MovDisordV3, PascalFrancis, Curation, bibRecord, 002C43

Impaired Self-Awareness of Motor Deficits in Parkinson's Disease: Association With Motor Asymmetry and Motor Phenotypes

Identifieur interne : 002C43 ( PascalFrancis/Curation ); précédent : 002C42; suivant : 002C44

Impaired Self-Awareness of Motor Deficits in Parkinson's Disease: Association With Motor Asymmetry and Motor Phenotypes

Auteurs : Franziska Maier [Allemagne] ; George P. Prigatano [États-Unis] ; Elke Kalbe [Allemagne] ; Michael T. Barbe [Allemagne] ; Carsten Eggers [Allemagne] ; Catharine J. Lewis [Allemagne] ; Richard S. Burns [États-Unis] ; Jeannine Morrone-Strupinsky [États-Unis] ; Guillermo Moguel-Cobos [États-Unis] ; Gereon R. Fink [Allemagne] ; Lars Timmermann [Allemagne]

Source :

Movement disorders [ 0885-3185 ] ; 2012.

RBID : Pascal:12-0393093

Descripteurs français

Pascal (Inist)
- Trouble moteur, Maladie de Parkinson, Anosognosie, Pathologie du système nerveux, Prise conscience, Asymétrie, Phénotype.

English descriptors

KwdEn :
- Anosognosia, Asymmetry, Awareness, Motor system disorder, Nervous system diseases, Parkinson disease, Phenotype.

Abstract

Background: This study investigated impaired self-awareness of motor deficits in nondemented, nondepressed Parkinson's disease (PD) patients during a defined clinical on state. Methods: Twenty-eight PD patients were examined. Patients' self-ratings and experts' ratings of patients' motor performance were compared. Patient-examiner discrepancies and level of impairment determined severity of impaired self-awareness. Motor exam assessed overall motor functioning, hemibody impairment, and 4 motor phenotypes. Neuropsychological tests were also conducted. Results: Signs of impaired self-awareness were present in 17 patients (60.7%). Higher severity of impaired self-awareness correlated significantly with higher postural-instability and gait-difficulty off scores (r = .575; P = .001), overall motor off scores (r = .569; P = .002), and higher left hemibody off scores (r = .490; P = .008). In multiple linear regression analyses, higher postural-instability and gait-difficulty off scores remained as the only significant predictor of impaired self-awareness severity. Conclusions: Postural instability and gait difficulties, disease severity, and right hemisphere dysfunction seem to contribute to impaired self-awareness.

