Deep brain stimulation and medication for parkinsonian tremor during secondary tasks
Identifieur interne : 001639 ( PascalFrancis/Corpus ); précédent : 001638; suivant : 001640Deep brain stimulation and medication for parkinsonian tremor during secondary tasks
Auteurs : Molly M. Sturman ; David E. Vaillancourt ; Leo Verhagen Metman ; Diane K. Sierens ; Roy A. E. Bakay ; Daniel M. CorcosSource :
- Movement disorders [ 0885-3185 ] ; 2007.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
This study examined the efficacy of subthalamic nucleus (STN), deep brain stimulation (DBS), and medication for resting tremor during performance of secondary tasks. Hand tremor was recorded using accelerometry and electromyography (EMG) from 10 patients with Parkinson's disease (PD) and ten matched control subjects. The PD subjects were examined off treatment, on STN DBS, on medication, and on STN DBS plus medication. In the first experiment, tremor was recorded in a quiet condition and during a cognitive task designed to enhance tremor. In the second experiment, tremor was recorded in a quiet condition and during isometric finger flexion (motor task) with the contralateral limb at 5% of the maximal voluntary contraction (MVC) that was designed to suppress tremor. Results showed that: (1) STN DBS and medication reduced tremor during a cognitive task that exacerbated tremor, (2) STN DBS normalized tremor frequency in both the quiet and cognitive task conditions, whereas tremor amplitude was only normalized in the quiet condition, (3) a secondary motor task reduced tremor in a similar manner to STN DBS. These findings demonstrate that STN DBS still suppresses tremor in the presence of a cognitive task. Furthermore, a secondary motor task of the opposite limb suppresses tremor to levels comparable to STN DBS.
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Format Inist (serveur)
NO : | PASCAL 07-0349120 INIST |
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ET : | Deep brain stimulation and medication for parkinsonian tremor during secondary tasks |
AU : | STURMAN (Molly M.); VAILLANCOURT (David E.); VERHAGEN METMAN (Leo); SIERENS (Diane K.); BAKAY (Roy A. E.); CORCOS (Daniel M.) |
AF : | Department of Movement Sciences, University of Illinois at Chicago/Chicago, Illinois/Etats-Unis (1 aut., 2 aut., 6 aut.); Department of Bioengineering, University of Illinois at Chicago/Chicago, Illinois/Etats-Unis (2 aut., 6 aut.); Department of Neurological Sciences, Rush University Medical Center/Chicago, Illinois/Etats-Unis (3 aut., 5 aut., 6 aut.); Department of Neurosurgery, Rush University Medical Center/Chicago, Illinois/Etats-Unis (3 aut., 5 aut.); Department of Neurological Surgery, Rockford Health System/Rockford, Illinois/Etats-Unis (4 aut.); Department of Physical Therapy, University of Illinois at Chicago/Chicago, Illinois/Etats-Unis (6 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2007; Vol. 22; No. 8; Pp. 1157-1163; Bibl. 34 ref. |
LA : | Anglais |
EA : | This study examined the efficacy of subthalamic nucleus (STN), deep brain stimulation (DBS), and medication for resting tremor during performance of secondary tasks. Hand tremor was recorded using accelerometry and electromyography (EMG) from 10 patients with Parkinson's disease (PD) and ten matched control subjects. The PD subjects were examined off treatment, on STN DBS, on medication, and on STN DBS plus medication. In the first experiment, tremor was recorded in a quiet condition and during a cognitive task designed to enhance tremor. In the second experiment, tremor was recorded in a quiet condition and during isometric finger flexion (motor task) with the contralateral limb at 5% of the maximal voluntary contraction (MVC) that was designed to suppress tremor. Results showed that: (1) STN DBS and medication reduced tremor during a cognitive task that exacerbated tremor, (2) STN DBS normalized tremor frequency in both the quiet and cognitive task conditions, whereas tremor amplitude was only normalized in the quiet condition, (3) a secondary motor task reduced tremor in a similar manner to STN DBS. These findings demonstrate that STN DBS still suppresses tremor in the presence of a cognitive task. Furthermore, a secondary motor task of the opposite limb suppresses tremor to levels comparable to STN DBS. |
CC : | 002B17; 002B17A01; 002B26I |
FD : | Système nerveux pathologie; Parkinson maladie; Tremblement; Chimiothérapie; Noyau sousthalamique; Stimulation cérébrale profonde |
FG : | Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie; Mouvement involontaire; Trouble neurologique; Système nerveux central |
ED : | Nervous system diseases; Parkinson disease; Tremor; Chemotherapy; Subthalamic nucleus; Deep brain stimulation |
EG : | Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Involuntary movement; Neurological disorder; Central nervous system |
SD : | Sistema nervioso patología; Parkinson enfermedad; Temblor; Quimioterapia; Núcleo subtalámico |
LO : | INIST-20953.354000159429990150 |
ID : | 07-0349120 |
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Pascal:07-0349120Le document en format XML
