance spectroscopy (1H-MRS), localized to the lentiform nucleus, was carried out in 12 patients with idiopathic Parkinson's disease (IPD), seven patients with multiple-system atrophy (MSA), seven patients with progressive supranuclear palsy (PSP), and 10 healthy age-matched controls. The study assessed the level of N-acetylaspartate (NAA), creatine-phosphocreatine (Cr), and choline (Cho) in the putamen and globus pallidus of these patients. NAA/Cho and NAA/Cr ratios were significantly reduced in MSA and PSP patients. No significant difference was found between IPD patients and controls. These results suggest an NAA deficit, due to neuronal loss, in the lentiform nucleus of MSA and PSP patients. 1H-MRS is a noninvasive technique that can provide useful information regarding striatal neuronal loss in basal ganglia of patients with atypical parkinsonian disorders and represents a potential tool for diagnosing these disorders.
DOI: 10.1002/mds.870120611
PubMed: 9399213
Affiliations:
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pubmed:9399213Le document en format XML
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<term>Cerebral Cortex (pathology)</term>
<term>Choline (metabolism)</term>
<term>Corpus Striatum (metabolism)</term>
<term>Creatinine (metabolism)</term>
<term>Female</term>
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<term>Globus Pallidus (pathology)</term>
<term>Humans</term>
<term>Levodopa (therapeutic use)</term>
<term>Magnetic Resonance Spectroscopy</term>
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<term>Parkinson Disease (drug therapy)</term>
<term>Parkinson Disease (pathology)</term>
<term>Parkinson Disease, Secondary (pathology)</term>
<term>Phosphocreatine (metabolism)</term>
<term>Protons (diagnostic use)</term>
<term>Putamen (metabolism)</term>
<term>Putamen (pathology)</term>
<term>Supranuclear Palsy, Progressive (pathology)</term>
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<term>Phosphocreatine</term>
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<term>Levodopa</term>
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<front><div type="abstract" xml:lang="en">Proton magnetic resonance spectroscopy (1H-MRS), localized to the lentiform nucleus, was carried out in 12 patients with idiopathic Parkinson's disease (IPD), seven patients with multiple-system atrophy (MSA), seven patients with progressive supranuclear palsy (PSP), and 10 healthy age-matched controls. The study assessed the level of N-acetylaspartate (NAA), creatine-phosphocreatine (Cr), and choline (Cho) in the putamen and globus pallidus of these patients. NAA/Cho and NAA/Cr ratios were significantly reduced in MSA and PSP patients. No significant difference was found between IPD patients and controls. These results suggest an NAA deficit, due to neuronal loss, in the lentiform nucleus of MSA and PSP patients. 1H-MRS is a noninvasive technique that can provide useful information regarding striatal neuronal loss in basal ganglia of patients with atypical parkinsonian disorders and represents a potential tool for diagnosing these disorders.</div>
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<Abstract><AbstractText>Proton magnetic resonance spectroscopy (1H-MRS), localized to the lentiform nucleus, was carried out in 12 patients with idiopathic Parkinson's disease (IPD), seven patients with multiple-system atrophy (MSA), seven patients with progressive supranuclear palsy (PSP), and 10 healthy age-matched controls. The study assessed the level of N-acetylaspartate (NAA), creatine-phosphocreatine (Cr), and choline (Cho) in the putamen and globus pallidus of these patients. NAA/Cho and NAA/Cr ratios were significantly reduced in MSA and PSP patients. No significant difference was found between IPD patients and controls. These results suggest an NAA deficit, due to neuronal loss, in the lentiform nucleus of MSA and PSP patients. 1H-MRS is a noninvasive technique that can provide useful information regarding striatal neuronal loss in basal ganglia of patients with atypical parkinsonian disorders and represents a potential tool for diagnosing these disorders.</AbstractText>
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