Striatal gray matter loss in Huntington's disease is leftward biased
Identifieur interne : 001637 ( PascalFrancis/Corpus ); précédent : 001636; suivant : 001638Striatal gray matter loss in Huntington's disease is leftward biased
Auteurs : Mark Mühlau ; Christian Gaser ; Afra M. Wohlschl Ger ; Adolf Weindl ; Michael St Dtler ; Michael Valet ; Claus Zimmer ; Jan Kassubek ; Alexander PeinemannSource :
- Movement disorders [ 0885-3185 ] ; 2007.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
In Huntington's disease (HD), the distribution of pathological changes throughout the brain is incompletely understood. Some studies have identified leftward-biased lateralization, whereas others did not. We performed magnetic resonance imaging and a voxel-based asymmetry analysis in 44 right-handed HD gene carriers (presymptomatic, n = 5; stage I, n = 28; stage II, n = 11) and 44 right-handed healthy controls. The group comparison revealed leftward-biased gray matter loss in the striatum. Further analyses showed no indication of asymmetry in presymptomatic HD patients but an increase in asymmetry in the course of the HD stages under examination. Our study demonstrates and discusses leftward-biased gray matter loss in HD.
Notice en format standard (ISO 2709)
Pour connaître la documentation sur le format Inist Standard.
pA |
|
---|
Format Inist (serveur)
NO : | PASCAL 07-0349122 INIST |
---|---|
ET : | Striatal gray matter loss in Huntington's disease is leftward biased |
AU : | MÜHLAU (Mark); GASER (Christian); WOHLSCHLÄGER (Afra M.); WEINDL (Adolf); STÄDTLER (Michael); VALET (Michael); ZIMMER (Claus); KASSUBEK (Jan); PEINEMANN (Alexander) |
AF : | Department of Neurology, Technische Universität Miinchen/Munich/Allemagne (1 aut., 3 aut., 4 aut., 5 aut., 6 aut., 9 aut.); Department of Psychiatry, University of Jena/Jena/Allemagne (2 aut.); Department of Neuroradiology, Technische Universität Miinchen/Munich/Allemagne (3 aut., 7 aut.); Department of Nuclear Medicine, Technische Universität Miinchen/Munich/Allemagne (3 aut.); Department of Neurology, University of Uim/Ulm/Allemagne (8 aut.) |
DT : | Publication en série; Courte communication, note brève; Niveau analytique |
SO : | Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2007; Vol. 22; No. 8; Pp. 1169-1173; Bibl. 15 ref. |
LA : | Anglais |
EA : | In Huntington's disease (HD), the distribution of pathological changes throughout the brain is incompletely understood. Some studies have identified leftward-biased lateralization, whereas others did not. We performed magnetic resonance imaging and a voxel-based asymmetry analysis in 44 right-handed HD gene carriers (presymptomatic, n = 5; stage I, n = 28; stage II, n = 11) and 44 right-handed healthy controls. The group comparison revealed leftward-biased gray matter loss in the striatum. Further analyses showed no indication of asymmetry in presymptomatic HD patients but an increase in asymmetry in the course of the HD stages under examination. Our study demonstrates and discusses leftward-biased gray matter loss in HD. |
CC : | 002B17; 002B17G; 002B17A03 |
FD : | Système nerveux pathologie; Chorée Huntington; Voxel; Morphométrie |
FG : | Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Maladie héréditaire; Système nerveux central pathologie |
ED : | Nervous system diseases; Huntington disease; Voxel; Morphometry |
EG : | Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Genetic disease; Central nervous system disease |
SD : | Sistema nervioso patología; Corea Huntington; Voxel; Morfometría |
LO : | INIST-20953.354000159429990170 |
ID : | 07-0349122 |
Links to Exploration step
Pascal:07-0349122Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Striatal gray matter loss in Huntington's disease is leftward biased</title>
<author><name sortKey="Muhlau, Mark" sort="Muhlau, Mark" uniqKey="Muhlau M" first="Mark" last="Mühlau">Mark Mühlau</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Neurology, Technische Universität Miinchen</s1>
<s2>Munich</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Gaser, Christian" sort="Gaser, Christian" uniqKey="Gaser C" first="Christian" last="Gaser">Christian Gaser</name>
<affiliation><inist:fA14 i1="02"><s1>Department of Psychiatry, University of Jena</s1>
<s2>Jena</s2>