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A08	`01`	`1`	`ENG`	`@1 Impaired Self-Awareness of Motor Deficits in Parkinson's Disease: Association With Motor Asymmetry and Motor Phenotypes`
A11	`01`	`1`		`@1 MAIER (Franziska)`
A11	`02`	`1`		`@1 PRIGATANO (George P.)`
A11	`03`	`1`		`@1 KALBE (Elke)`
A11	`04`	`1`		`@1 BARBE (Michael T.)`
A11	`05`	`1`		`@1 EGGERS (Carsten)`
A11	`06`	`1`		`@1 LEWIS (Catharine J.)`
A11	`07`	`1`		`@1 BURNS (Richard S.)`
A11	`08`	`1`		`@1 MORRONE-STRUPINSKY (Jeannine)`
A11	`09`	`1`		`@1 MOGUEL-COBOS (Guillermo)`
A11	`10`	`1`		`@1 FINK (Gereon R.)`
A11	`11`	`1`		`@1 TIMMERMANN (Lars)`
A14	`01`			`@1 Department of Neurology, University Hospital Cologne @2 Cologne @3 DEU @Z 1 aut. @Z 3 aut. @Z 4 aut. @Z 5 aut. @Z 6 aut. @Z 10 aut. @Z 11 aut.`
A14	`02`			`@1 Department of Clinical Neuropsychology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center @2 Phoenix, Arizona @3 USA @Z 2 aut. @Z 8 aut.`
A14	`03`			`@1 Institute of Neuroscience and Medicine, Cognitive Neurology Section, Research Center Jülich @3 DEU @Z 3 aut. @Z 4 aut. @Z 10 aut.`
A14	`04`			`@1 Institute for Gerontology, University of Vechta @2 Vechta @3 DEU @Z 3 aut.`
A14	`05`			`@1 Movement Disorders Clinic, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center @2 Phoenix, Arizona @3 USA @Z 7 aut. @Z 9 aut.`
A20				`@1 1443-1447`
A21				`@1 2012`
A23	`01`			`@0 ENG`
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C01	`01`		`ENG`	@0 Background: This study investigated impaired self-awareness of motor deficits in nondemented, nondepressed Parkinson's disease (PD) patients during a defined clinical on state. Methods: Twenty-eight PD patients were examined. Patients' self-ratings and experts' ratings of patients' motor performance were compared. Patient-examiner discrepancies and level of impairment determined severity of impaired self-awareness. Motor exam assessed overall motor functioning, hemibody impairment, and 4 motor phenotypes. Neuropsychological tests were also conducted. Results: Signs of impaired self-awareness were present in 17 patients (60.7%). Higher severity of impaired self-awareness correlated significantly with higher postural-instability and gait-difficulty off scores (r = .575; P = .001), overall motor off scores (r = .569; P = .002), and higher left hemibody off scores (r = .490; P = .008). In multiple linear regression analyses, higher postural-instability and gait-difficulty off scores remained as the only significant predictor of impaired self-awareness severity. Conclusions: Postural instability and gait difficulties, disease severity, and right hemisphere dysfunction seem to contribute to impaired self-awareness.
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C03	`01`	`X`	`FRE`	`@0 Trouble moteur @5 01`
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C03	`01`	`X`	`SPA`	`@0 Trastorno motor @5 01`
C03	`02`	`X`	`FRE`	`@0 Maladie de Parkinson @2 NM @5 02`
C03	`02`	`X`	`ENG`	`@0 Parkinson disease @2 NM @5 02`
C03	`02`	`X`	`SPA`	`@0 Parkinson enfermedad @2 NM @5 02`
C03	`03`	`X`	`FRE`	`@0 Anosognosie @5 03`
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C03	`04`	`X`	`SPA`	`@0 Sistema nervioso patología @5 04`
C03	`05`	`X`	`FRE`	`@0 Prise conscience @5 09`
C03	`05`	`X`	`ENG`	`@0 Awareness @5 09`
C03	`05`	`X`	`SPA`	`@0 Toma de conciencia @5 09`
C03	`06`	`X`	`FRE`	`@0 Asymétrie @5 10`
C03	`06`	`X`	`ENG`	`@0 Asymmetry @5 10`
C03	`06`	`X`	`SPA`	`@0 Asimetría @5 10`
C03	`07`	`X`	`FRE`	`@0 Phénotype @5 11`
C03	`07`	`X`	`ENG`	`@0 Phenotype @5 11`
C03	`07`	`X`	`SPA`	`@0 Fenotipo @5 11`
C07	`01`	`X`	`FRE`	`@0 Trouble neurologique @5 38`
C07	`01`	`X`	`ENG`	`@0 Neurological disorder @5 38`
C07	`01`	`X`	`SPA`	`@0 Trastorno neurológico @5 38`
C07	`02`	`X`	`FRE`	`@0 Pathologie de l'encéphale @5 39`
C07	`02`	`X`	`ENG`	`@0 Cerebral disorder @5 39`
C07	`02`	`X`	`SPA`	`@0 Encéfalo patología @5 39`
C07	`03`	`X`	`FRE`	`@0 Syndrome extrapyramidal @5 40`
C07	`03`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 40`
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C07	`04`	`X`	`FRE`	`@0 Maladie dégénérative @5 41`
C07	`04`	`X`	`ENG`	`@0 Degenerative disease @5 41`
C07	`04`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 41`
C07	`05`	`X`	`FRE`	`@0 Pathologie du système nerveux central @5 42`
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N21				`@1 303`
N44	`01`			`@1 OTO`
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Pascal:12-0393093

