MovDisordV3, PascalFrancis, Curation, bibRecord, 002C44

Age at Onset and Symptom Spread in Primary Adult-Onset Blepharospasm and Cervical Dystonia

Identifieur interne : 002C44 ( PascalFrancis/Curation ); précédent : 002C43; suivant : 002C45

Age at Onset and Symptom Spread in Primary Adult-Onset Blepharospasm and Cervical Dystonia

Auteurs : Davide Martino [Italie] ; Alfredo Berardelli [Italie] ; Giovanni Abbruzzese [Italie] ; Anna Rita Bentivoglio [Italie] ; Marcello Esposito [Italie] ; Giovanni Fabbrini [Italie] ; Arianna Guidubaldi [Italie] ; Paolo Girlanda [Italie] ; Rocco Liguori [Italie] ; Lucio Marinelli [Italie] ; Francesca Morgante [Italie] ; Lucio Santoro [Italie] ; Giovanni Defazio [Italie]

Source :

Movement disorders [ 0885-3185 ] ; 2012.

RBID : Pascal:12-0393102

Descripteurs français

Pascal (Inist)
- Blépharospasme, Dystonie, Pathologie du système nerveux, Epidémiologie, Neurologie.
Wicri :
- topic : Neurologie.

English descriptors

KwdEn :
- Blepharospasm, Dystonia, Epidemiology, Nervous system diseases, Neurology.

Abstract

Background: The site of dystonia onset is known to affect the risk of spread in primary adult-onset focal dystonia, but other factors possibly influencing spread are unknown. This study explored the relationship between age and spread of dystonia in primary adult-onset focal dystonia. Methods: Two survival models analyzed spread of dystonia in a large cohort of patients with primary blepharospasm (BSP) and cervical dystonia. The first model was based on time interval between onset and spread of dystonia, and the second model was based on age at spread. Results: Patients presenting with BSP had a 2-fold higher rate of spread than those presenting with cervical dystonia, regardless of the survival model used. However, survival analysis, based on age at spread, showed that spread develops at a similar age period in both groups, with most spread events occurring after the age of 50. Conclusions: The convergent age of spread in BSP and cervical dystonia is a novel finding indicating age as a factor modulating spread of dystonia. These findings may assist in informing prognostication for patients with primary adult-onset focal dystonia.

