MovDisordV3, PascalFrancis, Corpus, bibRecord, 000070

Age at Onset and Symptom Spread in Primary Adult-Onset Blepharospasm and Cervical Dystonia

Identifieur interne : 000070 ( PascalFrancis/Corpus ); précédent : 000069; suivant : 000071

Age at Onset and Symptom Spread in Primary Adult-Onset Blepharospasm and Cervical Dystonia

Auteurs : Davide Martino ; Alfredo Berardelli ; Giovanni Abbruzzese ; Anna Rita Bentivoglio ; Marcello Esposito ; Giovanni Fabbrini ; Arianna Guidubaldi ; Paolo Girlanda ; Rocco Liguori ; Lucio Marinelli ; Francesca Morgante ; Lucio Santoro ; Giovanni Defazio

Source :

Movement disorders [ 0885-3185 ] ; 2012.

RBID : Pascal:12-0393102

Descripteurs français

Pascal (Inist)
- Blépharospasme, Dystonie, Pathologie du système nerveux, Epidémiologie, Neurologie.

English descriptors

KwdEn :
- Blepharospasm, Dystonia, Epidemiology, Nervous system diseases, Neurology.

Abstract

Background: The site of dystonia onset is known to affect the risk of spread in primary adult-onset focal dystonia, but other factors possibly influencing spread are unknown. This study explored the relationship between age and spread of dystonia in primary adult-onset focal dystonia. Methods: Two survival models analyzed spread of dystonia in a large cohort of patients with primary blepharospasm (BSP) and cervical dystonia. The first model was based on time interval between onset and spread of dystonia, and the second model was based on age at spread. Results: Patients presenting with BSP had a 2-fold higher rate of spread than those presenting with cervical dystonia, regardless of the survival model used. However, survival analysis, based on age at spread, showed that spread develops at a similar age period in both groups, with most spread events occurring after the age of 50. Conclusions: The convergent age of spread in BSP and cervical dystonia is a novel finding indicating age as a factor modulating spread of dystonia. These findings may assist in informing prognostication for patients with primary adult-onset focal dystonia.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A03		`1`		`@0 Mov. disord.`
A05				`@2 27`
A06				`@2 11`
A08	`01`	`1`	`ENG`	`@1 Age at Onset and Symptom Spread in Primary Adult-Onset Blepharospasm and Cervical Dystonia`
A11	`01`	`1`		`@1 MARTINO (Davide)`
A11	`02`	`1`		`@1 BERARDELLI (Alfredo)`
A11	`03`	`1`		`@1 ABBRUZZESE (Giovanni)`
A11	`04`	`1`		`@1 BENTIVOGLIO (Anna Rita)`
A11	`05`	`1`		`@1 ESPOSITO (Marcello)`
A11	`06`	`1`		`@1 FABBRINI (Giovanni)`
A11	`07`	`1`		`@1 GUIDUBALDI (Arianna)`
A11	`08`	`1`		`@1 GIRLANDA (Paolo)`
A11	`09`	`1`		`@1 LIGUORI (Rocco)`
A11	`10`	`1`		`@1 MARINELLI (Lucio)`
A11	`11`	`1`		`@1 MORGANTE (Francesca)`
A11	`12`	`1`		`@1 SANTORO (Lucio)`
A11	`13`	`1`		`@1 DEFAZIO (Giovanni)`
A14	`01`			`@1 Department of Neurosciences and Sensory Organs and School of Motor Sciences, "Aldo Moro" University of Bari @2 Bari @3 ITA @Z 1 aut. @Z 13 aut.`
A14	`02`			`@1 Department of Neurology and Psychiatry, Sapienza University of Rome and IRCCS Neuromed Institute @2 Pozzilli @3 ITA @Z 2 aut. @Z 6 aut.`
A14	`03`			`@1 Department of Neurosciences, Ophthalmology and Genetics, University of Genoa @2 Genoa @3 ITA @Z 3 aut. @Z 10 aut.`
A14	`04`			`@1 Department of Neurosciences, Catholic University @2 Rome @3 ITA @Z 4 aut. @Z 7 aut.`
A14	`05`			`@1 Department of Neurology, Second University of Naples @2 Naples @3 ITA @Z 5 aut. @Z 12 aut.`
