Distinct Patterns of Regional Cerebral Glucose Metabolism in Parkinson's Disease with and without Mild Cognitive Impairment
Identifieur interne : 000F12 ( PascalFrancis/Checkpoint ); précédent : 000F11; suivant : 000F13Distinct Patterns of Regional Cerebral Glucose Metabolism in Parkinson's Disease with and without Mild Cognitive Impairment
Auteurs : Yoshiyuki Hosokai [Japon] ; Yoshiyuki Nishio [Japon] ; Kazumi Hirayama [Japon] ; Atsushi Takeda [Japon] ; Toshiyuki Ishioka [Japon] ; Yoichi Sawada [Japon] ; Kyoko Suzuki [Japon] ; Yasuto Itoyama [Japon] ; Shoki Takahashi [Japon] ; Hiroshi Fukuda [Japon] ; Etsuro Mori [Japon]Source :
- Movement disorders [ 0885-3185 ] ; 2009.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Glucose.
English descriptors
- KwdEn :
Abstract
There is no consensus with regard to the clinical and neuroimaging characteristics of prodromal dementia in Parkinson's disease (PD). To delineate functional neuroimaging features of PD with mild cognitive impairment (PDMCI) and with no cognitive impairment (PDNC), we compared regional cerebral glucose metabolism (CMRglc) amongst 13 patients with PDMCI, 27 with PDNC, and 13 healthy controls. The PDNC patients had limited areas of hypometabolism in the frontal and occipital cortices. In the PDMCI patients, there were extensive areas of hypometabolism in the posterior cortical regions, including the temporo-parieto-occipital junction, medial parietal, and inferior temporal cortices. The present results suggest that posterior cortical dysfunction is the primary neuroimaging feature of PD patients at risk for dementia.
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Distinct Patterns of Regional Cerebral Glucose Metabolism in Parkinson's Disease with and without Mild Cognitive Impairment</title>
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<author><name sortKey="Nishio, Yoshiyuki" sort="Nishio, Yoshiyuki" uniqKey="Nishio Y" first="Yoshiyuki" last="Nishio">Yoshiyuki Nishio</name>
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<author><name sortKey="Takeda, Atsushi" sort="Takeda, Atsushi" uniqKey="Takeda A" first="Atsushi" last="Takeda">Atsushi Takeda</name>
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<author><name sortKey="Ishioka, Toshiyuki" sort="Ishioka, Toshiyuki" uniqKey="Ishioka T" first="Toshiyuki" last="Ishioka">Toshiyuki Ishioka</name>
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<author><name sortKey="Sawada, Yoichi" sort="Sawada, Yoichi" uniqKey="Sawada Y" first="Yoichi" last="Sawada">Yoichi Sawada</name>
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<author><name sortKey="Suzuki, Kyoko" sort="Suzuki, Kyoko" uniqKey="Suzuki K" first="Kyoko" last="Suzuki">Kyoko Suzuki</name>
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<author><name sortKey="Takahashi, Shoki" sort="Takahashi, Shoki" uniqKey="Takahashi S" first="Shoki" last="Takahashi">Shoki Takahashi</name>
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<author><name sortKey="Fukuda, Hiroshi" sort="Fukuda, Hiroshi" uniqKey="Fukuda H" first="Hiroshi" last="Fukuda">Hiroshi Fukuda</name>
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<s2>Sendai</s2>
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<sZ>10 aut.</sZ>
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<placeName><settlement type="city">Sendai</settlement>
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<orgName type="university">Université du Tōhoku</orgName>
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<author><name sortKey="Mori, Etsuro" sort="Mori, Etsuro" uniqKey="Mori E" first="Etsuro" last="Mori">Etsuro Mori</name>
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<front><div type="abstract" xml:lang="en">There is no consensus with regard to the clinical and neuroimaging characteristics of prodromal dementia in Parkinson's disease (PD). To delineate functional neuroimaging features of PD with mild cognitive impairment (PDMCI) and with no cognitive impairment (PDNC), we compared regional cerebral glucose metabolism (CMRglc) amongst 13 patients with PDMCI, 27 with PDNC, and 13 healthy controls. The PDNC patients had limited areas of hypometabolism in the frontal and occipital cortices. In the PDMCI patients, there were extensive areas of hypometabolism in the posterior cortical regions, including the temporo-parieto-occipital junction, medial parietal, and inferior temporal cortices. The present results suggest that posterior cortical dysfunction is the primary neuroimaging feature of PD patients at risk for dementia.</div>