<s3>DEU</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Wohlschl Ger, Afra M" sort="Wohlschl Ger, Afra M" uniqKey="Wohlschl Ger A" first="Afra M." last="Wohlschl Ger">Afra M. Wohlschl Ger</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Neurology, Technische Universität Miinchen</s1>
<s2>Munich</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="03"><s1>Department of Neuroradiology, Technische Universität Miinchen</s1>
<s2>Munich</s2>
<s3>DEU</s3>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="04"><s1>Department of Nuclear Medicine, Technische Universität Miinchen</s1>
<s2>Munich</s2>
<s3>DEU</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Weindl, Adolf" sort="Weindl, Adolf" uniqKey="Weindl A" first="Adolf" last="Weindl">Adolf Weindl</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Neurology, Technische Universität Miinchen</s1>
<s2>Munich</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="St Dtler, Michael" sort="St Dtler, Michael" uniqKey="St Dtler M" first="Michael" last="St Dtler">Michael St Dtler</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Neurology, Technische Universität Miinchen</s1>
<s2>Munich</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Valet, Michael" sort="Valet, Michael" uniqKey="Valet M" first="Michael" last="Valet">Michael Valet</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Neurology, Technische Universität Miinchen</s1>
<s2>Munich</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Zimmer, Claus" sort="Zimmer, Claus" uniqKey="Zimmer C" first="Claus" last="Zimmer">Claus Zimmer</name>
<affiliation><inist:fA14 i1="03"><s1>Department of Neuroradiology, Technische Universität Miinchen</s1>
<s2>Munich</s2>
<s3>DEU</s3>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Kassubek, Jan" sort="Kassubek, Jan" uniqKey="Kassubek J" first="Jan" last="Kassubek">Jan Kassubek</name>
<affiliation><inist:fA14 i1="05"><s1>Department of Neurology, University of Uim</s1>
<s2>Ulm</s2>
<s3>DEU</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Peinemann, Alexander" sort="Peinemann, Alexander" uniqKey="Peinemann A" first="Alexander" last="Peinemann">Alexander Peinemann</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Neurology, Technische Universität Miinchen</s1>
<s2>Munich</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">07-0349122</idno>
<date when="2007">2007</date>
<idno type="stanalyst">PASCAL 07-0349122 INIST</idno>
<idno type="RBID">Pascal:07-0349122</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001637</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Striatal gray matter loss in Huntington's disease is leftward biased</title>
<author><name sortKey="Muhlau, Mark" sort="Muhlau, Mark" uniqKey="Muhlau M" first="Mark" last="Mühlau">Mark Mühlau</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Neurology, Technische Universität Miinchen</s1>
<s2>Munich</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Gaser, Christian" sort="Gaser, Christian" uniqKey="Gaser C" first="Christian" last="Gaser">Christian Gaser</name>
<affiliation><inist:fA14 i1="02"><s1>Department of Psychiatry, University of Jena</s1>
<s2>Jena</s2>
<s3>DEU</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Wohlschl Ger, Afra M" sort="Wohlschl Ger, Afra M" uniqKey="Wohlschl Ger A" first="Afra M." last="Wohlschl Ger">Afra M. Wohlschl Ger</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Neurology, Technische Universität Miinchen</s1>
<s2>Munich</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="03"><s1>Department of Neuroradiology, Technische Universität Miinchen</s1>
<s2>Munich</s2>
<s3>DEU</s3>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="04"><s1>Department of Nuclear Medicine, Technische Universität Miinchen</s1>
<s2>Munich</s2>
<s3>DEU</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Weindl, Adolf" sort="Weindl, Adolf" uniqKey="Weindl A" first="Adolf" last="Weindl">Adolf Weindl</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Neurology, Technische Universität Miinchen</s1>
<s2>Munich</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="St Dtler, Michael" sort="St Dtler, Michael" uniqKey="St Dtler M" first="Michael" last="St Dtler">Michael St Dtler</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Neurology, Technische Universität Miinchen</s1>
<s2>Munich</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Valet, Michael" sort="Valet, Michael" uniqKey="Valet M" first="Michael" last="Valet">Michael Valet</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Neurology, Technische Universität Miinchen</s1>