A14	`06`			`@1 Department of Neurosciences, Psychiatry, and Anaesthesiological Science, University of Messina @2 Messina @3 ITA @Z 8 aut. @Z 11 aut.`
A14	`07`			`@1 Department of Neurosciences, University of Bologna @2 Bologna @3 ITA @Z 9 aut.`
A20				`@1 1447-1450`
A21				`@1 2012`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 20953 @5 354000502036870230`
A44				`@0 0000 @1 © 2012 INIST-CNRS. All rights reserved.`
A45				`@0 16 ref.`
A47	`01`	`1`		`@0 12-0393102`
A60				`@1 P @3 CC`
A61				`@0 A`
A64	`01`	`1`		`@0 Movement disorders`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 Background: The site of dystonia onset is known to affect the risk of spread in primary adult-onset focal dystonia, but other factors possibly influencing spread are unknown. This study explored the relationship between age and spread of dystonia in primary adult-onset focal dystonia. Methods: Two survival models analyzed spread of dystonia in a large cohort of patients with primary blepharospasm (BSP) and cervical dystonia. The first model was based on time interval between onset and spread of dystonia, and the second model was based on age at spread. Results: Patients presenting with BSP had a 2-fold higher rate of spread than those presenting with cervical dystonia, regardless of the survival model used. However, survival analysis, based on age at spread, showed that spread develops at a similar age period in both groups, with most spread events occurring after the age of 50. Conclusions: The convergent age of spread in BSP and cervical dystonia is a novel finding indicating age as a factor modulating spread of dystonia. These findings may assist in informing prognostication for patients with primary adult-onset focal dystonia.
C02	`01`	`X`		`@0 002B17`
C02	`02`	`X`		`@0 002B17H`
C03	`01`	`X`	`FRE`	`@0 Blépharospasme @5 01`
C03	`01`	`X`	`ENG`	`@0 Blepharospasm @5 01`
C03	`01`	`X`	`SPA`	`@0 Blefaroespasmo @5 01`
C03	`02`	`X`	`FRE`	`@0 Dystonie @5 02`
C03	`02`	`X`	`ENG`	`@0 Dystonia @5 02`
C03	`02`	`X`	`SPA`	`@0 Distonía @5 02`
C03	`03`	`X`	`FRE`	`@0 Pathologie du système nerveux @5 03`
C03	`03`	`X`	`ENG`	`@0 Nervous system diseases @5 03`
C03	`03`	`X`	`SPA`	`@0 Sistema nervioso patología @5 03`
C03	`04`	`X`	`FRE`	`@0 Epidémiologie @5 09`
C03	`04`	`X`	`ENG`	`@0 Epidemiology @5 09`
C03	`04`	`X`	`SPA`	`@0 Epidemiología @5 09`
C03	`05`	`X`	`FRE`	`@0 Neurologie @5 10`
C03	`05`	`X`	`ENG`	`@0 Neurology @5 10`
C03	`05`	`X`	`SPA`	`@0 Neurología @5 10`
C07	`01`	`X`	`FRE`	`@0 Pathologie de l'oeil @5 37`
C07	`01`	`X`	`ENG`	`@0 Eye disease @5 37`
C07	`01`	`X`	`SPA`	`@0 Ojo patología @5 37`
C07	`02`	`X`	`FRE`	`@0 Pathologie de la paupière @5 38`
C07	`02`	`X`	`ENG`	`@0 Eyelid disease @5 38`
C07	`02`	`X`	`SPA`	`@0 Párpado patología @5 38`
C07	`03`	`X`	`FRE`	`@0 Syndrome extrapyramidal @5 39`
C07	`03`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 39`
C07	`03`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 39`
C07	`04`	`X`	`FRE`	`@0 Mouvement involontaire @5 40`
C07	`04`	`X`	`ENG`	`@0 Involuntary movement @5 40`
C07	`04`	`X`	`SPA`	`@0 Movimiento involuntario @5 40`
C07	`05`	`X`	`FRE`	`@0 Pathologie du muscle strié @5 41`
C07	`05`	`X`	`ENG`	`@0 Striated muscle disease @5 41`
C07	`05`	`X`	`SPA`	`@0 Músculo estriado patología @5 41`
C07	`06`	`X`	`FRE`	`@0 Trouble neurologique @5 43`
C07	`06`	`X`	`ENG`	`@0 Neurological disorder @5 43`
C07	`06`	`X`	`SPA`	`@0 Trastorno neurológico @5 43`
C07	`07`	`X`	`FRE`	`@0 Pathologie de l'encéphale @5 44`
C07	`07`	`X`	`ENG`	`@0 Cerebral disorder @5 44`