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A11	`01`	`1`		`@1 MARTINO (Davide)`
A11	`02`	`1`		`@1 BERARDELLI (Alfredo)`
A11	`03`	`1`		`@1 ABBRUZZESE (Giovanni)`
A11	`04`	`1`		`@1 BENTIVOGLIO (Anna Rita)`
A11	`05`	`1`		`@1 ESPOSITO (Marcello)`
A11	`06`	`1`		`@1 FABBRINI (Giovanni)`
A11	`07`	`1`		`@1 GUIDUBALDI (Arianna)`
A11	`08`	`1`		`@1 GIRLANDA (Paolo)`
A11	`09`	`1`		`@1 LIGUORI (Rocco)`
A11	`10`	`1`		`@1 MARINELLI (Lucio)`
A11	`11`	`1`		`@1 MORGANTE (Francesca)`
A11	`12`	`1`		`@1 SANTORO (Lucio)`
A11	`13`	`1`		`@1 DEFAZIO (Giovanni)`
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A14	`02`			`@1 Department of Neurology and Psychiatry, Sapienza University of Rome and IRCCS Neuromed Institute @2 Pozzilli @3 ITA @Z 2 aut. @Z 6 aut.`
A14	`03`			`@1 Department of Neurosciences, Ophthalmology and Genetics, University of Genoa @2 Genoa @3 ITA @Z 3 aut. @Z 10 aut.`
A14	`04`			`@1 Department of Neurosciences, Catholic University @2 Rome @3 ITA @Z 4 aut. @Z 7 aut.`
A14	`05`			`@1 Department of Neurology, Second University of Naples @2 Naples @3 ITA @Z 5 aut. @Z 12 aut.`
A14	`06`			`@1 Department of Neurosciences, Psychiatry, and Anaesthesiological Science, University of Messina @2 Messina @3 ITA @Z 8 aut. @Z 11 aut.`
A14	`07`			`@1 Department of Neurosciences, University of Bologna @2 Bologna @3 ITA @Z 9 aut.`
A20				`@1 1447-1450`
A21				`@1 2012`
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C01	`01`		`ENG`	@0 Background: The site of dystonia onset is known to affect the risk of spread in primary adult-onset focal dystonia, but other factors possibly influencing spread are unknown. This study explored the relationship between age and spread of dystonia in primary adult-onset focal dystonia. Methods: Two survival models analyzed spread of dystonia in a large cohort of patients with primary blepharospasm (BSP) and cervical dystonia. The first model was based on time interval between onset and spread of dystonia, and the second model was based on age at spread. Results: Patients presenting with BSP had a 2-fold higher rate of spread than those presenting with cervical dystonia, regardless of the survival model used. However, survival analysis, based on age at spread, showed that spread develops at a similar age period in both groups, with most spread events occurring after the age of 50. Conclusions: The convergent age of spread in BSP and cervical dystonia is a novel finding indicating age as a factor modulating spread of dystonia. These findings may assist in informing prognostication for patients with primary adult-onset focal dystonia.
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C03	`01`	`X`	`FRE`	`@0 Blépharospasme @5 01`
C03	`01`	`X`	`ENG`	`@0 Blepharospasm @5 01`
C03	`01`	`X`	`SPA`	`@0 Blefaroespasmo @5 01`
C03	`02`	`X`	`FRE`	`@0 Dystonie @5 02`
C03	`02`	`X`	`ENG`	`@0 Dystonia @5 02`
C03	`02`	`X`	`SPA`	`@0 Distonía @5 02`
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C07	`03`	`X`	`FRE`	`@0 Syndrome extrapyramidal @5 39`
C07	`03`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 39`
C07	`03`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 39`
C07	`04`	`X`	`FRE`	`@0 Mouvement involontaire @5 40`
C07	`04`	`X`	`ENG`	`@0 Involuntary movement @5 40`
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C07	`05`	`X`	`FRE`	`@0 Pathologie du muscle strié @5 41`
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C07	`06`	`X`	`FRE`	`@0 Trouble neurologique @5 43`
C07	`06`	`X`	`ENG`	`@0 Neurological disorder @5 43`
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C07	`07`	`X`	`FRE`	`@0 Pathologie de l'encéphale @5 44`
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C07	`07`	`X`	`SPA`	`@0 Encéfalo patología @5 44`
C07	`08`	`X`	`FRE`	`@0 Pathologie du système nerveux central @5 45`
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C07	`08`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 45`
N21				`@1 303`
N44	`01`			`@1 OTO`
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Pascal:12-0393102