</front>
</TEI>
<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0>
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<fA03 i2="1"><s0>Mov. disord.</s0>
</fA03>
<fA05><s2>24</s2>
</fA05>
<fA06><s2>6</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>Distinct Patterns of Regional Cerebral Glucose Metabolism in Parkinson's Disease with and without Mild Cognitive Impairment</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>HOSOKAI (Yoshiyuki)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>NISHIO (Yoshiyuki)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>HIRAYAMA (Kazumi)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>TAKEDA (Atsushi)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>ISHIOKA (Toshiyuki)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>SAWADA (Yoichi)</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>SUZUKI (Kyoko)</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>ITOYAMA (Yasuto)</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>TAKAHASHI (Shoki)</s1>
</fA11>
<fA11 i1="10" i2="1"><s1>FUKUDA (Hiroshi)</s1>
</fA11>
<fA11 i1="11" i2="1"><s1>MORI (Etsuro)</s1>
</fA11>
<fA14 i1="01"><s1>Department of Radiological Technology and Science, School of Health Science, Tohoku University</s1>
<s2>Sendai</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Department of Behavioral Neurology and Cognitive Neuroscience, Graduate School of Medicine, Tohoku University</s1>
<s2>Sendai</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Department of Neurology, Graduate School of Medicine, Tohoku University</s1>
<s2>Sendai</s2>
<s3>JPN</s3>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Department of Clinical Neuroscience, Graduate School of Medicine, Yamagata University</s1>
<s2>Yamagata</s2>
<s3>JPN</s3>
<sZ>7 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Department of Diagnostic Radiology, Graduate School of Medicine, Tohoku University</s1>
<s2>Sendai</s2>
<s3>JPN</s3>
<sZ>9 aut.</sZ>
</fA14>
<fA14 i1="06"><s1>Department of Radiology and Nuclear Medicine, Institute of Development, Aging, and Cancer, Tohoku University</s1>
<s2>Sendai</s2>
<s3>JPN</s3>
<sZ>10 aut.</sZ>
</fA14>
<fA20><s1>854-862</s1>
</fA20>
<fA21><s1>2009</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>20953</s2>
<s5>354000186181820090</s5>
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<fA44><s0>0000</s0>
<s1>© 2009 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>32 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>09-0223194</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Movement disorders</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>There is no consensus with regard to the clinical and neuroimaging characteristics of prodromal dementia in Parkinson's disease (PD). To delineate functional neuroimaging features of PD with mild cognitive impairment (PDMCI) and with no cognitive impairment (PDNC), we compared regional cerebral glucose metabolism (CMRglc) amongst 13 patients with PDMCI, 27 with PDNC, and 13 healthy controls. The PDNC patients had limited areas of hypometabolism in the frontal and occipital cortices. In the PDMCI patients, there were extensive areas of hypometabolism in the posterior cortical regions, including the temporo-parieto-occipital junction, medial parietal, and inferior temporal cortices. The present results suggest that posterior cortical dysfunction is the primary neuroimaging feature of PD patients at risk for dementia.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B17</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B17G</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Maladie de Parkinson</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Parkinson disease</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Parkinson enfermedad</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Déficit cognitif léger</s0>