C07	`07`	`X`	`SPA`	`@0 Encéfalo patología @5 44`
C07	`08`	`X`	`FRE`	`@0 Pathologie du système nerveux central @5 45`
C07	`08`	`X`	`ENG`	`@0 Central nervous system disease @5 45`
C07	`08`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 45`
N21				`@1 303`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 12-0393102 INIST
ET :	Age at Onset and Symptom Spread in Primary Adult-Onset Blepharospasm and Cervical Dystonia
AU :	MARTINO (Davide); BERARDELLI (Alfredo); ABBRUZZESE (Giovanni); BENTIVOGLIO (Anna Rita); ESPOSITO (Marcello); FABBRINI (Giovanni); GUIDUBALDI (Arianna); GIRLANDA (Paolo); LIGUORI (Rocco); MARINELLI (Lucio); MORGANTE (Francesca); SANTORO (Lucio); DEFAZIO (Giovanni)
AF :	Department of Neurosciences and Sensory Organs and School of Motor Sciences, "Aldo Moro" University of Bari/Bari/Italie (1 aut., 13 aut.); Department of Neurology and Psychiatry, Sapienza University of Rome and IRCCS Neuromed Institute/Pozzilli/Italie (2 aut., 6 aut.); Department of Neurosciences, Ophthalmology and Genetics, University of Genoa/Genoa/Italie (3 aut., 10 aut.); Department of Neurosciences, Catholic University/Rome/Italie (4 aut., 7 aut.); Department of Neurology, Second University of Naples/Naples/Italie (5 aut., 12 aut.); Department of Neurosciences, Psychiatry, and Anaesthesiological Science, University of Messina/Messina/Italie (8 aut., 11 aut.); Department of Neurosciences, University of Bologna/Bologna/Italie (9 aut.)
DT :	Publication en série; Courte communication, note brève; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2012; Vol. 27; No. 11; Pp. 1447-1450; Bibl. 16 ref.
LA :	Anglais
EA :	Background: The site of dystonia onset is known to affect the risk of spread in primary adult-onset focal dystonia, but other factors possibly influencing spread are unknown. This study explored the relationship between age and spread of dystonia in primary adult-onset focal dystonia. Methods: Two survival models analyzed spread of dystonia in a large cohort of patients with primary blepharospasm (BSP) and cervical dystonia. The first model was based on time interval between onset and spread of dystonia, and the second model was based on age at spread. Results: Patients presenting with BSP had a 2-fold higher rate of spread than those presenting with cervical dystonia, regardless of the survival model used. However, survival analysis, based on age at spread, showed that spread develops at a similar age period in both groups, with most spread events occurring after the age of 50. Conclusions: The convergent age of spread in BSP and cervical dystonia is a novel finding indicating age as a factor modulating spread of dystonia. These findings may assist in informing prognostication for patients with primary adult-onset focal dystonia.
CC :	002B17; 002B17H
FD :	Blépharospasme; Dystonie; Pathologie du système nerveux; Epidémiologie; Neurologie
FG :	Pathologie de l'oeil; Pathologie de la paupière; Syndrome extrapyramidal; Mouvement involontaire; Pathologie du muscle strié; Trouble neurologique; Pathologie de l'encéphale; Pathologie du système nerveux central
ED :	Blepharospasm; Dystonia; Nervous system diseases; Epidemiology; Neurology
EG :	Eye disease; Eyelid disease; Extrapyramidal syndrome; Involuntary movement; Striated muscle disease; Neurological disorder; Cerebral disorder; Central nervous system disease
SD :	Blefaroespasmo; Distonía; Sistema nervioso patología; Epidemiología; Neurología
LO :	INIST-20953.354000502036870230
ID :	12-0393102

