Striatal gray matter loss in Huntington's disease is leftward biased
Identifieur interne : 001637 ( PascalFrancis/Corpus ); précédent : 001636; suivant : 001638Striatal gray matter loss in Huntington's disease is leftward biased
Auteurs : Mark Mühlau ; Christian Gaser ; Afra M. Wohlschl Ger ; Adolf Weindl ; Michael St Dtler ; Michael Valet ; Claus Zimmer ; Jan Kassubek ; Alexander PeinemannSource :
- Movement disorders [ 0885-3185 ] ; 2007.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
In Huntington's disease (HD), the distribution of pathological changes throughout the brain is incompletely understood. Some studies have identified leftward-biased lateralization, whereas others did not. We performed magnetic resonance imaging and a voxel-based asymmetry analysis in 44 right-handed HD gene carriers (presymptomatic, n = 5; stage I, n = 28; stage II, n = 11) and 44 right-handed healthy controls. The group comparison revealed leftward-biased gray matter loss in the striatum. Further analyses showed no indication of asymmetry in presymptomatic HD patients but an increase in asymmetry in the course of the HD stages under examination. Our study demonstrates and discusses leftward-biased gray matter loss in HD.
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Pour connaître la documentation sur le format Inist Standard.
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Format Inist (serveur)
NO : | PASCAL 07-0349122 INIST |
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ET : | Striatal gray matter loss in Huntington's disease is leftward biased |
AU : | MÜHLAU (Mark); GASER (Christian); WOHLSCHLÄGER (Afra M.); WEINDL (Adolf); STÄDTLER (Michael); VALET (Michael); ZIMMER (Claus); KASSUBEK (Jan); PEINEMANN (Alexander) |
AF : | Department of Neurology, Technische Universität Miinchen/Munich/Allemagne (1 aut., 3 aut., 4 aut., 5 aut., 6 aut., 9 aut.); Department of Psychiatry, University of Jena/Jena/Allemagne (2 aut.); Department of Neuroradiology, Technische Universität Miinchen/Munich/Allemagne (3 aut., 7 aut.); Department of Nuclear Medicine, Technische Universität Miinchen/Munich/Allemagne (3 aut.); Department of Neurology, University of Uim/Ulm/Allemagne (8 aut.) |
DT : | Publication en série; Courte communication, note brève; Niveau analytique |
SO : | Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2007; Vol. 22; No. 8; Pp. 1169-1173; Bibl. 15 ref. |
LA : | Anglais |
EA : | In Huntington's disease (HD), the distribution of pathological changes throughout the brain is incompletely understood. Some studies have identified leftward-biased lateralization, whereas others did not. We performed magnetic resonance imaging and a voxel-based asymmetry analysis in 44 right-handed HD gene carriers (presymptomatic, n = 5; stage I, n = 28; stage II, n = 11) and 44 right-handed healthy controls. The group comparison revealed leftward-biased gray matter loss in the striatum. Further analyses showed no indication of asymmetry in presymptomatic HD patients but an increase in asymmetry in the course of the HD stages under examination. Our study demonstrates and discusses leftward-biased gray matter loss in HD. |
CC : | 002B17; 002B17G; 002B17A03 |
FD : | Système nerveux pathologie; Chorée Huntington; Voxel; Morphométrie |
FG : | Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Maladie héréditaire; Système nerveux central pathologie |
ED : | Nervous system diseases; Huntington disease; Voxel; Morphometry |
EG : | Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Genetic disease; Central nervous system disease |
SD : | Sistema nervioso patología; Corea Huntington; Voxel; Morfometría |
LO : | INIST-20953.354000159429990170 |
ID : | 07-0349122 |
Links to Exploration step
Pascal:07-0349122Le document en format XML
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<front><div type="abstract" xml:lang="en">In Huntington's disease (HD), the distribution of pathological changes throughout the brain is incompletely understood. Some studies have identified leftward-biased lateralization, whereas others did not. We performed magnetic resonance imaging and a voxel-based asymmetry analysis in 44 right-handed HD gene carriers (presymptomatic, n = 5; stage I, n = 28; stage II, n = 11) and 44 right-handed healthy controls. The group comparison revealed leftward-biased gray matter loss in the striatum. Further analyses showed no indication of asymmetry in presymptomatic HD patients but an increase in asymmetry in the course of the HD stages under examination. Our study demonstrates and discusses leftward-biased gray matter loss in HD.</div>
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<server><NO>PASCAL 07-0349122 INIST</NO>
<ET>Striatal gray matter loss in Huntington's disease is leftward biased</ET>
<AU>MÜHLAU (Mark); GASER (Christian); WOHLSCHLÄGER (Afra M.); WEINDL (Adolf); STÄDTLER (Michael); VALET (Michael); ZIMMER (Claus); KASSUBEK (Jan); PEINEMANN (Alexander)</AU>
<AF>Department of Neurology, Technische Universität Miinchen/Munich/Allemagne (1 aut., 3 aut., 4 aut., 5 aut., 6 aut., 9 aut.); Department of Psychiatry, University of Jena/Jena/Allemagne (2 aut.); Department of Neuroradiology, Technische Universität Miinchen/Munich/Allemagne (3 aut., 7 aut.); Department of Nuclear Medicine, Technische Universität Miinchen/Munich/Allemagne (3 aut.); Department of Neurology, University of Uim/Ulm/Allemagne (8 aut.)</AF>
<DT>Publication en série; Courte communication, note brève; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2007; Vol. 22; No. 8; Pp. 1169-1173; Bibl. 15 ref.</SO>
<LA>Anglais</LA>
<EA>In Huntington's disease (HD), the distribution of pathological changes throughout the brain is incompletely understood. Some studies have identified leftward-biased lateralization, whereas others did not. We performed magnetic resonance imaging and a voxel-based asymmetry analysis in 44 right-handed HD gene carriers (presymptomatic, n = 5; stage I, n = 28; stage II, n = 11) and 44 right-handed healthy controls. The group comparison revealed leftward-biased gray matter loss in the striatum. Further analyses showed no indication of asymmetry in presymptomatic HD patients but an increase in asymmetry in the course of the HD stages under examination. Our study demonstrates and discusses leftward-biased gray matter loss in HD.</EA>
<CC>002B17; 002B17G; 002B17A03</CC>
<FD>Système nerveux pathologie; Chorée Huntington; Voxel; Morphométrie</FD>
<FG>Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Maladie héréditaire; Système nerveux central pathologie</FG>
<ED>Nervous system diseases; Huntington disease; Voxel; Morphometry</ED>
<EG>Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Genetic disease; Central nervous system disease</EG>
<SD>Sistema nervioso patología; Corea Huntington; Voxel; Morfometría</SD>
<LO>INIST-20953.354000159429990170</LO>
<ID>07-0349122</ID>
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