Age at Onset and Symptom Spread in Primary Adult-Onset Blepharospasm and Cervical Dystonia
Identifieur interne : 000070 ( PascalFrancis/Corpus ); précédent : 000069; suivant : 000071Age at Onset and Symptom Spread in Primary Adult-Onset Blepharospasm and Cervical Dystonia
Auteurs : Davide Martino ; Alfredo Berardelli ; Giovanni Abbruzzese ; Anna Rita Bentivoglio ; Marcello Esposito ; Giovanni Fabbrini ; Arianna Guidubaldi ; Paolo Girlanda ; Rocco Liguori ; Lucio Marinelli ; Francesca Morgante ; Lucio Santoro ; Giovanni DefazioSource :
- Movement disorders [ 0885-3185 ] ; 2012.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
Background: The site of dystonia onset is known to affect the risk of spread in primary adult-onset focal dystonia, but other factors possibly influencing spread are unknown. This study explored the relationship between age and spread of dystonia in primary adult-onset focal dystonia. Methods: Two survival models analyzed spread of dystonia in a large cohort of patients with primary blepharospasm (BSP) and cervical dystonia. The first model was based on time interval between onset and spread of dystonia, and the second model was based on age at spread. Results: Patients presenting with BSP had a 2-fold higher rate of spread than those presenting with cervical dystonia, regardless of the survival model used. However, survival analysis, based on age at spread, showed that spread develops at a similar age period in both groups, with most spread events occurring after the age of 50. Conclusions: The convergent age of spread in BSP and cervical dystonia is a novel finding indicating age as a factor modulating spread of dystonia. These findings may assist in informing prognostication for patients with primary adult-onset focal dystonia.
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Format Inist (serveur)
NO : | PASCAL 12-0393102 INIST |
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ET : | Age at Onset and Symptom Spread in Primary Adult-Onset Blepharospasm and Cervical Dystonia |
AU : | MARTINO (Davide); BERARDELLI (Alfredo); ABBRUZZESE (Giovanni); BENTIVOGLIO (Anna Rita); ESPOSITO (Marcello); FABBRINI (Giovanni); GUIDUBALDI (Arianna); GIRLANDA (Paolo); LIGUORI (Rocco); MARINELLI (Lucio); MORGANTE (Francesca); SANTORO (Lucio); DEFAZIO (Giovanni) |
AF : | Department of Neurosciences and Sensory Organs and School of Motor Sciences, "Aldo Moro" University of Bari/Bari/Italie (1 aut., 13 aut.); Department of Neurology and Psychiatry, Sapienza University of Rome and IRCCS Neuromed Institute/Pozzilli/Italie (2 aut., 6 aut.); Department of Neurosciences, Ophthalmology and Genetics, University of Genoa/Genoa/Italie (3 aut., 10 aut.); Department of Neurosciences, Catholic University/Rome/Italie (4 aut., 7 aut.); Department of Neurology, Second University of Naples/Naples/Italie (5 aut., 12 aut.); Department of Neurosciences, Psychiatry, and Anaesthesiological Science, University of Messina/Messina/Italie (8 aut., 11 aut.); Department of Neurosciences, University of Bologna/Bologna/Italie (9 aut.) |
DT : | Publication en série; Courte communication, note brève; Niveau analytique |
SO : | Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2012; Vol. 27; No. 11; Pp. 1447-1450; Bibl. 16 ref. |
LA : | Anglais |
EA : | Background: The site of dystonia onset is known to affect the risk of spread in primary adult-onset focal dystonia, but other factors possibly influencing spread are unknown. This study explored the relationship between age and spread of dystonia in primary adult-onset focal dystonia. Methods: Two survival models analyzed spread of dystonia in a large cohort of patients with primary blepharospasm (BSP) and cervical dystonia. The first model was based on time interval between onset and spread of dystonia, and the second model was based on age at spread. Results: Patients presenting with BSP had a 2-fold higher rate of spread than those presenting with cervical dystonia, regardless of the survival model used. However, survival analysis, based on age at spread, showed that spread develops at a similar age period in both groups, with most spread events occurring after the age of 50. Conclusions: The convergent age of spread in BSP and cervical dystonia is a novel finding indicating age as a factor modulating spread of dystonia. These findings may assist in informing prognostication for patients with primary adult-onset focal dystonia. |
CC : | 002B17; 002B17H |
FD : | Blépharospasme; Dystonie; Pathologie du système nerveux; Epidémiologie; Neurologie |
FG : | Pathologie de l'oeil; Pathologie de la paupière; Syndrome extrapyramidal; Mouvement involontaire; Pathologie du muscle strié; Trouble neurologique; Pathologie de l'encéphale; Pathologie du système nerveux central |
ED : | Blepharospasm; Dystonia; Nervous system diseases; Epidemiology; Neurology |