Links to Exploration step

Pascal:12-0393102

Le document en format XML

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<author><name sortKey="Guidubaldi, Arianna" sort="Guidubaldi, Arianna" uniqKey="Guidubaldi A" first="Arianna" last="Guidubaldi">Arianna Guidubaldi</name>
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<author><name sortKey="Marinelli, Lucio" sort="Marinelli, Lucio" uniqKey="Marinelli L" first="Lucio" last="Marinelli">Lucio Marinelli</name>
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<author><name sortKey="Morgante, Francesca" sort="Morgante, Francesca" uniqKey="Morgante F" first="Francesca" last="Morgante">Francesca Morgante</name>
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<author><name sortKey="Santoro, Lucio" sort="Santoro, Lucio" uniqKey="Santoro L" first="Lucio" last="Santoro">Lucio Santoro</name>
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<author><name sortKey="Defazio, Giovanni" sort="Defazio, Giovanni" uniqKey="Defazio G" first="Giovanni" last="Defazio">Giovanni Defazio</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Age at Onset and Symptom Spread in Primary Adult-Onset Blepharospasm and Cervical Dystonia</title>
<author><name sortKey="Martino, Davide" sort="Martino, Davide" uniqKey="Martino D" first="Davide" last="Martino">Davide Martino</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Neurosciences and Sensory Organs and School of Motor Sciences, "Aldo Moro" University of Bari</s1>
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<author><name sortKey="Berardelli, Alfredo" sort="Berardelli, Alfredo" uniqKey="Berardelli A" first="Alfredo" last="Berardelli">Alfredo Berardelli</name>
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<s2>Pozzilli</s2>
<s3>ITA</s3>
<sZ>2 aut.</sZ>
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<author><name sortKey="Abbruzzese, Giovanni" sort="Abbruzzese, Giovanni" uniqKey="Abbruzzese G" first="Giovanni" last="Abbruzzese">Giovanni Abbruzzese</name>
<affiliation><inist:fA14 i1="03"><s1>Department of Neurosciences, Ophthalmology and Genetics, University of Genoa</s1>
<s2>Genoa</s2>
<s3>ITA</s3>
<sZ>3 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
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</author>
<author><name sortKey="Bentivoglio, Anna Rita" sort="Bentivoglio, Anna Rita" uniqKey="Bentivoglio A" first="Anna Rita" last="Bentivoglio">Anna Rita Bentivoglio</name>
<affiliation><inist:fA14 i1="04"><s1>Department of Neurosciences, Catholic University</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Esposito, Marcello" sort="Esposito, Marcello" uniqKey="Esposito M" first="Marcello" last="Esposito">Marcello Esposito</name>
<affiliation><inist:fA14 i1="05"><s1>Department of Neurology, Second University of Naples</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>5 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Fabbrini, Giovanni" sort="Fabbrini, Giovanni" uniqKey="Fabbrini G" first="Giovanni" last="Fabbrini">Giovanni Fabbrini</name>
<affiliation><inist:fA14 i1="02"><s1>Department of Neurology and Psychiatry, Sapienza University of Rome and IRCCS Neuromed Institute</s1>
<s2>Pozzilli</s2>
<s3>ITA</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Guidubaldi, Arianna" sort="Guidubaldi, Arianna" uniqKey="Guidubaldi A" first="Arianna" last="Guidubaldi">Arianna Guidubaldi</name>
<affiliation><inist:fA14 i1="04"><s1>Department of Neurosciences, Catholic University</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Girlanda, Paolo" sort="Girlanda, Paolo" uniqKey="Girlanda P" first="Paolo" last="Girlanda">Paolo Girlanda</name>
<affiliation><inist:fA14 i1="06"><s1>Department of Neurosciences, Psychiatry, and Anaesthesiological Science, University of Messina</s1>
<s2>Messina</s2>
<s3>ITA</s3>
<sZ>8 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Liguori, Rocco" sort="Liguori, Rocco" uniqKey="Liguori R" first="Rocco" last="Liguori">Rocco Liguori</name>
<affiliation><inist:fA14 i1="07"><s1>Department of Neurosciences, University of Bologna</s1>
<s2>Bologna</s2>
<s3>ITA</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Marinelli, Lucio" sort="Marinelli, Lucio" uniqKey="Marinelli L" first="Lucio" last="Marinelli">Lucio Marinelli</name>
<affiliation><inist:fA14 i1="03"><s1>Department of Neurosciences, Ophthalmology and Genetics, University of Genoa</s1>
<s2>Genoa</s2>
<s3>ITA</s3>
<sZ>3 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Morgante, Francesca" sort="Morgante, Francesca" uniqKey="Morgante F" first="Francesca" last="Morgante">Francesca Morgante</name>
