MovDisordV3, PascalFrancis, Corpus, bibRecord, 001638

Enhancement of rigidity in Parkinson's disease with activation

Identifieur interne : 001638 ( PascalFrancis/Corpus ); précédent : 001637; suivant : 001639

Enhancement of rigidity in Parkinson's disease with activation

Auteurs : MINNA HONG ; Joel S. Perlmutter ; Gammon M. Earhart

Source :

Movement disorders [ 0885-3185 ] ; 2007.

RBID : Pascal:07-0349121

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Parkinson maladie.

English descriptors

KwdEn :
- Nervous system diseases, Parkinson disease.

Abstract

Rigidity, a cardinal symptom of Parkinson's disease (PD), increases with movement of a contralateral limb. It is unclear whether this effect is specific for movement of a contralateral limb. The goal of this study was to test the hypothesis that ipsilateral or contralateral movement would enhance rigidity but that bilateral limb movements would maximally increase rigidity in people with PD. We assessed rigidity in 12 people with PD off meds, 12 matched controls, and 10 young controls, using a Rigidity Analyzer (Neurokinetics, Alberta, Canada). The elbow was passively moved repetitively into flexion and extension by the examiner, while the subjects engaged in different toe tapping conditions: no tapping, ipsilateral tapping, contralateral tapping, and bilateral tapping. Three 50-second trials were done for each condition and the order of the trials was randomized. A 2-way repeated measures ANOVA and Holm-Sidak post hoc tests were used to determine differences across conditions and groups. There was a significant effect of group, tapping conditions and an interaction of the two. Post hoc tests revealed that for the PD group, all tapping conditions were significantly different from the no tapping condition but not different from each other. There were no differences across conditions for the controls. We conclude that movement of either the contralateral or ipsilateral lower extremity can increase arm rigidity in people with PD but the effects from left and right are apparently not additive. Further, activation did not enhance muscle tone in controls suggesting that this procedure may help distinguish people with PD from controls.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A11	`03`	`1`		`@1 EARHART (Gammon M.)`
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C01	`01`		`ENG`	@0 Rigidity, a cardinal symptom of Parkinson's disease (PD), increases with movement of a contralateral limb. It is unclear whether this effect is specific for movement of a contralateral limb. The goal of this study was to test the hypothesis that ipsilateral or contralateral movement would enhance rigidity but that bilateral limb movements would maximally increase rigidity in people with PD. We assessed rigidity in 12 people with PD off meds, 12 matched controls, and 10 young controls, using a Rigidity Analyzer (Neurokinetics, Alberta, Canada). The elbow was passively moved repetitively into flexion and extension by the examiner, while the subjects engaged in different toe tapping conditions: no tapping, ipsilateral tapping, contralateral tapping, and bilateral tapping. Three 50-second trials were done for each condition and the order of the trials was randomized. A 2-way repeated measures ANOVA and Holm-Sidak post hoc tests were used to determine differences across conditions and groups. There was a significant effect of group, tapping conditions and an interaction of the two. Post hoc tests revealed that for the PD group, all tapping conditions were significantly different from the no tapping condition but not different from each other. There were no differences across conditions for the controls. We conclude that movement of either the contralateral or ipsilateral lower extremity can increase arm rigidity in people with PD but the effects from left and right are apparently not additive. Further, activation did not enhance muscle tone in controls suggesting that this procedure may help distinguish people with PD from controls.
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Format Inist (serveur)