Le document en format XML

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<author><name sortKey="Fabbrini, Giovanni" sort="Fabbrini, Giovanni" uniqKey="Fabbrini G" first="Giovanni" last="Fabbrini">Giovanni Fabbrini</name>
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<author><name sortKey="Guidubaldi, Arianna" sort="Guidubaldi, Arianna" uniqKey="Guidubaldi A" first="Arianna" last="Guidubaldi">Arianna Guidubaldi</name>
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<author><name sortKey="Girlanda, Paolo" sort="Girlanda, Paolo" uniqKey="Girlanda P" first="Paolo" last="Girlanda">Paolo Girlanda</name>
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<author><name sortKey="Liguori, Rocco" sort="Liguori, Rocco" uniqKey="Liguori R" first="Rocco" last="Liguori">Rocco Liguori</name>
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<author><name sortKey="Marinelli, Lucio" sort="Marinelli, Lucio" uniqKey="Marinelli L" first="Lucio" last="Marinelli">Lucio Marinelli</name>
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<author><name sortKey="Morgante, Francesca" sort="Morgante, Francesca" uniqKey="Morgante F" first="Francesca" last="Morgante">Francesca Morgante</name>
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<author><name sortKey="Santoro, Lucio" sort="Santoro, Lucio" uniqKey="Santoro L" first="Lucio" last="Santoro">Lucio Santoro</name>
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<author><name sortKey="Defazio, Giovanni" sort="Defazio, Giovanni" uniqKey="Defazio G" first="Giovanni" last="Defazio">Giovanni Defazio</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Age at Onset and Symptom Spread in Primary Adult-Onset Blepharospasm and Cervical Dystonia</title>
<author><name sortKey="Martino, Davide" sort="Martino, Davide" uniqKey="Martino D" first="Davide" last="Martino">Davide Martino</name>
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<author><name sortKey="Berardelli, Alfredo" sort="Berardelli, Alfredo" uniqKey="Berardelli A" first="Alfredo" last="Berardelli">Alfredo Berardelli</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology and Psychiatry, Sapienza University of Rome and IRCCS Neuromed Institute</s1>
<s2>Pozzilli</s2>
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<author><name sortKey="Abbruzzese, Giovanni" sort="Abbruzzese, Giovanni" uniqKey="Abbruzzese G" first="Giovanni" last="Abbruzzese">Giovanni Abbruzzese</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurosciences, Ophthalmology and Genetics, University of Genoa</s1>
<s2>Genoa</s2>
<s3>ITA</s3>
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<country>Italie</country>
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<author><name sortKey="Bentivoglio, Anna Rita" sort="Bentivoglio, Anna Rita" uniqKey="Bentivoglio A" first="Anna Rita" last="Bentivoglio">Anna Rita Bentivoglio</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Neurosciences, Catholic University</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>4 aut.</sZ>
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</inist:fA14>
<country>Italie</country>
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</author>
<author><name sortKey="Esposito, Marcello" sort="Esposito, Marcello" uniqKey="Esposito M" first="Marcello" last="Esposito">Marcello Esposito</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Neurology, Second University of Naples</s1>
<s2>Naples</s2>
<s3>ITA</s3>
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</inist:fA14>
<country>Italie</country>
</affiliation>
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<author><name sortKey="Fabbrini, Giovanni" sort="Fabbrini, Giovanni" uniqKey="Fabbrini G" first="Giovanni" last="Fabbrini">Giovanni Fabbrini</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology and Psychiatry, Sapienza University of Rome and IRCCS Neuromed Institute</s1>
<s2>Pozzilli</s2>
<s3>ITA</s3>
<sZ>2 aut.</sZ>
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</inist:fA14>
<country>Italie</country>
</affiliation>
</author>
<author><name sortKey="Guidubaldi, Arianna" sort="Guidubaldi, Arianna" uniqKey="Guidubaldi A" first="Arianna" last="Guidubaldi">Arianna Guidubaldi</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Neurosciences, Catholic University</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Italie</country>
</affiliation>
</author>
<author><name sortKey="Girlanda, Paolo" sort="Girlanda, Paolo" uniqKey="Girlanda P" first="Paolo" last="Girlanda">Paolo Girlanda</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Neurosciences, Psychiatry, and Anaesthesiological Science, University of Messina</s1>
<s2>Messina</s2>
<s3>ITA</s3>
<sZ>8 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Italie</country>
</affiliation>
</author>
<author><name sortKey="Liguori, Rocco" sort="Liguori, Rocco" uniqKey="Liguori R" first="Rocco" last="Liguori">Rocco Liguori</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Neurosciences, University of Bologna</s1>
<s2>Bologna</s2>
<s3>ITA</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Italie</country>
</affiliation>
</author>
<author><name sortKey="Marinelli, Lucio" sort="Marinelli, Lucio" uniqKey="Marinelli L" first="Lucio" last="Marinelli">Lucio Marinelli</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurosciences, Ophthalmology and Genetics, University of Genoa</s1>
<s2>Genoa</s2>
<s3>ITA</s3>
<sZ>3 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Italie</country>
</affiliation>
</author>
<author><name sortKey="Morgante, Francesca" sort="Morgante, Francesca" uniqKey="Morgante F" first="Francesca" last="Morgante">Francesca Morgante</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Neurosciences, Psychiatry, and Anaesthesiological Science, University of Messina</s1>
<s2>Messina</s2>
<s3>ITA</s3>
<sZ>8 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Italie</country>
</affiliation>
</author>
<author><name sortKey="Santoro, Lucio" sort="Santoro, Lucio" uniqKey="Santoro L" first="Lucio" last="Santoro">Lucio Santoro</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Neurology, Second University of Naples</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>5 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Italie</country>
</affiliation>
</author>