<affiliation><inist:fA14 i1="06"><s1>Department of Neurosciences, Psychiatry, and Anaesthesiological Science, University of Messina</s1>
<s2>Messina</s2>
<s3>ITA</s3>
<sZ>8 aut.</sZ>
<sZ>11 aut.</sZ>
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<author><name sortKey="Santoro, Lucio" sort="Santoro, Lucio" uniqKey="Santoro L" first="Lucio" last="Santoro">Lucio Santoro</name>
<affiliation><inist:fA14 i1="05"><s1>Department of Neurology, Second University of Naples</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>5 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Defazio, Giovanni" sort="Defazio, Giovanni" uniqKey="Defazio G" first="Giovanni" last="Defazio">Giovanni Defazio</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Neurosciences and Sensory Organs and School of Motor Sciences, "Aldo Moro" University of Bari</s1>
<s2>Bari</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2012">2012</date>
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<seriesStmt><title level="j" type="main">Movement disorders</title>
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<idno type="ISSN">0885-3185</idno>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Blepharospasm</term>
<term>Dystonia</term>
<term>Epidemiology</term>
<term>Nervous system diseases</term>
<term>Neurology</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Blépharospasme</term>
<term>Dystonie</term>
<term>Pathologie du   système nerveux</term>
<term>Epidémiologie</term>
<term>Neurologie</term>
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<front><div type="abstract" xml:lang="en">Background: The site of dystonia onset is known to affect the risk of spread in primary adult-onset focal dystonia, but other factors possibly influencing spread are unknown. This study explored the relationship between age and spread of dystonia in primary adult-onset focal dystonia. Methods: Two survival models analyzed spread of dystonia in a large cohort of patients with primary blepharospasm (BSP) and cervical dystonia. The first model was based on time interval between onset and spread of dystonia, and the second model was based on age at spread. Results: Patients presenting with BSP had a 2-fold higher rate of spread than those presenting with cervical dystonia, regardless of the survival model used. However, survival analysis, based on age at spread, showed that spread develops at a similar age period in both groups, with most spread events occurring after the age of 50. Conclusions: The convergent age of spread in BSP and cervical dystonia is a novel finding indicating age as a factor modulating spread of dystonia. These findings may assist in informing prognostication for patients with primary adult-onset focal dystonia.</div>
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<fA08 i1="01" i2="1" l="ENG"><s1>Age at Onset and Symptom Spread in Primary Adult-Onset Blepharospasm and Cervical Dystonia</s1>
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<fA11 i1="01" i2="1"><s1>MARTINO (Davide)</s1>
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<fA14 i1="01"><s1>Department of Neurosciences and Sensory Organs and School of Motor Sciences, "Aldo Moro" University of Bari</s1>
<s2>Bari</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>13 aut.</sZ>
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<fA14 i1="02"><s1>Department of Neurology and Psychiatry, Sapienza University of Rome and IRCCS Neuromed Institute</s1>
<s2>Pozzilli</s2>
<s3>ITA</s3>
<sZ>2 aut.</sZ>
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<fA14 i1="03"><s1>Department of Neurosciences, Ophthalmology and Genetics, University of Genoa</s1>
<s2>Genoa</s2>
<s3>ITA</s3>
<sZ>3 aut.</sZ>
<sZ>10 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Department of Neurosciences, Catholic University</s1>
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<s3>ITA</s3>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Department of Neurology, Second University of Naples</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>5 aut.</sZ>
<sZ>12 aut.</sZ>
</fA14>
<fA14 i1="06"><s1>Department of Neurosciences, Psychiatry, and Anaesthesiological Science, University of Messina</s1>
<s2>Messina</s2>
<s3>ITA</s3>
<sZ>8 aut.</sZ>
<sZ>11 aut.</sZ>
</fA14>
<fA14 i1="07"><s1>Department of Neurosciences, University of Bologna</s1>
<s2>Bologna</s2>
<s3>ITA</s3>
<sZ>9 aut.</sZ>
</fA14>