EG : | Eye disease; Eyelid disease; Extrapyramidal syndrome; Involuntary movement; Striated muscle disease; Neurological disorder; Cerebral disorder; Central nervous system disease |
SD : | Blefaroespasmo; Distonía; Sistema nervioso patología; Epidemiología; Neurología |
LO : | INIST-20953.354000502036870230 |
ID : | 12-0393102 |
Links to Exploration step
Pascal:12-0393102Le document en format XML
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<author><name sortKey="Santoro, Lucio" sort="Santoro, Lucio" uniqKey="Santoro L" first="Lucio" last="Santoro">Lucio Santoro</name>
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<author><name sortKey="Defazio, Giovanni" sort="Defazio, Giovanni" uniqKey="Defazio G" first="Giovanni" last="Defazio">Giovanni Defazio</name>
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<series><title level="j" type="main">Movement disorders</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Blepharospasm</term>
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<term>Neurology</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Blépharospasme</term>
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<front><div type="abstract" xml:lang="en">Background: The site of dystonia onset is known to affect the risk of spread in primary adult-onset focal dystonia, but other factors possibly influencing spread are unknown. This study explored the relationship between age and spread of dystonia in primary adult-onset focal dystonia. Methods: Two survival models analyzed spread of dystonia in a large cohort of patients with primary blepharospasm (BSP) and cervical dystonia. The first model was based on time interval between onset and spread of dystonia, and the second model was based on age at spread. Results: Patients presenting with BSP had a 2-fold higher rate of spread than those presenting with cervical dystonia, regardless of the survival model used. However, survival analysis, based on age at spread, showed that spread develops at a similar age period in both groups, with most spread events occurring after the age of 50. Conclusions: The convergent age of spread in BSP and cervical dystonia is a novel finding indicating age as a factor modulating spread of dystonia. These findings may assist in informing prognostication for patients with primary adult-onset focal dystonia.</div>
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<fA61><s0>A</s0>
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<fA64 i1="01" i2="1"><s0>Movement disorders</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Background: The site of dystonia onset is known to affect the risk of spread in primary adult-onset focal dystonia, but other factors possibly influencing spread are unknown. This study explored the relationship between age and spread of dystonia in primary adult-onset focal dystonia. Methods: Two survival models analyzed spread of dystonia in a large cohort of patients with primary blepharospasm (BSP) and cervical dystonia. The first model was based on time interval between onset and spread of dystonia, and the second model was based on age at spread. Results: Patients presenting with BSP had a 2-fold higher rate of spread than those presenting with cervical dystonia, regardless of the survival model used. However, survival analysis, based on age at spread, showed that spread develops at a similar age period in both groups, with most spread events occurring after the age of 50. Conclusions: The convergent age of spread in BSP and cervical dystonia is a novel finding indicating age as a factor modulating spread of dystonia. These findings may assist in informing prognostication for patients with primary adult-onset focal dystonia.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B17</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B17H</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Blépharospasme</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Blepharospasm</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Blefaroespasmo</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Dystonie</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Dystonia</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Distonía</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Pathologie du système nerveux</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Epidémiologie</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Epidemiology</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Epidemiología</s0>
<s5>09</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Neurologie</s0>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Neurology</s0>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Neurología</s0>