<s2>Munich</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Zimmer, Claus" sort="Zimmer, Claus" uniqKey="Zimmer C" first="Claus" last="Zimmer">Claus Zimmer</name>
<affiliation><inist:fA14 i1="03"><s1>Department of Neuroradiology, Technische Universität Miinchen</s1>
<s2>Munich</s2>
<s3>DEU</s3>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Kassubek, Jan" sort="Kassubek, Jan" uniqKey="Kassubek J" first="Jan" last="Kassubek">Jan Kassubek</name>
<affiliation><inist:fA14 i1="05"><s1>Department of Neurology, University of Uim</s1>
<s2>Ulm</s2>
<s3>DEU</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Peinemann, Alexander" sort="Peinemann, Alexander" uniqKey="Peinemann A" first="Alexander" last="Peinemann">Alexander Peinemann</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Neurology, Technische Universität Miinchen</s1>
<s2>Munich</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2007">2007</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Huntington disease</term>
<term>Morphometry</term>
<term>Nervous system diseases</term>
<term>Voxel</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term>
<term>Chorée Huntington</term>
<term>Voxel</term>
<term>Morphométrie</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">In Huntington's disease (HD), the distribution of pathological changes throughout the brain is incompletely understood. Some studies have identified leftward-biased lateralization, whereas others did not. We performed magnetic resonance imaging and a voxel-based asymmetry analysis in 44 right-handed HD gene carriers (presymptomatic, n = 5; stage I, n = 28; stage II, n = 11) and 44 right-handed healthy controls. The group comparison revealed leftward-biased gray matter loss in the striatum. Further analyses showed no indication of asymmetry in presymptomatic HD patients but an increase in asymmetry in the course of the HD stages under examination. Our study demonstrates and discusses leftward-biased gray matter loss in HD.</div>
</front>
</TEI>
<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0>
</fA01>
<fA03 i2="1"><s0>Mov. disord.</s0>
</fA03>
<fA05><s2>22</s2>
</fA05>
<fA06><s2>8</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>Striatal gray matter loss in Huntington's disease is leftward biased</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>MÜHLAU (Mark)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>GASER (Christian)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>WOHLSCHLÄGER (Afra M.)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>WEINDL (Adolf)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>STÄDTLER (Michael)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>VALET (Michael)</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>ZIMMER (Claus)</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>KASSUBEK (Jan)</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>PEINEMANN (Alexander)</s1>
</fA11>
<fA14 i1="01"><s1>Department of Neurology, Technische Universität Miinchen</s1>
<s2>Munich</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Department of Psychiatry, University of Jena</s1>
<s2>Jena</s2>
<s3>DEU</s3>
<sZ>2 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Department of Neuroradiology, Technische Universität Miinchen</s1>
<s2>Munich</s2>
<s3>DEU</s3>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Department of Nuclear Medicine, Technische Universität Miinchen</s1>
<s2>Munich</s2>
<s3>DEU</s3>
<sZ>3 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Department of Neurology, University of Uim</s1>
<s2>Ulm</s2>
<s3>DEU</s3>
<sZ>8 aut.</sZ>
</fA14>
<fA20><s1>1169-1173</s1>
</fA20>
<fA21><s1>2007</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>20953</s2>
<s5>354000159429990170</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2007 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>15 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>07-0349122</s0>
</fA47>
<fA60><s1>P</s1>
