MovDisordV3, PascalFrancis, Corpus, bibRecord, 001640

Gender differences in patients with Parkinson's disease treated with subthalamic deep brain stimulation

Identifieur interne : 001640 ( PascalFrancis/Corpus ); précédent : 001639; suivant : 001641

Gender differences in patients with Parkinson's disease treated with subthalamic deep brain stimulation

Auteurs : Ettore Accolla ; Elena Caputo ; Filippo Cogiamanian ; Filippo Tamma ; Simona Mrakic-Sposta ; Sara Marceglia ; Marcello Egidi ; Paolo Rampini ; Marco Locatelli ; Alberto Priori

Source :

Movement disorders [ 0885-3185 ] ; 2007.

RBID : Pascal:07-0349119

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Parkinson maladie, Sexe, Homme, Traitement, Noyau sousthalamique, Stimulation cérébrale profonde.

English descriptors

KwdEn :
- Deep brain stimulation, Human, Nervous system diseases, Parkinson disease, Sex, Subthalamic nucleus, Treatment.

Abstract

We investigated gender-differences in clinical phenomenology and response to deep brain stimulation (DBS) of the subthalamic nucleus (STN) in a group of patients with advanced Parkinson's disease (PD). Thirty-eight consecutive patients with PD (22 men and 16 women), bilaterally implanted for DBS of the STN, were evaluated 1 month before and 11 to 14 months after surgery. Gender differences in severity of the disease (HY and UPDRS), ability in the activities of daily living (ADL, UPDRS II), tremor and rigidity (UPDRS III), bradykinesia (UPDRS III and hand tapping test), levodopa-induced dyskinesias (LIDs, UPDRS IV), and levodopa equivalent daily dosage (LEDD) were analyzed before and after intervention. We found a predominantly male population, with no gender-related differences in age at onset, disease progression rate, or severity of disease. Nevertheless, women had more severe LIDs than men, only before the intervention. Bradykinesia was significantly less responsive to any kind of treatment (pharmacologic and neurosurgical) in women than in men. Finally, although STN-DBS induced similar total benefits in both genders, postoperative assessment suggested that the ADL improved more in women than in men. Women and men with advanced PD appear to differ in some clinical features and in response to dopaminergic and STN-DBS treatment.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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C01	`01`		`ENG`	@0 We investigated gender-differences in clinical phenomenology and response to deep brain stimulation (DBS) of the subthalamic nucleus (STN) in a group of patients with advanced Parkinson's disease (PD). Thirty-eight consecutive patients with PD (22 men and 16 women), bilaterally implanted for DBS of the STN, were evaluated 1 month before and 11 to 14 months after surgery. Gender differences in severity of the disease (HY and UPDRS), ability in the activities of daily living (ADL, UPDRS II), tremor and rigidity (UPDRS III), bradykinesia (UPDRS III and hand tapping test), levodopa-induced dyskinesias (LIDs, UPDRS IV), and levodopa equivalent daily dosage (LEDD) were analyzed before and after intervention. We found a predominantly male population, with no gender-related differences in age at onset, disease progression rate, or severity of disease. Nevertheless, women had more severe LIDs than men, only before the intervention. Bradykinesia was significantly less responsive to any kind of treatment (pharmacologic and neurosurgical) in women than in men. Finally, although STN-DBS induced similar total benefits in both genders, postoperative assessment suggested that the ADL improved more in women than in men. Women and men with advanced PD appear to differ in some clinical features and in response to dopaminergic and STN-DBS treatment.
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C03	`06`	`X`	`FRE`	`@0 Noyau sousthalamique @5 12`
C03	`06`	`X`	`ENG`	`@0 Subthalamic nucleus @5 12`
C03	`06`	`X`	`SPA`	`@0 Núcleo subtalámico @5 12`
C03	`07`	`X`	`FRE`	`@0 Stimulation cérébrale profonde @4 CD @5 96`
C03	`07`	`X`	`ENG`	`@0 Deep brain stimulation @4 CD @5 96`
C07	`01`	`X`	`FRE`	`@0 Encéphale pathologie @5 37`
C07	`01`	`X`	`ENG`	`@0 Cerebral disorder @5 37`
C07	`01`	`X`	`SPA`	`@0 Encéfalo patología @5 37`
C07	`02`	`X`	`FRE`	`@0 Extrapyramidal syndrome @5 38`
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C07	`02`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 38`
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N44	`01`			`@1 OTO`
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Format Inist (serveur)