<s5>10</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Pathologie de l'oeil</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Eye disease</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Ojo patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Pathologie de la paupière</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Eyelid disease</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Párpado patología</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Mouvement involontaire</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Involuntary movement</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Movimiento involuntario</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Pathologie du muscle strié</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Striated muscle disease</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Músculo estriado patología</s0>
<s5>41</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Trouble neurologique</s0>
<s5>43</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Neurological disorder</s0>
<s5>43</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Trastorno neurológico</s0>
<s5>43</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0>
<s5>44</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>44</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>44</s5>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Pathologie du système nerveux central</s0>
<s5>45</s5>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>45</s5>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>45</s5>
</fC07>
<fN21><s1>303</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 12-0393102 INIST</NO>
<ET>Age at Onset and Symptom Spread in Primary Adult-Onset Blepharospasm and Cervical Dystonia</ET>
<AU>MARTINO (Davide); BERARDELLI (Alfredo); ABBRUZZESE (Giovanni); BENTIVOGLIO (Anna Rita); ESPOSITO (Marcello); FABBRINI (Giovanni); GUIDUBALDI (Arianna); GIRLANDA (Paolo); LIGUORI (Rocco); MARINELLI (Lucio); MORGANTE (Francesca); SANTORO (Lucio); DEFAZIO (Giovanni)</AU>
<AF>Department of Neurosciences and Sensory Organs and School of Motor Sciences, "Aldo Moro" University of Bari/Bari/Italie (1 aut., 13 aut.); Department of Neurology and Psychiatry, Sapienza University of Rome and IRCCS Neuromed Institute/Pozzilli/Italie (2 aut., 6 aut.); Department of Neurosciences, Ophthalmology and Genetics, University of Genoa/Genoa/Italie (3 aut., 10 aut.); Department of Neurosciences, Catholic University/Rome/Italie (4 aut., 7 aut.); Department of Neurology, Second University of Naples/Naples/Italie (5 aut., 12 aut.); Department of Neurosciences, Psychiatry, and Anaesthesiological Science, University of Messina/Messina/Italie (8 aut., 11 aut.); Department of Neurosciences, University of Bologna/Bologna/Italie (9 aut.)</AF>
<DT>Publication en série; Courte communication, note brève; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2012; Vol. 27; No. 11; Pp. 1447-1450; Bibl. 16 ref.</SO>
<LA>Anglais</LA>
<EA>Background: The site of dystonia onset is known to affect the risk of spread in primary adult-onset focal dystonia, but other factors possibly influencing spread are unknown. This study explored the relationship between age and spread of dystonia in primary adult-onset focal dystonia. Methods: Two survival models analyzed spread of dystonia in a large cohort of patients with primary blepharospasm (BSP) and cervical dystonia. The first model was based on time interval between onset and spread of dystonia, and the second model was based on age at spread. Results: Patients presenting with BSP had a 2-fold higher rate of spread than those presenting with cervical dystonia, regardless of the survival model used. However, survival analysis, based on age at spread, showed that spread develops at a similar age period in both groups, with most spread events occurring after the age of 50. Conclusions: The convergent age of spread in BSP and cervical dystonia is a novel finding indicating age as a factor modulating spread of dystonia. These findings may assist in informing prognostication for patients with primary adult-onset focal dystonia.</EA>
<CC>002B17; 002B17H</CC>
<FD>Blépharospasme; Dystonie; Pathologie du système nerveux; Epidémiologie; Neurologie</FD>
<FG>Pathologie de l'oeil; Pathologie de la paupière; Syndrome extrapyramidal; Mouvement involontaire; Pathologie du muscle strié; Trouble neurologique; Pathologie de l'encéphale; Pathologie du système nerveux central</FG>
<ED>Blepharospasm; Dystonia; Nervous system diseases; Epidemiology; Neurology</ED>
<EG>Eye disease; Eyelid disease; Extrapyramidal syndrome; Involuntary movement; Striated muscle disease; Neurological disorder; Cerebral disorder; Central nervous system disease</EG>
<SD>Blefaroespasmo; Distonía; Sistema nervioso patología; Epidemiología; Neurología</SD>
<LO>INIST-20953.354000502036870230</LO>
<ID>12-0393102</ID>
</server>
</inist>
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