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<front><div type="abstract" xml:lang="en">This study examined the efficacy of subthalamic nucleus (STN), deep brain stimulation (DBS), and medication for resting tremor during performance of secondary tasks. Hand tremor was recorded using accelerometry and electromyography (EMG) from 10 patients with Parkinson's disease (PD) and ten matched control subjects. The PD subjects were examined off treatment, on STN DBS, on medication, and on STN DBS plus medication. In the first experiment, tremor was recorded in a quiet condition and during a cognitive task designed to enhance tremor. In the second experiment, tremor was recorded in a quiet condition and during isometric finger flexion (motor task) with the contralateral limb at 5% of the maximal voluntary contraction (MVC) that was designed to suppress tremor. Results showed that: (1) STN DBS and medication reduced tremor during a cognitive task that exacerbated tremor, (2) STN DBS normalized tremor frequency in both the quiet and cognitive task conditions, whereas tremor amplitude was only normalized in the quiet condition, (3) a secondary motor task reduced tremor in a similar manner to STN DBS. These findings demonstrate that STN DBS still suppresses tremor in the presence of a cognitive task. Furthermore, a secondary motor task of the opposite limb suppresses tremor to levels comparable to STN DBS.</div>
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<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Mouvement involontaire</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Involuntary movement</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Movimiento involuntario</s0>
<s5>41</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Trouble neurologique</s0>
<s5>42</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Neurological disorder</s0>
<s5>42</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Trastorno neurológico</s0>
<s5>42</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Système nerveux central</s0>
<s5>43</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Central nervous system</s0>
<s5>43</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Sistema nervioso central</s0>
<s5>43</s5>
</fC07>
<fN21><s1>225</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 07-0349120 INIST</NO>
<ET>Deep brain stimulation and medication for parkinsonian tremor during secondary tasks</ET>
<AU>STURMAN (Molly M.); VAILLANCOURT (David E.); VERHAGEN METMAN (Leo); SIERENS (Diane K.); BAKAY (Roy A. E.); CORCOS (Daniel M.)</AU>
<AF>Department of Movement Sciences, University of Illinois at Chicago/Chicago, Illinois/Etats-Unis (1 aut., 2 aut., 6 aut.); Department of Bioengineering, University of Illinois at Chicago/Chicago, Illinois/Etats-Unis (2 aut., 6 aut.); Department of Neurological Sciences, Rush University Medical Center/Chicago, Illinois/Etats-Unis (3 aut., 5 aut., 6 aut.); Department of Neurosurgery, Rush University Medical Center/Chicago, Illinois/Etats-Unis (3 aut., 5 aut.); Department of Neurological Surgery, Rockford Health System/Rockford, Illinois/Etats-Unis (4 aut.); Department of Physical Therapy, University of Illinois at Chicago/Chicago, Illinois/Etats-Unis (6 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2007; Vol. 22; No. 8; Pp. 1157-1163; Bibl. 34 ref.</SO>
<LA>Anglais</LA>
<EA>This study examined the efficacy of subthalamic nucleus (STN), deep brain stimulation (DBS), and medication for resting tremor during performance of secondary tasks. Hand tremor was recorded using accelerometry and electromyography (EMG) from 10 patients with Parkinson's disease (PD) and ten matched control subjects. The PD subjects were examined off treatment, on STN DBS, on medication, and on STN DBS plus medication. In the first experiment, tremor was recorded in a quiet condition and during a cognitive task designed to enhance tremor. In the second experiment, tremor was recorded in a quiet condition and during isometric finger flexion (motor task) with the contralateral limb at 5% of the maximal voluntary contraction (MVC) that was designed to suppress tremor. Results showed that: (1) STN DBS and medication reduced tremor during a cognitive task that exacerbated tremor, (2) STN DBS normalized tremor frequency in both the quiet and cognitive task conditions, whereas tremor amplitude was only normalized in the quiet condition, (3) a secondary motor task reduced tremor in a similar manner to STN DBS. These findings demonstrate that STN DBS still suppresses tremor in the presence of a cognitive task. Furthermore, a secondary motor task of the opposite limb suppresses tremor to levels comparable to STN DBS.</EA>
<CC>002B17; 002B17A01; 002B26I</CC>
<FD>Système nerveux pathologie; Parkinson maladie; Tremblement; Chimiothérapie; Noyau sousthalamique; Stimulation cérébrale profonde</FD>
<FG>Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie; Mouvement involontaire; Trouble neurologique; Système nerveux central</FG>
<ED>Nervous system diseases; Parkinson disease; Tremor; Chemotherapy; Subthalamic nucleus; Deep brain stimulation</ED>
<EG>Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Involuntary movement; Neurological disorder; Central nervous system</EG>
<SD>Sistema nervioso patología; Parkinson enfermedad; Temblor; Quimioterapia; Núcleo subtalámico</SD>
<LO>INIST-20953.354000159429990150</LO>
<ID>07-0349120</ID>
</server>
</inist>
</record>
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