NO :	PASCAL 07-0349119 INIST
ET :	Gender differences in patients with Parkinson's disease treated with subthalamic deep brain stimulation
AU :	ACCOLLA (Ettore); CAPUTO (Elena); COGIAMANIAN (Filippo); TAMMA (Filippo); MRAKIC-SPOSTA (Simona); MARCEGLIA (Sara); EGIDI (Marcello); RAMPINI (Paolo); LOCATELLI (Marco); PRIORI (Alberto)
AF :	Dipartimento di Science Neurologiche, Universita di Milano, Fondazione IRCCS Ospedale/Policlinico, Milano/Italie (1 aut., 3 aut., 5 aut., 6 aut., 7 aut., 8 aut., 9 aut., 10 aut.); Dipartimento di Neurologia Clinica, Ospedale San Paolo/Milano/Italie (2 aut., 4 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2007; Vol. 22; No. 8; Pp. 1150-1156; Bibl. 21 ref.
LA :	Anglais
EA :	We investigated gender-differences in clinical phenomenology and response to deep brain stimulation (DBS) of the subthalamic nucleus (STN) in a group of patients with advanced Parkinson's disease (PD). Thirty-eight consecutive patients with PD (22 men and 16 women), bilaterally implanted for DBS of the STN, were evaluated 1 month before and 11 to 14 months after surgery. Gender differences in severity of the disease (HY and UPDRS), ability in the activities of daily living (ADL, UPDRS II), tremor and rigidity (UPDRS III), bradykinesia (UPDRS III and hand tapping test), levodopa-induced dyskinesias (LIDs, UPDRS IV), and levodopa equivalent daily dosage (LEDD) were analyzed before and after intervention. We found a predominantly male population, with no gender-related differences in age at onset, disease progression rate, or severity of disease. Nevertheless, women had more severe LIDs than men, only before the intervention. Bradykinesia was significantly less responsive to any kind of treatment (pharmacologic and neurosurgical) in women than in men. Finally, although STN-DBS induced similar total benefits in both genders, postoperative assessment suggested that the ADL improved more in women than in men. Women and men with advanced PD appear to differ in some clinical features and in response to dopaminergic and STN-DBS treatment.
CC :	002B17; 002B17G; 002B17F
FD :	Système nerveux pathologie; Parkinson maladie; Sexe; Homme; Traitement; Noyau sousthalamique; Stimulation cérébrale profonde
FG :	Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie; Système nerveux central
ED :	Nervous system diseases; Parkinson disease; Sex; Human; Treatment; Subthalamic nucleus; Deep brain stimulation
EG :	Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Central nervous system
SD :	Sistema nervioso patología; Parkinson enfermedad; Sexo; Hombre; Tratamiento; Núcleo subtalámico
LO :	INIST-20953.354000159429990140
ID :	07-0349119

Links to Exploration step

Pascal:07-0349119

Le document en format XML

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<front><div type="abstract" xml:lang="en">We investigated gender-differences in clinical phenomenology and response to deep brain stimulation (DBS) of the subthalamic nucleus (STN) in a group of patients with advanced Parkinson's disease (PD). Thirty-eight consecutive patients with PD (22 men and 16 women), bilaterally implanted for DBS of the STN, were evaluated 1 month before and 11 to 14 months after surgery. Gender differences in severity of the disease (HY and UPDRS), ability in the activities of daily living (ADL, UPDRS II), tremor and rigidity (UPDRS III), bradykinesia (UPDRS III and hand tapping test), levodopa-induced dyskinesias (LIDs, UPDRS IV), and levodopa equivalent daily dosage (LEDD) were analyzed before and after intervention. We found a predominantly male population, with no gender-related differences in age at onset, disease progression rate, or severity of disease. Nevertheless, women had more severe LIDs than men, only before the intervention. Bradykinesia was significantly less responsive to any kind of treatment (pharmacologic and neurosurgical) in women than in men. Finally, although STN-DBS induced similar total benefits in both genders, postoperative assessment suggested that the ADL improved more in women than in men. Women and men with advanced PD appear to differ in some clinical features and in response to dopaminergic and STN-DBS treatment.</div>
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<ET>Gender differences in patients with Parkinson's disease treated with subthalamic deep brain stimulation</ET>
<AU>ACCOLLA (Ettore); CAPUTO (Elena); COGIAMANIAN (Filippo); TAMMA (Filippo); MRAKIC-SPOSTA (Simona); MARCEGLIA (Sara); EGIDI (Marcello); RAMPINI (Paolo); LOCATELLI (Marco); PRIORI (Alberto)</AU>
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<EA>We investigated gender-differences in clinical phenomenology and response to deep brain stimulation (DBS) of the subthalamic nucleus (STN) in a group of patients with advanced Parkinson's disease (PD). Thirty-eight consecutive patients with PD (22 men and 16 women), bilaterally implanted for DBS of the STN, were evaluated 1 month before and 11 to 14 months after surgery. Gender differences in severity of the disease (HY and UPDRS), ability in the activities of daily living (ADL, UPDRS II), tremor and rigidity (UPDRS III), bradykinesia (UPDRS III and hand tapping test), levodopa-induced dyskinesias (LIDs, UPDRS IV), and levodopa equivalent daily dosage (LEDD) were analyzed before and after intervention. We found a predominantly male population, with no gender-related differences in age at onset, disease progression rate, or severity of disease. Nevertheless, women had more severe LIDs than men, only before the intervention. Bradykinesia was significantly less responsive to any kind of treatment (pharmacologic and neurosurgical) in women than in men. Finally, although STN-DBS induced similar total benefits in both genders, postoperative assessment suggested that the ADL improved more in women than in men. Women and men with advanced PD appear to differ in some clinical features and in response to dopaminergic and STN-DBS treatment.</EA>
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<ED>Nervous system diseases; Parkinson disease; Sex; Human; Treatment; Subthalamic nucleus; Deep brain stimulation</ED>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Gender differences in patients with Parkinson's disease treated with subthalamic deep brain stimulation

Gender differences in patients with Parkinson's disease treated with subthalamic deep brain stimulation

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