Le document en format XML

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<author><name sortKey="Moguel Cobos, Guillermo" sort="Moguel Cobos, Guillermo" uniqKey="Moguel Cobos G" first="Guillermo" last="Moguel-Cobos">Guillermo Moguel-Cobos</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Movement Disorders Clinic, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center</s1>
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<author><name sortKey="Timmermann, Lars" sort="Timmermann, Lars" uniqKey="Timmermann L" first="Lars" last="Timmermann">Lars Timmermann</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University Hospital Cologne</s1>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Impaired Self-Awareness of Motor Deficits in Parkinson's Disease: Association With Motor Asymmetry and Motor Phenotypes</title>
<author><name sortKey="Maier, Franziska" sort="Maier, Franziska" uniqKey="Maier F" first="Franziska" last="Maier">Franziska Maier</name>
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<author><name sortKey="Prigatano, George P" sort="Prigatano, George P" uniqKey="Prigatano G" first="George P." last="Prigatano">George P. Prigatano</name>
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<author><name sortKey="Kalbe, Elke" sort="Kalbe, Elke" uniqKey="Kalbe E" first="Elke" last="Kalbe">Elke Kalbe</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University Hospital Cologne</s1>
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<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Institute for Gerontology, University of Vechta</s1>
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<author><name sortKey="Barbe, Michael T" sort="Barbe, Michael T" uniqKey="Barbe M" first="Michael T." last="Barbe">Michael T. Barbe</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University Hospital Cologne</s1>
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<author><name sortKey="Eggers, Carsten" sort="Eggers, Carsten" uniqKey="Eggers C" first="Carsten" last="Eggers">Carsten Eggers</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University Hospital Cologne</s1>
<s2>Cologne</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
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<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
</affiliation>
</author>
<author><name sortKey="Lewis, Catharine J" sort="Lewis, Catharine J" uniqKey="Lewis C" first="Catharine J." last="Lewis">Catharine J. Lewis</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University Hospital Cologne</s1>
<s2>Cologne</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
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<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
</affiliation>
</author>
<author><name sortKey="Burns, Richard S" sort="Burns, Richard S" uniqKey="Burns R" first="Richard S." last="Burns">Richard S. Burns</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Movement Disorders Clinic, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center</s1>
<s2>Phoenix, Arizona</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
</affiliation>
</author>
<author><name sortKey="Morrone Strupinsky, Jeannine" sort="Morrone Strupinsky, Jeannine" uniqKey="Morrone Strupinsky J" first="Jeannine" last="Morrone-Strupinsky">Jeannine Morrone-Strupinsky</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Clinical Neuropsychology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center</s1>
<s2>Phoenix, Arizona</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
</affiliation>
</author>
<author><name sortKey="Moguel Cobos, Guillermo" sort="Moguel Cobos, Guillermo" uniqKey="Moguel Cobos G" first="Guillermo" last="Moguel-Cobos">Guillermo Moguel-Cobos</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Movement Disorders Clinic, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center</s1>
<s2>Phoenix, Arizona</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
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<country>États-Unis</country>
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</author>
<author><name sortKey="Fink, Gereon R" sort="Fink, Gereon R" uniqKey="Fink G" first="Gereon R." last="Fink">Gereon R. Fink</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University Hospital Cologne</s1>
<s2>Cologne</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
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<country>Allemagne</country>
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<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Institute of Neuroscience and Medicine, Cognitive Neurology Section, Research Center Jülich</s1>
<s3>DEU</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
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<country>Allemagne</country>
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<author><name sortKey="Timmermann, Lars" sort="Timmermann, Lars" uniqKey="Timmermann L" first="Lars" last="Timmermann">Lars Timmermann</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University Hospital Cologne</s1>
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<country>Allemagne</country>
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<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2012">2012</date>
</imprint>
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<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anosognosia</term>
<term>Asymmetry</term>
<term>Awareness</term>
<term>Motor system disorder</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
<term>Phenotype</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Trouble moteur</term>
<term>Maladie de Parkinson</term>
<term>Anosognosie</term>
<term>Pathologie du   système nerveux</term>
<term>Prise conscience</term>
<term>Asymétrie</term>
<term>Phénotype</term>
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<front><div type="abstract" xml:lang="en">Background: This study investigated impaired self-awareness of motor deficits in nondemented, nondepressed Parkinson's disease (PD) patients during a defined clinical on state. Methods: Twenty-eight PD patients were examined. Patients' self-ratings and experts' ratings of patients' motor performance were compared. Patient-examiner discrepancies and level of impairment determined severity of impaired self-awareness. Motor exam assessed overall motor functioning, hemibody impairment, and 4 motor phenotypes. Neuropsychological tests were also conducted. Results: Signs of impaired self-awareness were present in 17 patients (60.7%). Higher severity of impaired self-awareness correlated significantly with higher postural-instability and gait-difficulty off scores (r = .575; P = .001), overall motor off scores (r = .569; P = .002), and higher left hemibody off scores (r = .490; P = .008). In multiple linear regression analyses, higher postural-instability and gait-difficulty off scores remained as the only significant predictor of impaired self-awareness severity. Conclusions: Postural instability and gait difficulties, disease severity, and right hemisphere dysfunction seem to contribute to impaired self-awareness.</div>
</front>
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<fA08 i1="01" i2="1" l="ENG"><s1>Impaired Self-Awareness of Motor Deficits in Parkinson's Disease: Association With Motor Asymmetry and Motor Phenotypes</s1>
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<fA11 i1="01" i2="1"><s1>MAIER (Franziska)</s1>
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<fA11 i1="02" i2="1"><s1>PRIGATANO (George P.)</s1>
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<fA11 i1="09" i2="1"><s1>MOGUEL-COBOS (Guillermo)</s1>
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<fA11 i1="10" i2="1"><s1>FINK (Gereon R.)</s1>
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<fA11 i1="11" i2="1"><s1>TIMMERMANN (Lars)</s1>
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<fA14 i1="01"><s1>Department of Neurology, University Hospital Cologne</s1>
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<fA14 i1="02"><s1>Department of Clinical Neuropsychology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center</s1>
<s2>Phoenix, Arizona</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
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<fA14 i1="03"><s1>Institute of Neuroscience and Medicine, Cognitive Neurology Section, Research Center Jülich</s1>
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</fA14>
<fA14 i1="05"><s1>Movement Disorders Clinic, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center</s1>
<s2>Phoenix, Arizona</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Impaired Self-Awareness of Motor Deficits in Parkinson's Disease: Association With Motor Asymmetry and Motor Phenotypes

Impaired Self-Awareness of Motor Deficits in Parkinson's Disease: Association With Motor Asymmetry and Motor Phenotypes

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