NO :	PASCAL 07-0349121 INIST
ET :	Enhancement of rigidity in Parkinson's disease with activation
AU :	MINNA HONG; PERLMUTTER (Joel S.); EARHART (Gammon M.)
AF :	Movement Science Program, Washington University School of Medicine/St. Louis, Missouri/Etats-Unis (1 aut., 2 aut., 3 aut.); Program in Physical Therapy, Washington University School of Medicine/St. Louis, Missouri/Etats-Unis (1 aut., 2 aut., 3 aut.); Department of Neurology, Washington University School of Medicine/St. Louis, Missouri/Etats-Unis (1 aut., 2 aut., 3 aut.); Department of Anatomy and Neurobiology, Washington University School of Medicine/St. Louis, Missouri/Etats-Unis (2 aut., 3 aut.); Department of Radiology, Washington University School of Medicine/St. Louis, Missouri/Etats-Unis (2 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2007; Vol. 22; No. 8; Pp. 1164-1168; Bibl. 18 ref.
LA :	Anglais
EA :	Rigidity, a cardinal symptom of Parkinson's disease (PD), increases with movement of a contralateral limb. It is unclear whether this effect is specific for movement of a contralateral limb. The goal of this study was to test the hypothesis that ipsilateral or contralateral movement would enhance rigidity but that bilateral limb movements would maximally increase rigidity in people with PD. We assessed rigidity in 12 people with PD off meds, 12 matched controls, and 10 young controls, using a Rigidity Analyzer (Neurokinetics, Alberta, Canada). The elbow was passively moved repetitively into flexion and extension by the examiner, while the subjects engaged in different toe tapping conditions: no tapping, ipsilateral tapping, contralateral tapping, and bilateral tapping. Three 50-second trials were done for each condition and the order of the trials was randomized. A 2-way repeated measures ANOVA and Holm-Sidak post hoc tests were used to determine differences across conditions and groups. There was a significant effect of group, tapping conditions and an interaction of the two. Post hoc tests revealed that for the PD group, all tapping conditions were significantly different from the no tapping condition but not different from each other. There were no differences across conditions for the controls. We conclude that movement of either the contralateral or ipsilateral lower extremity can increase arm rigidity in people with PD but the effects from left and right are apparently not additive. Further, activation did not enhance muscle tone in controls suggesting that this procedure may help distinguish people with PD from controls.
CC :	002B17; 002B17G; 002B17A03
FD :	Système nerveux pathologie; Parkinson maladie
FG :	Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie
ED :	Nervous system diseases; Parkinson disease
EG :	Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease
SD :	Sistema nervioso patología; Parkinson enfermedad
LO :	INIST-20953.354000159429990160
ID :	07-0349121