<author><name sortKey="Defazio, Giovanni" sort="Defazio, Giovanni" uniqKey="Defazio G" first="Giovanni" last="Defazio">Giovanni Defazio</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurosciences and Sensory Organs and School of Motor Sciences, "Aldo Moro" University of Bari</s1>
<s2>Bari</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Italie</country>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
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<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Blepharospasm</term>
<term>Dystonia</term>
<term>Epidemiology</term>
<term>Nervous system diseases</term>
<term>Neurology</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Blépharospasme</term>
<term>Dystonie</term>
<term>Pathologie du   système nerveux</term>
<term>Epidémiologie</term>
<term>Neurologie</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Neurologie</term>
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<front><div type="abstract" xml:lang="en">Background: The site of dystonia onset is known to affect the risk of spread in primary adult-onset focal dystonia, but other factors possibly influencing spread are unknown. This study explored the relationship between age and spread of dystonia in primary adult-onset focal dystonia. Methods: Two survival models analyzed spread of dystonia in a large cohort of patients with primary blepharospasm (BSP) and cervical dystonia. The first model was based on time interval between onset and spread of dystonia, and the second model was based on age at spread. Results: Patients presenting with BSP had a 2-fold higher rate of spread than those presenting with cervical dystonia, regardless of the survival model used. However, survival analysis, based on age at spread, showed that spread develops at a similar age period in both groups, with most spread events occurring after the age of 50. Conclusions: The convergent age of spread in BSP and cervical dystonia is a novel finding indicating age as a factor modulating spread of dystonia. These findings may assist in informing prognostication for patients with primary adult-onset focal dystonia.</div>
</front>
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<fA08 i1="01" i2="1" l="ENG"><s1>Age at Onset and Symptom Spread in Primary Adult-Onset Blepharospasm and Cervical Dystonia</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>MARTINO (Davide)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>BERARDELLI (Alfredo)</s1>
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<fA11 i1="03" i2="1"><s1>ABBRUZZESE (Giovanni)</s1>
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<fA11 i1="04" i2="1"><s1>BENTIVOGLIO (Anna Rita)</s1>
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<fA11 i1="05" i2="1"><s1>ESPOSITO (Marcello)</s1>
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<fA11 i1="06" i2="1"><s1>FABBRINI (Giovanni)</s1>
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<fA11 i1="07" i2="1"><s1>GUIDUBALDI (Arianna)</s1>
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<fA11 i1="08" i2="1"><s1>GIRLANDA (Paolo)</s1>
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<fA11 i1="09" i2="1"><s1>LIGUORI (Rocco)</s1>
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<fA11 i1="10" i2="1"><s1>MARINELLI (Lucio)</s1>
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<fA11 i1="11" i2="1"><s1>MORGANTE (Francesca)</s1>
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<fA11 i1="12" i2="1"><s1>SANTORO (Lucio)</s1>
</fA11>
<fA11 i1="13" i2="1"><s1>DEFAZIO (Giovanni)</s1>
</fA11>
<fA14 i1="01"><s1>Department of Neurosciences and Sensory Organs and School of Motor Sciences, "Aldo Moro" University of Bari</s1>
<s2>Bari</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>13 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Department of Neurology and Psychiatry, Sapienza University of Rome and IRCCS Neuromed Institute</s1>
<s2>Pozzilli</s2>
<s3>ITA</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
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<fA14 i1="03"><s1>Department of Neurosciences, Ophthalmology and Genetics, University of Genoa</s1>
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<s3>ITA</s3>
<sZ>3 aut.</sZ>
<sZ>10 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Department of Neurosciences, Catholic University</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Department of Neurology, Second University of Naples</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>5 aut.</sZ>
<sZ>12 aut.</sZ>
</fA14>
<fA14 i1="06"><s1>Department of Neurosciences, Psychiatry, and Anaesthesiological Science, University of Messina</s1>
<s2>Messina</s2>
<s3>ITA</s3>
<sZ>8 aut.</sZ>
<sZ>11 aut.</sZ>
</fA14>
<fA14 i1="07"><s1>Department of Neurosciences, University of Bologna</s1>
<s2>Bologna</s2>
<s3>ITA</s3>
<sZ>9 aut.</sZ>
</fA14>
<fA20><s1>1447-1450</s1>
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<fC01 i1="01" l="ENG"><s0>Background: The site of dystonia onset is known to affect the risk of spread in primary adult-onset focal dystonia, but other factors possibly influencing spread are unknown. This study explored the relationship between age and spread of dystonia in primary adult-onset focal dystonia. Methods: Two survival models analyzed spread of dystonia in a large cohort of patients with primary blepharospasm (BSP) and cervical dystonia. The first model was based on time interval between onset and spread of dystonia, and the second model was based on age at spread. Results: Patients presenting with BSP had a 2-fold higher rate of spread than those presenting with cervical dystonia, regardless of the survival model used. However, survival analysis, based on age at spread, showed that spread develops at a similar age period in both groups, with most spread events occurring after the age of 50. Conclusions: The convergent age of spread in BSP and cervical dystonia is a novel finding indicating age as a factor modulating spread of dystonia. These findings may assist in informing prognostication for patients with primary adult-onset focal dystonia.</s0>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Age at Onset and Symptom Spread in Primary Adult-Onset Blepharospasm and Cervical Dystonia

Age at Onset and Symptom Spread in Primary Adult-Onset Blepharospasm and Cervical Dystonia

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