<s3>CC</s3>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Movement disorders</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>In Huntington's disease (HD), the distribution of pathological changes throughout the brain is incompletely understood. Some studies have identified leftward-biased lateralization, whereas others did not. We performed magnetic resonance imaging and a voxel-based asymmetry analysis in 44 right-handed HD gene carriers (presymptomatic, n = 5; stage I, n = 28; stage II, n = 11) and 44 right-handed healthy controls. The group comparison revealed leftward-biased gray matter loss in the striatum. Further analyses showed no indication of asymmetry in presymptomatic HD patients but an increase in asymmetry in the course of the HD stages under examination. Our study demonstrates and discusses leftward-biased gray matter loss in HD.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B17</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B17G</s0>
</fC02>
<fC02 i1="03" i2="X"><s0>002B17A03</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Système nerveux pathologie</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Chorée Huntington</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Huntington disease</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Corea Huntington</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Voxel</s0>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Voxel</s0>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Voxel</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Morphométrie</s0>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Morphometry</s0>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Morfometría</s0>
<s5>10</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Encéphale pathologie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Maladie héréditaire</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Genetic disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Enfermedad hereditaria</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>41</s5>
</fC07>
<fN21><s1>225</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 07-0349122 INIST</NO>
<ET>Striatal gray matter loss in Huntington's disease is leftward biased</ET>
<AU>MÜHLAU (Mark); GASER (Christian); WOHLSCHLÄGER (Afra M.); WEINDL (Adolf); STÄDTLER (Michael); VALET (Michael); ZIMMER (Claus); KASSUBEK (Jan); PEINEMANN (Alexander)</AU>
<AF>Department of Neurology, Technische Universität Miinchen/Munich/Allemagne (1 aut., 3 aut., 4 aut., 5 aut., 6 aut., 9 aut.); Department of Psychiatry, University of Jena/Jena/Allemagne (2 aut.); Department of Neuroradiology, Technische Universität Miinchen/Munich/Allemagne (3 aut., 7 aut.); Department of Nuclear Medicine, Technische Universität Miinchen/Munich/Allemagne (3 aut.); Department of Neurology, University of Uim/Ulm/Allemagne (8 aut.)</AF>
<DT>Publication en série; Courte communication, note brève; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2007; Vol. 22; No. 8; Pp. 1169-1173; Bibl. 15 ref.</SO>
<LA>Anglais</LA>
<EA>In Huntington's disease (HD), the distribution of pathological changes throughout the brain is incompletely understood. Some studies have identified leftward-biased lateralization, whereas others did not. We performed magnetic resonance imaging and a voxel-based asymmetry analysis in 44 right-handed HD gene carriers (presymptomatic, n = 5; stage I, n = 28; stage II, n = 11) and 44 right-handed healthy controls. The group comparison revealed leftward-biased gray matter loss in the striatum. Further analyses showed no indication of asymmetry in presymptomatic HD patients but an increase in asymmetry in the course of the HD stages under examination. Our study demonstrates and discusses leftward-biased gray matter loss in HD.</EA>
<CC>002B17; 002B17G; 002B17A03</CC>
<FD>Système nerveux pathologie; Chorée Huntington; Voxel; Morphométrie</FD>
<FG>Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Maladie héréditaire; Système nerveux central pathologie</FG>
<ED>Nervous system diseases; Huntington disease; Voxel; Morphometry</ED>
<EG>Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Genetic disease; Central nervous system disease</EG>
<SD>Sistema nervioso patología; Corea Huntington; Voxel; Morfometría</SD>
<LO>INIST-20953.354000159429990170</LO>
<ID>07-0349122</ID>
</server>
</inist>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/PascalFrancis/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001637 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PascalFrancis/Corpus/biblio.hfd -nk 001637 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= PascalFrancis |étape= Corpus |type= RBID |clé= Pascal:07-0349122 |texte= Striatal gray matter loss in Huntington's disease is leftward biased }}
This area was generated with Dilib version V0.6.23. |