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Pascal:07-0349121

Le document en format XML

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<front><div type="abstract" xml:lang="en">Rigidity, a cardinal symptom of Parkinson's disease (PD), increases with movement of a contralateral limb. It is unclear whether this effect is specific for movement of a contralateral limb. The goal of this study was to test the hypothesis that ipsilateral or contralateral movement would enhance rigidity but that bilateral limb movements would maximally increase rigidity in people with PD. We assessed rigidity in 12 people with PD off meds, 12 matched controls, and 10 young controls, using a Rigidity Analyzer (Neurokinetics, Alberta, Canada). The elbow was passively moved repetitively into flexion and extension by the examiner, while the subjects engaged in different toe tapping conditions: no tapping, ipsilateral tapping, contralateral tapping, and bilateral tapping. Three 50-second trials were done for each condition and the order of the trials was randomized. A 2-way repeated measures ANOVA and Holm-Sidak post hoc tests were used to determine differences across conditions and groups. There was a significant effect of group, tapping conditions and an interaction of the two. Post hoc tests revealed that for the PD group, all tapping conditions were significantly different from the no tapping condition but not different from each other. There were no differences across conditions for the controls. We conclude that movement of either the contralateral or ipsilateral lower extremity can increase arm rigidity in people with PD but the effects from left and right are apparently not additive. Further, activation did not enhance muscle tone in controls suggesting that this procedure may help distinguish people with PD from controls.</div>
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<fC01 i1="01" l="ENG"><s0>Rigidity, a cardinal symptom of Parkinson's disease (PD), increases with movement of a contralateral limb. It is unclear whether this effect is specific for movement of a contralateral limb. The goal of this study was to test the hypothesis that ipsilateral or contralateral movement would enhance rigidity but that bilateral limb movements would maximally increase rigidity in people with PD. We assessed rigidity in 12 people with PD off meds, 12 matched controls, and 10 young controls, using a Rigidity Analyzer (Neurokinetics, Alberta, Canada). The elbow was passively moved repetitively into flexion and extension by the examiner, while the subjects engaged in different toe tapping conditions: no tapping, ipsilateral tapping, contralateral tapping, and bilateral tapping. Three 50-second trials were done for each condition and the order of the trials was randomized. A 2-way repeated measures ANOVA and Holm-Sidak post hoc tests were used to determine differences across conditions and groups. There was a significant effect of group, tapping conditions and an interaction of the two. Post hoc tests revealed that for the PD group, all tapping conditions were significantly different from the no tapping condition but not different from each other. There were no differences across conditions for the controls. We conclude that movement of either the contralateral or ipsilateral lower extremity can increase arm rigidity in people with PD but the effects from left and right are apparently not additive. Further, activation did not enhance muscle tone in controls suggesting that this procedure may help distinguish people with PD from controls.</s0>
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<server><NO>PASCAL 07-0349121 INIST</NO>
<ET>Enhancement of rigidity in Parkinson's disease with activation</ET>
<AU>MINNA HONG; PERLMUTTER (Joel S.); EARHART (Gammon M.)</AU>
<AF>Movement Science Program, Washington University School of Medicine/St. Louis, Missouri/Etats-Unis (1 aut., 2 aut., 3 aut.); Program in Physical Therapy, Washington University School of Medicine/St. Louis, Missouri/Etats-Unis (1 aut., 2 aut., 3 aut.); Department of Neurology, Washington University School of Medicine/St. Louis, Missouri/Etats-Unis (1 aut., 2 aut., 3 aut.); Department of Anatomy and Neurobiology, Washington University School of Medicine/St. Louis, Missouri/Etats-Unis (2 aut., 3 aut.); Department of Radiology, Washington University School of Medicine/St. Louis, Missouri/Etats-Unis (2 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2007; Vol. 22; No. 8; Pp. 1164-1168; Bibl. 18 ref.</SO>
<LA>Anglais</LA>
<EA>Rigidity, a cardinal symptom of Parkinson's disease (PD), increases with movement of a contralateral limb. It is unclear whether this effect is specific for movement of a contralateral limb. The goal of this study was to test the hypothesis that ipsilateral or contralateral movement would enhance rigidity but that bilateral limb movements would maximally increase rigidity in people with PD. We assessed rigidity in 12 people with PD off meds, 12 matched controls, and 10 young controls, using a Rigidity Analyzer (Neurokinetics, Alberta, Canada). The elbow was passively moved repetitively into flexion and extension by the examiner, while the subjects engaged in different toe tapping conditions: no tapping, ipsilateral tapping, contralateral tapping, and bilateral tapping. Three 50-second trials were done for each condition and the order of the trials was randomized. A 2-way repeated measures ANOVA and Holm-Sidak post hoc tests were used to determine differences across conditions and groups. There was a significant effect of group, tapping conditions and an interaction of the two. Post hoc tests revealed that for the PD group, all tapping conditions were significantly different from the no tapping condition but not different from each other. There were no differences across conditions for the controls. We conclude that movement of either the contralateral or ipsilateral lower extremity can increase arm rigidity in people with PD but the effects from left and right are apparently not additive. Further, activation did not enhance muscle tone in controls suggesting that this procedure may help distinguish people with PD from controls.</EA>
<CC>002B17; 002B17G; 002B17A03</CC>
<FD>Système nerveux pathologie; Parkinson maladie</FD>
<FG>Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie</FG>
<ED>Nervous system diseases; Parkinson disease</ED>
<EG>Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease</EG>
<SD>Sistema nervioso patología; Parkinson enfermedad</SD>
<LO>INIST-20953.354000159429990160</LO>
<ID>07-0349121</ID>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Enhancement of rigidity in Parkinson's disease with activation

Enhancement of rigidity in Parkinson's disease with activation

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