<s2>NM</s2>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>mild cognitive impairment</s0>
<s2>NM</s2>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Disturbio cognitivo ligero</s0>
<s2>NM</s2>
<s5>02</s5>
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<s5>04</s5>
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<s5>04</s5>
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<s5>04</s5>
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<s2>NK</s2>
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<fC03 i1="06" i2="X" l="ENG"><s0>Glucose</s0>
<s2>NK</s2>
<s5>10</s5>
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<fC03 i1="06" i2="X" l="SPA"><s0>Glucosa</s0>
<s2>NK</s2>
<s5>10</s5>
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<fC03 i1="07" i2="X" l="FRE"><s0>Métabolisme</s0>
<s5>11</s5>
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<s5>11</s5>
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<s5>11</s5>
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<s5>12</s5>
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<fC03 i1="08" i2="X" l="ENG"><s0>Emission tomography</s0>
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<fC03 i1="08" i2="X" l="SPA"><s0>Tomocentelleografía</s0>
<s5>12</s5>
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<s5>13</s5>
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<s5>13</s5>
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<s5>38</s5>
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<s5>38</s5>
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<fC07 i1="03" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
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<fC07 i1="05" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>41</s5>
</fC07>
<fN21><s1>166</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
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</pA>
</standard>
</inist>
<affiliations><list><country><li>Japon</li>
</country>
<region><li>Région de Tōhoku</li>
</region>
<settlement><li>Sendai</li>
</settlement>
<orgName><li>Université du Tōhoku</li>
</orgName>
</list>
<tree><country name="Japon"><region name="Région de Tōhoku"><name sortKey="Hosokai, Yoshiyuki" sort="Hosokai, Yoshiyuki" uniqKey="Hosokai Y" first="Yoshiyuki" last="Hosokai">Yoshiyuki Hosokai</name>
</region>
<name sortKey="Fukuda, Hiroshi" sort="Fukuda, Hiroshi" uniqKey="Fukuda H" first="Hiroshi" last="Fukuda">Hiroshi Fukuda</name>
<name sortKey="Hirayama, Kazumi" sort="Hirayama, Kazumi" uniqKey="Hirayama K" first="Kazumi" last="Hirayama">Kazumi Hirayama</name>
<name sortKey="Hosokai, Yoshiyuki" sort="Hosokai, Yoshiyuki" uniqKey="Hosokai Y" first="Yoshiyuki" last="Hosokai">Yoshiyuki Hosokai</name>
<name sortKey="Ishioka, Toshiyuki" sort="Ishioka, Toshiyuki" uniqKey="Ishioka T" first="Toshiyuki" last="Ishioka">Toshiyuki Ishioka</name>
<name sortKey="Itoyama, Yasuto" sort="Itoyama, Yasuto" uniqKey="Itoyama Y" first="Yasuto" last="Itoyama">Yasuto Itoyama</name>
<name sortKey="Mori, Etsuro" sort="Mori, Etsuro" uniqKey="Mori E" first="Etsuro" last="Mori">Etsuro Mori</name>
<name sortKey="Nishio, Yoshiyuki" sort="Nishio, Yoshiyuki" uniqKey="Nishio Y" first="Yoshiyuki" last="Nishio">Yoshiyuki Nishio</name>
<name sortKey="Sawada, Yoichi" sort="Sawada, Yoichi" uniqKey="Sawada Y" first="Yoichi" last="Sawada">Yoichi Sawada</name>
<name sortKey="Suzuki, Kyoko" sort="Suzuki, Kyoko" uniqKey="Suzuki K" first="Kyoko" last="Suzuki">Kyoko Suzuki</name>
<name sortKey="Suzuki, Kyoko" sort="Suzuki, Kyoko" uniqKey="Suzuki K" first="Kyoko" last="Suzuki">Kyoko Suzuki</name>
<name sortKey="Takahashi, Shoki" sort="Takahashi, Shoki" uniqKey="Takahashi S" first="Shoki" last="Takahashi">Shoki Takahashi</name>
<name sortKey="Takeda, Atsushi" sort="Takeda, Atsushi" uniqKey="Takeda A" first="Atsushi" last="Takeda">Atsushi Takeda</name>
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