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<fC01 i1="01" l="ENG"><s0>Background: The site of dystonia onset is known to affect the risk of spread in primary adult-onset focal dystonia, but other factors possibly influencing spread are unknown. This study explored the relationship between age and spread of dystonia in primary adult-onset focal dystonia. Methods: Two survival models analyzed spread of dystonia in a large cohort of patients with primary blepharospasm (BSP) and cervical dystonia. The first model was based on time interval between onset and spread of dystonia, and the second model was based on age at spread. Results: Patients presenting with BSP had a 2-fold higher rate of spread than those presenting with cervical dystonia, regardless of the survival model used. However, survival analysis, based on age at spread, showed that spread develops at a similar age period in both groups, with most spread events occurring after the age of 50. Conclusions: The convergent age of spread in BSP and cervical dystonia is a novel finding indicating age as a factor modulating spread of dystonia. These findings may assist in informing prognostication for patients with primary adult-onset focal dystonia.</s0>
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<s5>44</s5>
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<s5>45</s5>
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<server><NO>PASCAL 12-0393102 INIST</NO>
<ET>Age at Onset and Symptom Spread in Primary Adult-Onset Blepharospasm and Cervical Dystonia</ET>
<AU>MARTINO (Davide); BERARDELLI (Alfredo); ABBRUZZESE (Giovanni); BENTIVOGLIO (Anna Rita); ESPOSITO (Marcello); FABBRINI (Giovanni); GUIDUBALDI (Arianna); GIRLANDA (Paolo); LIGUORI (Rocco); MARINELLI (Lucio); MORGANTE (Francesca); SANTORO (Lucio); DEFAZIO (Giovanni)</AU>
<AF>Department of Neurosciences and Sensory Organs and School of Motor Sciences, "Aldo Moro" University of Bari/Bari/Italie (1 aut., 13 aut.); Department of Neurology and Psychiatry, Sapienza University of Rome and IRCCS Neuromed Institute/Pozzilli/Italie (2 aut., 6 aut.); Department of Neurosciences, Ophthalmology and Genetics, University of Genoa/Genoa/Italie (3 aut., 10 aut.); Department of Neurosciences, Catholic University/Rome/Italie (4 aut., 7 aut.); Department of Neurology, Second University of Naples/Naples/Italie (5 aut., 12 aut.); Department of Neurosciences, Psychiatry, and Anaesthesiological Science, University of Messina/Messina/Italie (8 aut., 11 aut.); Department of Neurosciences, University of Bologna/Bologna/Italie (9 aut.)</AF>
<DT>Publication en série; Courte communication, note brève; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2012; Vol. 27; No. 11; Pp. 1447-1450; Bibl. 16 ref.</SO>
<LA>Anglais</LA>
<EA>Background: The site of dystonia onset is known to affect the risk of spread in primary adult-onset focal dystonia, but other factors possibly influencing spread are unknown. This study explored the relationship between age and spread of dystonia in primary adult-onset focal dystonia. Methods: Two survival models analyzed spread of dystonia in a large cohort of patients with primary blepharospasm (BSP) and cervical dystonia. The first model was based on time interval between onset and spread of dystonia, and the second model was based on age at spread. Results: Patients presenting with BSP had a 2-fold higher rate of spread than those presenting with cervical dystonia, regardless of the survival model used. However, survival analysis, based on age at spread, showed that spread develops at a similar age period in both groups, with most spread events occurring after the age of 50. Conclusions: The convergent age of spread in BSP and cervical dystonia is a novel finding indicating age as a factor modulating spread of dystonia. These findings may assist in informing prognostication for patients with primary adult-onset focal dystonia.</EA>
<CC>002B17; 002B17H</CC>
<FD>Blépharospasme; Dystonie; Pathologie du   système nerveux; Epidémiologie; Neurologie</FD>
<FG>Pathologie de l'oeil; Pathologie de la paupière; Syndrome extrapyramidal; Mouvement involontaire; Pathologie du muscle strié; Trouble neurologique; Pathologie de l'encéphale; Pathologie du   système nerveux central</FG>
<ED>Blepharospasm; Dystonia; Nervous system diseases; Epidemiology; Neurology</ED>
<EG>Eye disease; Eyelid disease; Extrapyramidal syndrome; Involuntary movement; Striated muscle disease; Neurological disorder; Cerebral disorder; Central nervous system disease</EG>
<SD>Blefaroespasmo; Distonía; Sistema nervioso patología; Epidemiología; Neurología</SD>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Age at Onset and Symptom Spread in Primary Adult-Onset Blepharospasm and Cervical Dystonia

Age at Onset and Symptom Spread in Primary Adult-Onset Blepharospasm and Cervical Dystonia

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